{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:31:22Z","timestamp":1790512282176,"version":"4.1.0"},"reference-count":160,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Intercellular communication is essential for tissue homeostasis and function. Understanding how cells interact with each other is paramount, as crosstalk between cells is often dysregulated in diseases and can contribute to their progression. Cells communicate with each other through several modalities, including paracrine secretion and specialized structures ensuring physical contact between them. Among these intercellular specialized structures, tunneling nanotubes (TNTs) are now recognized as a means of cell-to-cell communication through the exchange of cellular cargo, controlled by a variety of biological triggers, as described here. Intercellular communication is fundamental to brain function. It allows the dialogue between the many cells, including neurons, astrocytes, oligodendrocytes, glial cells, microglia, necessary for the proper development and function of the brain. We highlight here the role of TNTs in connecting these cells, for the physiological functioning of the brain and in pathologies such as stroke, neurodegenerative diseases, and gliomas. Understanding these processes could pave the way for future therapies.<\/jats:p>","DOI":"10.3390\/cancers14051207","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T10:00:40Z","timestamp":1645783240000},"page":"1207","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Intercellular Communication in the Brain through Tunneling Nanotubes"],"prefix":"10.3390","volume":"14","author":[{"given":"Khattar E.","family":"Khattar","sequence":"first","affiliation":[{"name":"Institut de G\u00e9nomique Fonctionnelle, University Montpellier, CNRS, INSERM, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Safi","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9nomique Fonctionnelle, University Montpellier, CNRS, INSERM, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5557-8975","authenticated-orcid":false,"given":"Anne-Marie","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"University Paris Est Cr\u00e9teil, INSERM, IMRB, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0183-5953","authenticated-orcid":false,"given":"Marie-Luce","family":"Vignais","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9nomique Fonctionnelle, University Montpellier, CNRS, INSERM, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.4049\/jimmunol.173.3.1511","article-title":"Cutting Edge: Membrane Nanotubes Connect Immune Cells","volume":"173","author":"Nedvetzki","year":"2004","journal-title":"J. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1126\/science.1093133","article-title":"Nanotubular Highways for Intercellular Organelle Transport","volume":"303","author":"Rustom","year":"2004","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/549322a","article-title":"How the Internet of Cells Has Biologists Buzzing","volume":"549","author":"Baker","year":"2017","journal-title":"Nat. News"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3389\/fnmol.2017.00333","article-title":"Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions","volume":"10","author":"Ariazi","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e105789","DOI":"10.15252\/embj.2020105789","article-title":"Peering into Tunneling Nanotubes-The Path Forward","volume":"40","author":"Zurzolo","year":"2021","journal-title":"EMBO J."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Dong, L., Gopalan, V., Holland, O., and Neuzil, J. (2020). Mitocans Revisited: Mitochondrial Targeting as Efficient Anti-Cancer Therapy. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21217941"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.trecan.2017.10.003","article-title":"Mitochondrial Transfer in the Leukemia Microenvironment","volume":"3","author":"Griessinger","year":"2017","journal-title":"Trends Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1042\/BCJ20170712","article-title":"The Role of Metabolism and Tunneling Nanotube-Mediated Intercellular Mitochondria Exchange in Cancer Drug Resistance","volume":"475","author":"Hekmatshoar","year":"2018","journal-title":"Biochem. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.tcb.2020.11.008","article-title":"The Ways of Actin: Why Tunneling Nanotubes Are Unique Cell Protrusions","volume":"31","author":"Ljubojevic","year":"2021","journal-title":"Trends Cell Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"559548","DOI":"10.3389\/fonc.2020.559548","article-title":"A Ticket to Ride: The Implications of Direct Intercellular Communication via Tunneling Nanotubes in Peritoneal and Other Invasive Malignancies","volume":"10","author":"Lou","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s13014-019-1416-8","article-title":"Perspectives of Cellular Communication through Tunneling Nanotubes in Cancer Cells and the Connection to Radiation Effects","volume":"14","author":"Matejka","year":"2019","journal-title":"Radiat. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Nakhle, J., Rodriguez, A.-M., and Vignais, M.-L. (2020). Multifaceted Roles of Mitochondrial Components and Metabolites in Metabolic Diseases and Cancer. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124405"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.trecan.2020.04.012","article-title":"Tunneling Nanotubes: The Fuel of Tumor Progression?","volume":"6","author":"Pinto","year":"2020","journal-title":"Trends Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1080\/15384101.2018.1445906","article-title":"Intercellular Mitochondria Trafficking Highlighting the Dual Role of Mesenchymal Stem Cells as Both Sensors and Rescuers of Tissue Injury","volume":"17","author":"Rodriguez","year":"2018","journal-title":"Cell Cycle"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Valdebenito, S., Lou, E., Baldoni, J., Okafo, G., and Eugenin, E. (2018). The Novel Roles of Connexin Channels and Tunneling Nanotubes in Cancer Pathogenesis. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19051270"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ceb.2021.03.003","article-title":"Tunneling Nanotubes: Reshaping Connectivity","volume":"71","author":"Zurzolo","year":"2021","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.trecan.2017.08.001","article-title":"Imaging Tunneling Membrane Tubes Elucidates Cell Communication in Tumors","volume":"3","author":"Lou","year":"2017","journal-title":"Trends Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.bbadis.2016.12.015","article-title":"Visualization of Prion-like Transfer in Huntington\u2019s Disease Models","volume":"1863","author":"Jansen","year":"2017","journal-title":"Biochim. Biophys. Acta BBA Mol. Basis Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/s41593-018-0238-6","article-title":"Propagation and Spread of Pathogenic Protein Assemblies in Neurodegenerative Diseases","volume":"21","author":"Jucker","year":"2018","journal-title":"Nat. Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-019-01977-2","article-title":"\u03b1-Synuclein and Astrocytes: Tracing the Pathways from Homeostasis to Neurodegeneration in Lewy Body Disease","volume":"138","author":"Sorrentino","year":"2019","journal-title":"Acta Neuropathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/s41467-018-08178-7","article-title":"Correlative Cryo-Electron Microscopy Reveals the Structure of TNTs in Neuronal Cells","volume":"10","author":"Pepe","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6837","DOI":"10.1523\/JNEUROSCI.3532-16.2017","article-title":"Tweety-Homolog 1 Drives Brain Colonization of Gliomas","volume":"37","author":"Jung","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/s41467-021-21117-3","article-title":"Tumor Cell Plasticity, Heterogeneity, and Resistance in Crucial Microenvironmental Niches in Glioma","volume":"12","author":"Jung","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1016\/j.celrep.2019.02.063","article-title":"Modeling Patient-Derived Glioblastoma with Cerebral Organoids","volume":"26","author":"Linkous","year":"2019","journal-title":"Cell Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature16071","article-title":"Brain Tumour Cells Interconnect to a Functional and Resistant Network","volume":"528","author":"Osswald","year":"2015","journal-title":"Nature"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e1181","DOI":"10.1002\/cnr2.1181","article-title":"Tunneling Nanotube-like Structures in Brain Tumors","volume":"2","author":"Osswald","year":"2019","journal-title":"Cancer Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1042\/BCJ20200710","article-title":"Patient-Derived Glioblastoma Stem Cells Transfer Mitochondria through Tunneling Nanotubes in Tumor Organoids","volume":"478","author":"Pinto","year":"2021","journal-title":"Biochem. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1126\/science.aar5555","article-title":"Harmful Networks in the Brain and Beyond","volume":"359","author":"Winkler","year":"2018","journal-title":"Science"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/neuonc\/noaa275","article-title":"Tumor Cell Network Integration in Glioma Represents a Stemness Feature","volume":"23","author":"Xie","year":"2021","journal-title":"Neuro-Oncology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1042\/BCJ20200990","article-title":"Two Routes of Direct Intercellular Communication in Brain Cancer","volume":"478","author":"Winkler","year":"2021","journal-title":"Biochem. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"5779","DOI":"10.4049\/jimmunol.180.9.5779","article-title":"Cutting Edge: Membrane Nanotubes In Vivo: A Feature of MHC Class II+ Cells in the Mouse Cornea","volume":"180","author":"Chinnery","year":"2008","journal-title":"J. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Lou, E., Fujisawa, S., Morozov, A., Barlas, A., Romin, Y., Dogan, Y., Gholami, S., Moreira, A.L., Manova-Todorova, K., and Moore, M.A.S. (2012). Tunneling Nanotubes Provide a Unique Conduit for Intercellular Transfer of Cellular Contents in Human Malignant Pleural Mesothelioma. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0033093"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"9484","DOI":"10.1038\/s41598-018-27649-x","article-title":"Chemotherapy-Induced Tunneling Nanotubes Mediate Intercellular Drug Efflux in Pancreatic Cancer","volume":"8","author":"Desir","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Civita, P., M. Leite, D., and Pilkington, G.J. (2019). Pre-Clinical Drug Testing in 2D and 3D Human In Vitro Models of Glioblastoma Incorporating Non-Neoplastic Astrocytes: Tunneling Nano Tubules and Mitochondrial Transfer Modulates Cell Behavior and Therapeutic Respons. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20236017"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41551-020-00643-3","article-title":"Human Mini-Brain Models","volume":"5","author":"Tan","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/s41551-019-0363-x","article-title":"A Bioprinted Human-Glioblastoma-on-a-Chip for the Identification of Patient-Specific Responses to Chemoradiotherapy","volume":"3","author":"Yi","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e1806590","DOI":"10.1002\/adma.201806590","article-title":"3D-Bioprinted Mini-Brain: A Glioblastoma Model to Study Cellular Interactions and Therapeutics","volume":"31","author":"Heinrich","year":"2019","journal-title":"Adv. Mater."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.3389\/fbioe.2020.582650","article-title":"Mass Generation, Neuron Labeling, and 3D Imaging of Minibrains","volume":"8","author":"Govindan","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_39","first-page":"994","article-title":"Miro1 Regulates Intercellular Mitochondrial Transport & Enhances Mesenchymal Stem Cell Rescue Efficacy","volume":"33","author":"Ahmad","year":"2014","journal-title":"EMBO J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nm.2736","article-title":"Mitochondrial Transfer from Bone-Marrow-Derived Stromal Cells to Pulmonary Alveoli Protects against Acute Lung Injury","volume":"18","author":"Islam","year":"2012","journal-title":"Nat. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e22187","DOI":"10.7554\/eLife.22187","article-title":"Horizontal Transfer of Whole Mitochondria Restores Tumorigenic Potential in Mitochondrial DNA-Deficient Cancer Cells","volume":"6","author":"Dong","year":"2017","journal-title":"eLife"},{"key":"ref_42","first-page":"e61970","article-title":"Transpupillary Two-Photon In Vivo Imaging of the Mouse Retina","volume":"13","author":"Wang","year":"2021","journal-title":"J. Vis. Exp."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41586-020-2589-x","article-title":"Interpericyte Tunnelling Nanotubes Regulate Neurovascular Coupling","volume":"585","author":"Quintero","year":"2020","journal-title":"Nature"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e107264","DOI":"10.15252\/embj.2020107264","article-title":"Photoreceptor Nanotubes Mediate the in Vivo Exchange of Intracellular Material","volume":"40","author":"Yan","year":"2021","journal-title":"EMBO J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e53732","DOI":"10.15252\/embr.202153732","article-title":"Nanotube-like Processes Facilitate Material Transfer between Photoreceptors","volume":"22","author":"Kalargyrou","year":"2021","journal-title":"EMBO Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"16798","DOI":"10.1038\/s41598-021-96332-5","article-title":"Astrocyte-to-Neuron Transportation of Enhanced Green Fluorescent Protein in Cerebral Cortex Requires F-Actin Dependent Tunneling Nanotubes","volume":"11","author":"Chen","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1093\/neuonc\/nox070","article-title":"Tumor Microtubes Convey Resistance to Surgical Lesions and Chemotherapy in Gliomas","volume":"19","author":"Weil","year":"2017","journal-title":"Neuro-Oncology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1182\/blood-2015-07-655860","article-title":"Protective Mitochondrial Transfer from Bone Marrow Stromal Cells to Acute Myeloid Leukemic Cells during Chemotherapy","volume":"128","author":"Moschoi","year":"2016","journal-title":"Blood"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"8547","DOI":"10.1038\/s41598-017-08950-7","article-title":"The Role of Rho-GTPases and Actin Polymerization during Macrophage Tunneling Nanotube Biogenesis","volume":"7","author":"Hanna","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1038\/ncb1990","article-title":"M-Sec Promotes Membrane Nanotube Formation by Interacting with Ral and the Exocyst Complex","volume":"11","author":"Hase","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"7177","DOI":"10.1074\/jbc.RA118.005659","article-title":"The Chaperone ERp29 Is Required for Tunneling Nanotube Formation by Stabilizing MSec","volume":"294","author":"Pergu","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_52","first-page":"767","article-title":"LST1 Promotes the Assembly of a Molecular Machinery Responsible for Tunneling Nanotube Formation","volume":"126","author":"Schiller","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"D\u2019Aloia, A., Arrigoni, E., Costa, B., Berruti, G., Martegani, E., Sacco, E., and Ceriani, M. (2021). RalGPS2 Interacts with Akt and PDK1 Promoting Tunneling Nanotubes Formation in Bladder Cancer and Kidney Cells Microenvironment. Cancers, 13.","DOI":"10.3390\/cancers13246330"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41565-021-01000-4","article-title":"Intercellular Nanotubes Mediate Mitochondrial Trafficking between Cancer and Immune Cells","volume":"17","author":"Saha","year":"2022","journal-title":"Nat. Nanotechnol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"7826","DOI":"10.1038\/s41598-019-44346-5","article-title":"Stress-Induced Tunneling Nanotubes Support Treatment Adaptation in Prostate Cancer","volume":"9","author":"Kretschmer","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"39632","DOI":"10.1038\/srep39632","article-title":"Differential Identity of Filopodia and Tunneling Nanotubes Revealed by the Opposite Functions of Actin Regulatory Complexes","volume":"6","author":"Delage","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1242\/jcs.129239","article-title":"Myo10 Is a Key Regulator of TNT Formation in Neuronal Cells","volume":"126","author":"Gousset","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/cdd.2010.147","article-title":"Tunneling-Nanotube Development in Astrocytes Depends on P53 Activation","volume":"18","author":"Wang","year":"2011","journal-title":"Cell Death Differ."