{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:05:07Z","timestamp":1784909107818,"version":"3.55.0"},"reference-count":214,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Creativity and Management Office (RCMO)"},{"name":"Universiti Sains Malaysia (USM)"},{"name":"School of Medical Sciences, USM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Hematological malignancies (HMs) are a heterogeneous group of blood neoplasia generally characterized by abnormal blood-cell production. Detection of HMs-specific molecular biomarkers (e.g., surface antigens, nucleic acid, and proteomic biomarkers) is crucial in determining clinical states and monitoring disease progression. Early diagnosis of HMs, followed by an effective treatment, can remarkably extend overall survival of patients. However, traditional and advanced HMs\u2019 diagnostic strategies still lack selectivity and sensitivity. More importantly, commercially available chemotherapeutic drugs are losing their efficacy due to adverse effects, and many patients develop resistance against these drugs. To overcome these limitations, the development of novel potent and reliable theranostic agents is urgently needed to diagnose and combat HMs at an early stage. Recently, gold nanomaterials (GNMs) have shown promise in the diagnosis and treatment of HMs. Magnetic resonance and the surface-plasmon-resonance properties of GNMs have made them a suitable candidate in the diagnosis of HMs via magnetic-resonance imaging and colorimetric or electrochemical sensing of cancer-specific biomarkers. Furthermore, GNMs-based photodynamic therapy, photothermal therapy, radiation therapy, and targeted drug delivery enhanced the selectivity and efficacy of anticancer drugs or drug candidates. Therefore, surface-tuned GNMs could be used as sensitive, reliable, and accurate early HMs, metastatic HMs, and MRD-detection tools, as well as selective, potent anticancer agents. However, GNMs may induce endothelial leakage to exacerbate cancer metastasis. Studies using clinical patient samples, patient-derived HMs models, or healthy-animal models could give a precise idea about their theranostic potential as well as biocompatibility. The present review will investigate the theranostic potential of vectorized GNMs in HMs and future challenges before clinical theranostic applications in HMs.<\/jats:p>","DOI":"10.3390\/cancers14133047","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T21:55:19Z","timestamp":1655848519000},"page":"3047","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Theranostic Potentials of Gold Nanomaterials in Hematological Malignancies"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8922-9500","authenticated-orcid":false,"given":"Md Salman","family":"Shakil","sequence":"first","affiliation":[{"name":"Department of Mathematics and Natural Sciences, Brac University, 66 Mohakhali, Dhaka 1212, Bangladesh"},{"name":"Department of Pharmacology & Toxicology, University of Otago, Dunedin 9016, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahruba Sultana","family":"Niloy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0649-733X","authenticated-orcid":false,"given":"Kazi Mustafa","family":"Mahmud","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0088-0565","authenticated-orcid":false,"given":"Mohammad Amjad","family":"Kamal","sequence":"additional","affiliation":[{"name":"Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610064, China"},{"name":"King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia"},{"name":"Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh"},{"name":"Enzymoics, 7 Peterlee Place, Novel Global Community Educational Foundation, Hebersham, NSW 2770, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5937-6473","authenticated-orcid":false,"given":"Md Asiful","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia"},{"name":"Institute of Metabolism and Systems Research, University of Birmingham, Birmingham B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Button, E., Chan, R.J., Chambers, S., Butler, J., and Yates, P. (2017). A systematic review of prognostic factors at the end of life for people with a hematological malignancy. BMC Cancer, 17.","DOI":"10.1186\/s12885-017-3207-7"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Lapotko, D., Lukianova, E., Shnip, A., Zheltov, G., Potapnev, M., Savitsky, V., Klimovich, O., and Oraevsky, A. (2005, January 25). Laser activated nanothermolysis of leukemia cells monitored by photothermal microscopy. Proceedings of the Photons Plus Ultrasound: Imaging and Sensing 2005: The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-Optics, San Jose, CA, USA.","DOI":"10.1117\/12.596372"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"242","DOI":"10.21037\/atm.2018.05.30","article-title":"Diagnostic molecular techniques in haematology: Recent advances","volume":"6","author":"Koutsi","year":"2018","journal-title":"Ann. Transl. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1046\/j.1365-2257.1998.00141.x","article-title":"Modern molecular diagnostics and the management of haematological malignancies","volume":"20","author":"Morgan","year":"1998","journal-title":"Clin. Lab. Haematol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez, R., Ayala, R., and Mart\u00ednez-L\u00f3pez, J. (2019). Minimal Residual Disease Monitoring with Next-Generation Sequencing Methodologies in Hematological Malignancies. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20112832"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF03194661","article-title":"Methods of minimal residual disease (MRD) detection in childhood haematological malignancies","volume":"48","author":"Derwich","year":"2007","journal-title":"J. Appl. Genet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1182\/blood-2013-05-506170","article-title":"Minimal residual disease testing in multiple myeloma by flow cytometry: Major heterogeneity","volume":"122","author":"Flanders","year":"2013","journal-title":"Blood"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/s41375-020-0885-y","article-title":"Detection of chronic lymphocytic leukemia subpopulations in peripheral blood by phage ligands of tumor immunoglobulin B cell receptors","volume":"35","author":"Mimmi","year":"2021","journal-title":"Leukemia"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s12943-017-0730-8","article-title":"Monitoring multiple myeloma by idiotype-specific peptide binders of tumor-derived exosomes","volume":"16","author":"Iaccino","year":"2017","journal-title":"Mol. Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Klener, P., and Klanova, M. (2020). Drug Resistance in Non-Hodgkin Lymphomas. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21062081"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/s12185-020-02830-z","article-title":"Introduction by the Guest Editor: Recent advances in biology and treatment of multiple myeloma","volume":"111","author":"Tanaka","year":"2020","journal-title":"Int. J. Hematol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1182\/blood-2013-10-492223","article-title":"Advances in the treatment of hematologic malignancies using immunoconjugates","volume":"123","author":"Press","year":"2014","journal-title":"Blood"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"128","DOI":"10.6004\/jnccn.2014.0010","article-title":"Hematopoietic stem cell transplantation for hematologic malignancies in older adults: Geriatric principles in the transplant clinic","volume":"12","author":"Wildes","year":"2014","journal-title":"J. Natl. Compr. Canc. Netw."