{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:05:45Z","timestamp":1788473145374,"version":"build-2803163510"},"reference-count":156,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD103609"],"award-info":[{"award-number":["HD103609"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Melanin is the pigment that protects DNA from ultraviolet (UV) damage by absorbing excess energy. Melanin is produced in a process called melanogenesis. When melanogenesis is altered, diseases such as albinism result. Albinism can result in an increased skin cancer risk. Conversely, black pigment cell (melanocyte) development pathways can be misregulated, causing excessive melanocyte growth that leads to melanoma (cancer of melanocytes). Zebrafish is an emerging model organism used to study pigment disorders due to their high fecundity, visible melanin development in melanophores (melanocytes in mammals) from 24 h post-fertilization, and conserved melanogenesis pathways. Here, we reviewed the conserved developmental pathways in zebrafish melanophores and mammalian melanocytes. Additionally, we summarized the progress made in understanding pigment cell disease and evidence supporting the strong potential for using zebrafish to find novel treatment options for albinism.<\/jats:p>","DOI":"10.3390\/cancers14071752","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T21:22:14Z","timestamp":1648675334000},"page":"1752","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Zebrafish Syndromic Albinism Models as Tools for Understanding and Treating Pigment Cell Disease in Humans"],"prefix":"10.3390","volume":"14","author":[{"given":"Sam J.","family":"Neuffer","sequence":"first","affiliation":[{"name":"School of Molecular Biosciences, Washington State University Vancouver, Vancouver, WA 98686, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3992-027X","authenticated-orcid":false,"given":"Cynthia D.","family":"Cooper","sequence":"additional","affiliation":[{"name":"School of Molecular Biosciences, Washington State University Vancouver, Vancouver, WA 98686, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Pralea, I.E., Moldovan, R.C., Petrache, A.M., Ilie\u0219, M., Heghe\u0219, S.C., Ielciu, I., Nicoar\u0103, R., Moldovan, M., Ene, M., and Radu, M. (2019). From Extraction to Advanced Analytical Methods: The Challenges of Melanin Analysis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20163943"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1128\/aem.60.10.3864-3866.1994","article-title":"Decreased susceptibility of melanized Cryptococcus neoformans to UV light","volume":"60","author":"Wang","year":"1994","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00284-001-0069-6","article-title":"A UV tolerant mutant of Bacillus thuringiensis subsp. kurstaki producing melanin","volume":"44","author":"Saxena","year":"2002","journal-title":"Curr. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1751-1097.2007.00226.x","article-title":"The protective role of melanin against UV damage in human skin","volume":"84","author":"Brenner","year":"2008","journal-title":"Photochem. Photobiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11160-020-09603-1","article-title":"Effect of ultraviolet radiation (UVR) on the life stages of fish","volume":"30","author":"Alves","year":"2020","journal-title":"Rev. Fish Biol. Fish."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.fbr.2016.12.003","article-title":"Functions of fungal melanin beyond virulence","volume":"31","author":"Cordero","year":"2017","journal-title":"Fungal Biol. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0167-4889(96)00063-8","article-title":"Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: Regulation by ultraviolet B","volume":"1313","author":"Chakraborty","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.cell.2006.12.045","article-title":"Central role of p53 in the suntan response and pathologic hyperpigmentation","volume":"128","author":"Cui","year":"2007","journal-title":"Cell"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1210\/endo.137.5.8612494","article-title":"Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis","volume":"137","author":"Suzuki","year":"1996","journal-title":"Endocrinology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.ceb.2013.04.008","article-title":"Lysosome-related organelles: Unusual compartments become mainstream","volume":"25","author":"Marks","year":"2013","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ceb.2019.05.003","article-title":"Lysosome-related organelles as functional adaptations of the endolysosomal system","volume":"59","author":"Delevoye","year":"2019","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/ni1000","article-title":"Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse","volume":"4","author":"Clark","year":"2003","journal-title":"Nat. