{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:34:00Z","timestamp":1788791640429,"version":"build-2803163510"},"reference-count":134,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III (Spanish Ministry of Health) and FEDER funds","award":["PI15\/00626"],"award-info":[{"award-number":["PI15\/00626"]}]},{"name":"Instituto de Salud Carlos III (Spanish Ministry of Health) and FEDER funds","award":["PI18\/00144"],"award-info":[{"award-number":["PI18\/00144"]}]},{"name":"Instituto de Salud Carlos III (Spanish Ministry of Health) and FEDER funds","award":["ICI20\/00044"],"award-info":[{"award-number":["ICI20\/00044"]}]},{"name":"Instituto de Salud Carlos III (Spanish Ministry of Health) and FEDER funds","award":["FEHH\/Janssen"],"award-info":[{"award-number":["FEHH\/Janssen"]}]},{"name":"Spanish Society of Hematology and Hemotherapy","award":["PI15\/00626"],"award-info":[{"award-number":["PI15\/00626"]}]},{"name":"Spanish Society of Hematology and Hemotherapy","award":["PI18\/00144"],"award-info":[{"award-number":["PI18\/00144"]}]},{"name":"Spanish Society of Hematology and Hemotherapy","award":["ICI20\/00044"],"award-info":[{"award-number":["ICI20\/00044"]}]},{"name":"Spanish Society of Hematology and Hemotherapy","award":["FEHH\/Janssen"],"award-info":[{"award-number":["FEHH\/Janssen"]}]},{"name":"Ministry of Universities, Government of Spain","award":["PI15\/00626"],"award-info":[{"award-number":["PI15\/00626"]}]},{"name":"Ministry of Universities, Government of Spain","award":["PI18\/00144"],"award-info":[{"award-number":["PI18\/00144"]}]},{"name":"Ministry of Universities, Government of Spain","award":["ICI20\/00044"],"award-info":[{"award-number":["ICI20\/00044"]}]},{"name":"Ministry of Universities, Government of Spain","award":["FEHH\/Janssen"],"award-info":[{"award-number":["FEHH\/Janssen"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Growing evidence shows that nerves play an active role in cancer development and progression by altering crucial molecular pathways and cell functions. Conversely, the use of neurotropic drugs, such as tricyclic antidepressants (TCAs), may modulate these molecular signals with a therapeutic purpose based on a direct antitumoral effect and beyond the TCA use to treat neuropathic pain in oncology patients. In this review, we discuss the TCAs\u2019 safety and their central effects against neuropathic pain in cancer, and the antitumoral effects of TCAs in in vitro and preclinical studies, as well as in the clinical setting. The current evidence points out that TCAs are safe and beneficial to treat neuropathic pain associated with cancer and chemotherapy, and they block different molecular pathways used by cancer cells from different locations for tumor growth and promotion. Likewise, ongoing clinical trials evaluating the antineoplastic effects of TCAs are discussed. TCAs are very biologically active compounds, and their repurposing as antitumoral drugs is a promising and straightforward approach to treat specific cancer subtypes and to further define their molecular targets, as well as an interesting starting point to design analogues with increased antitumoral activity.<\/jats:p>","DOI":"10.3390\/cancers14133248","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T11:12:35Z","timestamp":1656760355000},"page":"3248","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Antitumoral Effects of Tricyclic Antidepressants: Beyond Neuropathic Pain Treatment"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2705-2682","authenticated-orcid":false,"given":"Antonio","family":"Asensi-Cant\u00f3","sequence":"first","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Cat\u00f3lica de Murcia (UCAM), 30107 Guadalupe, Spain"},{"name":"Servicio de Farmacia Hospitalaria, Hospital Universitario Santa Luc\u00eda, 30202 Cartagena, Spain"},{"name":"Grupo de Investigaci\u00f3n en Patolog\u00eda Molecular y Farmacogen\u00e9tica, Servicios de Anatom\u00eda Patol\u00f3gica y An\u00e1lisis Cl\u00ednicos, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB), Hospital Universitario Santa Luc\u00eda, 30202 Cartagena, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"L\u00f3pez-Abell\u00e1n","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Cat\u00f3lica de Murcia (UCAM), 30107 Guadalupe, Spain"},{"name":"Grupo de Investigaci\u00f3n en Patolog\u00eda Molecular y Farmacogen\u00e9tica, Servicios de Anatom\u00eda Patol\u00f3gica y An\u00e1lisis Cl\u00ednicos, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB), Hospital Universitario Santa Luc\u00eda, 30202 Cartagena, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0122-4116","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Castillo-Guardiola","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Patolog\u00eda Molecular y Farmacogen\u00e9tica, Servicios de Anatom\u00eda Patol\u00f3gica y An\u00e1lisis Cl\u00ednicos, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB), Hospital