{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:59:29Z","timestamp":1790812769474,"version":"4.1.0"},"reference-count":68,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PID2020-114871RB-I00"],"award-info":[{"award-number":["PID2020-114871RB-I00"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/01363"],"award-info":[{"award-number":["PI20\/01363"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CIBERES","award":["CB06\/06\/0027"],"award-info":[{"award-number":["CB06\/06\/0027"]}]},{"name":"PROMETEO Generalitat Valenciana","award":["2017\/023\/UV"],"award-info":[{"award-number":["2017\/023\/UV"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Paclitaxel is a microtubule-stabilizing chemotherapeutic agent. Despite its widespread use, it damages healthy tissues such as skin. The goal of this study was to prove that the real impact of paclitaxel-induced skin toxicity could be underestimated because the adverse events might appear asymptomatic. Methods: Gynecological cancer patients were recruited. Skin parameters measurements were taken after three and six paclitaxel cycles. Measurements were conducted using specific probes which measure hydration, transepidermal water loss (TEWL), sebum, elasticity and firmness, erythema, roughness, smoothness, skin thickness, and desquamation levels. Further, a 3D epidermis model was incubated with paclitaxel to analyze gene and protein expression of aquaporin 3, collagen type 1, elastin, and fibronectin. Results: Paclitaxel induced alterations in the skin parameters with no visible clinical manifestations. Gynecological cancer patients under paclitaxel treatment had a decrease in hydration, TEWL, sebum, elasticity, and thickness of the skin, while erythema, roughness, and desquamation were increased. The molecular markers, related to hydration and the support of the skin layers, and analyzed in the 3D epidermis model, were decreased. Conclusions: Results suggest that paclitaxel modifies gene and protein expression of skin-related molecular markers, and impairs different physical, physiological, and biomechanical properties of the skin of cancer patients at a subclinical level.<\/jats:p>","DOI":"10.3390\/cancers14051146","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T09:34:38Z","timestamp":1645608878000},"page":"1146","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Paclitaxel Induces Epidermal Molecular Changes and Produces Subclinical Alterations in the Skin of Gynecological Cancer Patients"],"prefix":"10.3390","volume":"14","author":[{"given":"Paula","family":"Montero","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1313-3449","authenticated-orcid":false,"given":"Mart\u00edn","family":"P\u00e9rez-Leal","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Universidad Europea de Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Alejandro","family":"P\u00e9rez-Fidalgo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hospital Cl\u00ednico Universitario de Valencia, 46010 Valencia, Spain"},{"name":"Biomedical Research Networking Centre on Cancer (CIBERONC), Health Institute Carlos III, 28029 Madrid, Spain"},{"name":"INCLIVA Biomedical Research Institute, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Sanz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain"},{"name":"Health Sciences, Pre-Departmental Section of Medicine, Jaume I University of Castell\u00f3n de la Plana, 12071 Castell\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Estornut","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Roger","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain"},{"name":"Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Health Institute Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Milara","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain"},{"name":"Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Health Institute Carlos III, 28029 Madrid, Spain"},{"name":"Pharmacy Unit, University General Hospital Consortium, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3806-3691","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Cervantes","sequence":"additional","affiliation":[{"name":"INCLIVA Biomedical Research Institute, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Cortijo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain"},{"name":"Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Health Institute Carlos III, 28029 Madrid, Spain"},{"name":"Research and Teaching Unit, University General Hospital Consortium, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,23]]},"reference":[{"key":"ref_1","unstructured":"Lattime, E.C., and Gerson, S.L. (2014). Chapter 12\u2014Selectively replicating oncolytic adenoviruses combined with chemotherapy, radiotherapy, or molecular targeted therapy for treatment of human cancers. Gene Therapy of Cancer, Academic Press. [3rd ed.]."},{"key":"ref_2","unstructured":"Brittain, H.G. (2019). Chapter Three\u2014Paclitaxel. Profiles of Drug Substances, Excipients and Related Methodology, Academic Press."