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/1097-0142(19900201)65:3+<786::AID-CNCR2820651326>3.0.CO;2-H","article-title":"Bone marrow transplantation in hematologic malignancies. Current status","volume":"65","author":"Santos","year":"1990","journal-title":"Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Allegra, A.G., Mannino, F., Innao, V., Musolino, C., and Allegra, A. (2020). Radioprotective Agents and Enhancers Factors. Preventive and Therapeutic Strategies for Oxidative Induced Radiotherapy Damages in Hematological Malignancies. Antioxidants, 9.","DOI":"10.3390\/antiox9111116"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/bjh.16247","article-title":"GATA2 deficiency and haematopoietic stem cell transplantation: Challenges for the clinical practitioner","volume":"188","author":"Bogaert","year":"2020","journal-title":"Br. J. Haematol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"558","DOI":"10.3109\/10428190903572219","article-title":"Failure of molecular diagnostics in chronic myeloid leukemia: An aberrant form of e13a2 BCR-ABL transcript causing false-negative results by standard polymerase chain reaction","volume":"51","author":"Jurcek","year":"2010","journal-title":"Leuk. Lymphoma"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e305","DOI":"10.1038\/bcj.2015.29","article-title":"Haematological cancer and quality of life: A systematic literature review","volume":"5","author":"Porro","year":"2015","journal-title":"Blood Cancer J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/bmt.2017.16","article-title":"Next-generation sequencing indicates false-positive MRD results and better predicts prognosis after SCT in patients with childhood ALL","volume":"52","author":"Kotrova","year":"2017","journal-title":"Bone Marrow Transpl."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/08880018.2019.1636168","article-title":"Comparison between flow cytometry and standard PCR in the evaluation of MRD in children with acute lymphoblastic leukemia treated with the GBTLI LLA\u20142009 protocol","volume":"36","author":"Rocha","year":"2019","journal-title":"Pediatr. Hematol. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1038\/s41375-019-0413-0","article-title":"Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph\u2009+\u2009ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1","volume":"33","author":"Pfeifer","year":"2019","journal-title":"Leukemia"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/leu.2012.231","article-title":"Improved flow cytometric detection of minimal residual disease in childhood acute lymphoblastic leukemia","volume":"27","author":"Denys","year":"2013","journal-title":"Leukemia"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s12668-014-0134-9","article-title":"Surface enhanced Raman spectroscopy-based method for leukemia biomarker detection using magnetic core@ gold shell nanoparticles","volume":"4","author":"Mehn","year":"2014","journal-title":"Bionanoscience"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.bbmt.2011.03.011","article-title":"Immunosuppressive effects of multiple myeloma are overcome by PD-L1 blockade","volume":"17","author":"Hallett","year":"2011","journal-title":"Biol. Blood Marrow Transpl."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1039\/C7NR09436A","article-title":"Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates","volume":"10","author":"Yasinska","year":"2018","journal-title":"Nanoscale"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"10410","DOI":"10.1021\/acs.chemrev.5b00193","article-title":"Gold Nanomaterials at Work in Biomedicine","volume":"115","author":"Yang","year":"2015","journal-title":"Chem. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"990","DOI":"10.3389\/fbioe.2020.00990","article-title":"Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities","volume":"8","author":"Hu","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/wnan.1341","article-title":"Biomedical applications of gold nanomaterials: Opportunities and challenges","volume":"7","author":"Sasidharan","year":"2015","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"202187","DOI":"10.1155\/2011\/202187","article-title":"Gold Nanoparticles: Promising Nanomaterials for the Diagnosis of Cancer and HIV\/AIDS","volume":"2011","author":"Kumar","year":"2011","journal-title":"J. Nanomater."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1039\/C1NR11188D","article-title":"Gold nanoparticles: Preparation, properties, and applications in bionanotechnology","volume":"4","author":"Yeh","year":"2012","journal-title":"Nanoscale"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s40089-021-00332-2","article-title":"Promise of gold nanomaterials as a lung cancer theranostic agent: A systematic review","volume":"11","author":"Niloy","year":"2021","journal-title":"Int. Nano Lett."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2174\/1389200221666200610173724","article-title":"Gold Nanoparticles; Potential Nanotheranostic Agent in Breast Cancer: A Comprehensive Review with Systematic Search Strategy","volume":"21","author":"Khandker","year":"2020","journal-title":"Curr. Drug Metab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"40","DOI":"10.31083\/j.fbl2702040","article-title":"Noble metal nanomaterials for the diagnosis and treatment of hematological malignancies","volume":"27","author":"Huang","year":"2022","journal-title":"Front. Biosci."},{"key":"ref_35","first-page":"235","article-title":"Exposure to airborne gold nanoparticles: A review of current toxicological data on the respiratory tract","volume":"22","author":"Marchetti","year":"2021","journal-title":"J. Nanoparticle Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1182\/blood-2010-05-282632","article-title":"Incidence of hematologic malignancies in Europe by morphologic subtype: Results of the HAEMACARE project","volume":"116","author":"Sant","year":"2010","journal-title":"Blood"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"i3","DOI":"10.1093\/annonc\/mdl443","article-title":"Epidemiology of hematological malignancies","volume":"18","author":"Bordoni","year":"2007","journal-title":"Ann. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Loda, M., Mucci, L.A., Mittelstadt, M.L., Van Hemelrijck, M., and Cotter, M.B. (2017). Epidemiology of Hematologic Malignancies. Pathology and Epidemiology of Cancer, Springer International Publishing.","DOI":"10.1007\/978-3-319-35153-7"},{"key":"ref_39","unstructured":"cBioPortal (2022, January 29). Leukemia. Available online: https:\/\/bit.ly\/3uz1IM4."},{"key":"ref_40","unstructured":"cBioPortal (2022, January 29). Lymphoma. Available online: https:\/\/bit.ly\/3usTDbt."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41568-020-0245-2","article-title":"Bone marrow niches in haematological malignancies","volume":"20","author":"Bonnet","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/nrc3895","article-title":"DNMT3A in haematological malignancies","volume":"15","author":"Yang","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.2147\/CMAR.S174476","article-title":"Abnormal microRNA expression in the course of hematological malignancies","volume":"10","author":"Szymczyk","year":"2018","journal-title":"Cancer Manag. