{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T23:26:18Z","timestamp":1772321178865,"version":"3.50.1"},"reference-count":40,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Introduction: Cancer patients are at high risk of developing septic shock (SSh) and are increasingly admitted to ICU given their improved long-term prognosis. We, therefore, compared the prognosis of cancer and non-cancer patients with SSh. Methods: We conducted a monocentric, retrospective cohort study (2013\u20132019) on patients admitted to ICU for SSh. We compared the clinical characteristics and management and studied short- and long-term mortality with ICU and in-hospital mortality and 1-year survival according to cancer status. Results: We analyzed 239 ICU stays in 210 patients, 59.5% of whom were men (n = 125), with a median age of 66.5 (IQR 56.3\u201377.0). Of the 121 cancer patients (57.6% of all patients), 70 had solid tumors (33.3%), and 51 had hematological malignancies (24.3%). When comparing ICU stays of patients with versus without cancer (n = 148 vs. n = 91 stays, respectively), mortality reached 30.4% (n = 45) vs. 30.0% (n = 27) in the ICU (p = 0.95), and 41.6% (n = 59) vs. 35.6% (n = 32) in hospital (p = 0.36), respectively. ICU length of stay (LOS) was 5.0 (2.0\u201311.3) vs. 6.0 (3.0\u201315.0) days (p = 0.27), whereas in-hospital LOS was 25.5 (13.8\u201342.0) vs. 19.5 (10.8\u201341.0) days (p = 0.33). Upon multivariate analysis, renal replacement therapy (OR = 2.29, CI95%: 1.06\u20134.93, p = 0.03), disseminated intravascular coagulation (OR = 5.89, CI95%: 2.49\u201313.92, p &lt; 0.01), and mechanical ventilation (OR = 7.85, CI95%: 2.90\u201321.20, p &lt; 0.01) were associated with ICU mortality, whereas malignancy, hematological, or solid tumors were not (OR = 1.41, CI95%: 0.65\u20133.04; p = 0.38). Similarly, overall cancer status was not associated with in-hospital mortality (OR = 1.99, CI95%: 0.98\u20134.03, p = 0.06); however, solid cancers were associated with increased in-hospital mortality (OR = 2.52, CI95%: 1.12\u20135.67, p = 0.03). Lastly, mortality was not significantly different at 365-day follow-up between patients with and without cancer. Conclusions: In-hospital and ICU mortality, as well as LOS, were not different in SSh patients with and without cancer, suggesting that malignancies should no longer be considered a barrier to ICU admission.<\/jats:p>","DOI":"10.3390\/cancers14133196","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T20:47:56Z","timestamp":1656535676000},"page":"3196","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparison of Short- and Long-Term Mortality in Patients with or without Cancer Admitted to the ICU for Septic Shock: A Retrospective Observational Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9141-6439","authenticated-orcid":false,"given":"Pierrick","family":"Le Borgne","sequence":"first","affiliation":[{"name":"Emergency Department, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"},{"name":"INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative NanoMedicine (RNM), F\u00e9d\u00e9ration de M\u00e9decine Translationnelle (FMTS), University of Strasbourg, 67000 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e9a","family":"Feuillassier","sequence":"additional","affiliation":[{"name":"Emergency Department, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1043-6452","authenticated-orcid":false,"given":"Maleka","family":"Schenck","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation, H\u00f4pital de Hautepierre, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Etienne","family":"Herbrecht","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation, H\u00f4pital de Hautepierre, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-5053","authenticated-orcid":false,"given":"Ralf","family":"Janssen-Langenstein","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation, H\u00f4pital de Hautepierre, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celestine","family":"Simand","sequence":"additional","affiliation":[{"name":"Institut de Canc\u00e9rologie Strasbourg Europe, Service d\u2019H\u00e9matologie, 67200 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3293-4903","authenticated-orcid":false,"given":"Justine","family":"Gantzer","sequence":"additional","affiliation":[{"name":"Institut de Canc\u00e9rologie Strasbourg Europe, Service d\u2019Oncologie M\u00e9dicale, 67200 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3097-727X","authenticated-orcid":false,"given":"Simon","family":"Nannini","sequence":"additional","affiliation":[{"name":"Institut de Canc\u00e9rologie Strasbourg Europe, Service d\u2019Oncologie M\u00e9dicale, 67200 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc-Matthieu","family":"Fornecker","sequence":"additional","affiliation":[{"name":"Institut de Canc\u00e9rologie Strasbourg Europe, Service d\u2019H\u00e9matologie, 67200 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Alam\u00e9","sequence":"additional","affiliation":[{"name":"Emergency Department, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"Department of Public Health, University Hospital of Strasbourg, 67000 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9354-6525","authenticated-orcid":false,"given":"Vincent","family":"Castelain","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation, H\u00f4pital de Hautepierre, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7481-5101","authenticated-orcid":false,"given":"Francis","family":"Schneider","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation, H\u00f4pital de Hautepierre, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rapha\u00ebl","family":"Clere-Jehl","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive R\u00e9animation, H\u00f4pital de Hautepierre, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"},{"name":"INSERM (French National Institute of Health and Medical Research), UMR_S1109, Immuno-Rhumatologie Mol\u00e9culaire, Centre de Recherche d\u2019Immunologie et d\u2019H\u00e9matologie, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle (FMTS), University of Strasbourg, 67000 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock 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