{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:33:35Z","timestamp":1791855215922,"version":"4.3.4"},"reference-count":38,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"JSPS KAKENHI","doi-asserted-by":"publisher","award":["JP20K10251"],"award-info":[{"award-number":["JP20K10251"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>This study aimed to clarify the advantages and disadvantages of conventional visual inspection (CVI), endoscopic white light imaging (WLI), and narrow-band imaging (NBI) and to examine the diagnostic accuracy of intraepithelial papillary capillary loops (IPCL) for the detection of oral squamous cell carcinoma (OSCC). This cross-sectional study included 60 participants with oral mucosal diseases suspected of having oral potentially malignant disorders (OPMDs) or OSCC. The patients underwent CVI, WLI, NBI, and incisional biopsy. Images were evaluated to assess the lesion size, color, texture, and IPCL. Oral lichen planus (OLP) and oral leukoplakia lesions were observed in larger areas with NBI than with WLI; 75.0% were associated with low-grade (Type 0\u2013II) IPCL. Various types of oral leukoplakia were seen; however, all OSCC cases showed high-grade (Type III\u2013IV) IPCL. The diagnostic accuracy of high-grade IPCL for OSCC showed a sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 100%, 80.9%, 59.1%, 100%, and 85.0%, respectively. A non-homogeneous lesion with high-grade IPCL strongly suggested malignancy. Overall, our results indicate that WLI and NBI are powerful tools for detecting precancerous and cancerous lesions using IPCL. However, NBI is influenced by mucosal thickness; therefore, image interpretation is important for accurate diagnosis.<\/jats:p>","DOI":"10.3390\/cancers14102415","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T08:37:02Z","timestamp":1652431022000},"page":"2415","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Diagnostic Accuracy of High-Grade Intraepithelial Papillary Capillary Loops by Narrow Band Imaging for Early Detection of Oral Malignancy: A Cross-Sectional Clinicopathological Imaging Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Airi","family":"Ota","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Reconstructive Surgery, Division of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, Morioka 020-8505, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4642-8611","authenticated-orcid":false,"given":"Ikuya","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Reconstructive Surgery, Division of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, Morioka 020-8505, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9212-0445","authenticated-orcid":false,"given":"Yu","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Reconstructive Surgery, Division of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, Morioka 020-8505, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7072-3157","authenticated-orcid":false,"given":"Toshimi","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Division of Internal Medicine, School of Dentistry, Iwate Medical University, Morioka 020-8505, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Reconstructive Surgery, Division of Clinical Pathology, School of Dentistry, Iwate Medical University, Morioka 028-3695, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Reconstructive Surgery, Division of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, Morioka 020-8505, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"E2358","DOI":"10.1002\/hed.24300","article-title":"Narrow band imaging for the diagnosis of head and neck squamous cell carcinoma: A systematic review","volume":"38","author":"Cosway","year":"2016","journal-title":"Head Neck"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.ijom.2021.01.012","article-title":"Clinicopathologic factors associated with malignant transformation of oral leukoplakias: A retrospective cohort study","volume":"50","author":"Pettersson","year":"2021","journal-title":"Int. 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