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e101230","DOI":"10.15252\/embj.2018101230","article-title":"The Wnt\/Ca2+ Pathway Is Involved in Interneuronal Communication Mediated by Tunneling Nanotubes","volume":"38","author":"Vargas","year":"2019","journal-title":"EMBO J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"16803","DOI":"10.1038\/s41598-020-74013-z","article-title":"Rab35 and Its Effectors Promote Formation of Tunneling Nanotubes in Neuronal Cells","volume":"10","author":"Bhat","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1242\/jcs.200667","article-title":"Role of Connexin 43 in Different Forms of Intercellular Communication\u2014Gap Junctions, Extracellular Vesicles and Tunnelling Nanotubes","volume":"130","author":"Morel","year":"2017","journal-title":"J. Cell Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/neuonc\/nox207","article-title":"Targeting Different Domains of Gap Junction Protein to Control Malignant Glioma","volume":"20","author":"Wang","year":"2018","journal-title":"Neuro-Oncology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1158\/0008-5472.CAN-18-0773","article-title":"CD38-Driven Mitochondrial Trafficking Promotes Bioenergetic Plasticity in Multiple Myeloma","volume":"79","author":"Marlein","year":"2019","journal-title":"Cancer Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"160057","DOI":"10.1098\/rsob.160057","article-title":"The Missing Link: Does Tunnelling Nanotube-Based Supercellularity Provide a New Understanding of Chronic and Lifestyle Diseases?","volume":"6","author":"Rustom","year":"2016","journal-title":"Open Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s12264-014-1522-4","article-title":"Tunneling Nanotubes between Rat Primary Astrocytes and C6 Glioma Cells Alter Proliferation Potential of Glioma Cells","volume":"31","author":"Zhang","year":"2015","journal-title":"Neurosci. Bull."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1242\/jcs.02507","article-title":"Hydrogen Peroxide Alters Membrane and Cytoskeleton Properties and Increases Intercellular Connections in Astrocytes","volume":"118","author":"Zhu","year":"2005","journal-title":"J. Cell Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1182\/blood-2017-03-772939","article-title":"NADPH Oxidase-2 Derived Superoxide Drives Mitochondrial Transfer from Bone Marrow Stromal Cells to Leukemic Blasts","volume":"130","author":"Marlein","year":"2017","journal-title":"Blood"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.3389\/fonc.2020.01691","article-title":"Influence of \u03b1-Particle Radiation on Intercellular Communication Networks of Tunneling Nanotubes in U87 Glioblastoma Cells","volume":"10","author":"Matejka","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"101450","DOI":"10.1016\/j.isci.2020.101450","article-title":"Tunneling Nanotubes Mediate Adaptation of Glioblastoma Cells to Temozolomide and Ionizing Radiation Treatment","volume":"23","author":"Valdebenito","year":"2020","journal-title":"iScience"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.4049\/jimmunol.1500845","article-title":"Potential Role of the Formation of Tunneling Nanotubes in HIV-1 Spread in Macrophages","volume":"196","author":"Hashimoto","year":"2016","journal-title":"J. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"El Najjar, F., Cifuentes-Mu\u00f1oz, N., Chen, J., Zhu, H., Buchholz, U.J., Moncman, C.L., and Dutch, R.E. (2016). Human Metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005922"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e00749-17","DOI":"10.1128\/JVI.00749-17","article-title":"Pseudorabies Virus US3-Induced Tunneling Nanotubes Contain Stabilized Microtubules, Interact with Neighboring Cells via Cadherins, and Allow Intercellular Molecular Communication","volume":"91","author":"Jansens","year":"2017","journal-title":"J. Virol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1080\/19336896.2016.1223003","article-title":"Tunneling Nanotubes: A Possible Highway in the Spreading of Tau and Other Prion-like Proteins in Neurodegenerative Diseases","volume":"10","author":"Abounit","year":"2016","journal-title":"Prion"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.15252\/embj.201593411","article-title":"Tunneling Nanotubes Spread Fibrillar \u03b1-Synuclein by Intercellular Trafficking of Lysosomes","volume":"35","author":"Abounit","year":"2016","journal-title":"EMBO J."