Universitario Santa Luc\u00eda, 30202 Cartagena, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"Hurtado","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Patolog\u00eda Molecular y Farmacogen\u00e9tica, Servicios de Anatom\u00eda Patol\u00f3gica y An\u00e1lisis Cl\u00ednicos, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB), Hospital Universitario Santa Luc\u00eda, 30202 Cartagena, Spain"},{"name":"Grupo de Investigaci\u00f3n en Inmunobiolog\u00eda para la Acuicultura, Departamento de Biolog\u00eda Celular e Histolog\u00eda, Facultad de Biolog\u00eda, Universidad de Murcia, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Mart\u00ednez-Penella","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Cat\u00f3lica de Murcia (UCAM), 30107 Guadalupe, Spain"},{"name":"Servicio de Farmacia Hospitalaria, Hospital Universitario Santa Luc\u00eda, 30202 Cartagena, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9940-0415","authenticated-orcid":false,"given":"Gin\u00e9s","family":"Luengo-Gil","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Patolog\u00eda Molecular y Farmacogen\u00e9tica, Servicios de Anatom\u00eda Patol\u00f3gica y An\u00e1lisis Cl\u00ednicos, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB), Hospital Universitario Santa Luc\u00eda, 30202 Cartagena, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Conesa-Zamora","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Cat\u00f3lica de Murcia (UCAM), 30107 Guadalupe, Spain"},{"name":"Grupo de Investigaci\u00f3n en Patolog\u00eda Molecular y Farmacogen\u00e9tica, Servicios de Anatom\u00eda Patol\u00f3gica y An\u00e1lisis Cl\u00ednicos, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB), Hospital Universitario Santa Luc\u00eda, 30202 Cartagena, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1236361","DOI":"10.1126\/science.1236361","article-title":"Autonomic nerve development contributes to prostate cancer progression","volume":"341","author":"Magnon","year":"2013","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1073\/pnas.1512603113","article-title":"Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer","volume":"113","author":"Saloman","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1158\/2159-8290.CD-18-1398","article-title":"Tumor neurobiology and the war of nerves in cancer","volume":"9","author":"Faulkner","year":"2019","journal-title":"Cancer Discov."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ccell.2017.11.007","article-title":"\u03b22 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer","volume":"33","author":"Renz","year":"2018","journal-title":"Cancer Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1126\/scitranslmed.3009569","article-title":"Denervation suppresses gastric tumorigenesis","volume":"6","author":"Zhao","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/a0038550","article-title":"A brief history of the development of antidepressant drugs: From monoamines to glutamate","volume":"23","author":"Hillhouse","year":"2015","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"ref_7","first-page":"40","article-title":"Antimuscarinic and other receptor-blocking properties of antidepressants","volume":"58","author":"Richelson","year":"1983","journal-title":"Mayo Clin. Proc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jad.2016.09.057","article-title":"Antidepressants and colorectal cancer: A population-based nested case-control study","volume":"207","author":"Lee","year":"2017","journal-title":"J. Affect. Disord."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S1470-2045(06)70622-2","article-title":"Use of antidepressants and risk of colorectal cancer: A nested case-control study","volume":"7","author":"Xu","year":"2006","journal-title":"Lancet Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/pds.1808","article-title":"Antidepressant use and colorectal cancer risk","volume":"18","author":"Coogan","year":"2009","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"11687","DOI":"10.18632\/oncotarget.7049","article-title":"Antidepressants in association with reducing risk of oral cancer occurrence: A nationwide population-based cohort and nested case-control studies","volume":"7","author":"Chung","year":"2016","journal-title":"Oncotarget"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1002\/ijc.30919","article-title":"Use of antidepressants and risk of epithelial ovarian cancer","volume":"141","author":"Dehlendorff","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/bcp.13498","article-title":"Association between antidepressant medication use and epithelial ovarian cancer risk: A systematic review and meta-analysis of observational studies","volume":"84","author":"Huo","year":"2018","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/pon.3929","article-title":"Relationship between antidepressant prescription and breast cancer: A