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1517\/13543784.14.9.1161","article-title":"Targeted therapy for haematological malignancies: Clinical update from the American Society of Hematology, 2004","volume":"14","author":"Haas","year":"2005","journal-title":"Expert. Opin. Investig. Drugs"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci. Signal"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/ng.2532","article-title":"The genomic landscape of hypodiploid acute lymphoblastic leukemia","volume":"45","author":"Holmfeldt","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1056\/NEJMoa1605949","article-title":"TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes","volume":"375","author":"Welch","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41586-018-0623-z","article-title":"Functional genomic landscape of acute myeloid leukaemia","volume":"562","author":"Tyner","year":"2018","journal-title":"Nature"},{"key":"ref_50","unstructured":"TCGA, Firehose Legacy (2022, January 29). Acute Myeloid Leukemia. Available online: https:\/\/bit.ly\/3vPyg4p."},{"key":"ref_51","unstructured":"TARGET (2022, January 29). Pediatric Acute Myeloid Leukemia. Available online: https:\/\/bit.ly\/3tA7cow."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s41586-019-1012-y","article-title":"Efficacy of MEK inhibition in patients with histiocytic neoplasms","volume":"567","author":"Diamond","year":"2019","journal-title":"Nature"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature10496","article-title":"Frequent pathway mutations of splicing machinery in myelodysplasia","volume":"478","author":"Yoshida","year":"2011","journal-title":"Nature"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1056\/NEJMoa1516192","article-title":"Genomic Classification and Prognosis in Acute Myeloid Leukemia","volume":"374","author":"Papaemmanuil","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1182\/blood-2013-08-518886","article-title":"Clinical and biological implications of driver mutations in myelodysplastic syndromes","volume":"122","author":"Papaemmanuil","year":"2013","journal-title":"Blood"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1056\/NEJMoa1312542","article-title":"Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2","volume":"369","author":"Nangalia","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ng.3230","article-title":"The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias","volume":"47","author":"Andersson","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/ng.3691","article-title":"Deregulation of DUX4 and ERG in acute lymphoblastic leukemia","volume":"48","author":"Zhang","year":"2016","journal-title":"Nat. Genet."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.cell.2013.01.019","article-title":"Evolution and impact of subclonal mutations in chronic lymphocytic leukemia","volume":"152","author":"Landau","year":"2013","journal-title":"Cell"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nature15395","article-title":"Mutations driving CLL and their evolution in progression and relapse","volume":"526","author":"Landau","year":"2015","journal-title":"Nature"},{"key":"ref_61","unstructured":"TARGET (2022, January 29). Pediatric Acute Lymphoid Leukemia\u2014Phase II. Available online: https:\/\/bit.ly\/3h9oZjw."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature14666","article-title":"Non-coding recurrent mutations in chronic lymphocytic leukaemia","volume":"526","author":"Puente","year":"2015","journal-title":"Nature"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/ng.1032","article-title":"Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia","volume":"44","author":"Quesada","year":"2011","journal-title":"Nat. Genet."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1038\/ng.3442","article-title":"The mutational landscape of cutaneous T cell lymphoma and S\u00e9zary syndrome","volume":"47","author":"Abate","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41591-018-0016-8","article-title":"Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes","volume":"24","author":"Chapuy","year":"2018","journal-title":"Nat. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1073\/pnas.1121343109","article-title":"Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing","volume":"109","author":"Lohr","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cell.2017.09.027","article-title":"Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma","volume":"171","author":"Reddy","year":"2017","journal-title":"Cell"},{"key":"ref_68","unstructured":"TCGA, PanCancer Atlas (2022, January 29). Diffuse Large B-Cell Lymphoma. Available online: https:\/\/bit.ly\/2REehXx."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1182\/blood-2013-02-483727","article-title":"Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing","volume":"122","author":"Morin","year":"2013","journal-title":"Blood"},{"key":"ref_70","unstructured":"TCGA, Firehose Legacy (2022, January 29). Lymphoid Neoplasm Diffuse Large B-cell Lymphoma. Available online: https:\/\/bit.ly\/3uvhass."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"025605","DOI":"10.1088\/1361-6528\/ab484a","article-title":"Aptamer\/magnetic nanoparticles decorated with fluorescent gold nanoclusters for selective detection and collection of human promyelocytic leukemia (HL-60) cells from a mixture","volume":"31","author":"Haghighi","year":"2020","journal-title":"Nanotechnology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"8176","DOI":"10.1016\/j.electacta.2011.05.124","article-title":"Sensitive DNA impedance biosensor for detection of cancer, chronic lymphocytic leukemia, based on gold nanoparticles\/gold modified electrode","volume":"56","author":"Ensafi","year":"2011","journal-title":"Electrochim. Acta"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bioelechem.2016.12.001","article-title":"Amplified detection of leukemia cancer cells using an aptamer-conjugated gold-coated magnetic nanoparticles on a nitrogen-doped graphene modified electrode","volume":"114","author":"Khoshfetrat","year":"2017","journal-title":"Bioelectrochemistry"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1007\/s12274-014-0599-4","article-title":"Novel nanocomposites based on a strawberry-like gold-coated magnetite (Fe@ Au) for protein separation in multiple myeloma serum samples","volume":"8","author":"Lodeiro","year":"2015","journal-title":"Nano Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.talanta.2014.03.056","article-title":"An aptamer-based quartz crystal microbalance biosensor for sensitive and selective detection of leukemia cells using silver-enhanced gold nanoparticle label","volume":"126","author":"Shan","year":"2014","journal-title":"Talanta"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.snb.2014.12.104","article-title":"A label-free immunosensor for detecting common acute lymphoblastic leukemia antigen (CD10) based on gold nanoparticles by quartz crystal microbalance","volume":"210","author":"Yan","year":"2015","journal-title":"Sens. Actuators B Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.talanta.2012.07.075","article-title":"Folic acid as delivery vehicles: Targeting folate conjugated fluorescent nanoparticles to tumors imaging","volume":"101","author":"Ai","year":"2012","journal-title":"Talanta"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bioelechem.2017.12.010","article-title":"A new composite consisting of electrosynthesized conducting polymers, graphene sheets and biosynthesized gold nanoparticles for biosensing acute lymphoblastic leukemia","volume":"121","author":"Barazesh","year":"2018","journal-title":"Bioelectrochemistry"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"MacLaughlin, C., Parker, E.P., Walker, G., and Wang, C. (2012). Polymer-Coated Surface Enhanced Raman Scattering (SERS) Gold Nanoparticles for Multiplexed Labeling of Chronic Lymphocytic Leukemia Cells, SPIE.","DOI":"10.1117\/12.909192"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.canlet.2009.11.011","article-title":"Detection of chronic lymphocytic leukemia cell surface markers using surface enhanced Raman scattering gold nanoparticles","volume":"292","author":"Nguyen","year":"2010","journal-title":"Cancer Lett."