{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:24:56Z","timestamp":1772252696363,"version":"3.50.1"},"reference-count":38,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Patients with cancer are concerned about the effects of the COVID-19 vaccination. We conducted an online survey on the COVID-19 vaccination status and side effects among patients with cancer in Japan between 8 and 14 August 2021. We included 1182 female patients with cancer aged 20\u201370 years and registered on an online patient website. Of the patients, 944 had breast cancer, 216 had gynecological cancer, 798 were undergoing drug\/radiation therapy, and 370 were in follow-up. At the time of the survey, 885 patients had already received at least one dose. Of these, 580 had also received their second dose. The incidence rate of side effects was equivalent to previous reports. In patients with breast cancer, problems such as the onset or worsening of lymphedema or axillary lymphadenopathy metastasis requiring differential diagnosis were encountered following vaccination. A total of 768 patients were concerned about the vaccine at some point, and 726 consulted with their attending physicians about the timing or side effects of the vaccination. Of the 110 patients undergoing chemotherapy or radiation therapy, 75 adjusted the timing of the vaccination based on their therapy. The cross-analysis revealed that 81% of those who consulted their physician had received at least one dose of the COVID-19 vaccination compared with 65% of those who had not consulted their physician. Consulting with a physician about the COVID-19 vaccination was found to alleviate the concerns of patients with cancer and encourage them to get vaccinated.<\/jats:p>","DOI":"10.3390\/cancers14102556","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T22:57:22Z","timestamp":1653346642000},"page":"2556","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["COVID-19 Vaccination in Patients with Cancer"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3643-9862","authenticated-orcid":false,"given":"Hitomi","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Breast and Endocrinology Surgery, Ichinomiya Nishi Hospital, Ichinomiya 494-0001, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6720-8995","authenticated-orcid":false,"given":"Tomohiro","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Advanced Research Laboratories, Tokyo City University, Tokyo 158-0082, Japan"},{"name":"Graduate School of Education, Kyoto University, Kyoto 606-8501, Japan"},{"name":"Graduate School of Global Environmental Studies, Sophia University, Tokyo 102-8554, Japan"},{"name":"School of Integrative and Global Majors, University of Tsukuba, Tsukuba 305-8577, Japan"},{"name":"Graduate School of Information Technology, Kobe Institute of Computing, Kobe 650-0001, Japan"},{"name":"School of Social and Behavioral Sciences, Nanjing University, Nanjing 210023, China"},{"name":"Institute for Humanities in Africa, University of Cape Town, Rondebosch 7701, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0223-4949","authenticated-orcid":false,"given":"Nobuko","family":"Ueda","sequence":"additional","affiliation":[{"name":"Peer Ring Association, Yokohama 224-0001, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Peer Ring Association, Yokohama 224-0001, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrinology Surgery, Ichinomiya Nishi Hospital, Ichinomiya 494-0001, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Namiki","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrinology Surgery, Ichinomiya Nishi Hospital, Ichinomiya 494-0001, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norikazu","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrinology Surgery, Ichinomiya Nishi Hospital, Ichinomiya 494-0001, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chika","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrinology Surgery, Ichinomiya Nishi Hospital, Ichinomiya 494-0001, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Tozaki","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrinology Surgery, Ichinomiya Nishi Hospital, Ichinomiya 494-0001, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisayuki","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrinology Surgery, Ichinomiya Nishi Hospital, Ichinomiya 494-0001, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Torii","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrinology Surgery, Ichinomiya Nishi Hospital, Ichinomiya 494-0001, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Okubo","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrinology Surgery, Ichinomiya Nishi Hospital, Ichinomiya 494-0001, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyosuke","family":"Ishiguro","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrinology Surgery, Ichinomiya Nishi Hospital, Ichinomiya 494-0001, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3919\/jjsa.83.1","article-title":"Impact of COVID-19 on breast cancer patients","volume":"83","author":"Suzuki","year":"2022","journal-title":"J. Jpn. Surg. Assoc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s12282-020-01214-9","article-title":"Recommendations for the management of breast cancer patients during the COVID-19 pandemic from the Japan Breast Cancer Society","volume":"28","author":"Kawate","year":"2021","journal-title":"Breast Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1053\/j.seminoncol.2021.10.002","article-title":"COVID-19 vaccine-related axillary lymphadenopathy in breast cancer patients: Case series with a review of literature","volume":"48","author":"Lim","year":"2021","journal-title":"Semin. Oncol."