population based study in Taiwan","volume":"25","author":"Chen","year":"2016","journal-title":"Psychooncology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s10549-005-9056-0","article-title":"Antidepressant use and breast cancer risk","volume":"95","author":"Chien","year":"2006","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/01.ede.0000147103.92638.c0","article-title":"Breast cancer risk among users of antidepressant medications","volume":"16","year":"2005","journal-title":"Epidemiology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1586\/14737175.6.9.1363","article-title":"Review of the epidemiological literature on antidepressant use and breast cancer risk","volume":"6","author":"Coogan","year":"2006","journal-title":"Expert Rev. Neurother."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.mehy.2013.08.031","article-title":"Is amisulpride safe when prescribed to breast and prostate cancer patients?","volume":"81","author":"Pasquini","year":"2013","journal-title":"Med. Hypotheses"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.jad.2017.11.039","article-title":"Prostate cancer and antidepressants: A nationwide population-based nested case-control study","volume":"227","author":"Lin","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Hsieh, Y.H., Chiu, W.C., Lin, C.F., Chan, H.L., Liang, H.Y., Lee, Y., McIntyre, R.S., and Chen, V.C.H. (2015). Antidepressants and gastric cancer: A nationwide population-based nested case-control study. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0143668"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00001648-200003000-00015","article-title":"Antidepressant medications and risk for cancer","volume":"11","author":"Dalton","year":"2000","journal-title":"Epidemiology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.annepidem.2013.04.006","article-title":"Risk of non-Hodgkin lymphoma in relation to tricyclic antidepressant use","volume":"23","author":"Lowry","year":"2013","journal-title":"Ann. Epidemiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/sj.bjc.6605996","article-title":"Tricyclic antidepressants and the incidence of certain cancers: A study using the GPRD","volume":"104","author":"Walker","year":"2011","journal-title":"Br. J. Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/bjc.2016.109","article-title":"Use of tricyclic antidepressants and risk of glioma: A nationwide case-control study","volume":"114","author":"Pottegard","year":"2016","journal-title":"Br. J. Cancer"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1176\/ajp.115.3.245","article-title":"Imipramine: A potent new anti-depressant compound","volume":"115","author":"AZIMA","year":"1958","journal-title":"Am. J. Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/0091270010394852","article-title":"Efficacy of antidepressants as analgesics: A review","volume":"52","author":"Dharmshaktu","year":"2012","journal-title":"J. Clin. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.tips.2006.05.004","article-title":"Antidepressants and pain","volume":"27","author":"Ardid","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0304-3959(92)90144-Z","article-title":"Antidepressant-induced analgesia in chronic non-malignant pain: A meta-analysis of 39 placebo-controlled studies","volume":"49","author":"Onghena","year":"1992","journal-title":"Pain"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","article-title":"Pharmacotherapy for neuropathic pain in adults: A systematic review and meta-analysis","volume":"14","author":"Finnerup","year":"2015","journal-title":"Lancet Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1055\/s-2007-1017095","article-title":"Tricyclic antidepressants in the treatment of cancer pain: A review","volume":"20","author":"Magni","year":"1987","journal-title":"Pharmacopsychiatry"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/j.1875-9114.1990.tb02582.x","article-title":"Antidepressants in the Management of Chronic Pain Syndromes","volume":"10","author":"Egbunike","year":"1990","journal-title":"Pharmacother. J. Hum. Pharmacol. Drug Ther."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Obata, H. (2017). Analgesic mechanisms of antidepressants for neuropathic pain. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112483"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1177\/1049909111412539","article-title":"A Comparative Efficacy of Amitriptyline, Gabapentin, and Pregabalin in Neuropathic Cancer Pain: A Prospective Randomized Double-Blind Placebo-Controlled Study","volume":"29","author":"Mishra","year":"2012","journal-title":"Am. J. Hosp. Palliat. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1177\/1049909108322288","article-title":"Management of neuropathic cancer pain following WHO analgesic ladder: A prospective study","volume":"25","author":"Mishra","year":"2009","journal-title":"Am. J. Hosp. Palliat. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/BF02333665","article-title":"Antidepressants for cancer pain and other painful syndromes with deafferentation component: Comparison of Amitriptyline and Trazodone","volume":"8","author":"Ventafridda","year":"1987","journal-title":"Ital. J. Neurol. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jpainsymman.2007.02.043","article-title":"Amitriptyline in the Treatment of Chemotherapy-Induced Neuropathic Symptoms","volume":"35","author":"Kautio","year":"2008","journal-title":"J. Pain Symptom Manag."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00540-010-0913-6","article-title":"Low-dose gabapentin as useful adjuvant to opioids for neuropathic cancer pain when combined with low-dose imipramine","volume":"24","author":"Arai","year":"2010","journal-title":"J. Anesth."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s005200000215","article-title":"Mirtazapine may be useful in treating nausea and insomnia of cancer chemotherapy","volume":"9","author":"Kast","year":"2001","journal-title":"Support. Care Cancer"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0885-3924(02)00381-0","article-title":"An open-label, crossover trial of mirtazapine (15 and 30 mg) in cancer patients with pain and other distressing symptoms","volume":"23","author":"Theobald","year":"2002","journal-title":"J. Pain Symptom Manag."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4698","DOI":"10.2174\/0929867326666190107163756","article-title":"Management of Peripheral Neuropathy Induced by Chemotherapy","volume":"26","author":"Fradkin","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/00006842-198801000-00009","article-title":"Treatment of depression in cancer patients is associated with better life adaptation: A pilot study","volume":"50","author":"Evans","year":"1988","journal-title":"Psychosom. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/(SICI)1099-1611(199807\/08)7:4<291::AID-PON361>3.0.CO;2-U","article-title":"A controlled trial of fluoxetine and desipramine in depressed women with advanced cancer","volume":"7","author":"Holland","year":"1998","journal-title":"Psychooncology"},{"key":"ref_43","first-page":"195","article-title":"Eine doppelblinde vergleichsstudie zur wirksamkeit und vertraglichkeit von paroxetin und amitriptylin bei der behandlung von brustkrebs-Patientinnen mit klinisch nachgewiesener depression","volume":"122","author":"Zaninelli","year":"2000","journal-title":"Zentralbl. Gynakol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1012518831494","article-title":"Treatment of depression in patients with breast cancer: A comparison between paroxetine and amitriptyline","volume":"70","author":"Pezzella","year":"2001","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.genhosppsych.2014.05.010","article-title":"Reevaluating the role of antidepressants in cancer-related depression: A systematic review and meta-analysis","volume":"36","author":"Riblet","year":"2014","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1089\/jpm.2013.0412","article-title":"A pilot study to evaluate symptom-oriented selection of antidepressants in patients with cancer","volume":"17","author":"Raddin","year":"2014","journal-title":"J. Palliat. Med."},{"key":"ref_47","first-page":"CD011006","article-title":"Antidepressants for the treatment of depression in people with cancer","volume":"2018","author":"Ostuzzi","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1001\/jamaoncol.2018.0131","article-title":"Oral Ketamine vs Placebo in Patients With Cancer-Related Neuropathic Pain: A Randomized Clinical Trial","volume":"4","author":"Fallon","year":"2018","journal-title":"JAMA Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1007\/s00520-014-2158-7","article-title":"A phase III randomized, placebo-controlled study of topical amitriptyline and ketamine for chemotherapy-induced peripheral neuropathy (CIPN): A University of Rochester CCOP study of 462 cancer survivors","volume":"22","author":"Gewandter","year":"2014","journal-title":"Support. Care Cancer"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s00520-010-0911-0","article-title":"A double-blind, placebo-controlled trial of a topical treatment for chemotherapy-induced peripheral neuropathy: NCCTG trial N06CA","volume":"19","author":"Barton","year":"2011","journal-title":"Support. Care Cancer"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00520-011-1141-9","article-title":"The relationship between numbness, tingling, and shooting\/burning pain in patients with chemotherapy-induced peripheral neuropathy (CIPN) as measured by the EORTC QLQ-CIPN20 instrument, N06CA","volume":"20","author":"Wolf","year":"2012","journal-title":"Support. Care Cancer"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.expneurol.2007.03.022","article-title":"Antidepressants inhibit interferon-gamma-induced microglial production of IL-6 and nitric