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1039\/C3CC47622G","article-title":"Colorimetric assay of K-562 cells based on folic acid-conjugated porous bimetallic Pd@Au nanoparticles for point-of-care testing","volume":"50","author":"Ge","year":"2014","journal-title":"Chem. Commun."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12951-016-0192-y","article-title":"BioCode gold-nanobeacon for the detection of fusion transcripts causing chronic myeloid leukemia","volume":"14","author":"Cordeiro","year":"2016","journal-title":"J. Nanobiotechnol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3788\/COL20080612.0879","article-title":"Two-photon imaging of lymphoma cells targeted by gold nanoparticles","volume":"6","author":"Qu","year":"2008","journal-title":"Chin. Opt. Lett."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2136840","DOI":"10.1155\/2018\/2136840","article-title":"Spectral Photon-Counting Molecular Imaging for Quantification of Monoclonal Antibody-Conjugated Gold Nanoparticles Targeted to Lymphoma and Breast Cancer: An In Vitro Study","volume":"2018","author":"Moghiseh","year":"2018","journal-title":"Contrast Media Mol. Imaging"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Sarmento, B., and das Neves, J. (2018). Chapter 1\u2014From the \u201cMagic Bullet\u201d to Advanced Nanomaterials for Active Targeting in Diagnostics and Therapeutics. Biomedical Applications of Functionalized Nanomaterials, Elsevier.","DOI":"10.1016\/B978-0-323-50878-0.00001-X"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"6843","DOI":"10.2147\/IJN.S215711","article-title":"Counteracting the effect of leukemia exosomes by antiangiogenic gold nanoparticles","volume":"14","author":"Fernandes","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/j.talanta.2009.11.017","article-title":"Electrochemical biosensor based on nanogold-modified poly-eriochrome black T film for BCR\/ABL fusion gene assay by using hairpin LNA probe","volume":"80","author":"Lin","year":"2010","journal-title":"Talanta"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF02031373","article-title":"On the physical rationale of laser induced hyperthermia","volume":"5","author":"Svaasand","year":"1990","journal-title":"Lasers Med. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1166\/jnn.2016.10770","article-title":"Advanced Gold Nanomaterials for Photothermal Therapy of Cancer","volume":"16","author":"Ahmad","year":"2016","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"16918","DOI":"10.1002\/anie.202003748","article-title":"Photoactivated Polymersome Nanomotors: Traversing Biological Barriers","volume":"59","author":"Shao","year":"2020","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1021\/nl5045378","article-title":"In vivo analysis of biodegradable liposome gold nanoparticles as efficient agents for photothermal therapy of cancer","volume":"15","author":"Rengan","year":"2015","journal-title":"Nano Lett."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jare.2010.02.002","article-title":"Gold nanoparticles: Optical properties and implementations in cancer diagnosis and photothermal therapy","volume":"1","author":"Huang","year":"2010","journal-title":"J. Adv. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/lsm.20359","article-title":"Selective laser nano-thermolysis of human leukemia cells with microbubbles generated around clusters of gold nanoparticles","volume":"38","author":"Lapotko","year":"2006","journal-title":"Lasers Surg. Med."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Liopo, A., Conjusteau, A., Konopleva, M., Andreeff, M., and Oraevsky, A. (2011). Photothermal therapy of acute leukemia cells in the near-infrared region using gold nanorods CD-33 conjugates. Optical Interactions with Tissue and Cells XXII, SPIE.","DOI":"10.1117\/12.878802"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.tips.2009.02.005","article-title":"Siglecs as targets for therapy in immune-cell-mediated disease","volume":"30","author":"Paulson","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_96","first-page":"137","article-title":"Photothermal Targetting therapy of A20 Mouse Lymphoma model using Anti CD-138 Antibody conjugated Gold Nanospheres","volume":"2","author":"Yang","year":"2014","journal-title":"J. Hematol. Thromboembolic Dis."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"119827","DOI":"10.1016\/j.biomaterials.2020.119827","article-title":"Advances in nanomaterials for photodynamic therapy applications: Status and challenges","volume":"237","author":"Chen","year":"2020","journal-title":"Biomaterials"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1016\/j.biomaterials.2012.01.035","article-title":"Gold nanomaterials conjugated with indocyanine green for dual-modality photodynamic and photothermal therapy","volume":"33","author":"Kuo","year":"2012","journal-title":"Biomaterials"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ica.2012.05.038","article-title":"Gold nanoparticles for diagnostic sensing and therapy","volume":"393","author":"Lu","year":"2012","journal-title":"Inorg. Chim. Acta"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"720579","DOI":"10.1155\/2013\/720579","article-title":"Size-dependent photodynamic activity of gold nanoparticles conjugate of water soluble purpurin-18-N-methyl-d-glucamine","volume":"2013","author":"Lkhagvadulam","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1751-1097.1991.tb03669.x","article-title":"The photodegradation of porphyrins in cells can be used to estimate the lifetime of singlet oxygen","volume":"53","author":"Moan","year":"1991","journal-title":"Photochem. Photobiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/1011-1344(90)85096-F","article-title":"Chlorins as photosensitizers in biology and medicine","volume":"6","author":"Spikes","year":"1990","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1002\/smll.201202155","article-title":"Photosensitizer-gold nanorod composite for targeted multimodal therapy","volume":"9","author":"Wang","year":"2013","journal-title":"Small"},{"key":"ref_104","first-page":"241","article-title":"Photodynamic responsiveness of human leukemia Jurkat\/A4 cells with multidrug resistant phenotype","volume":"36","author":"Philchenkov","year":"2014","journal-title":"Exp. Oncol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s11060-019-03103-4","article-title":"5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas","volume":"141","author":"Mahmoudi","year":"2019","journal-title":"J. Neurooncol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"51043","DOI":"10.1117\/1.JBO.20.5.051043","article-title":"Role of 5-aminolevulinic acid-conjugated gold nanoparticles for photodynamic therapy of cancer","volume":"20","author":"Zhang","year":"2015","journal-title":"J. Biomed. Opt."