{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T13:21:25Z","timestamp":1781184085911,"version":"3.54.1"},"reference-count":49,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Sinonasal squamous cell carcinoma (SNSCC) is a rare and aggressive malignancy with poor prognosis. Human papilloma virus (HPV) can induce SNSCC although its incidence and impact on patients\u2019 outcomes remains unclear. We performed a retrospective cohort study of patients with SNSCC treated consecutively in a comprehensive cancer center. HPV status was determined with p16 immunohistochemistry followed by RNA in situ hybridization (RNAscope). The incidence, clinical characteristics, and oncologic outcomes of HPV+SNSCC were assessed. P16 prognostic value was evaluated. Fifty-nine patients were included. Eleven (18.6%) SNSCC were p16+ with five (8.4%) doubtful cases. RNAscope was positive in nine cases (15.2%). Patients with HPV+SNSCC were younger (p = 0.0298) with a primary tumor originating mainly in nasal fossa (p &lt; 10\u22124). Pathologic findings were not different according to HPV status. Among patients who were curatively treated, overall survival was better for HPV+SNSCC (p = 0.022). No prognostic value of p16 expression was reported. Patients with HPV+SNSCC have better oncologic outcomes, probably due to earlier tumor stage with primary location predominantly in the nasal fossa, a more suitable epicenter to perform a surgical resection with clear margins. P16 expression seems not to be a good surrogate of HPV status in SNSCC.<\/jats:p>","DOI":"10.3390\/cancers14081874","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T12:11:14Z","timestamp":1649419874000},"page":"1874","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prognostic Analysis of HPV Status in Sinonasal Squamous Cell Carcinoma"],"prefix":"10.3390","volume":"14","author":[{"given":"Alexandre","family":"Tendron","sequence":"first","affiliation":[{"name":"Head and Neck Oncology Department, Gustave Roussy Cancer Campus, Universit\u00e9 Paris Saclay, 94805 Villejuif, France"},{"name":"Molecular Radiotherapy and Therapeutic Innovation, UMR 1030, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Classe","sequence":"additional","affiliation":[{"name":"Molecular Radiotherapy and Therapeutic Innovation, UMR 1030, 94805 Villejuif, France"},{"name":"Pathology Department, Gustave Roussy Cancer Campus, Universit\u00e9 Paris Saclay, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Casiraghi","sequence":"additional","affiliation":[{"name":"Pathology Department, Gustave Roussy Cancer Campus, Universit\u00e9 Paris Saclay, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Pere","sequence":"additional","affiliation":[{"name":"Virology Department, European Hospital Georges Pompidou, 75015 Paris, France"},{"name":"Functional Genomics of Solid Tumors (FunGeST), INSERM, Centre de Recherche des Cordeliers, Paris and Sorbonne Universit\u00e9, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Even","sequence":"additional","affiliation":[{"name":"Head and Neck Oncology Department, Gustave Roussy Cancer Campus, Universit\u00e9 Paris Saclay, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7604-4964","authenticated-orcid":false,"given":"Philippe","family":"Gorphe","sequence":"additional","affiliation":[{"name":"Head and Neck Oncology Department, Gustave Roussy Cancer Campus, Universit\u00e9 Paris Saclay, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1260-1762","authenticated-orcid":false,"given":"Antoine","family":"Moya-Plana","sequence":"additional","affiliation":[{"name":"Head and Neck Oncology Department, Gustave Roussy Cancer Campus, Universit\u00e9 Paris Saclay, 94805 Villejuif, France"},{"name":"Inserm U981, Melanoma Group, Gustave Roussy Cancer Campus, Universit\u00e9 Paris Saclay, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/lary.24264","article-title":"Epidemiology of sinonasal squamous cell carcinoma: A comprehensive analysis of 4994 patients","volume":"124","author":"Sanghvi","year":"2014","journal-title":"Laryngoscope"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2500\/105065899782106698","article-title":"Malignant tumors of the nose and paranasal sinuses: Hospital of the University of Pennsylvania experience 1990\u20131997","volume":"13","author":"Tufano","year":"1999","journal-title":"Am. 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