oxide","volume":"206","author":"Hashioka","year":"2007","journal-title":"Exp. Neurol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.neuropharm.2008.06.045","article-title":"Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants","volume":"55","author":"Hwang","year":"2008","journal-title":"Neuropharmacology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.tins.2015.08.001","article-title":"Depression as a Microglial Disease","volume":"38","author":"Yirmiya","year":"2015","journal-title":"Trends Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1111\/jcmm.15022","article-title":"Induction of apoptosis through extrinsic\/intrinsic pathways and suppression of ERK\/NF-\u03baB signalling participate in anti-glioblastoma of imipramine","volume":"24","author":"Hsu","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"9350","DOI":"10.1111\/jcmm.16874","article-title":"Imipramine impedes glioma progression by inhibiting YAP as a Hippo pathway independent manner and synergizes with temozolomide","volume":"25","author":"Wang","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.bbrc.2011.08.093","article-title":"The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells","volume":"413","author":"Jeon","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_58","first-page":"1073274818798594","article-title":"Tricyclic Antidepressants Modulate Stressed Mitochondria in Glioblastoma Multiforme Cells","volume":"25","author":"Ludyga","year":"2018","journal-title":"Cancer Control"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1007\/s00280-017-3329-2","article-title":"Reversing glioma malignancy: A new look at the role of antidepressant drugs as adjuvant therapy for glioblastoma multiforme","volume":"79","author":"Lesiak","year":"2017","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"127ra36","DOI":"10.1126\/scitranslmed.3003016","article-title":"Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma","volume":"4","author":"Munson","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.ccell.2015.08.012","article-title":"Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit","volume":"28","author":"Shchors","year":"2015","journal-title":"Cancer Cell"},{"key":"ref_62","first-page":"391","article-title":"The in vitro effects of tricyclic drugs and dexamethasone on cellular Respiration of malignant glioma","volume":"30","author":"Higgins","year":"2010","journal-title":"Anticancer Res."},{"key":"ref_63","first-page":"829","article-title":"Potentiation of cytotoxicity by combination of imatinib and chlorimipramine in glioma","volume":"32","author":"Bilir","year":"2008","journal-title":"Int. J. Oncol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Macdonald, T.J., Liu, J., Yu, B., Malhotra, A., Munson, J., Park, J.C., Wang, K., Fei, B., Bellamkonda, R., and Arbiser, J. (2021). Liposome-imipramine blue inhibits sonic hedgehog medulloblastoma in vivo. Cancers, 13.","DOI":"10.3390\/cancers13061220"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"174073","DOI":"10.1016\/j.ejphar.2021.174073","article-title":"Differential impact of imipramine on thapsigargin- and tunicamycin-induced endoplasmic reticulum stress and mitochondrial dysfunction in neuroblastoma SH-SY5Y cells","volume":"902","author":"Brodnanova","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s11060-010-0209-6","article-title":"Enhancement of vinorelbine-induced cytotoxicity and apoptosis by clomipramine and lithium chloride in human neuroblastoma cancer cell line SH-SY5Y","volume":"100","author":"Bilir","year":"2010","journal-title":"J. Neurooncol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1158\/1078-0432.CCR-15-2535","article-title":"Inhibition of FoxM1-Mediated DNA repair by imipramine blue suppresses breast cancer growth and metastasis","volume":"22","author":"Rajamanickam","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"103586","DOI":"10.1016\/j.etap.2021.103586","article-title":"The proliferation effects of fluoxetine and amitriptyline on human breast cancer cells and the underlying molecular mechanisms","volume":"83","author":"Lei","year":"2021","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e1203","DOI":"10.1038\/cddis.2014.113","article-title":"High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy","volume":"5","author":"Rossi","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF01203070","article-title":"Membrane interactions of some catamphiphilic drugs and relation to their multidrug-resistance-reversing ability","volume":"122","author":"Pajeva","year":"1996","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s12276-020-0389-x","article-title":"New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells","volume":"52","author":"Rodrigues","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1038\/onc.2015.291","article-title":"Imipramine blue halts head and neck cancer invasion through promoting F-box and leucine-rich repeat protein 14-mediated Twist1 degradation","volume":"35","author":"Yang","year":"2016","journal-title":"Oncogene"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"735183","DOI":"10.3389\/fonc.2021.735183","article-title":"Suppression of EGFR\/PKC-\u03b4\/NF-\u03baB Signaling Associated With Imipramine-Inhibited Progression of Non-Small Cell Lung Cancer","volume":"11","author":"Yueh","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3892\/or.2021.8095","article-title":"Sensitizing TRAIL-resistant A549 lung cancer cells and enhancing TRAIL-induced apoptosis with the antidepressant amitriptyline","volume":"46","author":"ZINNAH","year":"2021","journal-title":"Oncol. Rep."