{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:43:42Z","timestamp":1790221422638,"version":"4.1.0"},"reference-count":32,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T00:00:00Z","timestamp":1650153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>This large, retrospective, single-centre study evaluated the diagnostic performance of 18F-choline positron emission tomography\/contrast-enhanced computed tomography (PET\/ceCT) in preoperative parathyroid adenoma detection in primary hyperparathyroidism cases after negative\/inconclusive ultrasound or other imaging findings. We included patients who underwent surgery and 18F-choline PET\/ceCT for inconclusive imaging results between 2015 and 2020. We compared the 18F-choline PET\/ceCT results with surgical and histopathological findings and identified the variables influencing the correlation between 18F-choline PET\/ceCT and surgical findings. Of 215 enrolled patients, 269 glands (mean lesion size, 10.9 \u00b1 8.0 mm) were analysed. There were 165 unilocular and 50 multilocular lesions; the mean preoperative calcium level was 2.18 \u00b1 0.19 mmol\/L. Among 860 estimated lesions, 219 were classified as true positive, 21 as false positive, and 28 as false negative. The per-lesion sensitivity was 88.66%; specificity, 96.57%; positive predictive value, 91.40%; and negative predictive value, 95.39%. The detection and cure rates were 82.0% and 95.0%, respectively. On univariate and multivariate analyses, the maximum standardised uptake value (SUVmax), lesion size, and unilocularity correlated with the pathologic findings of hyperfunctioning glands. 18F-choline PET\/ceCT presents favourable diagnostic performance as a second-line imaging method, with SUVmax, lesion size, and unilocularity predicting a high correlation between the 18F-choline PET\/ceCT and surgical findings.<\/jats:p>","DOI":"10.3390\/cancers14082029","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T04:21:28Z","timestamp":1650255688000},"page":"2029","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Diagnostic Performance of 18F-Choline Positron Emission Tomography\/Contrast-Enhanced Computed Tomography in Adenoma Detection in Primary Hyperparathyroidism after Inconclusive Imaging: A Retrospective Study of 215 Patients"],"prefix":"10.3390","volume":"14","author":[{"given":"Johan","family":"Benjamin","sequence":"first","affiliation":[{"name":"Service de Chirurgie Endocrinienne, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 69495 Pierre-B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Maillard","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Endocrinienne, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 69495 Pierre-B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Morelec","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Nucl\u00e9aire, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 69495 Pierre-B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Got","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Nucl\u00e9aire, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 69495 Pierre-B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2515-7840","authenticated-orcid":false,"given":"Fran\u00e7oise","family":"Borson-Chazot","sequence":"additional","affiliation":[{"name":"F\u00e9d\u00e9ration d\u2019Endocrinologie, H\u00f4pital Louis Pradel, 69500 Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Lifante","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Endocrinienne, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 69495 Pierre-B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s40336-014-0089-4","article-title":"SPECT\/CT in hyperparathyroidism","volume":"2","author":"Spanu","year":"2014","journal-title":"Clin. 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