{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:01:30Z","timestamp":1789189290961,"version":"build-2803163510"},"reference-count":65,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["Horizon2020, 945218"],"award-info":[{"award-number":["Horizon2020, 945218"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>For physicians, it is important to know which treatment outcomes are prioritized overall by older patients with cancer, since this will help them to tailor the amount of information and treatment recommendations. Older patients might prioritize other outcomes than younger patients. Our objective is to summarize which outcomes matter most to older patients with cancer. A systematic review was conducted, in which we searched Embase and Medline on 22 December 2020. Studies were eligible if they reported some form of prioritization of outcome categories relative to each other in patients with all types of cancer and if they included at least three outcome categories. Subsequently, for each study, the highest or second-highest outcome category was identified and presented in relation to the number of studies that included that outcome category. An adapted Newcastle\u2013Ottawa Scale was used to assess the risk of bias. In total, 4374 patients were asked for their priorities in 28 studies that were included. Only six of these studies had a population with a median age above 70. Of all the studies, 79% identified quality of life as the highest or second-highest priority, followed by overall survival (67%), progression- and disease-free survival (56%), absence of severe or persistent treatment side effects (54%), and treatment response (50%). Absence of transient short-term side effects was prioritized in 16%. The studies were heterogeneous considering age, cancer type, and treatment settings. Overall, quality of life, overall survival, progression- and disease-free survival, and severe and persistent side effects of treatment are the outcomes that receive the highest priority on a group level when patients with cancer need to make trade-offs in oncologic treatment decisions.<\/jats:p>","DOI":"10.3390\/cancers14051147","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T22:54:02Z","timestamp":1645656842000},"page":"1147","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Patient Preferences for Treatment Outcomes in Oncology with a Focus on the Older Patient\u2014A Systematic Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9046-8525","authenticated-orcid":false,"given":"Petronella A. L. (Nelleke)","family":"Seghers","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine, Diakonessenhuis, 3582 KE Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Wiersma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Diakonessenhuis, 3582 KE Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Festen","sequence":"additional","affiliation":[{"name":"University Center for Geriatric Medicine, University Medical Hospital Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8491-1407","authenticated-orcid":false,"given":"Mariken E.","family":"Stegmann","sequence":"additional","affiliation":[{"name":"Department of General Practice and Elderly Care Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3244-7299","authenticated-orcid":false,"given":"Pierre","family":"Soubeyran","sequence":"additional","affiliation":[{"name":"Department of Oncology, Institut Bergoni\u00e9, Universit\u00e9 de Bordeaux, 33076 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siri","family":"Rostoft","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Oslo University Hospital, 0424 Oslo, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo, 0318 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9270-2768","authenticated-orcid":false,"given":"Shane","family":"O\u2019Hanlon","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, St. Vincent\u2019s University Hospital, D04 T6F4 Dublin, Ireland"},{"name":"School of Medicine, University College Dublin, D04 V1W8 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanneke E. A.","family":"Portielje","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Leiden University Medical Center-LUMC, 2333 ZA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marije E.","family":"Hamaker","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Diakonessenhuis, 3582 KE Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e305","DOI":"10.1016\/S1470-2045(18)30348-6","article-title":"Geriatric Oncology 2, Functional versus Chronological Age: Geriatric Assessments to Guide Decision Making in Older Patients with Cancer","volume":"19","author":"Li","year":"2018","journal-title":"Lancet Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1200\/JCO.21.00165","article-title":"Decision Making in Older Adults with Cancer","volume":"39","author":"DuMontier","year":"2021","journal-title":"J. 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