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"16926","DOI":"10.18632\/oncotarget.4700","article-title":"Anti-tumoral effect of desmethylclomipramine in lung cancer stem cells","volume":"6","author":"Giacobbe","year":"2015","journal-title":"Oncotarget"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Wang, Z., Mi, T., Bradley, H.L., Metts, J., Sabnis, H., Zhu, W., Arbiser, J., and Bunting, K.D. (2021). Pimozide and imipramine blue exploit mitochondrial vulnerabilities and reactive oxygen species to cooperatively target high risk acute myeloid leukemia. Antioxidants, 10.","DOI":"10.3390\/antiox10060956"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1158\/1535-7163.MCT-13-0688","article-title":"The NADPH oxidase inhibitor imipramine-blue in the treatment of burkitt lymphoma","volume":"13","author":"Klingenberg","year":"2014","journal-title":"Mol. Cancer Ther."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.leukres.2010.03.007","article-title":"SLC6A4 expression and anti-proliferative responses to serotonin transporter ligands chlomipramine and fluoxetine in primary B-cell malignancies","volume":"34","author":"Chamba","year":"2010","journal-title":"Leuk. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.bmcl.2013.01.020","article-title":"Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt\u2019s lymphoma","volume":"23","author":"Bright","year":"2013","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Lim, E.Y., Park, J., Kim, Y.T., and Kim, M.J. (2020). Imipramine inhibits migration and invasion in metastatic castration-resistant prostate cancer PC-3 cells via AKT-mediated NF-\u03baB signaling pathway. Molecules, 25.","DOI":"10.3390\/molecules25204619"},{"key":"ref_81","first-page":"e14291","article-title":"Effect of imipramine on ether \u00e0-go-go potassium channel (Kv1.10) expression in DU145 prostate cancer cells","volume":"54","author":"Yalin","year":"2022","journal-title":"Andrologia"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.1038\/onc.2014.25","article-title":"Targeting autophagy overcomes Enzalutamide resistance in castration-resistant prostate cancer cells and improves therapeutic response in a xenograft model","volume":"33","author":"Nguyen","year":"2014","journal-title":"Oncogene"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/CAD.0b013e32834b1894","article-title":"The effect of tricyclic antidepressants on cutaneous melanoma cell lines and primary cell cultures","volume":"23","author":"Parker","year":"2012","journal-title":"Anticancer. Drugs"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00232-001-0181-3","article-title":"Effects of imipramine on ion channels and proliferation of IGR1 melanoma cells","volume":"188","author":"Gessner","year":"2002","journal-title":"J. Membr. Biol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Evason, K.J., Francisco, M.T., Juric, V., Balakrishnan, S., Lopez Pazmino, M.D.P., Gordan, J.D., Kakar, S., Spitsbergen, J., Goga, A., and Stainier, D.Y.R. (2015). Identification of Chemical Inhibitors of \u03b2-Catenin-Driven Liver Tumorigenesis in Zebrafish. PLoS Genet., 11.","DOI":"10.1371\/journal.pgen.1005305"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.3892\/or.2017.5723","article-title":"Desipramine induces apoptosis in hepatocellular carcinoma cells","volume":"38","author":"Yang","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000073663","article-title":"Effect of the antidepressant desipramine on cytosolic Ca2+ movement and proliferation in human osteosarcoma cells","volume":"69","author":"Jan","year":"2003","journal-title":"Pharmacology"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1742-7843.2004.950304.x","article-title":"Effect of nortriptyline on intracellular Ca2+ handling and proliferation in human osteosarcoma cells","volume":"95","author":"Hsu","year":"2004","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1440-1681.2008.05065.x","article-title":"Desipramine-induced Ca2+-independent apoptosis in MG63 human osteosarcoma cells: Dependence on P38 mitogen-activated protein kinase-regulated activation of caspase 3","volume":"36","author":"Lu","year":"2009","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1124\/mol.110.068122","article-title":"The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases: In vitro and in silico evidence","volume":"79","author":"Mao","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1097\/CAD.0b013e3283628c21","article-title":"The antidepressant amitriptyline shows potent therapeutic activity against multiple myeloma","volume":"24","author":"Zhang","year":"2013","journal-title":"Anticancer. Drugs"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3906\/biy-1802-11","article-title":"In vitro anticancer effect of tricyclic antidepressant nortriptyline on multiple myeloma","volume":"42","author":"Biber","year":"2018","journal-title":"Turkish J. Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/fcp.12712","article-title":"Antidepressants with anti-tumor potential in treating glioblastoma: A narrative review","volume":"36","author":"Abadi","year":"2022","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/274176a0","article-title":"Tricyclic antidepressants block histamine H1 receptors of mouse neuroblastoma cells","volume":"274","author":"Richelson","year":"1978","journal-title":"Nature"},{"key":"ref_95","first-page":"218","article-title":"Tricyclic antidepressants induce sphingomyelinase deficiency in fibroblast and neuroblastoma cell cultures","volume":"35","author":"Albouz","year":"1981","journal-title":"Biomedicine"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/j.1471-4159.1985.tb04081.x","article-title":"5-Hydroxytryptamine Uptake and Imipramine Binding Sites in Neurotumor NCB-20 Cells","volume":"45","author":"Nakaki","year":"1985","journal-title":"J. Neurochem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/0006-8993(89)91546-1","article-title":"Psychotropic drug block voltage-gated ion channels in neuroblastoma cells","volume":"476","author":"Ogata","year":"1989","journal-title":"Brain Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0014-2999(02)01971-4","article-title":"Inhibition of SK3 channels in the TE671 human medulloblastoma cell line by desipramine and imipramine","volume":"448","author":"Carignani","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s002040100228","article-title":"Assessment of DNA damage in C6 glioma cells after antidepressant treatment using an alkaline comet assay","volume":"75","author":"Slamon","year":"2001","journal-title":"Arch. Toxicol."},{"key":"ref_100","first-page":"803","article-title":"Caspase 3 gene expression and [Ca2+]i homeostasis underlying desipramine-induced C6 glioma cell apoptosis","volume":"23","author":"Qi","year":"2002","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1385\/JMN:27:1:029","article-title":"Differential induction of apoptosis by antidepressants in glioma and neuroblastoma cell lines: Evidence for p-c-Jun, cytochrome c, and caspase-3 involvement","volume":"27","author":"Levkovitz","year":"2005","journal-title":"J. Mol. Neurosci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11060-010-0237-2","article-title":"Desipramine induces apoptosis in rat glioma cells via endoplasmic reticulum stress-dependent CHOP pathway","volume":"101","author":"Ma","year":"2011","journal-title":"J. Neurooncol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"254","DOI":"10.2174\/1871520611313020011","article-title":"Antidepressant Desipramine Leads to C6 Glioma Cell Autophagy: Implication for the Adjuvant Therapy of Cancer","volume":"13","author":"Ma","year":"2013","journal-title":"Anticancer. Agents Med. Chem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.molbrainres.2004.10.009","article-title":"Effects of desipramine treatment on tyrosine hydroxylase gene expression in cultured neuroblastoma cells and rat brain tissue","volume":"133","author":"Zhu","year":"2005","journal-title":"Mol. Brain Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.brainres.2007.12.019","article-title":"Antidepressants induce acute CREB phosphorylation and CRE-mediated gene expression in glial cells: A possible contribution to GDNF production","volume":"1196","author":"Hisaoka","year":"2008","journal-title":"Brain Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"13678","DOI":"10.1074\/jbc.M114.622415","article-title":"Tricyclic antidepressant amitriptyline-induced glial cell linederived neurotrophic factor production involves pertussis toxin-sensitive G\u03b1i\/o activation in astroglial cells","volume":"290","author":"Miyano","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Koehler, A., Karve, A., Desai, P., Arbiser, J., Plas, D.R., Qi, X., Read, R.D., Sasaki, A.T., Gawali, V.S., and Toukam, D.K. (2021). Reuse of molecules for glioblastoma therapy. Pharmaceuticals, 14.","DOI":"10.3390\/ph14020099"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00702-013-1099-5","article-title":"Dexamethasone in the presence of desipramine enhances MAPK\/ERK1\/2 signaling possibly via its interference with \u03b2-arrestin","volume":"121","author":"Lucki","year":"2014","journal-title":"J. Neural Transm."