{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T20:59:49Z","timestamp":1773694789369,"version":"3.50.1"},"reference-count":47,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Mesothelioma, a malignant neoplasm of mesothelial cells, has overall poor prognosis. Cell adhesion molecules (CAMs) are proteins that contribute to the immune response. In this study the clinical utility and prognostic significance of serum and pleural fluid soluble CAM (sCAM) levels were assessed in patients with mesothelioma. Mesothelioma patients were retrospectively recruited (2016\u20132020). Clinical characteristics, serum and pleural sCAM levels (sE-cadherin, sE-selectin, intercellular adhesion molecule 1 (sICAM-1) and vascular cell adhesion molecule 1 (sVCAM-1)) and histopathological characteristics were gathered. A total of 51 healthy controls were also recruited for a secondary cross-sectional analysis. 92 mesothelioma patients were analyzed (mean age 64.5 years, 87% males, performance status 0\u20132). Patients with increased pleural sE-cadherin had higher risk for disease progression (adjusted HR 1.11 (1.02, 1.20), p = 0.013). Serum and pleural sE-selectin were decreased in patients with high-grade mesothelioma. Patients with increased serum or pleural sE-selectin levels had lower risk for death (adjusted HR 0.88 (0.81, 0.96), p = 0.003; 0.90 (0.82, 0.99), p = 0.039, respectively). Serum sE-cadherin, sE-selectin and sICAM-1 levels were significantly increased in mesothelioma patients compared to healthy controls. Further studies are needed to indicate the clinical utility of serum and pleural sCAMs in mesothelioma patients.<\/jats:p>","DOI":"10.3390\/cancers14122825","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T10:49:14Z","timestamp":1654771754000},"page":"2825","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum and Pleural Soluble Cell Adhesion Molecules in Mesothelioma Patients: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Sofia","family":"Tsagkouli","sequence":"first","affiliation":[{"name":"Third Department of Medicine, School of Medicine, Sotiria Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2970-088X","authenticated-orcid":false,"given":"Ioannis G.","family":"Kyriakoulis","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, School of Medicine, Sotiria Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8986-2704","authenticated-orcid":false,"given":"Konstantinos G.","family":"Kyriakoulis","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, School of Medicine, Sotiria Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Fyta","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, School of Medicine, Sotiria Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandros","family":"Syrigos","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, School of Medicine, Sotiria Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9256-9656","authenticated-orcid":false,"given":"Petros","family":"Bakakos","sequence":"additional","affiliation":[{"name":"First Department of Chest Medicine, School of Medicine, Sotiria Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5107-6430","authenticated-orcid":false,"given":"Adrianni","family":"Charpidou","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, School of Medicine, Sotiria Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2563-0968","authenticated-orcid":false,"given":"Elias","family":"Kotteas","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, School of Medicine, Sotiria Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"ref_1","first-page":"70","article-title":"Mesothelioma: A review","volume":"12","author":"Mott","year":"2012","journal-title":"Ochsner J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0140-6736(05)67025-0","article-title":"Malignant mesothelioma","volume":"366","author":"Robinson","year":"2005","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1200\/JCO.1998.16.1.145","article-title":"Prognostic factors in patients with pleural mesothelioma: The European Organization for Research and Treatment of Cancer experience","volume":"16","author":"Curran","year":"1998","journal-title":"J. Clin. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1055\/s-0039-1693406","article-title":"Malignant Mesothelioma: Has Anything Changed?","volume":"40","author":"Kim","year":"2019","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S285","DOI":"10.21037\/jtd.2017.10.16","article-title":"Surgery for malignant pleural mesothelioma: An international guidelines review","volume":"10","author":"Ricciardi","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3109\/09687689709044318","article-title":"Cell adhesion: More than just glue (review)","volume":"15","author":"Buckley","year":"1998","journal-title":"Mol. Membr. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00441-014-1809-9","article-title":"Leukocyte recruitment in inflammation: Basic concepts and new mechanistic insights based on new models and microscopic imaging technologies","volume":"355","author":"Leick","year":"2014","journal-title":"Cell Tissue Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1471-4914(03)00071-6","article-title":"The role of selectins in inflammation and disease","volume":"9","author":"Ley","year":"2003","journal-title":"Trends Mol. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.sbi.2003.10.007","article-title":"Cadherin-mediated cell-cell adhesion: Sticking together as a family","volume":"13","author":"Patel","year":"2003","journal-title":"Curr. Opin. Struct. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.3389\/fimmu.2019.01078","article-title":"Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment","volume":"10","author":"Guenther","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1091\/mbc.E16-01-0058","article-title":"Roles for E-cadherin cell surface regulation in cancer","volume":"27","author":"Petrova","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.surg.2007.01.016","article-title":"ICAM-1 expression determines malignant potential of cancer","volume":"141","author":"Roland","year":"2007","journal-title":"Surgery"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.3109\/07357900902769749","article-title":"Cell adhesion molecules: Role and clinical significance in cancer","volume":"27","author":"Makrilia","year":"2009","journal-title":"Cancer Investig."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Bulska-Bedkowska, W., Czajka-Francuz, P., Jurek-Cison, S., Owczarek, A.J., Francuz, T., and Chudek, J. (2022). The Predictive Role of Serum Levels of Soluble Cell Adhesion Molecules (sCAMs) in the Therapy of Advanced Breast Cancer-A Single-Centre Study. Medicina, 58.","DOI":"10.3390\/medicina58020153"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1016\/S0959-8049(01)00318-5","article-title":"Serum levels of E-selectin, ICAM-1 and VCAM-1 in colorectal cancer patients: Correlations with clinicopathological features, patient survival and tumour surgery","volume":"37","author":"Alexiou","year":"2001","journal-title":"Eur. J. Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/j.1572-0241.2003.07259.x","article-title":"Clinical significance of serum levels of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in gastric cancer patients","volume":"98","author":"Alexiou","year":"2003","journal-title":"Am. J. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies","volume":"61","author":"Altman","year":"2008","journal-title":"J. Clin. Epidemiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1177\/030089169908500107","article-title":"Serum-soluble E-cadherin fragments in lung cancer","volume":"85","author":"Cioffi","year":"1999","journal-title":"Tumori"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1016\/j.jss.2011.11.009","article-title":"Clinical significance of serum soluble E-cadherin in colorectal carcinoma","volume":"175","author":"Okugawa","year":"2012","journal-title":"J. Surg. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1002\/ijc.29982","article-title":"Beyond a tumor suppressor: Soluble E-cadherin promotes the progression of cancer","volume":"138","author":"Hu","year":"2016","journal-title":"Int. J. Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"408047","DOI":"10.1155\/2014\/408047","article-title":"Levels of soluble E-cadherin in breast, gastric, and colorectal cancers","volume":"2014","author":"Repetto","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1080\/00365520310003985","article-title":"Dual role of serum soluble E-cadherin as a biological marker of metastatic development in gastric cancer","volume":"38","author":"Juhasz","year":"2003","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_23","first-page":"83","article-title":"The clinical significance of soluble E-cadherin in nonsmall cell lung cancer","volume":"28","author":"Charalabopoulos","year":"2006","journal-title":"Exp. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/modpathol.2011.144","article-title":"Epithelial-mesenchymal transition in malignant mesothelioma","volume":"25","author":"Fassina","year":"2012","journal-title":"Mod. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40364-021-00299-4","article-title":"E-Cadherin expression in human tumors: A tissue microarray study on 10,851 tumors","volume":"9","author":"Burandt","year":"2021","journal-title":"Biomark. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1177\/172460080201700107","article-title":"Soluble selectin levels in patients with lung cancer","volume":"17","author":"Roselli","year":"2002","journal-title":"Int. J. Biol. Markers"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1378\/chest.10-0157","article-title":"Soluble adhesion molecules E-cadherin, intercellular adhesion molecule-1, and E-selectin as lung cancer biomarkers","volume":"138","author":"Gogali","year":"2010","journal-title":"Chest"},{"key":"ref_29","first-page":"1427","article-title":"Prognostic value of circulating soluble E-selectin concentrations in node-negative breast cancer patients","volume":"5","author":"Hebbar","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1016\/S0959-8049(02)00218-6","article-title":"Soluble adhesion molecules (E-selectin, ICAM-1 and VCAM-1) in breast carcinoma","volume":"38","author":"Fitzsimons","year":"2002","journal-title":"Eur. J. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Kang, S.A., Blache, C.A., Bajana, S., Hasan, N., Kamal, M., Morita, Y., Gupta, V., Tsolmon, B., Suh, K.S., and Gorenstein, D.G. (2016). The effect of soluble E-selectin on tumor progression and metastasis. BMC Cancer, 16.","DOI":"10.1186\/s12885-016-2366-2"},{"key":"ref_32","first-page":"71","article-title":"Serum levels of soluble intercellular adhesion molecule-1 and E-selectin in metastatic breast carcinoma: Correlations with clinicopathological features and prognosis","volume":"14","author":"Zhang","year":"1999","journal-title":"Int. J. Oncol."},{"key":"ref_33","first-page":"269","article-title":"Serum levels of soluble E-selectin in colorectal cancer","volume":"51","author":"Uner","year":"2004","journal-title":"Neoplasma"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/bjc.1998.476","article-title":"Circulating intercellular adhesion molecule-1 and E-selectin levels in gastric cancer","volume":"78","author":"Benekli","year":"1998","journal-title":"Br. J. Cancer"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"676731","DOI":"10.1155\/2012\/676731","article-title":"Cancer cell adhesion and metastasis: Selectins, integrins, and the inhibitory potential of heparins","volume":"2012","author":"Bendas","year":"2012","journal-title":"Int. J. Cell Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.semcancer.2010.04.005","article-title":"Selectins promote tumor metastasis","volume":"20","author":"Borsig","year":"2010","journal-title":"Semin. Cancer Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/376517a0","article-title":"Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1","volume":"376","author":"Koch","year":"1995","journal-title":"Nature"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/JLB.2MR0220-549R","article-title":"ICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis","volume":"108","author":"Bui","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1378\/chest.110.1.107","article-title":"Detection of soluble adhesion molecules in pleural effusions","volume":"110","author":"Hoffmann","year":"1996","journal-title":"Chest"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"153029","DOI":"10.1016\/j.prp.2020.153029","article-title":"Soluble intercellular cell adhesion molecule-1 in lung cancer: A meta-analysis","volume":"216","author":"Wu","year":"2020","journal-title":"Pathol. Res. Pract."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3390\/pathophysiology29010006","article-title":"Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors","volume":"29","author":"Pospelova","year":"2022","journal-title":"Pathophysiology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1038\/bjc.1998.309","article-title":"Serum concentrations of soluble adhesion molecules in patients with colorectal cancer","volume":"77","author":"Velikova","year":"1998","journal-title":"Br. J. Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"7871","DOI":"10.1007\/s13277-014-2050-6","article-title":"Serum levels of vascular cell adhesion molecule-1 (VCAM-1) may have diagnostic, predictive, and prognostic roles in patients with lung cancer treated with platinum-based chemotherapy","volume":"35","author":"Tas","year":"2014","journal-title":"Tumour Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1177\/000331970405500406","article-title":"Cigarette smoking increases plasma concentrations of vascular cell adhesion molecule-1 in patients with coronary artery disease","volume":"55","author":"Cavusoglu","year":"2004","journal-title":"Angiology"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Kong, D.H., Kim, Y.K., Kim, M.R., Jang, J.H., and Lee, S. (2018). Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Immunological Disorders and Cancer. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19041057"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1189\/jlb.0106038","article-title":"Emerging roles for ectodomain shedding in the regulation of inflammatory responses","volume":"79","author":"Garton","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1667\/RR0380.1","article-title":"Adhesion molecules in radiotherapy","volume":"166","author":"Baluna","year":"2006","journal-title":"Radiat. Res."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/12\/2825\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:25:50Z","timestamp":1760138750000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/12\/2825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,8]]},"references-count":47,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["cancers14122825"],"URL":"https:\/\/doi.org\/10.3390\/cancers14122825","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,8]]}}}