},{"key":"ref_4","first-page":"20210040","article-title":"COVID-19 vaccine-related lymph node activation\u2014Patterns of uptake on PET-CT","volume":"7","author":"Shah","year":"2021","journal-title":"BJR Case Rep."},{"key":"ref_5","unstructured":"(2022, March 17). Peer Ring Association. Available online: http:\/\/site.peer-ring.com."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S1470-2045(20)30388-0","article-title":"The impact of the COVID-19 pandemic on cancer deaths due to delays in diagnosis in England, UK: A national, population-based, modelling study","volume":"21","author":"Maringe","year":"2020","journal-title":"Lancet Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S1470-2045(20)30309-0","article-title":"Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: A multicentre, retrospective, cohort study","volume":"21","author":"Tian","year":"2020","journal-title":"Lancet Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13045-021-01046-w","article-title":"COVID-19 vaccines for patients with cancer: Benefits likely outweigh risks","volume":"14","author":"Hwang","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ejca.2021.01.046","article-title":"SARS-CoV-2 vaccines for cancer patients: A call to action","volume":"148","author":"Corti","year":"2021","journal-title":"Eur. J. Cancer"},{"key":"ref_10","unstructured":"Japanese Society of Medical Oncology (2022, March 17). Q & A on COVID-19 Vaccination and Cancer Treatment. Available online: https:\/\/www.jsmo.or.jp\/news\/coronavirus-information\/qa_vaccinel_3gakkai.html."},{"key":"ref_11","unstructured":"National Comprehensive Cancer Network (2022, January 28). COVID-19 Vaccination and Cancer Patients. Available online: https:\/\/www.nccn.org\/covid-19."},{"key":"ref_12","unstructured":"The Royal College of Surgeons of England (2022, January 28). Vaccinated Patients Guidance. Available online: https:\/\/www.rcseng.ac.uk\/coronavirus\/vaccinated-patients-guidance."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s10549-021-06293-6","article-title":"COVID-19 vaccination and breast cancer surgery timing","volume":"188","author":"Ko","year":"2021","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_14","unstructured":"Japanese Society for Radiation Oncology (2022, January 28). Suggestions on SARS-CoV-2 Vaccination. Available online: https:\/\/www.jastro.or.jp\/medicalpersonnel\/news\/20210226.pdf."},{"key":"ref_15","unstructured":"European Society for Medical Oncology (2022, January 28). COVID-19 Vaccination in Cancer Patients: ESMO Statements. Available online: https:\/\/www.esmo.org\/covid-19-and-cancer\/covid-19-vaccination?hit=ehp."},{"key":"ref_16","unstructured":"American Society of Clinical Oncology (2022, January 28). COVID-19 Vaccines & Patients with Cancer. Available online: https:\/\/www.asco.org\/covid-resources\/vaccines-patients-cancer."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1158\/2159-8290.CD-20-1817","article-title":"Priority COVID-19 Vaccination for Patients with Cancer while Vaccine Supply Is Limited","volume":"11","author":"Ribas","year":"2021","journal-title":"Cancer Discov."},{"key":"ref_18","unstructured":"National Cancer Institute (2022, January 28). COVID-19: What People with Cancer Should Know, Available online: https:\/\/www.cancer.gov\/about-cancer\/coronavirus\/coronavirus-cancer-patient-information."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S1470-2045(21)00155-8","article-title":"Short-term safety of the BNT162b2 mRNA COVID-19 vaccine in patients with cancer treated with immune checkpoint inhibitors","volume":"22","author":"Waissengrin","year":"2021","journal-title":"Lancet Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1001\/jama.2021.5374","article-title":"Reactogenicity Following Receipt of mRNA-Based COVID-19 Vaccines","volume":"325","author":"Gee","year":"2021","journal-title":"JAMA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1056\/NEJMoa2110475","article-title":"Safety of the BNT162b2 mRNA COVID-19 Vaccine in a Nationwide Setting","volume":"385","author":"Barda","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1001\/jamaoncol.2021.2675","article-title":"Serologic Status and Toxic Effects of the SARS-CoV-2 BNT162b2 Vaccine in Patients Undergoing Treatment for Cancer","volume":"7","author":"Waldhorn","year":"2021","journal-title":"JAMA Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S1473-3099(21)00224-3","article-title":"Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: A prospective observational study","volume":"21","author":"Menni","year":"2021","journal-title":"Lancet Infect. Dis."