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1517\/14656566.3.6.755","article-title":"Paclitaxel in cancer therapy","volume":"3","author":"Mekhail","year":"2002","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1002\/1097-0142(20000601)88:11<2619::AID-CNCR26>3.0.CO;2-J","article-title":"Paclitaxel-induced cell death: Where the cell cycle and apoptosis come together","volume":"88","author":"Wang","year":"2000","journal-title":"Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199601043340101","article-title":"Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer","volume":"334","author":"McGuire","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/jnci\/92.9.699","article-title":"Randomized intergroup trial of cisplatin-paclitaxel versus cisplatin-cyclophosphamide in women with advanced epithelial ovarian cancer: Three-year results","volume":"92","author":"Piccart","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ygyno.2005.10.036","article-title":"Phase II trial of weekly paclitaxel (80 mg\/m2) in platinum and paclitaxel-resistant ovarian and primary peritoneal cancers: A Gynecologic Oncology Group study","volume":"101","author":"Markman","year":"2006","journal-title":"Gynecol. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s11658-019-0164-y","article-title":"Progress in research on paclitaxel and tumor immunotherapy","volume":"24","author":"Zhu","year":"2019","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1038\/sj.bjc.6601496","article-title":"The taxanes: Toxicity and quality of life considerations in advanced ovarian cancer","volume":"89","author":"Guastalla","year":"2003","journal-title":"Br. J. Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.2165\/00002018-200023050-00005","article-title":"Risks and benefits of taxanes in breast and ovarian cancer","volume":"23","author":"Michaud","year":"2000","journal-title":"Drug Saf."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"113121","DOI":"10.1016\/j.expneurol.2019.113121","article-title":"Pathogenesis of paclitaxel-induced peripheral neuropathy: A current review of in vitro and in vivo findings using rodent and human model systems","volume":"324","author":"Staff","year":"2020","journal-title":"Exp. Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1001\/jamadermatol.2018.3465","article-title":"Evaluation of Prevention Interventions for Taxane-Induced Dermatologic Adverse Events: A Systematic Review","volume":"154","author":"Marks","year":"2018","journal-title":"JAMA Dermatol."},{"key":"ref_13","first-page":"61","article-title":"Photodistributed erythema multiforme: Paclitaxel-related, photosensitive conditions in patients with cancer","volume":"8","author":"Cohen","year":"2009","journal-title":"J. Drugs Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1684\/ejd.2016.2833","article-title":"Dermatological adverse events with taxane chemotherapy","volume":"26","author":"Sibaud","year":"2016","journal-title":"Eur. J. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/00000421-200212000-00015","article-title":"Acral erythrodysesthesia syndrome caused by intravenous infusion of docetaxel in breast cancer","volume":"25","author":"Eich","year":"2002","journal-title":"Am. J. Clin. Oncol."},{"key":"ref_16","first-page":"188","article-title":"Paclitaxel-induced cutaneous change mimicking malignancy in a previous cutaneous eruption","volume":"51","author":"Caballero","year":"2018","journal-title":"Rev. Esp. Patol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/jdv.13475","article-title":"Taxanes-induced cutaneous eruption: Another histopathologic mimicker of malignancy","volume":"30","author":"Machan","year":"2016","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_18","first-page":"965","article-title":"IFN-gamma enhances paclitaxel-induced apoptosis that is modulated by activation of caspases 8 and 3 with a concomitant down regulation of the AKT survival pathway in cultured human keratinocytes","volume":"13","author":"Hokeness","year":"2005","journal-title":"Oncol. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"E2189","DOI":"10.1073\/pnas.1525096113","article-title":"Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish","volume":"113","author":"Lisse","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1038\/s41598-020-60990-8","article-title":"Paclitaxel-induced peripheral neuropathy is caused by epidermal ROS and mitochondrial damage through conserved MMP-13 activation","volume":"10","author":"Cirrincione","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e15511","DOI":"10.1200\/JCO.2020.38.15_suppl.e15511","article-title":"Mechanisms of skin toxicity of paclitaxel: An in vitro preclinical assessment","volume":"38","author":"Cervantes","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1046\/j.1523-1747.1999.00573.x","article-title":"Organotypic keratinocyte cocultures in defined medium with regular epidermal morphogenesis and differentiation","volume":"112","author":"Stark","year":"1999","journal-title":"J. Investig. Dermatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.tiv.2017.03.010","article-title":"A new reconstructed human epidermis for in vitro skin irritation testing","volume":"42","author":"Catarino","year":"2017","journal-title":"Toxicol. In Vitro"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/bs.mie.2015.07.015","article-title":"In Vitro Model of the Epidermis: Connecting Protein Function to 3D Structure","volume":"569","author":"Arnette","year":"2016","journal-title":"Methods Enzymol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1111\/1523-1747.ep12540324","article-title":"Methods for Cultivation of Keratinocytes with an Air-Liquid Interface","volume":"81","author":"Woodley","year":"1983","journal-title":"J. Investig. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Lamb, R., and Ambler, C.A. (2013). Keratinocytes propagated in serum-free, feeder-free culture conditions fail to form stratified epidermis in a reconstituted skin model. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0052494"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.3390\/ijms14034684","article-title":"Irradiated human dermal fibroblasts are as efficient as mouse fibroblasts as a feeder layer to improve human epidermal cell culture lifespan","volume":"14","author":"Bisson","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/srt.12037","article-title":"International guidelines for the in vivo assessment of skin properties in non-clinical settings: Part 2. transepidermal water loss and skin hydration","volume":"19","author":"Plessis","year":"2013","journal-title":"Skin Res. Technol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/srt.12256","article-title":"Skin characteristics: Normative data for elasticity, erythema, melanin, and thickness at 16 different anatomical locations","volume":"22","author":"Nedelec","year":"2016","journal-title":"Skin Res. Technol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/ics.12068","article-title":"Skin physiology in men and women: In vivo evaluation of 300 people including TEWL, SC hydration, sebum content and skin surface pH","volume":"35","author":"Luebberding","year":"2013","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000056341","article-title":"EEMCO Guidance for the Assessment of Transepidermal Water Loss in Cosmetic Sciences","volume":"14","author":"Rogiers","year":"2001","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_32","unstructured":"Serup, J., Jemec, G.B.E., and Grove, G.L. (2013). Handbook of Non-Invasive Methods and the Skin, CRC Press. [2nd ed.]."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1111\/jocd.13649","article-title":"Noninvasive evaluation of the influence of aucubin-containing cosmetic macroemulsion on selected skin parameters","volume":"20","author":"Nowak","year":"2021","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/jocd.13305","article-title":"Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial","volume":"19","author":"Rattanawiwatpong","year":"2020","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/1523-1747.ep12465212","article-title":"Barrier function of human keratinocyte cultures grown at the air-liquid interface","volume":"96","author":"Mak","year":"1991","journal-title":"J. Investig. Dermatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1200\/JCO.2001.19.20.4065","article-title":"Mechanism-based pharmacokinetic model for paclitaxel","volume":"19","author":"Henningsson","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1200\/JCO.1995.13.1.180","article-title":"Nonlinear pharmacokinetics and metabolism of paclitaxel and its pharmacokinetic\/pharmacodynamic relationships in humans","volume":"13","author":"Gianni","year":"1995","journal-title":"J. Clin. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/oxfordjournals.annonc.a059349","article-title":"Theoretical and practical aspects of paclitaxel scheduling","volume":"6","author":"Gianni","year":"1995","journal-title":"Ann. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1634\/theoncologist.9-suppl_2-3","article-title":"Preclinical pharmacology of the taxanes: Implications of the differences","volume":"9","author":"Gligorov","year":"2004","journal-title":"Oncologist"},{"key":"ref_40","first-page":"33","article-title":"Skin Hydration Assessment through Modern Non-Invasive Bioengineering Technologies","volume":"9","author":"Constantin","year":"2014","journal-title":"Maedica"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/srt.12167","article-title":"The effects of water exposure on biophysical properties of normal skin","volume":"21","author":"Firooz","year":"2015","journal-title":"Skin Res. Technol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.abb.2011.01.014","article-title":"Aquaporin-3 in keratinocytes and skin: Its role and interaction with phospholipase D2","volume":"508","author":"Qin","year":"2011","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_43","first-page":"s20","article-title":"Hydrating skin by stimulating biosynthesis of aquaporins","volume":"6","author":"Dumas","year":"2007","journal-title":"J. Drugs Dermatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-94-024-1057-0_1","article-title":"Molecular Biology of Aquaporins","volume":"969","author":"Li","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2174\/1574886313666180828163016","article-title":"Taxane Induced Cystoid Macular Edema: Case Report and Integrated Pathogenic Theory","volume":"14","author":"Kanakis","year":"2019","journal-title":"Curr. Drug Saf."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.anndiagpath.2018.02.005","article-title":"Prognostic impact of Apaf-1, Cyclin D1, and AQP-5 in serous ovarian carcinoma treated with the first-line chemotherapy","volume":"35","author":"Abdelrahman","year":"2018","journal-title":"Ann. Diagn. Pathol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"a015370","DOI":"10.1101\/cshperspect.a015370","article-title":"Natural and sun-induced aging of human skin","volume":"5","author":"Fisher","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1177\/0963689717725755","article-title":"Fighting against Skin Aging","volume":"27","author":"Zhang","year":"2018","journal-title":"Cell Transplant."