{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T07:56:02Z","timestamp":1784793362736,"version":"3.55.0"},"reference-count":42,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:00:00Z","timestamp":1644969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA118493 and R01CA118493 Supplement"],"award-info":[{"award-number":["R01CA118493 and R01CA118493 Supplement"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Cutaneous melanoma (CM) has consistently been associated with intermittent sun exposure, while the association with chronic sun exposure is debated. The goal of this research was to examine the complex relationship between CM, sun sensitivity and sun exposure based on theoretical concepts of how these factors may be associated. Detailed sun exposure histories across life periods and various measures of sun sensitivity were collected in a population-based case\u2013control study of melanoma in Iowa, USA. Participants were asked about their hours of sun exposure per day between March and October each year over periods or decades of life to estimate cumulative lifetime hours of sun exposure. Increased odds ratios (ORs) for CM were seen for most standard measures of sun sensitivity except for the tendency to sunburn. Minimal associations were seen with total hours of sun exposure early in life. However, an interaction was seen between fair skin color and lifetime hours of sun exposure, where the strongest associations with CM were seen among medium-skinned and dark-skinned participants. This suggests that cumulative sun exposure at high levels may increase CM among non-sun-sensitive individuals typically at lower risk of CM. Such a finding has implications for the prevention effort for melanoma regarding time in the sun among darker-skinned individuals.<\/jats:p>","DOI":"10.3390\/cancers14041008","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T20:26:41Z","timestamp":1645043201000},"page":"1008","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cumulative Sun Exposure and Melanoma in a Population-Based Case\u2013Control Study: Does Sun Sensitivity Matter?"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9943-580X","authenticated-orcid":false,"given":"Leslie K.","family":"Dennis","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA"},{"name":"Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,16]]},"reference":[{"key":"ref_1","unstructured":"U.S. Department of Health and Human Services (2014). The Surgeon General\u2019s Call to Action to Prevent Skin Cancer."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ward, W.H., and Farma, J.M. (2017). Epidemiology of Melanoma. Cutaneous Melanoma: Etiology and Therapy, Codon Publications.","DOI":"10.15586\/codon.cutaneousmelanoma.2017"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-2133.2004.05708.x","article-title":"Global perspectives of contemporary epidemiological trends of cutaneous malignant melanoma","volume":"150","author":"Lens","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1016\/j.ejca.2004.06.003","article-title":"Cutaneous malignant melanoma in Europe","volume":"40","author":"Coebergh","year":"2004","journal-title":"Eur. J. Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/j.1365-2133.2006.07163.x","article-title":"Comparative analysis of incidence and clinical features of cutaneous malignant melanoma in Crete (Greece) and southern Germany (central Baden-Wurttemberg)","volume":"154","author":"Lasithiotakis","year":"2006","journal-title":"Br. J. Dermatol."},{"key":"ref_6","unstructured":"Howlader, N.A., Krapcho, M., Miller, D., Brest, A., Yu, M., Ruhl, J., Tatalovich, Z., Mariotto, A., Lewis, D.R., and Chen, H.S. (2022, February 13). SEER Cancer Statistics Review, 1975\u20132017, Available online: https:\/\/seer.cancer.gov\/csr\/1975_2017\/."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.canep.2017.04.004","article-title":"Sun exposure and skin cancer, and the puzzle of cutaneous melanoma: A perspective on Fears et al. Mathematical Models of Age and Ultraviolet Effects on the Incidence of Skin Cancer among Whites in the United States. American Journal of Epidemiology 1977; 105: 420\u2013427","volume":"48","author":"Armstrong","year":"2017","journal-title":"Cancer Epidemiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejca.2004.10.016","article-title":"Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure","volume":"41","author":"Gandini","year":"2005","journal-title":"Eur. J. Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/j.1440-0960.1997.tb01000.x","article-title":"Sun exposure and skin cancer","volume":"38","author":"Armstrong","year":"1997","journal-title":"Australas. J. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.ejca.2005.03.034","article-title":"Meta-analysis of risk factors for cutaneous melanoma: III. Family history, actinic damage and phenotypic factors","volume":"41","author":"Gandini","year":"2005","journal-title":"Eur. J. Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.annepidem.2008.04.006","article-title":"Sunburns and risk of cutaneous melanoma: Does age matter? A comprehensive meta-analysis","volume":"18","author":"Dennis","year":"2008","journal-title":"Ann. Epidemiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/(SICI)1097-0215(19971009)73:2<198::AID-IJC6>3.0.CO;2-R","article-title":"Melanoma and sun exposure: An overview of published studies","volume":"73","author":"Elwood","year":"1997","journal-title":"Int. J. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/00008390-199904000-00013","article-title":"Cutaneous malignant melanoma and sun exposure in Spain","volume":"9","year":"1999","journal-title":"Melanoma Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1097\/00001648-200109000-00015","article-title":"Occupational sunlight exposure and cancer incidence among Swedish construction workers","volume":"12","author":"Hakansson","year":"2001","journal-title":"Epidemiology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/j.1524-4725.1988.tb03588.x","article-title":"Epidemiology of malignant melanoma: Intermittent or total accumulated exposure to the sun?","volume":"14","author":"Armstrong","year":"1988","journal-title":"J. Dermatol. Surg. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/BF00052747","article-title":"A theory of site distribution of melanomas: Queensland, Australia","volume":"3","author":"Green","year":"1992","journal-title":"Cancer Causes Control"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/(SICI)1097-0215(19980911)77:6<843::AID-IJC8>3.0.CO;2-U","article-title":"p53 expression and risk factors for cutaneous melanoma: A case-control study","volume":"77","author":"Whiteman","year":"1998","journal-title":"Int. J. Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/jnci\/95.11.806","article-title":"Melanocytic nevi, solar keratoses, and divergent pathways to cutaneous melanoma","volume":"95","author":"Whiteman","year":"2003","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/BF00051303","article-title":"Sun exposure, pigmentary traits, and risk of cutaneous malignant melanoma: A case-control study in a Mediterranean population","volume":"7","author":"Rodenas","year":"1996","journal-title":"Cancer Causes Control"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/978-3-642-82641-2_3","article-title":"The causes of malignant melanoma: Results from the West Australian Lions Melanoma Research Project","volume":"102","author":"Holman","year":"1986","journal-title":"Recent Results Cancer Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1001\/jamadermatol.2018.1774","article-title":"Sunscreen Use and Melanoma Risk Among Young Australian Adults","volume":"154","author":"Watts","year":"2018","journal-title":"JAMA Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s10552-008-9130-0","article-title":"Risk associations of melanoma in a Southern European population: Results of a case\/control study","volume":"19","author":"Nikolaou","year":"2008","journal-title":"Cancer Causes Control"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1136\/oem.2004.018374","article-title":"Increased incidence of cutaneous malignant melanoma among longshoremen in Genoa, Italy: The role of sunlight and occupational exposure","volume":"62","author":"Puntoni","year":"2005","journal-title":"Occup. Environ. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1468-3083.2009.03353.x","article-title":"Smoking, sun exposure, number of nevi and previous neoplasias are risk factors for melanoma in older patients (60 years and over)","volume":"24","author":"Nagore","year":"2010","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/jdv.12488","article-title":"Ultraviolet exposure and risk of melanoma and basal cell carcinoma in Ulm and Dresden, Germany","volume":"29","author":"Kaskel","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/oxfordjournals.aje.a117092","article-title":"Case-control study of malignant melanoma in Washington State. I. Constitutional factors and sun exposure","volume":"139","author":"White","year":"1994","journal-title":"Am. J. Epidemiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1093\/oxfordjournals.aje.a114140","article-title":"An inquiry into the epidemiology of melanoma","volume":"122","author":"Graham","year":"1985","journal-title":"Am. J. Epidemiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2188\/jea.JE20160166","article-title":"Patterns of Ultraviolet Radiation Exposure and Skin Cancer Risk: The E3N-SunExp Study","volume":"28","author":"Savoye","year":"2018","journal-title":"J. Epidemiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/00008390-199812000-00013","article-title":"Parallel risk assessment of melanoma and basal cell carcinoma: Skin characteristics and sun exposure","volume":"8","author":"Rosso","year":"1998","journal-title":"Melanoma Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"284","DOI":"10.2340\/00015555-1078","article-title":"Polymorphisms of GSTM1 and GSTT1, sun exposure and the risk of melanoma: A case-control study","volume":"91","author":"Fortes","year":"2011","journal-title":"Acta Derm. Venereol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1158\/1055-9965.EPI-09-1249","article-title":"Indoor tanning and risk of melanoma: A case-control study in a highly exposed population","volume":"19","author":"Lazovich","year":"2010","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.ejca.2010.10.008","article-title":"Relationship between sun exposure and melanoma risk for tumours in different body sites in a large case-control study in a temperate climate","volume":"47","author":"Chang","year":"2011","journal-title":"Eur. J. Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/ijc.2910350403","article-title":"Cutaneous melanoma in relation to intermittent and constant sun exposure--the Western Canada Melanoma Study","volume":"35","author":"Elwood","year":"1985","journal-title":"Int. J. Cancer"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.annepidem.2007.09.003","article-title":"Cutaneous melanoma and obesity in the Agricultural Health Study","volume":"18","author":"Dennis","year":"2008","journal-title":"Ann. Epidemiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1046\/j.1365-4362.2001.01132.x","article-title":"Risk factors for cutaneous melanoma: A case-control study in Argentina","volume":"40","author":"Loria","year":"2001","journal-title":"Int. J. Dermatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ejca.2003.09.030","article-title":"Exposure to the sun and sunbeds and the risk of cutaneous melanoma in the UK: A case-control study","volume":"40","author":"Bataille","year":"2004","journal-title":"Eur. J. Cancer"},{"key":"ref_37","first-page":"418","article-title":"Risk factors in elderly people for lentigo maligna compared with other melanomas: A double case-control study","volume":"145","author":"Madjlessi","year":"2009","journal-title":"Arch. Dermatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/bjc.1986.10","article-title":"Malignant melanoma in relation to moles, pigmentation, and exposure to fluorescent and other lighting sources","volume":"53","author":"Elwood","year":"1986","journal-title":"Br. J. Cancer"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1289\/ehp.93101252","article-title":"Effect of intermittent exposure to sunlight on melanoma risk among indoor workers and sun-sensitive individuals","volume":"101","author":"Nelemans","year":"1993","journal-title":"Environ. Health Perspect."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1001\/archderm.1988.01670060015008","article-title":"The validity and practicality of sun-reactive skin types I through VI","volume":"124","author":"Fitzpatrick","year":"1988","journal-title":"Arch. Dermatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1001\/jamadermatol.2020.4616","article-title":"UV Exposure and the Risk of Cutaneous Melanoma in Skin of Color: A Systematic Review","volume":"157","author":"Lopes","year":"2021","journal-title":"JAMA Dermatol."},{"key":"ref_42","first-page":"1","article-title":"Sun Sensitivity and Sunburns as Related to Cutaneous Melanoma among Populations of Spanish Descent: A Meta-Analysis","volume":"1","author":"Dennis","year":"2015","journal-title":"J. Dermatol. Res. Ther."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/4\/1008\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:21:11Z","timestamp":1760134871000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/4\/1008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,16]]},"references-count":42,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["cancers14041008"],"URL":"https:\/\/doi.org\/10.3390\/cancers14041008","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,16]]}}}