{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T10:33:51Z","timestamp":1769510031846,"version":"3.49.0"},"reference-count":30,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kyowa Kirin International (United Kingdom)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The Naloxegol Cancer Study (NACASY) was a multinational European study aimed to evaluate the 4-week safety and efficacy of naloxegol in a real-world setting in patients with cancer pain diagnosed with opioid-induced constipation. The primary safety endpoint was the incidence of adverse events leading to study discontinuation. We recruited 170 patients who received at least one dose of naloxegol (i.e., safety population). Out of 170 patients, 20 (11.8%, 95%CI 6.9\u201316.6) discontinued the study due to adverse events, and, of them, 12 (7.1%, 95%CI 3.2\u201310.9%) were study discontinuations due to naloxegol-related adverse events. From 76 patients subjects who had completed both 4 weeks of treatment and 28 days of the diary, 55 patients (72.4%, 95% CI 62.3\u201382.4%) were regarded as responders (i.e., showed \u22653 bowel-movements per week and an increase of \u22651 bowel-movement over baseline) to naloxegol treatment. The Patient Assessment of Constipation\u2014Quality of Life Questionnaire total score and all its subscales improved from baseline to 4 weeks of follow up. Our findings support and provide new evidence about the beneficial effect of naloxegol in terms of improvement of constipation and quality-of-life in patients with cancer-related pain and opioid-induced constipation and show a safety profile consistent with previous pivotal and real-world studies.<\/jats:p>","DOI":"10.3390\/cancers14051128","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T09:34:38Z","timestamp":1645608878000},"page":"1128","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A Prospective, Real-World, Multinational Study of Naloxegol for Patients with Cancer Pain Diagnosed with Opioid-Induced Constipation\u2014The NACASY Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4207-4799","authenticated-orcid":false,"given":"Andrew","family":"Davies","sequence":"first","affiliation":[{"name":"Trinity College Dublin, University College Dublin, Our Lady\u2019s Hospice Dublin\u2019, D6W RY72 Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saverio","family":"Cinieri","sequence":"additional","affiliation":[{"name":"Medical Oncology, ASL Brindisi\u2013P.O. \u201cA. Perrino\u201d, 72100 Brindisi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1777-2130","authenticated-orcid":false,"given":"Denis","family":"Dupoiron","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Anesth\u00e9sie\u2013Douleur, Institut de Cancerologie de l\u2019Ouest\u2013Site Paul Papin, 49055 Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7825-0734","authenticated-orcid":false,"given":"Sofia","family":"Espa\u00f1a Fernandez","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Institut Catal\u00e0 d\u2019Oncologia-Badalona, 08916 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Leclerc","sequence":"additional","affiliation":[{"name":"Doleur, CHU Amiens Picardie, 80054 Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Montesarchio","sequence":"additional","affiliation":[{"name":"UOC Ongologia, A.O.R.N. dei Colli\u2013Monaldi\u2013Coutgno\u2013C.T.O. Hospitals, 80131 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyriaki","family":"Mystakidou","sequence":"additional","affiliation":[{"name":"Palliative Care Unit \u201cJenny Karezi\u201d, School of Medicine, University of Athens, 11526 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Serna","sequence":"additional","affiliation":[{"name":"Hospital Universitari Vall D\u2019hebron, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Tack","sequence":"additional","affiliation":[{"name":"University Hospital Gasthuisberg, 3000 Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the NACASY Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.2217\/fon-2016-0423","article-title":"Cancer pain: A review of epidemiology, clinical quality and value impact","volume":"13","author":"Neufeld","year":"2017","journal-title":"Future Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"iv166","DOI":"10.1093\/annonc\/mdy152","article-title":"Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines","volume":"29","author":"Fallon","year":"2018","journal-title":"Ann. 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