{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:17:55Z","timestamp":1790572675472,"version":"4.1.0"},"reference-count":47,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society (ACS) Research Scholar Grant","doi-asserted-by":"publisher","award":["RSG-15-003-01-CCE"],"award-info":[{"award-number":["RSG-15-003-01-CCE"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society (ACS) Research Scholar Grant","doi-asserted-by":"publisher","award":["1P50CA211015-01A1"],"award-info":[{"award-number":["1P50CA211015-01A1"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society (ACS) Research Scholar Grant","doi-asserted-by":"publisher","award":["1R21CA223757-01"],"award-info":[{"award-number":["1R21CA223757-01"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of California Research Coordinating Committee","award":["RSG-15-003-01-CCE"],"award-info":[{"award-number":["RSG-15-003-01-CCE"]}]},{"name":"University of California Research Coordinating Committee","award":["1P50CA211015-01A1"],"award-info":[{"award-number":["1P50CA211015-01A1"]}]},{"name":"University of California Research Coordinating Committee","award":["1R21CA223757-01"],"award-info":[{"award-number":["1R21CA223757-01"]}]},{"name":"UCLA Jonsson Comprehensive Cancer Center Seed Grant","award":["RSG-15-003-01-CCE"],"award-info":[{"award-number":["RSG-15-003-01-CCE"]}]},{"name":"UCLA Jonsson Comprehensive Cancer Center Seed Grant","award":["1P50CA211015-01A1"],"award-info":[{"award-number":["1P50CA211015-01A1"]}]},{"name":"UCLA Jonsson Comprehensive Cancer Center Seed Grant","award":["1R21CA223757-01"],"award-info":[{"award-number":["1R21CA223757-01"]}]},{"DOI":"10.13039\/100000054","name":"UCLA SPORE in Brain Cancer","doi-asserted-by":"publisher","award":["RSG-15-003-01-CCE"],"award-info":[{"award-number":["RSG-15-003-01-CCE"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"UCLA SPORE in Brain Cancer","doi-asserted-by":"publisher","award":["1P50CA211015-01A1"],"award-info":[{"award-number":["1P50CA211015-01A1"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"UCLA SPORE in Brain Cancer","doi-asserted-by":"publisher","award":["1R21CA223757-01"],"award-info":[{"award-number":["1R21CA223757-01"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Characterization of hypoxia and tissue acidosis could advance the understanding of glioma biology and improve patient management. In this study, we evaluated the ability of a pH- and oxygen-sensitive magnetic resonance imaging (MRI) technique to differentiate glioma genotypes, including isocitrate dehydrogenase (IDH) mutation, 1p\/19q co-deletion, and epidermal growth factor receptor (EGFR) amplification, and investigated its prognostic value. A total of 159 adult glioma patients were scanned with pH- and oxygen-sensitive MRI at 3T. We quantified the pH-sensitive measure of magnetization transfer ratio asymmetry (MTRasym) and oxygen-sensitive measure of R2\u2019 within the tumor region-of-interest. IDH mutant gliomas showed significantly lower MTRasym \u00d7 R2\u2019 (p &lt; 0.001), which differentiated IDH mutation status with sensitivity and specificity of 90.0% and 71.9%. Within IDH mutants, 1p\/19q codeletion was associated with lower tumor acidity (p &lt; 0.0001, sensitivity 76.9%, specificity 91.3%), while IDH wild-type, EGFR-amplified gliomas were more hypoxic (R2\u2019 p = 0.024, sensitivity 66.7%, specificity 76.9%). Both R2\u2019 and MTRasym \u00d7 R2\u2019 were significantly associated with patient overall survival (R2\u2019: p = 0.045; MTRasym \u00d7 R2\u2019: p = 0.002) and progression-free survival (R2\u2019: p = 0.010; MTRasym \u00d7 R2\u2019: p &lt; 0.0001), independent of patient age, treatment status, and IDH status. The pH- and oxygen-sensitive MRI is a clinically feasible and potentially valuable imaging technique for distinguishing glioma subtypes and providing additional prognostic value to clinical practice.<\/jats:p>","DOI":"10.3390\/cancers14102520","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T13:56:12Z","timestamp":1653054972000},"page":"2520","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Diagnostic and Prognostic Value of pH- and Oxygen-Sensitive Magnetic Resonance Imaging in Glioma: A Retrospective Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8828-1841","authenticated-orcid":false,"given":"Jingwen","family":"Yao","sequence":"first","affiliation":[{"name":"UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, University of California, Los Angeles, CA 90024, USA"},{"name":"Department 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of California, Los Angeles, CA 90024, USA"},{"name":"Neuroscience Interdepartmental Program, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chencai","family":"Wang","sequence":"additional","affiliation":[{"name":"UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, University of California, Los Angeles, CA 90024, USA"},{"name":"Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Raymond","sequence":"additional","affiliation":[{"name":"UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, University of California, Los Angeles, CA 90024, USA"},{"name":"Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney B.","family":"Pope","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Salamon","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Lai","sequence":"additional","affiliation":[{"name":"UCLA Neuro-Oncology Program, University of California, Los Angeles, CA 90024, USA"},{"name":"Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Ji","sequence":"additional","affiliation":[{"name":"UCLA Neuro-Oncology Program, University of California, Los Angeles, CA 90024, USA"},{"name":"Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phioanh L.","family":"Nghiemphu","sequence":"additional","affiliation":[{"name":"UCLA Neuro-Oncology Program, University of California, Los Angeles, CA 90024, USA"},{"name":"Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda M.","family":"Liau","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, 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