},{"key":"ref_75","first-page":"3678","article-title":"Transfer of Polyglutamine Aggregates in Neuronal Cells Occurs in Tunneling Nanotubes","volume":"126","author":"Costanzo","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s40478-016-0386-4","article-title":"Tunneling Nanotube (TNT)-Mediated Neuron-to Neuron Transfer of Pathological Tau Protein Assemblies","volume":"4","author":"Tardivel","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/19336896.2015.1025189","article-title":"Prion Aggregates Transfer through Tunneling Nanotubes in Endocytic Vesicles","volume":"9","author":"Zhu","year":"2015","journal-title":"Prion"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Konno, T., Melo, E.P., Chambers, J.E., and Avezov, E. (2021). Intracellular Sources of ROS\/H2O2 in Health and Neurodegeneration: Spotlight on Endoplasmic Reticulum. Cells, 10.","DOI":"10.3390\/cells10020233"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41419-020-03355-3","article-title":"The Redox Language in Neurodegenerative Diseases: Oxidative Post-Translational Modifications by Hydrogen Peroxide","volume":"12","author":"Lee","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.4103\/1673-5374.324840","article-title":"Significance of Intercellular Communication for Neurodegenerative Diseases","volume":"17","author":"Cihankaya","year":"2022","journal-title":"Neural Regen. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.expneurol.2016.03.009","article-title":"The Multifaceted Role of Astrocytes in Regulating Myelination","volume":"283","author":"Lindsay","year":"2016","journal-title":"Exp. Neurol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"101128","DOI":"10.1016\/j.arr.2020.101128","article-title":"Inter and Intracellular Mitochondrial Trafficking in Health and Disease","volume":"62","author":"Shanmughapriya","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1002\/1873-3468.12755","article-title":"Chansporter Complexes in Cell Signaling","volume":"591","author":"Abbott","year":"2017","journal-title":"FEBS Lett."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S1044-7431(03)00068-X","article-title":"Neurons and Astrocytes Secrete Factors That Cause Stem Cells to Differentiate into Neurons and Astrocytes, Respectively","volume":"23","author":"Chang","year":"2003","journal-title":"Mol. Cell Neurosci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e01795","DOI":"10.1016\/j.heliyon.2019.e01795","article-title":"High Glucose Conditioned Neonatal Astrocytes Results in Impaired Mitogenic Activity in Cerebral Microvessel Endothelial Cells in Co-Culture","volume":"5","author":"Cohen","year":"2019","journal-title":"Heliyon"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","article-title":"Reactive Astrocytes: Production, Function, and Therapeutic Potential","volume":"46","author":"Liddelow","year":"2017","journal-title":"Immunity"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.3389\/fimmu.2020.01416","article-title":"Crosstalk Between Astrocytes and Microglia: An Overview","volume":"11","author":"Matejuk","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Nutma, E., van Gent, D., Amor, S., and Peferoen, L.A.N. (2020). Astrocyte and Oligodendrocyte Cross-Talk in the Central Nervous System. Cells, 9.","DOI":"10.3390\/cells9030600"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/jnr.20060","article-title":"Differential Regulation of Neurotrophin Expression in Basal Forebrain Astrocytes by Neuronal Signals","volume":"76","author":"Wu","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.mvr.2012.02.009","article-title":"Neurotrophin Production in Brain Pericytes during Hypoxia: A Role of Pericytes for Neuroprotection","volume":"83","author":"Ishitsuka","year":"2012","journal-title":"Microvasc. Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1590\/S0100-879X2001000500008","article-title":"Cross-Talk between Neurons and Glia: Highlights on Soluble Factors","volume":"34","author":"Gomes","year":"2001","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e42156","DOI":"10.7554\/eLife.42156","article-title":"Oligodendrocytes Regulate Presynaptic Properties and Neurotransmission through BDNF Signaling in the Mouse Brainstem","volume":"8","author":"Jang","year":"2019","journal-title":"eLife"},{"key":"ref_93","first-page":"342","article-title":"The Astrocyte Odyssey","volume":"86","author":"Wang","year":"2008","journal-title":"Prog. Neurobiol."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Flores, K.R., Viccaro, F., Aquilini, M., Scarpino, S., Ronchetti, F., Mancini, R., Di Napoli, A., Scozzi, D., and Ricci, A. (2020). Protective Role of Brain Derived Neurotrophic Factor (BDNF) in Obstructive Sleep Apnea Syndrome (OSAS) Patients. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0227834"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/glia.20810","article-title":"Long-Term Accumulation of Microglia with Proneurogenic Phenotype Concomitant with Persistent Neurogenesis in Adult Subventricular Zone after Stroke","volume":"57","author":"Thored","year":"2009","journal-title":"Glia"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1460-9568.2005.04539.x","article-title":"Neurogenic Niche Modulation by Activated Microglia: Transforming Growth Factor Beta Increases Neurogenesis in the Adult Dentate Gyrus","volume":"23","author":"Battista","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nri.2017.125","article-title":"Microglia and Macrophages in Brain Homeostasis and Disease","volume":"18","author":"Li","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"239","DOI":"10.15252\/embj.201592705","article-title":"Astrocytes as Secretory Cells of the Central Nervous System: Idiosyncrasies of Vesicular Secretion","volume":"35","author":"Verkhratsky","year":"2016","journal-title":"EMBO J."