{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:45:28Z","timestamp":1790516728009,"version":"4.1.0"},"reference-count":73,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T00:00:00Z","timestamp":1654992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ligue contre le Cancer (Comit\u00e9 Haute-Vienne, Comit\u00e9 Corr\u00e8ze and Comit\u00e9 Creuse)"},{"name":"National Health Service (Direction G\u00e9n\u00e9rale de la Sant\u00e9, Paris)"},{"name":"Centre Hospitalier Universitaire"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The Epstein-Barr virus (EBV) is associated with angioimmunoblastic T cell lymphoma (AITL), a peripheral T lymphoma of poor prognosis in at least 90% of cases. The role of EBV in this pathology is unknown. Using next-generation sequencing, we sequenced the entire EBV genome in biopsies from 18 patients with AITL, 16 patients with another EBV-associated lymphoma, and 2 controls. We chose an EBV target capture method, given the high specificity of this technique, followed by a second capture to increase sensitivity. We identified two main viral strains in AITL, one of them associated with the mutations BNRF1 S542N and BZLF1 A206S and with mutations in the EBNA-3 and LMP-2 genes. This strain was characterized in patients with short post-diagnosis survival. The main mutations found during AITL on the most mutated latency or tegument genes were identified and discussed. We showed that the virus was clonal in all the AITL samples, suggesting that it may be involved in this pathology. Additionally, EBV was latent in all the AITL samples; for one sample only, the virus was found to be latent and probably replicative, depending on the cells. These various elements support the role of EBV in AITL.<\/jats:p>","DOI":"10.3390\/cancers14122899","type":"journal-article","created":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T09:26:48Z","timestamp":1655026008000},"page":"2899","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Epstein-Barr Virus (EBV) Is Mostly Latent and Clonal in Angioimmunoblastic T Cell Lymphoma (AITL)"],"prefix":"10.3390","volume":"14","author":[{"given":"Racha","family":"Bahri","sequence":"first","affiliation":[{"name":"Microbiology Department, Faculty of Pharmacy, 87025 Limoges, France"},{"name":"Unit\u00e9 Mixte de Recherche CNRS (Centre National de la Recherche Scientifique) 7276 and INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) U1262, 87025 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Boyer","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche CNRS (Centre National de la Recherche Scientifique) 7276 and INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) U1262, 87025 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8869-5385","authenticated-orcid":false,"given":"Mohamad Adnan","family":"Halabi","sequence":"additional","affiliation":[{"name":"Microbiology Department, Faculty of Pharmacy, 87025 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Chaunavel","sequence":"additional","affiliation":[{"name":"Pathology Department, University Hospital Dupuytren, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Feuillard","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche CNRS (Centre National de la Recherche Scientifique) 7276 and INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) U1262, 87025 Limoges, France"},{"name":"Biological Hematology Department University Hospital Dupuytren, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Jaccard","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche CNRS (Centre National de la Recherche Scientifique) 7276 and INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) U1262, 87025 Limoges, France"},{"name":"Clinical Hematology Department, University Hospital Dupuytren, 87042 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4092-7164","authenticated-orcid":false,"given":"Sylvie","family":"Ranger-Rogez","sequence":"additional","affiliation":[{"name":"Microbiology Department, Faculty of Pharmacy, 87025 Limoges, France"},{"name":"Unit\u00e9 Mixte de Recherche CNRS (Centre National de la Recherche Scientifique) 7276 and INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) U1262, 87025 Limoges, France"},{"name":"Virology Department, University Hospital Dupuytren, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1038\/sj.onc.1206556","article-title":"Epstein-barr virus and oncogenesis: From latent genes to tumours","volume":"22","author":"Young","year":"2003","journal-title":"Oncogene"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2006.10.009","article-title":"Lineage structures in the genome sequences of three epstein-barr virus strains","volume":"359","author":"McGeoch","year":"2007","journal-title":"Virology"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Romero-Masters, J.C., Huebner, S.M., Ohashi, M., Bristol, J.A., Benner, B.E., Barlow, E.A., Turk, G.L., Nelson, S.E., Baiu, D.C., and Van Sciver, N. 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