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1182\/blood-2015-09-671636","article-title":"Mutations in AP3D1 associated with immunodeficiency and seizures define a new type of Hermansky-Pudlak syndrome","volume":"127","author":"Ammann","year":"2016","journal-title":"Blood"},{"key":"ref_14","unstructured":"Janeway, C., Walport, M., and Travers, P. (2011). Immunobiology: The Immune System in Health and Disease, Garland Science. [5th ed.]."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"249482","DOI":"10.1155\/2010\/249482","article-title":"Direct microbicidal activity of cytotoxic T-lymphocytes","volume":"2010","author":"Oykhman","year":"2010","journal-title":"J. Biomed Biotechnol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/genetics\/9.5.487","article-title":"Linkage of Albino Allelomorphs in Rats and Mice","volume":"9","author":"Feldman","year":"1924","journal-title":"Genetics"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1093\/hmg\/6.10.1613","article-title":"Homologous pigmentation mutations in human, mouse and other model organisms","volume":"6","author":"Jackson","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Braasch, I., Schartl, M., and Volff, J.N. (2007). Evolution of pigment synthesis pathways by gene and genome duplication in fish. BMC Evol. Biol., 7.","DOI":"10.1186\/1471-2148-7-74"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Esposito, R., D\u2019Aniello, S., Squarzoni, P., Pezzotti, M.R., Ristoratore, F., and Spagnuolo, A. (2012). New insights into the evolution of metazoan tyrosinase gene family. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0035731"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/pcmr.12205","article-title":"oca2 Regulation of chromatophore differentiation and number is cell type specific in zebrafish","volume":"27","author":"Beirl","year":"2014","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.semcdb.2008.09.008","article-title":"Mechanisms for reaching the differentiated state: Insights from neural crest-derived melanocytes","volume":"20","author":"Cooper","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ydbio.2017.07.017","article-title":"A defect in the mitochondrial protein Mpv17 underlies the transparent casper zebrafish","volume":"430","author":"Beltre","year":"2017","journal-title":"Dev. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ydbio.2005.11.014","article-title":"Zebrafish Foxd3 is required for development of a subset of neural crest derivatives","volume":"290","author":"Lister","year":"2006","journal-title":"Dev. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ydbio.2007.10.045","article-title":"colgate\/hdac1 Repression of foxd3 expression is required to permit mitfa-dependent melanogenesis","volume":"313","author":"Ignatius","year":"2008","journal-title":"Dev. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.ydbio.2009.06.010","article-title":"Foxd3 controls melanophore specification in the zebrafish neural crest by regulation of Mitf","volume":"332","author":"Curran","year":"2009","journal-title":"Dev. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ydbio.2010.04.023","article-title":"Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest","volume":"344","author":"Curran","year":"2010","journal-title":"Dev. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Van Otterloo, E., Li, W., Bonde, G., Day, K.M., Hsu, M.Y., and Cornell, R.A. (2010). Differentiation of zebrafish melanophores depends on transcription factors AP2 alpha and AP2 epsilon. PLoS Genet., 6.","DOI":"10.1371\/journal.pgen.1001122"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Clancey, L.F., Beirl, A.J., Linbo, T.H., and Cooper, C.D. (2013). Maintenance of melanophore morphology and survival is cathepsin and vps11 dependent in zebrafish. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0065096"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/ics.12466","article-title":"Intrinsic and extrinsic regulation of human skin melanogenesis and pigmentation","volume":"40","author":"Serre","year":"2018","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ydbio.2021.04.007","article-title":"Immunoglobulin superfamily receptor Junctional adhesion molecule 3 (Jam3) requirement for melanophore survival and patterning during formation of zebrafish stripes","volume":"476","author":"Eom","year":"2021","journal-title":"Dev. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquaculture.2007.04.077","article-title":"The husbandry of zebrafish (Danio rerio): A review","volume":"269","author":"Lawrence","year":"2007","journal-title":"Aquaculture"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1093\/beheco\/arm059","article-title":"Strategic egg allocation in the zebrafish, Danio rerio","volume":"18","author":"Skinner","year":"2007","journal-title":"Behav. Ecol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Uusi-Heikkil\u00e4, S., B\u00f6ckenhoff, L., Wolter, C., and Arlinghaus, R. (2012). Differential allocation by female zebrafish (Danio rerio) to different-sized males--an example in a fish species lacking parental care. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0048317"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e908","DOI":"10.21769\/BioProtoc.908","article-title":"Isolation of Mouse Embryo Fibroblasts","volume":"3","author":"Durkin","year":"2013","journal-title":"Bio. Protoc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1111\/pcmr.12995","article-title":"A novel BLOC1S5-related HPS-11 patient and zebrafish with bloc1s5 disruption","volume":"34","author":"Zhong","year":"2021","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"17718","DOI":"10.1038\/s41598-019-54058-5","article-title":"Characterizing renal involvement in Hermansky-Pudlak Syndrome in a zebrafish model","volume":"9","author":"Schenk","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/med.21426","article-title":"Trends in Regenerative Medicine: Repigmentation in Vitiligo Through Melanocyte Stem Cell Mobilization","volume":"37","author":"Birlea","year":"2017","journal-title":"Med. Res. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/dvdy.10334","article-title":"Pigment cell organization in the hypodermis of zebrafish","volume":"227","author":"Hirata","year":"2003","journal-title":"Dev. Dyn."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.gde.2017.05.001","article-title":"Intercellular transfer of organelles during body pigmentation","volume":"45","author":"Tadokoro","year":"2017","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Moreiras, H., Seabra, M.C., and Barral, D.C. (2021). Melanin Transfer in the Epidermis: The Pursuit of Skin Pigmentation Control Mechanisms. Int. J. Mol. Sci., 22.","DOI":"10.20944\/preprints202104.0441.v1"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/pcmr.12929","article-title":"HPS11 and OCA8: Two new types of albinism associated with mutations in BLOC1S5 and DCT genes","volume":"34","author":"Garrido","year":"2021","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e04543","DOI":"10.7554\/eLife.04543","article-title":"An intracellular anion channel critical for pigmentation","volume":"3","author":"Bellono","year":"2014","journal-title":"Elife"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1091\/mbc.E20-03-0200","article-title":"SLC45A2 protein stability and regulation of melanosome pH determine melanocyte pigmentation","volume":"31","author":"Le","year":"2020","journal-title":"Mol. Biol. Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.abd.2019.09.023","article-title":"Albinism: Epidemiology, genetics, cutaneous characterization, psychosocial factors","volume":"94","author":"Maia","year":"2019","journal-title":"An. Bras. Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1600-0749.2006.00345.x","article-title":"The physical and chemical properties of eumelanin","volume":"19","author":"Meredith","year":"2006","journal-title":"Pigment Cell Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/14756366.2016.1256882","article-title":"Skin whitening agents: Medicinal chemistry perspective of tyrosinase inhibitors","volume":"32","author":"Pillaiyar","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0014-5793(92)80820-7","article-title":"Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA","volume":"309","author":"Chhajlani","year":"1992","journal-title":"FEBS Lett."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.gene.2007.07.005","article-title":"Evolution of melanocortin receptors in teleost fish: The melanocortin type 1 receptor","volume":"401","author":"Selz","year":"2007","journal-title":"Gene"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1016\/j.bbadis.2017.02.027","article-title":"MC1R signaling. Intracellular partners and pathophysiological implications","volume":"1863","author":"Herraiz","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/pcmr.12806","article-title":"Loss-of-function mutations in the melanocortin 1 receptor cause disruption of dorso-ventral countershading in teleost fish","volume":"32","author":"Cal","year":"2019","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1101\/gad.14.2.158","article-title":"Direct regulation of nacre, a zebrafish MITF homolog required for pigment cell formation, by the Wnt pathway","volume":"14","author":"Dorsky","year":"2000","journal-title":"Genes Dev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"14013","DOI":"10.1074\/jbc.C000113200","article-title":"Induction of melanocyte-specific microphthalmia-associated transcription factor by Wnt-3a","volume":"275","author":"Takeda","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/pcmr.12568","article-title":"An ongoing role for Wnt signaling in differentiating melanocytes in vivo","volume":"30","author":"Vibert","year":"2017","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2011.05.004","article-title":"Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration","volume":"145","author":"Rabbani","year":"2011","journal-title":"Cell"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"a008029","DOI":"10.1101\/cshperspect.a008029","article-title":"Wnt signaling in skin development, homeostasis, and disease","volume":"5","author":"Lim","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cub.2005.01.031","article-title":"BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma","volume":"15","author":"Patton","year":"2005","journal-title":"Curr. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1002\/dvdy.21910","article-title":"Kit and foxd3 genetically interact to regulate melanophore survival in zebrafish","volume":"238","author":"Cooper","year":"2009","journal-title":"Dev. Dyn."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ejcsup.2013.07.011","article-title":"Targeted therapy in melanoma\u2014The role of BRAF, RAS and KIT mutations","volume":"11","author":"Goldinger","year":"2013","journal-title":"EJC Suppl."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.1242\/dev.126.15.3425","article-title":"Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development","volume":"126","author":"Parichy","year":"1999","journal-title":"Development"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1006\/dbio.2000.9899","article-title":"Mutational analysis of endothelin receptor b1 (rose) during neural crest and pigment pattern development in the zebrafish Danio rerio","volume":"227","author":"Parichy","year":"2000","journal-title":"Dev. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni1097","article-title":"Protein kinase C and beyond","volume":"5","author":"Spitaler","year":"2004","journal-title":"Nat. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1042\/bj3140305","article-title":"Signalling mechanisms of endothelin-induced mitogenesis and melanogenesis in human melanocytes","volume":"314","author":"Imokawa","year":"1996","journal-title":"Biochem. J."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"D\u2019Mello, S.A., Finlay, G.J., Baguley, B.C., and Askarian-Amiri, M.E. (2016). Signaling Pathways in Melanogenesis. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17071144"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1096\/fj.07-9080com","article-title":"Epistatic connections between microphthalmia-associated transcription factor and endothelin signaling in Waardenburg syndrome and other pigmentary disorders","volume":"22","author":"Nishimura","year":"2008","journal-title":"FASEB J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"608","DOI":"10.12688\/f1000research.24625.1","article-title":"Recent advances in understanding the molecular basis of melanogenesis in melanocytes","volume":"9","author":"Ohbayashi","year":"2020","journal-title":"F1000Research"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1242\/jcs.040667","article-title":"Melanosomes at a glance","volume":"121","author":"Wasmeier","year":"2008","journal-title":"J. Cell Sci."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Hellstr\u00f6m, A.R., Watt, B., Fard, S.S., Tenza, D., Mannstr\u00f6m, P., Narfstr\u00f6m, K., Ekesten, B., Ito, S., Wakamatsu, K., and Larsson, J. (2011). Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation. PLoS Genet., 7.","DOI":"10.1371\/journal.pgen.1002285"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"44064","DOI":"10.1038\/srep44064","article-title":"Melanosomal formation of PMEL core amyloid is driven by aromatic residues","volume":"7","author":"Hee","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.cub.2012.09.020","article-title":"BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32\/38 guanine nucleotide exchange factor","volume":"22","author":"Gerondopoulos","year":"2012","journal-title":"Curr. Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1091\/mbc.e06-12-1066","article-title":"BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles","volume":"18","author":"Setty","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1083\/jcb.201410026","article-title":"BLOC-2 targets recycling endosomal tubules to melanosomes for cargo delivery","volume":"209","author":"Dennis","year":"2015","journal-title":"J. Cell Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"5882","DOI":"10.1074\/jbc.M111.325746","article-title":"Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1)","volume":"287","author":"Lee","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cub.2015.11.020","article-title":"BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling Endosomes","volume":"26","author":"Delevoye","year":"2016","journal-title":"Curr. Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0079-6123(09)17910-4","article-title":"The sandy (sdy) mouse: A dysbindin-1 mutant relevant to schizophrenia research","volume":"179","author":"Talbot","year":"2009","journal-title":"Prog. Brain Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1182\/blood-2004-04-1538","article-title":"Reduced pigmentation (rp), a mouse model of Hermansky-Pudlak syndrome, encodes a novel component of the BLOC-1 complex","volume":"104","author":"Gwynn","year":"2004","journal-title":"Blood"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"28191","DOI":"10.1074\/jbc.M204011200","article-title":"BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules","volume":"277","author":"Starcevic","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"790","DOI":"10.2108\/zsj.28.790","article-title":"A novel deletion mutation of mouse ruby-eye 2 named ru2(d)\/Hps5(ru2-d) inhibits melanocyte differentiation and its impaired differentiation is rescued by L-tyrosine","volume":"28","author":"Hirobe","year":"2011","journal-title":"Zoolog. Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1755-148X.2011.00845.x","article-title":"How are proliferation and differentiation of melanocytes regulated?","volume":"24","author":"Hirobe","year":"2011","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/ng1087","article-title":"Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6","volume":"33","author":"Zhang","year":"2003","journal-title":"Nat. Genet."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1534\/genetics.113.154898","article-title":"snow white, a zebrafish model of Hermansky-Pudlak Syndrome type 5","volume":"195","author":"Daly","year":"2013","journal-title":"Genetics"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1093\/emboj\/17.5.1304","article-title":"A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3","volume":"17","author":"Sandoval","year":"1998","journal-title":"EMBO J."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1091\/mbc.12.7.2075","article-title":"AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes","volume":"12","author":"Huizing","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"5356","DOI":"10.1091\/mbc.e05-07-0626","article-title":"Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes","volume":"16","author":"Theos","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1091\/mbc.e06-05-0379","article-title":"BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes","volume":"17","author":"Tenza","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1083\/jcb.200907122","article-title":"AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis","volume":"187","author":"Delevoye","year":"2009","journal-title":"J. Cell Biol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e105117","DOI":"10.15252\/embj.2020105117","article-title":"AP-3 vesicle uncoating occurs after HOPS-dependent vacuole tethering","volume":"39","author":"Schoppe","year":"2020","journal-title":"EMBO J."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/brain\/awaa459","article-title":"Bi-allelic variants in HOPS complex subunit VPS41 cause cerebellar ataxia and abnormal membrane trafficking","volume":"144","author":"Sanderson","year":"2021","journal-title":"Brain"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1182\/blood-2005-11-4377","article-title":"Identification of a homozygous deletion in the AP3B1 gene causing Hermansky-Pudlak syndrome, type 2","volume":"108","author":"Jung","year":"2006","journal-title":"Blood"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"15835","DOI":"10.1038\/ncomms15835","article-title":"Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes","volume":"8","author":"Patwardhan","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1074\/jbc.M115.684043","article-title":"RUTBC1 Functions as a GTPase-activating Protein for Rab32\/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes","volume":"291","author":"Marubashi","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.2353\/ajpath.2008.080056","article-title":"A mutation in Rab38 small GTPase causes abnormal lung surfactant homeostasis and aberrant alveolar structure in mice","volume":"173","author":"Osanai","year":"2008","journal-title":"Am. J. Pathol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"L243","DOI":"10.1152\/ajplung.00242.2009","article-title":"Altered lung surfactant system in a Rab38-deficient rat model of Hermansky-Pudlak syndrome","volume":"298","author":"Osanai","year":"2010","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1006\/bbrc.1997.8007","article-title":"Metal ligand-binding specificities of the tyrosinase-related proteins","volume":"242","author":"Furumura","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/BJ20042070","article-title":"Mutations in dopachrome tautomerase (Dct) affect eumelanin\/pheomelanin synthesis, but do not affect intracellular trafficking of the mutant protein","volume":"391","author":"Costin","year":"2005","journal-title":"Biochem. J."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1086\/324340","article-title":"Mutations in the human orthologue of the mouse underwhite gene (uw) underlie a new form of oculocutaneous albinism, OCA4","volume":"69","author":"Newton","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"183318","DOI":"10.1016\/j.bbamem.2020.183318","article-title":"Membrane transport proteins in melanosomes: Regulation of ions for pigmentation","volume":"1862","author":"Wiriyasermkul","year":"2020","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_98","first-page":"e1115","article-title":"Microinjection of zebrafish embryos to analyze gene function","volume":"25","author":"Rosen","year":"2009","journal-title":"J. Vis. Exp."