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Schiera, G., Di Liegro, C.M., and Di Liegro, I. (2019). Cell-to-Cell Communication in Learning and Memory: From Neuro- and Glio-Transmission to Information Exchange Mediated by Extracellular Vesicles. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010266"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neuroscience.2018.04.003","article-title":"Cell-to-Cell Communication by Extracellular Vesicles: Focus on Microglia","volume":"405","author":"Paolicelli","year":"2019","journal-title":"Neuroscience"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"213","DOI":"10.15252\/embr.201439668","article-title":"Active Endocannabinoids Are Secreted on Extracellular Membrane Vesicles","volume":"16","author":"Gabrielli","year":"2015","journal-title":"EMBO Rep."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/emboj.2011.489","article-title":"Microvesicles Released from Microglia Stimulate Synaptic Activity via Enhanced Sphingolipid Metabolism","volume":"31","author":"Antonucci","year":"2012","journal-title":"EMBO J."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/glia.23708","article-title":"Stimulus-Dependent Modifications in Astrocyte-Derived Extracellular Vesicle Cargo Regulate Neuronal Excitability","volume":"68","author":"Dasgheyb","year":"2020","journal-title":"Glia"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.brainres.2019.04.009","article-title":"Exosome-Shuttled MiR-92b-3p from Ischemic Preconditioned Astrocytes Protects Neurons against Oxygen and Glucose Deprivation","volume":"1717","author":"Xu","year":"2019","journal-title":"Brain Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12951-020-00665-8","article-title":"Neuron-Derived Exosomes-Transmitted MiR-124-3p Protect Traumatically Injured Spinal Cord by Suppressing the Activation of Neurotoxic Microglia and Astrocytes","volume":"18","author":"Jiang","year":"2020","journal-title":"J. Nanobiotechnol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bbamem.2012.01.024","article-title":"Gap Junction Communication in Myelinating Glia","volume":"1828","author":"Solsona","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3389\/fneur.2020.00703","article-title":"The Multifaceted Role of Astrocyte Connexin 43 in Ischemic Stroke Through Forming Hemichannels and Gap Junctions","volume":"11","author":"Liang","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s12038-018-9811-0","article-title":"Connexin 43\/47 Channels Are Important for Astrocyte\/Oligodendrocyte Cross-Talk in Myelination and Demyelination","volume":"43","author":"Basu","year":"2018","journal-title":"J. Biosci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/jcbfm.2012.45","article-title":"Deletion of Astroglial Connexins Weakens the Blood-Brain Barrier","volume":"32","author":"Ezan","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"R38","DOI":"10.1016\/j.cub.2014.11.029","article-title":"Neurobiology: All Synapses Are Created Equal","volume":"25","author":"Pereda","year":"2015","journal-title":"Curr Biol"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"8881","DOI":"10.1523\/JNEUROSCI.1302-06.2006","article-title":"Cooperative Astrocyte and Dendritic Spine Dynamics at Hippocampal Excitatory Synapses","volume":"26","author":"Haber","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1523\/JNEUROSCI.4466-06.2007","article-title":"Direct Astrocytic Contacts Regulate Local Maturation of Dendritic Spines","volume":"27","author":"Nishida","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Wang, X., Bukoreshtliev, N.V., and Gerdes, H.-H. (2012). Developing Neurons Form Transient Nanotubes Facilitating Electrical Coupling and Calcium Signaling with Distant Astrocytes. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047429"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nature05300","article-title":"Electrical Activity in Early Neuronal Development","volume":"444","author":"Spitzer","year":"2006","journal-title":"Nature"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12987-018-0114-5","article-title":"Tunneling Nanotubes Evoke Pericyte\/Endothelial Communication during Normal and Tumoral Angiogenesis","volume":"15","author":"Errede","year":"2018","journal-title":"Fluids Barriers CNS"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12974-021-02158-3","article-title":"Crosstalk between Astrocytes and Microglia Results in Increased Degradation of \u03b1-Synuclein and Amyloid-\u03b2 Aggregates","volume":"18","author":"Rostami","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.1016\/j.cell.2021.09.007","article-title":"Microglia Jointly Degrade Fibrillar Alpha-Synuclein Cargo by Distribution through Tunneling Nanotubes","volume":"184","author":"Scheiblich","year":"2021","journal-title":"Cell"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.redox.2014.05.006","article-title":"Mitochondrial Reactive Oxygen Species: A Double Edged Sword in Ischemia\/Reperfusion vs. Preconditioning","volume":"2","author":"Kalogeris","year":"2014","journal-title":"Redox Biol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e438","DOI":"10.1038\/cddis.2012.177","article-title":"Tunneling-Nanotube Direction Determination in Neurons and Astrocytes","volume":"3","author":"Sun","year":"2012","journal-title":"Cell Death Dis."