{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:58:48Z","timestamp":1789181928741,"version":"build-2803163510"},"reference-count":129,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"KU-KIST Graduate School of Converging Science and Technology of Korea University","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"name":"Intramural Research Program of Korea Institute of Science and Technology","award":["2E31621"],"award-info":[{"award-number":["2E31621"]}]},{"name":"Medical Intelligence for Digitally Assisted Surgery of Korea Institute of Science and Technology.","award":["2E31571"],"award-info":[{"award-number":["2E31571"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>One of the promising cancer treatment methods is photothermal therapy (PTT), which has achieved good therapeutic efficiency through nanoparticle-based photoabsorbers. Because of the various functions of nanoparticles, such as targeting properties, high light-to-heat conversion, and photostability, nanoparticle-mediated PTT successfully induces photothermal damage in tumor tissues with minimal side effects on surrounding healthy tissues. The therapeutic efficacy of PTT originates from cell membrane disruption, protein denaturation, and DNA damage by light-induced heat, but these biological impacts only influence localized tumor areas. This conventional nanoparticle-mediated PTT still attracts attention as a novel cancer immunotherapy, because PTT causes immune responses against cancer. PTT-induced immunogenic cell death activates immune cells for systemic anti-cancer effect. Additionally, the excellent compatibility of PTT with other treatment methods (e.g., chemotherapy and immune checkpoint blockade therapy) reinforces the therapeutic efficacy of PTT as combined immunotherapy. In this review, we investigate various PTT agents of nanoparticles and compare their applications to reveal how nanoparticle-mediated PTT undergoes a transition from thermotherapy to immunotherapy.<\/jats:p>","DOI":"10.3390\/cancers14082044","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T22:04:02Z","timestamp":1650319442000},"page":"2044","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["How Did Conventional Nanoparticle-Mediated Photothermal Therapy Become \u201cHot\u201d in Combination with Cancer Immunotherapy?"],"prefix":"10.3390","volume":"14","author":[{"given":"Wan Su","family":"Yun","sequence":"first","affiliation":[{"name":"KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Ho","family":"Park","sequence":"additional","affiliation":[{"name":"NanoBio Materials Laboratory, Department of Materials Science and Engineering, College of Engineering, Seoul National University, 1 Gwanak-ro, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Kwon","family":"Lim","sequence":"additional","affiliation":[{"name":"KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol-Hee","family":"Ahn","sequence":"additional","affiliation":[{"name":"NanoBio Materials Laboratory, Department of Materials Science and Engineering, College of Engineering, Seoul National University, 1 Gwanak-ro, Seoul 08826, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1195-0872","authenticated-orcid":false,"given":"In-Cheol","family":"Sun","sequence":"additional","affiliation":[{"name":"Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology, 5, Seoul 02792, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7919-188X","authenticated-orcid":false,"given":"Kwangmeyung","family":"Kim","sequence":"additional","affiliation":[{"name":"KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seoul 02841, Korea"},{"name":"Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology, 5, Seoul 02792, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Breasted, J.H. 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