{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:39:18Z","timestamp":1788824358622,"version":"build-2803163510"},"reference-count":123,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Benzofuran is a heterocyclic compound found naturally in plants and it can also be obtained through synthetic reactions. Multiple physicochemical characteristics and versatile features distinguish benzofuran, and its chemical structure is composed of fused benzene and furan rings. Benzofuran derivatives are essential compounds that hold vital biological activities to design novel therapies with enhanced efficacy compared to conventional treatments. Therefore, medicinal chemists used its core to synthesize new derivatives that can be applied to a variety of disorders. Benzofuran exhibited potential effectiveness in chronic diseases such as hypertension, neurodegenerative and oxidative conditions, and dyslipidemia. In acute infections, benzofuran revealed anti-infective properties against microorganisms like viruses, bacteria, and parasites. In recent years, the complex nature and the number of acquired or resistant cancer cases have been largely increasing. Benzofuran derivatives revealed potential anticancer activity with lower incidence or severity of adverse events normally encountered during chemotherapeutic treatments. This review discusses the structure\u2013activity relationship (SAR) of several benzofuran derivatives in order to elucidate the possible substitution alternatives and structural requirements for a highly potent and selective anticancer activity.<\/jats:p>","DOI":"10.3390\/cancers14092196","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T12:06:01Z","timestamp":1651147561000},"page":"2196","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Structure\u2013Activity Relationship of Benzofuran Derivatives with Potential Anticancer Activity"],"prefix":"10.3390","volume":"14","author":[{"given":"Joviana","family":"Farhat","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Population Health, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9307-3644","authenticated-orcid":false,"given":"Lara","family":"Alzyoud","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Al Ain University, Abu Dhabi P.O. Box 64141, United Arab Emirates"},{"name":"Health and Biomedical Research Center, Al Ain University, Abu Dhabi P.O. Box 64141, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Alwahsh","sequence":"additional","affiliation":[{"name":"Leibniz-Institut F\u00fcr Analytische Wissenschaften-ISAS e.V., 44139 Dortmund, Germany"},{"name":"Institute of Pathology and Medical Research Center (ZMF), University Medical Center Mannheim, Heid Elberg University, 68167 Mannheim, Germany"},{"name":"Department of Pharmacy, Faculty of Pharmacy, AlZaytoonah University of Jordan, P.O. Box 130, Amman 11733, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7804-8050","authenticated-orcid":false,"given":"Basem","family":"Al-Omari","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates"},{"name":"KU Research and Data Intelligence Support Center (RDISC) AW 8474000331, Khalifa University of Science and Technology, Abu Dhabi P.O. Box 127788, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.pharep.2016.11.007","article-title":"A Review on Antioxidant Potential of Bioactive Heterocycle Benzofuran: Natural and Synthetic Derivatives","volume":"69","author":"Chand","year":"2017","journal-title":"Pharmacol. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ejmech.2015.01.021","article-title":"Bioactive Benzofuran Derivatives: An Insight on Lead Developments, Radioligands and Advances of the Last Decade","volume":"97","author":"Radadiya","year":"2015","journal-title":"Eur. J. Med. 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