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1038\/cdd.2017.51","article-title":"Mesenchymal Stem Cells Sense Mitochondria Released from Damaged Cells as Danger Signals to Activate Their Rescue Properties","volume":"24","author":"Augeul","year":"2017","journal-title":"Cell Death Differ."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/cns.13124","article-title":"Prophylactic Treatment of Hyperbaric Oxygen Treatment Mitigates Inflammatory Response via Mitochondria Transfer","volume":"25","author":"Lippert","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Ren, D., Zheng, P., Zou, S., Gong, Y., Wang, Y., Duan, J., Deng, J., Chen, H., Feng, J., and Zhong, C. (2021). GJA1-20K Enhances Mitochondria Transfer from Astrocytes to Neurons via Cx43-TnTs After Traumatic Brain Injury. Cell. Mol. Neurobiol., 1\u20139.","DOI":"10.1007\/s10571-021-01070-x"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/cdd.2014.211","article-title":"Transfer of Mitochondria via Tunneling Nanotubes Rescues Apoptotic PC12 Cells","volume":"22","author":"Wang","year":"2015","journal-title":"Cell Death Differ."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1007\/s12035-015-9225-z","article-title":"Rescue of Brain Function Using Tunneling Nanotubes Between Neural Stem Cells and Brain Microvascular Endothelial Cells","volume":"53","author":"Wang","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"9633","DOI":"10.1073\/pnas.1404651111","article-title":"Transcellular Degradation of Axonal Mitochondria","volume":"111","author":"Davis","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Levoux, J., Prola, A., Lafuste, P., Gervais, M., Braud, L., Schirmann, A., Hersant, B., Sid-Ahmed, M., Ben-Larbi, S., and Komrskova, K. (2020). Platelets Promote Pro-Angiogenic Activity of Mesenchymal Stem Cells Via Mitochondrial Transfer and Metabolic Reprogramming, Social Science Research Network.","DOI":"10.2139\/ssrn.3545511"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1126\/science.1110647","article-title":"Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo","volume":"308","author":"Nimmerjahn","year":"2005","journal-title":"Science"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1523\/JNEUROSCI.4363-08.2009","article-title":"Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals","volume":"29","author":"Wake","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.clinthera.2016.02.030","article-title":"Nanotube Formation: A Rapid Form of \u201cAlarm Signaling\u201d?","volume":"38","author":"Weng","year":"2016","journal-title":"Clin. Ther."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tins.2018.09.006","article-title":"Mast Cells in Neuroimmune Interactions","volume":"42","author":"Forsythe","year":"2019","journal-title":"Trends Neurosci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"185","DOI":"10.31083\/j.jin.2021.01.313","article-title":"The Role of Mast Cells in the Gut and Brain","volume":"20","author":"Traina","year":"2021","journal-title":"J. Integr. Neurosci"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1002\/jcp.25584","article-title":"TNT-Induced Phagocytosis: Tunneling Nanotubes Mediate the Transfer of Pro-Phagocytic Signals From Apoptotic to Viable Cells: Transfer of Ps Via Tnts Induces Phagocytosis","volume":"232","author":"Bittins","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"e12747","DOI":"10.1111\/jpi.12747","article-title":"Melatonin Reshapes the Mitochondrial Network and Promotes Intercellular Mitochondrial Transfer via Tunneling Nanotubes after Ischemic-like Injury in Hippocampal HT22 Cells","volume":"71","author":"Nasoni","year":"2021","journal-title":"J. Pineal Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"111593","DOI":"10.1016\/j.biopha.2021.111593","article-title":"Melatonin Rescues Cerebral Ischemic Events through Upregulated Tunneling Nanotube-Mediated Mitochondrial Transfer and Downregulated Mitochondrial Oxidative Stress in Rat Brain","volume":"139","author":"Yip","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"166246","DOI":"10.1016\/j.bbadis.2021.166246","article-title":"Amyloid-\u03b2 Induced Membrane Damage Instigates Tunneling Nanotube-like Conduits by P21-Activated Kinase Dependent Actin Remodulation","volume":"1867","author":"Dilna","year":"2021","journal-title":"Biochim. Biophys. Acta BBA Mol. Basis Dis."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/ncb1841","article-title":"Prions Hijack Tunnelling Nanotubes for Intercellular Spread","volume":"11","author":"Gousset","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1083\/jcb.201807068","article-title":"Rhes Travels from Cell to Cell and Transports Huntington Disease Protein via TNT-like Protrusion","volume":"218","author":"Sharma","year":"2019","journal-title":"J. Cell Biol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"42984","DOI":"10.1038\/srep42984","article-title":"\u03b1-Synuclein Transfer through Tunneling Nanotubes Occurs in SH-SY5Y Cells and Primary Brain Pericytes from Parkinson\u2019s Disease Patients","volume":"7","author":"Dieriks","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"11835","DOI":"10.1523\/JNEUROSCI.0983-17.2017","article-title":"Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes","volume":"37","author":"Rostami","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"930","DOI":"10.3389\/fnins.2019.00930","article-title":"Intracellular