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1194\/jlr.R700013-JLR200","article-title":"Thematic review series: Skin lipids. The role of epidermal lipids in cutaneous permeability barrier homeostasis","volume":"48","author":"Feingold","year":"2007","journal-title":"J. Lipid Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/1523-1747.ep12522718","article-title":"Fibronectin in the skin","volume":"81","author":"Clark","year":"1983","journal-title":"J. Investig. Dermatol."},{"key":"ref_51","first-page":"163","article-title":"Molecular-level insights into aging processes of skin elastin","volume":"128","author":"Schmelzer","year":"2016","journal-title":"Biochimie"},{"key":"ref_52","first-page":"s12","article-title":"The role of elastin and collagen in cutaneous aging: Intrinsic aging versus photoexposure","volume":"7","author":"Uitto","year":"2008","journal-title":"J. Drugs Dermatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejphar.2016.02.059","article-title":"Paclitaxel inhibits cell proliferation and collagen lattice contraction via TGF-\u03b2 signaling pathway in human tenon\u2019s fibroblasts in vitro","volume":"777","author":"Chen","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00417-009-1221-4","article-title":"Paclitaxel inhibits growth, migration and collagen production of human Tenon\u2019s fibroblasts\u2014Potential use in drug-eluting glaucoma drainage devices","volume":"248","author":"Choritz","year":"2010","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-2133.2006.07597.x","article-title":"Taxane-induced scleroderma","volume":"156","author":"Itoh","year":"2007","journal-title":"Br. J. Dermatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e238","DOI":"10.1111\/j.1600-0846.2012.00634.x","article-title":"Use of Cutometer area parameters in evaluating age-related changes in the skin elasticity of the cheek","volume":"19","author":"Ohshima","year":"2013","journal-title":"Skin Res. Technol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1600-0846.2008.00302.x","article-title":"Influence of age and regional differences on skin elasticity as measured by the Cutometer","volume":"14","author":"Ryu","year":"2008","journal-title":"Skin Res. Technol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1600-0846.2009.00363.x","article-title":"Skin-textile friction and skin elasticity in young and aged persons","volume":"15","author":"Gerhardt","year":"2009","journal-title":"Skin Res. Technol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.det.2007.08.006","article-title":"Cutaneous reactions to chemotherapy: Commonly seen, less described, little understood","volume":"26","author":"Sanborn","year":"2008","journal-title":"Dermatol. Clin."},{"key":"ref_60","first-page":"595","article-title":"Periarticular Thenar Erythema and Onycholysis Syndrome: A Manifestation of Taxane-Induced Cutaneous Toxicity","volume":"108","year":"2017","journal-title":"Actas Dermosifiliogr."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1001\/archdermatol.2012.2830","article-title":"Paclitaxel-induced acral erythema","volume":"148","author":"Richards","year":"2012","journal-title":"Arch. Dermatol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4103\/ijp.IJP_547_17","article-title":"Rare occurrence of hand-foot syndrome due to paclitaxel: A rare case report","volume":"50","author":"Kataria","year":"2018","journal-title":"Indian J. Pharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.3109\/00016480802590451","article-title":"Weekly paclitaxel for platin-resistant stage IV head and neck cancer patients","volume":"129","author":"Grau","year":"2009","journal-title":"Acta Otolaryngol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"207084","DOI":"10.1155\/2010\/207084","article-title":"Hypersensitivity reactions associated with platinum antineoplastic agents: A systematic review","volume":"2010","author":"Makrilia","year":"2010","journal-title":"Met. Based Drugs"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1188\/20.CJON.561-565","article-title":"Skin Toxicity: Clinical Summary of the ONS GuidelinesTM for Cancer Treatment-Related Skin Toxicity","volume":"24","author":"Wiley","year":"2020","journal-title":"Clin. J. Oncol. Nurs."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1188\/20.ONF.539-556","article-title":"ONS GuidelinesTM for Cancer Treatment-Related Skin Toxicity","volume":"47","author":"Williams","year":"2020","journal-title":"Oncol. Nurs. Forum"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e13118","DOI":"10.1111\/ecc.13118","article-title":"Prophylactic management for taxane-induced nail toxicity: A systematic review and meta-analysis","volume":"28","author":"Huang","year":"2019","journal-title":"Eur. J. Cancer Care"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1748-717X-7-12","article-title":"Skin toxicity from external beam radiation therapy in breast cancer patients: Protective effects of Resveratrol, Lycopene, Vitamin C and anthocianin (Ixor\u00ae)","volume":"7","author":"Calvanese","year":"2012","journal-title":"Radiat. Oncol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/5\/1146\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:25:26Z","timestamp":1760135126000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/5\/1146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,23]]},"references-count":68,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["cancers14051146"],"URL":"https:\/\/doi.org\/10.3390\/cancers14051146","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,23]]}}}