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0167-8140(98)00130-3","article-title":"Impact of localized radiotherapy on blood immune cells counts and function in humans","volume":"50","author":"Belka","year":"1999","journal-title":"Radiother. Oncol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11051-020-4765-1","article-title":"Evidence for biological effects in the radiosensitization of leukemia cell lines by PEGylated gold nanoparticles","volume":"22","author":"Coughlin","year":"2020","journal-title":"J. Nanoparticle Res."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Mendes, R., Fernandes, A.R., and Baptista, P.V. (2017). Gold Nanoparticle Approach to the Selective Delivery of Gene Silencing in Cancer-The Case for Combined Delivery?. Genes, 8.","DOI":"10.3390\/genes8030094"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.molmed.2015.01.001","article-title":"Cancer nanomedicine: From targeted delivery to combination therapy","volume":"21","author":"Xu","year":"2015","journal-title":"Trends Mol. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e252","DOI":"10.1038\/mtna.2015.23","article-title":"siRNA Versus miRNA as Therapeutics for Gene Silencing","volume":"4","author":"Lam","year":"2015","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1182\/blood-2008-03-144790","article-title":"Molecular biology of bcr-abl1-positive chronic myeloid leukemia","volume":"113","author":"Cortes","year":"2009","journal-title":"Blood"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.omtn.2017.05.003","article-title":"Gold Nanoparticles for BCR-ABL1 Gene Silencing: Improving Tyrosine Kinase Inhibitor Efficacy in Chronic Myeloid Leukemia","volume":"7","author":"Vinhas","year":"2017","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Vuelta, E., Garc\u00eda-Tu\u00f1\u00f3n, I., Hern\u00e1ndez-Carabias, P., M\u00e9ndez, L., and S\u00e1nchez-Mart\u00edn, M. (2021). Future Approaches for Treating Chronic Myeloid Leukemia: CRISPR Therapy. Biology, 10.","DOI":"10.20944\/preprints202101.0212.v1"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/cgt.2016.33","article-title":"Coinhibition of overexpressed genes in acute myeloid leukemia subtype M2 by gold nanoparticles functionalized with five antisense oligonucleotides and one anti-CD33(+)\/CD34(+) aptamer","volume":"23","author":"Zaimy","year":"2016","journal-title":"Cancer Gene Ther."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s10637-013-0045-6","article-title":"A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma","volume":"32","author":"Rosenberg","year":"2014","journal-title":"Investig. New Drugs"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1158\/1078-0432.CCR-15-0489","article-title":"A 13 mer LNA-i-miR-221 Inhibitor Restores Drug Sensitivity in Melphalan-Refractory Multiple Myeloma Cells","volume":"22","author":"Morelli","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1073\/pnas.0907904107","article-title":"miR-221 overexpression contributes to liver tumorigenesis","volume":"107","author":"Pineau","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.biomaterials.2018.03.013","article-title":"Targeting epigenetic pathway with gold nanoparticles for acute myeloid leukemia therapy","volume":"167","author":"Deng","year":"2018","journal-title":"Biomaterials"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"5348","DOI":"10.1038\/s41598-019-41866-y","article-title":"Multifunctional Gold Nanoparticles Overcome MicroRNA Regulatory Network Mediated-Multidrug Resistant Leukemia","volume":"9","author":"Deng","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_121","first-page":"587","article-title":"Organ toxicity and efficacy of high-dose daunorubicin-based chemotherapy in the treatment of acute leukemia","volume":"34","author":"Liu","year":"2013","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1046\/j.1365-2141.2001.02551.x","article-title":"A multicentre, open, non-comparative phase II study of a combination of fludarabine phosphate, cytarabine and granulocyte colony-stimulating factor in relapsed and refractory acute myeloid leukaemia and de novo refractory anaemia with excess of blasts in transformation","volume":"112","author":"Jackson","year":"2001","journal-title":"Br. J. Haematol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2147\/DDDT.S5603","article-title":"Development of fludarabine formulations in the treatment of chronic lymphocytic leukemia","volume":"3","author":"Janssens","year":"2009","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1166\/jnn.2016.12349","article-title":"Using Gold Nanoparticles as Delivery Vehicles for Targeted Delivery of Chemotherapy Drug Fludarabine Phosphate to Treat Hematological Cancers","volume":"16","author":"Song","year":"2016","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1166\/jnn.2009.221","article-title":"Effect of colloidal gold nanoparticles on cell interface and their enhanced intracellular uptake of arsenic trioxide in leukemia cancer cells","volume":"9","author":"Guo","year":"2009","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1166\/jbn.2008.015","article-title":"Fabrication of gold nanoparticle for potential application in multiple myeloma","volume":"4","author":"Patra","year":"2008","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0300-9084(84)90018-X","article-title":"Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review","volume":"66","year":"1984","journal-title":"Biochimie"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s13204-020-01589-3","article-title":"Photochemically prepared monodisperse gold nanoparticles as doxorubicin carrier and its cytotoxicity on leukemia cancer cells","volume":"11","author":"Dizman","year":"2021","journal-title":"Appl. Nanosci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/pbc.24273","article-title":"Doxorubicin or daunorubicin given upfront in a therapeutic window are equally effective in children with newly diagnosed acute lymphoblastic leukemia. A randomized comparison in trial CoALL 07-03","volume":"60","author":"Escherich","year":"2013","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ijpharm.2015.04.072","article-title":"Targeted and controlled release delivery of daunorubicin to T-cell acute lymphoblastic leukemia by aptamer-modified gold nanoparticles","volume":"489","author":"Danesh","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13045-016-0241-x","article-title":"Synergism between the mTOR inhibitor rapamycin and FAK down-regulation in the treatment of acute lymphoblastic leukemia","volume":"9","author":"Shi","year":"2016","journal-title":"J. Hematol. Oncol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"15113","DOI":"10.1073\/pnas.2436348100","article-title":"Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling","volume":"100","author":"Brown","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1038\/onc.2015.515","article-title":"Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): A master regulator of mRNA translation involved in tumorigenesis","volume":"35","author":"Musa","year":"2016","journal-title":"Oncogene"},{"key":"ref_134","first-page":"641","article-title":"Gold nanoparticles enhance the effect of tyrosine kinase inhibitors in acute myeloid leukemia therapy","volume":"11","author":"Petrushev","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41375-018-0357-9","article-title":"Targeting FLT3 mutations in AML: Review of current knowledge and evidence","volume":"33","author":"Daver","year":"2019","journal-title":"Leukemia"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1186\/s11671-015-1154-2","article-title":"Design of FLT3 Inhibitor\u2014Gold Nanoparticle Conjugates as Potential Therapeutic Agents for the Treatment of Acute Myeloid Leukemia","volume":"10","author":"Simon","year":"2015","journal-title":"Nanoscale Res. Lett."