and Intercellular Mitochondrial Dynamics in Parkinson\u2019s Disease","volume":"13","author":"Valdinocci","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s43018-020-00159-4","article-title":"Pathway-Based Classification of Glioblastoma Uncovers a Mitochondrial Subtype with Therapeutic Vulnerabilities","volume":"2","author":"Garofano","year":"2021","journal-title":"Nat. Cancer"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.3389\/fonc.2020.615400","article-title":"Genetic Architectures and Cell-of-Origin in Glioblastoma","volume":"10","author":"Kim","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.cell.2019.06.024","article-title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma","volume":"178","author":"Neftel","year":"2019","journal-title":"Cell"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Vieira de Castro, J., Gon\u00e7alves, C.S., Hormigo, A., and Costa, B.M. (2020). Exploiting the Complexities of Glioblastoma Stem Cells: Insights for Cancer Initiation and Therapeutic Targeting. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21155278"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ccell.2021.01.006","article-title":"Proteogenomic and Metabolomic Characterization of Human Glioblastoma","volume":"39","author":"Wang","year":"2021","journal-title":"Cancer Cell"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Yabo, Y.A., Niclou, S.P., and Golebiewska, A. (2021). Cancer Cell Heterogeneity and Plasticity: A Paradigm Shift in Glioblastoma. Neuro-Oncology, (online ahead of print).","DOI":"10.1093\/neuonc\/noab269"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1172\/JCI89587","article-title":"Overcoming Therapeutic Resistance in Glioblastoma: The Way Forward","volume":"127","author":"Osuka","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.devcel.2021.12.007","article-title":"Quiescent Human Glioblastoma Cancer Stem Cells Drive Tumor Initiation, Expansion, and Recurrence Following Chemotherapy","volume":"57","author":"Xie","year":"2022","journal-title":"Dev. Cell"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.trecan.2020.01.009","article-title":"Glioblastoma Stem Cells: Driving Resilience through Chaos","volume":"6","author":"Prager","year":"2020","journal-title":"Trends Cancer"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"130510","DOI":"10.1172\/jci.insight.130510","article-title":"Asymmetric Cell Division Promotes Therapeutic Resistance in Glioblastoma Stem Cells","volume":"6","author":"Hitomi","year":"2021","journal-title":"JCI Insight"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1158\/0008-5472.CAN-19-0855","article-title":"ERK-Mediated Loss of MiR-199a-3p and Induction of EGR1 Act as a \u201cToggle Switch\u201d of GBM Cell Dedifferentiation into NANOG- and OCT4-Positive Cells","volume":"80","author":"Almairac","year":"2020","journal-title":"Cancer Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1016\/j.celrep.2020.01.089","article-title":"Gliomas Interact with Non-Glioma Brain Cells via Extracellular Vesicles","volume":"30","author":"Gao","year":"2020","journal-title":"Cell Rep."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Guelfi, S., Orsetti, B., Deleuze, V., Rigau, V., Bauchet, L., Duffau, H., Rothhut, B., and Hugnot, J.-P. (2021). SLUG and Truncated TAL1 Reduce Glioblastoma Stem Cell Growth Downstream of Notch1 and Define Distinct Vascular Subpopulations in Glioblastoma Multiforme. Cancers, 13.","DOI":"10.3390\/cancers13215393"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.cell.2020.03.034","article-title":"Roadmap for the Emerging Field of Cancer Neuroscience","volume":"181","author":"Monje","year":"2020","journal-title":"Cell"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"14556","DOI":"10.1038\/s41598-021-93775-8","article-title":"Tunneling Nanotubes, TNT, Communicate Glioblastoma with Surrounding Non-Tumor Astrocytes to Adapt Them to Hypoxic and Metabolic Tumor Conditions","volume":"11","author":"Valdebenito","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3389\/fbioe.2019.00403","article-title":"Differential Exchange of Multifunctional Liposomes Between Glioblastoma Cells and Healthy Astrocytes via Tunneling Nanotubes","volume":"7","author":"Formicola","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40478-020-00897-7","article-title":"Astrocytes Rescue Neuronal Health after Cisplatin Treatment through Mitochondrial Transfer","volume":"8","author":"English","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"9073","DOI":"10.1038\/srep09073","article-title":"MitoCeption as a New Tool to Assess the Effects of Mesenchymal Stem\/Stromal Cell Mitochondria on Cancer Cell Metabolism and Function","volume":"5","author":"Caicedo","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"436","DOI":"10.2144\/btn-2020-0114","article-title":"Methods for Simultaneous and Quantitative Isolation of Mitochondrial DNA, Nuclear DNA and RNA from Mammalian Cells","volume":"69","author":"Nakhle","year":"2020","journal-title":"Biotechniques"},{"key":"ref_160","first-page":"e55245","article-title":"MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells","volume":"120","author":"Bokus","year":"2017","journal-title":"J. Vis. 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