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1167\/iovs.10-5957","article-title":"The loss of vacuolar protein sorting 11 (vps11) causes retinal pathogenesis in a vertebrate model of syndromic albinism","volume":"52","author":"Thomas","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"L461","DOI":"10.1152\/ajplung.00056.2011","article-title":"Rab38 targets to lamellar bodies and normalizes their sizes in lung alveolar type II epithelial cells","volume":"301","author":"Zhang","year":"2011","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/path.5213","article-title":"Melanoma subtypes: Genomic profiles, prognostic molecular markers and therapeutic possibilities","volume":"247","author":"Rabbie","year":"2019","journal-title":"J. Pathol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/cncr.31551","article-title":"Annual Report to the Nation on the Status of Cancer, part I: National cancer statistics","volume":"124","author":"Cronin","year":"2018","journal-title":"Cancer"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/jamadermatol.2019.3353","article-title":"Age-Specific Incidence of Melanoma in the United States","volume":"156","author":"Paulson","year":"2020","journal-title":"JAMA Dermatol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/24620","article-title":"Control of neural crest cell fate by the Wnt signalling pathway","volume":"396","author":"Dorsky","year":"1998","journal-title":"Nature"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"43295","DOI":"10.18632\/oncotarget.9232","article-title":"The role of Wnt\/\u03b2-catenin signaling pathway in melanoma epithelial-to-mesenchymal-like switching: Evidences from patients-derived cell lines","volume":"7","author":"Kovacs","year":"2016","journal-title":"Oncotarget"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.fitote.2016.02.002","article-title":"Modulation of WNT\/\u03b2-catenin pathway in melanoma by biologically active components derived from plants","volume":"109","author":"Czyz","year":"2016","journal-title":"Fitoterapia"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1038\/s41467-019-11107-x","article-title":"Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets","volume":"10","author":"Newell","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.ccell.2021.01.011","article-title":"Melanoma models for the next generation of therapies","volume":"39","author":"Patton","year":"2021","journal-title":"Cancer Cell"},{"key":"ref_109","unstructured":"Federico, J.R., and Krishnamurthy, K. (2022, February 08). Albinism. [Updated 27 August 2021], StatPerls [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK519018\/."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/pcmr.12543","article-title":"A new type of syndromic albinism associated with mutations in AP3D1","volume":"30","author":"Montoliu","year":"2017","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/ng1196-307","article-title":"Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome","volume":"14","author":"Nagle","year":"1996","journal-title":"Nat. Genet."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/sj.bmt.1705600","article-title":"Hematopoietic cell transplantation for Chediak-Higashi syndrome","volume":"39","author":"Eapen","year":"2007","journal-title":"Bone Marrow Transplant."},{"key":"ref_113","unstructured":"Ajitkumar, A., Yarrarapu, S.N.S., and Ramphul, K. (2022, February 08). Chediak Higashi Syndrome. [Updated 17 February 2022], StatPearls [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK507881\/."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/hmg\/6.7.1091","article-title":"Identification of mutations in two major mRNA isoforms of the Chediak-Higashi syndrome gene in human and mouse","volume":"6","author":"Barbosa","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Song, Y., Dong, Z., Luo, S., Yang, J., Lu, Y., Gao, B., and Fan, T. (2020). Identification of a compound heterozygote in LYST gene: A case report on Chediak-Higashi syndrome. BMC Med. Genet., 21.","DOI":"10.1186\/s12881-019-0922-8"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1167\/iovs.08-2791","article-title":"Lyst mutation in mice recapitulates iris defects of human exfoliation syndrome","volume":"50","author":"Trantow","year":"2009","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/tra.12244","article-title":"LYST controls the biogenesis of the endosomal compartment required for secretory lysosome function","volume":"16","author":"Sepulveda","year":"2015","journal-title":"Traffic"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1084\/jem.20141461","article-title":"Lysosomal trafficking regulator Lyst links membrane trafficking to toll-like receptor-mediated inflammatory responses","volume":"214","author":"Westphal","year":"2017","journal-title":"J. Exp. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"26307","DOI":"10.1073\/pnas.2003724117","article-title":"Genome mapping of a LYST mutation in corn snakes indicates that vertebrate chromatophore vesicles are lysosome-related organelles","volume":"117","author":"Burgelin","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ccm.2016.04.012","article-title":"Hermansky-Pudlak Syndrome","volume":"37","author":"Young","year":"2016","journal-title":"Clin. Chest. Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13023-019-1023-7","article-title":"Hermansky-Pudlak syndrome and oculocutaneous albinism in Chinese children with pigmentation defects and easy bruising","volume":"14","author":"Power","year":"2019","journal-title":"Orphanet. J. Rare Dis."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/humu.23968","article-title":"Hermansky-Pudlak syndrome: Mutation update","volume":"41","author":"Huizing","year":"2020","journal-title":"Hum. Mutat."},{"key":"ref_123","unstructured":"Huizing, M., Malicdan, M.C.V., Gochuico, B.R., and Gahl, W.A. (2022, February 08). Hermansky-Pudlak Syndrome, GeneReviews [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1287\/."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"5530","DOI":"10.1038\/ncomms6530","article-title":"Vesicles derived via AP-3-dependent recycling contribute to asynchronous release and influence information transfer","volume":"5","author":"Evstratova","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_125","first-page":"1839","article-title":"Pulmonary Fibrosis in Hermansky-Pudlak Syndrome","volume":"13","author":"Vicary","year":"2016","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"29180","DOI":"10.1074\/jbc.M114.576561","article-title":"Biogenesis of lysosome-related organelles complex-1 subunit 1 (BLOS1) interacts with sorting nexin 2 and the endosomal sorting complex required for transport-I (ESCRT-I) component TSG101 to mediate the sorting of epidermal growth factor receptor into endosomal compartments","volume":"289","author":"Zhang","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1534\/genetics.117.300621","article-title":"Development of the Swimbladder Surfactant System and Biogenesis of Lysosome-Related Organelles Is Regulated by BLOS1 in Zebrafish","volume":"208","author":"Chen","year":"2018","journal-title":"Genetics"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1093\/hmg\/9.19.2781","article-title":"Oa1 knock-out: New insights on the pathogenesis of ocular albinism type 1","volume":"9","author":"Incerti","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1093\/hmg\/ddz100","article-title":"Prader-Willi syndrome imprinting centre deletion mice have impaired baseline and 5-HT2CR-mediated response inhibition","volume":"28","author":"Davies","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Spikol, E.D., Laverriere, C.E., Robnett, M., Carter, G., Wolfe, E.M., and Glasgow, E. (2016). Zebrafish Models of Prader-Willi Syndrome: Fast Track to Pharmacotherapeutics. Diseases, 4.","DOI":"10.3390\/diseases4010013"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1750-1172-2-43","article-title":"Oculocutaneous albinism","volume":"2","author":"Ek","year":"2007","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"905472","DOI":"10.1155\/2014\/905472","article-title":"Mutational analysis of oculocutaneous albinism: A compact review","volume":"2014","author":"Kamaraj","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"8603","DOI":"10.1523\/JNEUROSCI.19-19-08603.1999","article-title":"Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish","volume":"19","author":"Neuhauss","year":"1999","journal-title":"J. Neurosci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3345\/kjp.2011.54.2.55","article-title":"Systematic review of the clinical and genetic aspects of Prader-Willi syndrome","volume":"54","author":"Jin","year":"2011","journal-title":"Korean J. Pediatr."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1101\/gr.128652.111","article-title":"HERC2 rs12913832 modulates human pigmentation by attenuating chromatin-loop formation between a long-range enhancer and the OCA2 promoter","volume":"22","author":"Visser","year":"2012","journal-title":"Genome Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2147\/TACG.S57386","article-title":"Angelman syndrome: Review of clinical and molecular aspects","volume":"7","author":"Bird","year":"2014","journal-title":"Appl. Clin. Genet."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/pcmr.12688","article-title":"Molecular characterization of a series of 990 index patients with albinism","volume":"31","author":"Lasseaux","year":"2018","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/tra.12646","article-title":"The road to LROs: Insights into lysosome-related organelles from Hermansky-Pudlak syndrome and other rare diseases","volume":"20","author":"Bowman","year":"2019","journal-title":"Traffic"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1038\/s41436-020-0867-5","article-title":"BLOC1S5 pathogenic variants cause a new type of Hermansky-Pudlak syndrome","volume":"22","author":"Pennamen","year":"2020","journal-title":"Genet. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41436-020-00997-8","article-title":"Dopachrome tautomerase variants in patients with oculocutaneous albinism","volume":"23","author":"Pennamen","year":"2021","journal-title":"Genet. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0896-6273(00)80519-X","article-title":"Mutation in AP-3 delta in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles","volume":"21","author":"Kantheti","year":"1998","journal-title":"Neuron"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"103583","DOI":"10.1016\/j.ejmg.2018.11.017","article-title":"Biallelic mutations in AP3D1 cause Hermansky-Pudlak syndrome type 10 associated with immunodeficiency and seizure disorder","volume":"62","author":"Mohammed","year":"2019","journal-title":"Eur. J. Med. Genet."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1167\/iovs.05-1596","article-title":"The Zebrafish fade out mutant: A novel genetic model for Hermansky-Pudlak syndrome","volume":"47","author":"Bahadori","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4103\/jhrs.JHRS_38_19","article-title":"A Successful Case for Deselection of Albino Embryo and Live Birth of Albinism-Free Healthy Baby Followed by PGT-M","volume":"13","author":"Patel","year":"2020","journal-title":"J. Hum. Reprod. Sci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jdermsci.2017.10.007","article-title":"A single-arm open-label clinical trial of autologous epidermal cell transplantation for stable vitiligo: A 30-month follow-up","volume":"89","author":"Orouji","year":"2018","journal-title":"J. Dermatol. Sci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1097\/CM9.0000000000000794","article-title":"Deciphering skin re-pigmentation patterns in vitiligo: An update on the cellular and molecular events involved","volume":"133","author":"Lei","year":"2020","journal-title":"Chin. Med. J."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.stemcr.2019.05.022","article-title":"In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids","volume":"13","author":"Korogi","year":"2019","journal-title":"Stem. Cell Rep."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s40291-019-00392-3","article-title":"Rare Opportunities: CRISPR\/Cas-Based Therapy Development for Rare Genetic Diseases","volume":"23","author":"Papasavva","year":"2019","journal-title":"Mol. Diagn. Ther."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/oxfordjournals.jhered.a108551","article-title":"Mocha, a new coat color and behavior mutation on chromosome 10 of the mouse","volume":"65","author":"Lane","year":"1974","journal-title":"J. Hered."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1172\/JCI79792","article-title":"Chitinase 3-like-1 and its receptors in Hermansky-Pudlak syndrome-associated lung disease","volume":"125","author":"Zhou","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1001\/archderm.135.7.774","article-title":"Dermatologic manifestations of Hermansky-Pudlak syndrome in patients with and without a 16-base pair duplication in the HPS1 gene","volume":"135","author":"Toro","year":"1999","journal-title":"Arch Dermatol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ydbio.2010.12.004","article-title":"mitfa is required at multiple stages of melanocyte differentiation but not to establish the melanocyte stem cell","volume":"350","author":"Johnson","year":"2011","journal-title":"Dev. Biol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/exd.13937","article-title":"Melanosome maturation proteins Oca2, Mitfa and Vps11 are differentially required for cisplatin resistance in zebrafish melanocytes","volume":"28","author":"Peterson","year":"2019","journal-title":"Exp. Dermatol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1038\/sj.onc.1206933","article-title":"Cisplatin: Mode of cytotoxic action and molecular basis of resistance","volume":"22","author":"Siddik","year":"2003","journal-title":"Oncogene"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Weng, C.H., Wu, C.S., Wu, J.C., Kung, M.L., Wu, M.H., and Tai, M.H. (2020). Cisplatin-Induced Giant Cells Formation Is Involved in Chemoresistance of Melanoma Cells. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21217892"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/dvdy.24550","article-title":"Insights from zebrafish on human pigment cell disease and treatment","volume":"246","author":"Cooper","year":"2017","journal-title":"Dev. Dyn."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/7\/1752\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:46:29Z","timestamp":1760136389000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/7\/1752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,30]]},"references-count":156,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["cancers14071752"],"URL":"https:\/\/doi.org\/10.3390\/cancers14071752","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,30]]}}}