},{"key":"ref_24","unstructured":"Pharmaceuticals and Medical Devices Agency (2022, January 28). COMIRNATY Intramuscular Injection, Available online: https:\/\/www.info.pmda.go.jp\/go\/pdf\/672212_631341DA1025_1_10."},{"key":"ref_25","unstructured":"Centers for Disease Control and Prevention (2022, January 28). Moderna COVID-19 Vaccine: What Healthcare Professionals Need to Know, Available online: https:\/\/www2.cdc.gov\/vaccines\/ed\/covid19\/moderna\/40140.asp."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/RLU.0000000000003648","article-title":"Axillary Lymph Nodes Hypermetabolism after BNT162b2 mRNA COVID-19 Vaccination in Cancer Patients Undergoing 18F-FDG PET\/CT: A Cohort Study","volume":"46","author":"Bernstine","year":"2021","journal-title":"Clin. Nucl. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"134","DOI":"10.2967\/jnumed.121.262194","article-title":"COVID-19 mRNA Vaccination: Age and Immune Status and Its Association with Axillary Lymph Node PET\/CT Uptake","volume":"63","author":"Eifer","year":"2022","journal-title":"J. Nucl. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13244-021-01062-x","article-title":"Axillary lymphadenopathy at the time of COVID-19 vaccination: Ten recommendations from the European Society of Breast Imaging (EUSOBI)","volume":"12","author":"Schiaffino","year":"2021","journal-title":"Insights Imaging"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.acra.2021.06.003","article-title":"COVID-19 Vaccination Induced Lymphadenopathy in a Specialized Breast Imaging Clinic in Israel: Analysis of 163 cases","volume":"28","author":"Faermann","year":"2021","journal-title":"Acad. Radiol."},{"key":"ref_30","unstructured":"Society of Breast Imaging Patient Care and Delivery Committee (2022, January 28). SBI Recommendations for the Management of Axillary Adenopathy in Patients with Recent COVID-19 Vaccination. Available online: https:\/\/www.sbi-online.org\/Portals\/0\/Position%20Statements\/2021\/SBI-recommendations-for-managing-axillary-adenopathy-post-COVID-vaccination.pdf."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"E323","DOI":"10.1148\/radiol.2021210436","article-title":"Multidisciplinary Recommendations Regarding Post-Vaccine Adenopathy and Radiologic Imaging: Radiology Scientific Expert Panel","volume":"300","author":"Becker","year":"2021","journal-title":"Radiology"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Gao, J., Zheng, P., Jia, Y., Chen, H., Mao, Y., Chen, S., Wang, Y., Fu, H., and Dai, J. (2020). Mental health problems and social media exposure during COVID-19 outbreak. PLoS ONE, 15.","DOI":"10.2139\/ssrn.3541120"},{"key":"ref_33","first-page":"S162","article-title":"Information Overload and Infodemic in the COVID-19 Pandemic","volume":"70","author":"Rathore","year":"2020","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Chen, C.P., Kung, P.T., Wang, Y.H., and Tsai, W.C. (2019). Effect of time interval from diagnosis to treatment for cervical cancer on survival: A nationwide cohort study. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0221946"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10549-016-3960-3","article-title":"The relationship between time to initiation of adjuvant chemotherapy and survival in breast cancer: A systematic review and meta-analysis","volume":"160","author":"Raphael","year":"2016","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1245\/s10434-016-5486-7","article-title":"Time to Treatment: Measuring Quality Breast Cancer Care","volume":"23","author":"Polverini","year":"2016","journal-title":"Ann. Surg. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1200\/JCO.2008.18.1891","article-title":"Intervals Longer Than 20 Weeks From Breast-Conserving Surgery to Radiation Therapy Are Associated with Inferior Outcome for Women with Early-Stage Breast Cancer Who Are Not Receiving Chemotherapy","volume":"27","author":"Olivotto","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1001\/jamaoncol.2015.4508","article-title":"Time to Surgery and Breast Cancer Survival in the United States","volume":"2","author":"Bleicher","year":"2016","journal-title":"JAMA Oncol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/10\/2556\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:16:42Z","timestamp":1760138202000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/10\/2556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,23]]},"references-count":38,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["cancers14102556"],"URL":"https:\/\/doi.org\/10.3390\/cancers14102556","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-1352502\/v1","asserted-by":"object"}]},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,23]]}}}