{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T16:22:41Z","timestamp":1781886161834,"version":"3.54.5"},"reference-count":53,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Translational Cancer Research Network","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"name":"UNSW School of Biotechnology &amp; Biomolecular Sciences","award":["Next Generation Sequencing grant"],"award-info":[{"award-number":["Next Generation Sequencing grant"]}]},{"name":"Royal Australian and New Zealand College of Obstetricians and Gynecologists","award":["Mary Elizabeth Courier Research Scholarship"],"award-info":[{"award-number":["Mary Elizabeth Courier Research Scholarship"]}]},{"DOI":"10.13039\/501100001773","name":"UNSW Sydney","doi-asserted-by":"publisher","award":["Scientia fellowship (NOK)"],"award-info":[{"award-number":["Scientia fellowship (NOK)"]}],"id":[{"id":"10.13039\/501100001773","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001171","name":"Cancer Institute of New South Wales","doi-asserted-by":"publisher","award":["2021\/CDF1120 (FLB)"],"award-info":[{"award-number":["2021\/CDF1120 (FLB)"]}],"id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Obesity is a risk factor for endometrial cancer. The aim of this study was to determine whether actively replicating microbiota in the endometrium differ between obese vs. lean and cancer vs. benign states. We performed 16S rRNA amplicon sequencing on endometrial tissues from lean and obese women with and without endometrial cancer, and lean and obese mice. Results displayed human endometrial microbiota clustered into three community types (R = 0.363, p = 0.001). Lactobacillus was dominant in community type 1 (C1) while community type 2 (C2) had high levels of Proteobacteria and more cancer samples when compared to C1 (p = 0.007) and C3 (p = 0.0002). A significant increase in the prevalence of the C2 community type was observed across body mass index and cancer (\u03c72 = 14.24, p = 0.0002). The relative abundance of Lactobacillus was lower in cancer samples (p = 0.0043), and an OTU with 100% similarity to Lactobacillus iners was enriched in control samples (p = 0.0029). Mouse endometrial microbiota also clustered into three community types (R = 0.419, p = 0.001) which were not influenced by obesity. In conclusion, obesity and cancer are associated with community type prevalence in the human endometrium, and Lactobacillus abundance is associated with normal uterine histologies in humans and mice.<\/jats:p>","DOI":"10.3390\/cancers14092141","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T21:16:28Z","timestamp":1650921388000},"page":"2141","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Differences in the Active Endometrial Microbiota across Body Weight and Cancer in Humans and Mice"],"prefix":"10.3390","volume":"14","author":[{"given":"Nadeem O.","family":"Kaakoush","sequence":"first","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M.","family":"Olzomer","sequence":"additional","affiliation":[{"name":"School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, NSW 2052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melidya","family":"Kosasih","sequence":"additional","affiliation":[{"name":"School of Women\u2019s and Children\u2019s Health, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy R.","family":"Martin","sequence":"additional","affiliation":[{"name":"School of Women\u2019s and Children\u2019s Health, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia"},{"name":"Department of Obstetrics and Gynecology, Royal North Shore Hospital, St Leonards, Sydney, NSW 2065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farokh","family":"Fargah","sequence":"additional","affiliation":[{"name":"Laverty Pathology-North Ryde, Macquarie Park, Sydney, NSW 2113, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Lambie","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Canterbury Health Laboratories, Christchurch 8011, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella","family":"Susic","sequence":"additional","affiliation":[{"name":"School of Women\u2019s and Children\u2019s Health, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0214-3238","authenticated-orcid":false,"given":"Kyle L.","family":"Hoehn","sequence":"additional","affiliation":[{"name":"School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, NSW 2052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7036-8968","authenticated-orcid":false,"given":"Rhonda","family":"Farrell","sequence":"additional","affiliation":[{"name":"Chris O\u2019Brien Lifehouse, Camperdown, NSW 2050, Australia"},{"name":"Prince of Wales Private Hospital, Randwick, NSW 2031, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8897-8438","authenticated-orcid":false,"given":"Frances L.","family":"Byrne","sequence":"additional","affiliation":[{"name":"School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, NSW 2052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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