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1080\/10428194.2016.1265116","article-title":"Current trends in molecular diagnostics of chronic myeloid leukemia","volume":"58","author":"Vinhas","year":"2017","journal-title":"Leuk. Lymphoma"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/jrs.4266","article-title":"Raman spectroscopy of combinatory anticancer drug release from gold nanoparticles inside a single leukemia cell","volume":"44","author":"Ganbold","year":"2013","journal-title":"J. Raman Spectrosc."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1126\/science.2649979","article-title":"The purine path to chemotherapy","volume":"244","author":"Elion","year":"1989","journal-title":"Science"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nrc1800","article-title":"Acute lymphoblastic leukaemia: A model for the pharmacogenomics of cancer therapy","volume":"6","author":"Cheok","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1021\/la702782k","article-title":"Gold nanoparticles enhance the anti-leukemia action of a 6-mercaptopurine chemotherapeutic agent","volume":"24","author":"Podsiadlo","year":"2008","journal-title":"Langmuir"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Ko\u017ami\u0144ski, P., Halik, P.K., Chesori, R., and Gniazdowska, E. (2020). Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103483"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1007\/s12288-019-01245-z","article-title":"Adverse effects with intravenous methotrexate in children with acute lymphoblastic leukemia\/lymphoma: A retrospective study","volume":"36","author":"Mandal","year":"2020","journal-title":"Indian J. Hematol. Blood Transfus."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1177\/1535370214536648","article-title":"Ligand exchange on gold nanoparticles for drug delivery and enhanced therapeutic index evaluated in acute myeloid leukemia models","volume":"239","author":"Egusa","year":"2014","journal-title":"Exp. Biol. Med."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.nano.2007.07.001","article-title":"Attaching folic acid on gold nanoparticles using noncovalent interaction via different polyethylene glycol backbones and targeting of cancer cells","volume":"3","author":"Bhattacharya","year":"2007","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ajps.2018.09.004","article-title":"Folate-targeted nanostructured chitosan\/chondroitin sulfate complex carriers for enhanced delivery of bortezomib to colorectal cancer cells","volume":"14","author":"Soe","year":"2019","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1182\/blood.V104.11.3649.3649","article-title":"Plasma Cell Folate Receptor Overexpression Differentiates Multiple Myeloma from Monoclonal Gammopathy of Undetermined Significance and Smoldering Myeloma","volume":"104","author":"Greipp","year":"2004","journal-title":"Blood"},{"key":"ref_148","first-page":"64","article-title":"Therapeutic effect of antimyeloma antibodies conjugated with gold nanoparticles on the growth of myeloma cell line","volume":"2","author":"Abdalla","year":"2012","journal-title":"Int. Multidiscip. Res. J."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/adma.200602098","article-title":"Gold nanoparticles inhibit the proliferation of multiple myeloma cells","volume":"19","author":"Bhattacharya","year":"2007","journal-title":"Adv. Mater."},{"key":"ref_150","first-page":"688","article-title":"Gold nanoparticles conjugated with rituximab for the treatment of chronic lymphocytic leukaemia","volume":"64","author":"Boca","year":"2016","journal-title":"Farmacia"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.addr.2009.11.006","article-title":"Targeted hyperthermia using metal nanoparticles","volume":"62","author":"Cherukuri","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"803","DOI":"10.2165\/00003495-200363080-00005","article-title":"Rituximab: A review of its use in non-Hodgkin\u2019s lymphoma and chronic lymphocytic leukaemia","volume":"63","author":"Plosker","year":"2003","journal-title":"Drugs"},{"key":"ref_153","first-page":"1","article-title":"In vitro decrease of the BCL-2 protein levels in lymphoma cells induced by gold nanoparticles and gold nanoparticles-anti-CD20","volume":"1","year":"2014","journal-title":"Nanosci. Technol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"20252","DOI":"10.1021\/jp907423z","article-title":"Selective recognition of rituximab-functionalized gold nanoparticles by lymphoma cells studied with 3D imaging","volume":"113","author":"Weiss","year":"2009","journal-title":"J. Phys. Chem. C"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/sj.leu.2402769","article-title":"Clinicopathologic correlations of bone marrow angiogenesis in chronic myeloid leukemia: A morphometric study","volume":"17","author":"Korkolopoulou","year":"2003","journal-title":"Leukemia"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jconrel.2018.08.034","article-title":"Nanomedicines for the treatment of hematological malignancies","volume":"287","author":"Deshantri","year":"2018","journal-title":"J. Control Release"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"e5344","DOI":"10.1002\/aoc.5344","article-title":"Novel green synthesis of Boswellia serrata leaf aqueous extract conjugated gold nanoparticles with excellent anti-acute myeloid leukemia property in comparison to mitoxantrone in a leukemic mice model: Introducing a new chemotherapeutic drug","volume":"34","author":"Ahmeda","year":"2020","journal-title":"Appl. Organomet. Chem."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"e5369","DOI":"10.1002\/aoc.5369","article-title":"Green formulation and chemical characterization of Lens culinaris seed aqueous extract conjugated gold nanoparticles for the treatment of acute myeloid leukemia in comparison to mitoxantrone in a leukemic mouse model","volume":"34","author":"Ahmeda","year":"2020","journal-title":"Appl. Organomet. Chem."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"e5290","DOI":"10.1002\/aoc.5290","article-title":"Green synthesis and chemical characterization of gold nanoparticle synthesized using Camellia sinensis leaf aqueous extract for the treatment of acute myeloid leukemia in comparison to daunorubicin in a leukemic mouse model","volume":"34","author":"Ahmeda","year":"2020","journal-title":"Appl. Organomet. Chem."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"e5271","DOI":"10.1002\/aoc.5271","article-title":"Novel green synthesis of Hibiscus sabdariffa flower extract conjugated gold nanoparticles with excellent anti-acute myeloid leukemia effect in comparison to daunorubicin in a leukemic rodent model","volume":"34","author":"Zangeneh","year":"2020","journal-title":"Appl. Organomet. Chem."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"e5267","DOI":"10.1002\/aoc.5267","article-title":"Green synthesis and chemical characterization of Thymus vulgaris leaf aqueous extract conjugated gold nanoparticles for the treatment of acute myeloid leukemia in comparison to doxorubicin in a leukemic mouse model","volume":"34","author":"Hemmati","year":"2020","journal-title":"Appl. Organomet. Chem."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0891-5849(94)00198-S","article-title":"Superoxide and hydrogen peroxide in relation to mammalian cell proliferation","volume":"18","author":"Burdon","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s12015-019-09949-5","article-title":"The Dual Role of ROS in Hematological Malignancies: Stem Cell Protection and Cancer Cell Metastasis","volume":"16","author":"Samimi","year":"2020","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Sillar, J.R., Germon, Z.P., DeIuliis, G.N., and Dun, M.D. (2019). The Role of Reactive Oxygen Species in Acute Myeloid Leukaemia. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20236003"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1021\/acs.accounts.9b00136","article-title":"Nanomedicines for Reactive Oxygen Species Mediated Approach: An Emerging Paradigm for Cancer Treatment","volume":"52","author":"Kwon","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13046-018-0797-0","article-title":"Reactive oxygen species in haematopoiesis: Leukaemic cells take a walk on the wild side","volume":"37","author":"Ijurko","year":"2018","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"7719","DOI":"10.1038\/sj.onc.1203249","article-title":"More than one way to die: Apoptosis, necrosis and reactive oxygen damage","volume":"18","author":"Fiers","year":"1999","journal-title":"Oncogene"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00204-008-0304-z","article-title":"Intracellular redox status and oxidative stress: Implications for cell proliferation, apoptosis, and carcinogenesis","volume":"82","author":"Segura","year":"2008","journal-title":"Arch. Toxicol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1021\/acs.analchem.8b00118","article-title":"Chemically Regulated ROS Generation from Gold Nanoparticles for Enzyme-Free Electrochemiluminescent Immunosensing","volume":"90","author":"Higashi","year":"2018","journal-title":"Anal. Chem."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"504001","DOI":"10.1088\/1361-6528\/aae272","article-title":"A gold nanoparticle system for the enhancement of radiotherapy and simultaneous monitoring of reactive-oxygen-species formation","volume":"29","author":"Choi","year":"2018","journal-title":"Nanotechnology"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1038\/srep02146","article-title":"High levels of reactive oxygen species in gold nanoparticle-targeted cancer cells following femtosecond pulse irradiation","volume":"3","author":"Minai","year":"2013","journal-title":"Sci. Rep."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"6204","DOI":"10.1039\/D0BM01547D","article-title":"Ultra-small platinum nanoparticles on gold nanorods induced intracellular ROS fluctuation to drive megakaryocytic differentiation of leukemia cells","volume":"8","author":"Wen","year":"2020","journal-title":"Biomater. Sci."},{"key":"ref_173","first-page":"182353","article-title":"Pegylated gold nanoparticles induce apoptosis in human chronic myeloid leukemia cells","volume":"2014","author":"Huang","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1477-3155-5-4","article-title":"Potential therapeutic application of gold nanoparticles in B-chronic lymphocytic leukemia (BCLL): Enhancing apoptosis","volume":"5","author":"Mukherjee","year":"2007","journal-title":"J. Nanobiotechnol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/1099-1573(200009)14:6<463::AID-PTR611>3.0.CO;2-G","article-title":"Antiinflammatory activity and chemical composition of extracts of Verbena officinalis","volume":"14","author":"Deepak","year":"2000","journal-title":"Phytother. Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"7118","DOI":"10.1166\/jnn.2016.11357","article-title":"Gold nanoshells with verbascoside induce the apoptosis of drug-resistant leukemia cells through caspases pathway and inhibit tumor growth","volume":"16","author":"Ma","year":"2016","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"102290","DOI":"10.1016\/j.nano.2020.102290","article-title":"Tri-ethylene glycol modified class B and class C CpG conjugated gold nanoparticles for the treatment of lymphoma","volume":"30","author":"Lin","year":"2020","journal-title":"Nanomedicine"},{"key":"ref_178","first-page":"330","article-title":"Apoptosis induction in human leukemia cell lines by gold nanoparticles synthesized using the green biosynthetic approach","volume":"16","author":"Namvar","year":"2016","journal-title":"J. Nanomater."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4172\/2157-7013.1000278","article-title":"Biologically Synthesized Gold Nanoparticles using Ocimum sanctum (Tulsi Leaf Extract) Induced Anti-Tumor Response in a T Cell Daltons Lymphoma","volume":"8","author":"Gautam","year":"2017","journal-title":"J. Cell Sci. Ther."},{"key":"ref_180","first-page":"357","article-title":"Targeted Intracellular Heat Transfer in Cancer Therapy: Assessment of Asparagine-laminated Gold Nanoparticles in Cell Model of T cell Leukemia","volume":"46","author":"Shahriari","year":"2017","journal-title":"Iran J. Public Health"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/MPH.0000000000001386","article-title":"Expression and Activity of Matrix Metalloproteinases in Leukemia","volume":"41","author":"Bagheri","year":"2019","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_182","first-page":"14","article-title":"In Vitro Cytotoxicity of Folate-Silica-Gold Nanorods on Mouse Acute Lymphoblastic Leukemia and Spermatogonial Cells","volume":"21","author":"Eslahi","year":"2019","journal-title":"Cell J."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"e10143","DOI":"10.1002\/btm2.10143","article-title":"Nanoparticles in the clinic: An update","volume":"4","author":"Anselmo","year":"2019","journal-title":"Bioeng. Transl. Med."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Shakil, M.S., Parveen, S., Rana, Z., Walsh, F., Movassaghi, S., S\u00f6hnel, T., Azam, M., Shaheen, M.A., Jamieson, S.M.F., and Hanif, M. (2021). High Antiproliferative Activity of Hydroxythiopyridones over Hydroxypyridones and Their Organoruthenium Complexes. Biomedicines, 9.","DOI":"10.3390\/biomedicines9020123"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"7952","DOI":"10.1021\/acsabm.0c01069","article-title":"In Vivo Toxicity Studies of Chitosan-Coated Cobalt Ferrite Nanocomplex for Its Application as MRI Contrast Dye","volume":"3","author":"Shakil","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Arruga, F., Gyau, B.B., Iannello, A., Vitale, N., Vaisitti, T., and Deaglio, S. (2020). Immune Response Dysfunction in Chronic Lymphocytic Leukemia: Dissecting Molecular Mechanisms and Microenvironmental Conditions. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21051825"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11899-011-0106-x","article-title":"Immune reconstitution in chronic lymphocytic leukemia","volume":"7","author":"Riches","year":"2012","journal-title":"Curr. Hematol. Malig. Rep."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"14331","DOI":"10.1073\/pnas.1916206117","article-title":"Reversible suppression of T cell function in the bone marrow microenvironment of acute myeloid leukemia","volume":"117","author":"Lamble","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"E14","DOI":"10.3816\/CLML.2010.n.011","article-title":"Lymphoma and immunosuppression: A report of a case associated with efalizumab therapy","volume":"10","author":"MacKenzie","year":"2010","journal-title":"Clin. Lymphoma Myeloma Leuk."},{"key":"ref_190","first-page":"282","article-title":"Immunosuppression and infection in multiple myeloma","volume":"13","author":"Jacobson","year":"1986","journal-title":"Semin. Oncol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1039\/C4CC07644C","article-title":"Nanoparticle-blood interactions: The implications on solid tumour targeting","volume":"51","author":"Lazarovits","year":"2015","journal-title":"Chem. Commun."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1007\/s11051-010-9911-8","article-title":"Toxicity and cellular uptake of gold nanoparticles: What we have learned so far?","volume":"12","author":"Alkilany","year":"2010","journal-title":"J. Nanoparticle Res."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"426028","DOI":"10.1155\/2014\/426028","article-title":"Immunomodulation of nanoparticles in nanomedicine applications","volume":"2014","author":"Jiao","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1900133","DOI":"10.1002\/advs.201900133","article-title":"Immunotoxicity Considerations for Next Generation Cancer Nanomedicines","volume":"6","author":"Hannon","year":"2019","journal-title":"Adv. Sci."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1021\/tx100209t","article-title":"Unexpected toxicity of monolayer protected gold clusters eliminated by PEG-thiol place exchange reactions","volume":"23","author":"Simpson","year":"2010","journal-title":"Chem. Res. Toxicol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"353695","DOI":"10.1155\/2013\/353695","article-title":"Uptake of Gold Nanoparticles in Several Rat Organs after Intraperitoneal Administration In Vivo: A Fluorescence Study","volume":"2013","author":"Abdelhalim","year":"2013","journal-title":"BioMed Res. Int."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"12890","DOI":"10.1038\/s41598-019-48748-3","article-title":"In vivo evaluation of safety, biodistribution and pharmacokinetics of laser-synthesized gold nanoparticles","volume":"9","author":"Bailly","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1259\/bjr\/13169882","article-title":"Gold nanoparticles: A new X-ray contrast agent","volume":"79","author":"Hainfeld","year":"2006","journal-title":"Br. J. Radiol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2147\/IJN.S8428","article-title":"Toxicologic effects of gold nanoparticles in vivo by different administration routes","volume":"5","author":"Zhang","year":"2010","journal-title":"Int. J. Nanomed."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Rambanapasi, C., Zeevaart, J.R., Buntting, H., Bester, C., Kotze, D., Hayeshi, R., and Grobler, A. (2016). Bioaccumulation and Subchronic Toxicity of 14 nm Gold Nanoparticles in Rats. Molecules, 21.","DOI":"10.3390\/molecules21060763"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1080\/17458080.2015.1014934","article-title":"Comparative cytotoxicity evaluation of different size gold nanoparticles in human dermal fibroblasts","volume":"10","author":"Mateo","year":"2015","journal-title":"J. Exp. Nanosci."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"10644","DOI":"10.1021\/la0513712","article-title":"Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: A microscopic overview","volume":"21","author":"Shukla","year":"2005","journal-title":"Langmuir"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1073\/pnas.1911734116","article-title":"Unexpected intracellular biodegradation and recrystallization of gold nanoparticles","volume":"117","author":"Balfourier","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41565-018-0356-z","article-title":"Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness","volume":"14","author":"Peng","year":"2019","journal-title":"Nat. Nanotechnol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1182\/blood-2012-01-379024","article-title":"Myeloma as a model for the process of metastasis: Implications for therapy","volume":"120","author":"Ghobrial","year":"2012","journal-title":"Blood"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.critrevonc.2014.12.013","article-title":"The inherent metastasis of leukaemia and its exploitation by sonodynamic therapy","volume":"94","author":"Trendowski","year":"2015","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1182\/blood.V91.2.623","article-title":"The metastatic characteristics of murine lymphoma cell lines in vivo are manifested after target organ invasion","volume":"91","author":"Aoudjit","year":"1998","journal-title":"Blood"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41565-019-0372-7","article-title":"Opening the vascular gate","volume":"14","author":"Malinova","year":"2019","journal-title":"Nat. Nanotechnol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/FJC.0000000000000382","article-title":"Potential of Food and Natural Products to Promote Endothelial and Vascular Health","volume":"68","author":"Auger","year":"2016","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1182\/blood.V90.6.2323","article-title":"An in vitro model for toxin-mediated vascular leak syndrome: Ricin toxin A chain increases the permeability of human endothelial cell monolayers","volume":"90","author":"Lindstrom","year":"1997","journal-title":"Blood"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"111869","DOI":"10.1016\/j.bios.2019.111869","article-title":"Bimetallic nanoparticles decorated hollow nanoporous carbon framework as nanozyme biosensor for highly sensitive electrochemical sensing of uric acid","volume":"150","author":"Wang","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"D1073","DOI":"10.1093\/nar\/gky984","article-title":"PDX Finder: A portal for patient-derived tumor xenograft model discovery","volume":"47","author":"Conte","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_213","unstructured":"MMHCdb (2022, January 29). Patient Derived Xenograft Search Results. Available online: https:\/\/bit.ly\/2RKS1vT."},{"key":"ref_214","unstructured":"PDX-Finder (2022, January 29). Hematopoietic and Lymphoid System Cancer. Available online: https:\/\/bit.ly\/3oYTH0N."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/13\/3047\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:36:41Z","timestamp":1760139401000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/13\/3047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,21]]},"references-count":214,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["cancers14133047"],"URL":"https:\/\/doi.org\/10.3390\/cancers14133047","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,21]]}}}