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s43440-019-00009-w","article-title":"Neuroprotective effects of mirtazapine and imipramine and their effect in pro- and anti-apoptotic gene expression in human neuroblastoma cells","volume":"72","author":"Lieberknecht","year":"2020","journal-title":"Pharmacol. Reports"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1515\/med-2018-0080","article-title":"High expression levels of fascin-1 protein in human gliomas and its clinical relevance","volume":"13","author":"Zhang","year":"2018","journal-title":"Open Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"215717","DOI":"10.1016\/j.canlet.2022.215717","article-title":"The antidepressant imipramine inhibits breast cancer growth by targeting estrogen receptor signaling and DNA repair events","volume":"540","author":"Timilsina","year":"2022","journal-title":"Cancer Lett."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1002\/cam4.746","article-title":"Fascin-1 as a novel diagnostic marker of triple-negative breast cancer","volume":"5","author":"Wang","year":"2016","journal-title":"Cancer Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/jclinpath-2013-201698","article-title":"Strong association of fascin expression with triple negative breast cancer and basal-like phenotype in African-American women","volume":"67","author":"Esnakula","year":"2014","journal-title":"J. Clin. Pathol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1158\/1078-0432.CCR-05-2281","article-title":"Prognostic significance of basal-like phenotype and fascin expression in node-negative invasive breast carcinomas","volume":"12","author":"Honrado","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"e358","DOI":"10.1016\/S1470-2045(21)00343-0","article-title":"Novel therapeutic strategies: Targeting epithelial\u2013mesenchymal transition in colorectal cancer","volume":"22","author":"Zhang","year":"2021","journal-title":"Lancet Oncol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejphar.2006.04.053","article-title":"Characterization of cytotoxic actions of tricyclic antidepressants on human HT29 colon carcinoma cells","volume":"541","author":"Arimochi","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"ref_117","first-page":"217","article-title":"A cell-based fascin bioassay identifies compounds with potential anti-metastasis or cognition-enhancing functions","volume":"6","author":"Kraft","year":"2013","journal-title":"DMM Dis. Model. Mech."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00109-020-01877-z","article-title":"Novel anti-invasive properties of a Fascin1 inhibitor on colorectal cancer cells","volume":"98","author":"Rodrigues","year":"2020","journal-title":"J. Mol. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"38886","DOI":"10.1074\/jbc.M111.286245","article-title":"Signal Transducers and Activators of Transcription 3 (STAT3) directly regulates cytokine-induced fascin expression and is required for breast cancer cell migration","volume":"286","author":"Snyder","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"25162","DOI":"10.18632\/oncotarget.7301","article-title":"Docosahexaenoic acid inhibits 12-O-tetradecanoylphorbol-13-acetate-induced fascin-1-dependent breast cancer cell migration by suppressing the PKC\u03b4- and Wnt-1\/\u03b2-catenin-mediated pathways","volume":"7","author":"Lii","year":"2016","journal-title":"Oncotarget"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"902","DOI":"10.3892\/ol.2014.1804","article-title":"Signal transducer and activator of transcription 3 signaling upregulates fascin via nuclear factor-\u03baB in gastric cancer: Implications in cell invasion and migration","volume":"7","author":"Yao","year":"2014","journal-title":"Oncol. Lett."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1158\/0008-5472.CAN-13-3009","article-title":"Hypoxia-Inducible factor-1 promotes pancreatic ductal adenocarcinoma invasion and metastasis by activating transcription of the actin-Bundling protein fascin","volume":"74","author":"Zhao","year":"2014","journal-title":"Cancer Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00775-011-0836-1","article-title":"Platinum anticancer agents and antidepressants: Desipramine enhances platinum-based cytotoxicity in human colon cancer cells","volume":"17","author":"Kabolizadeh","year":"2012","journal-title":"J. Biol. Inorg. Chem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1158\/2159-8290.CD-13-0183","article-title":"A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors","volume":"3","author":"Jahchan","year":"2013","journal-title":"Cancer Discov."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Lohinai, Z., Dome, P., Szilagyi, Z., Ostoros, G., Moldvay, J., Hegedus, B., Dome, B., and Weiss, G.J. (2016). From bench to bedside: Attempt to evaluate repositioning of drugs in the treatment of metastatic small cell lung cancer (SCLC). PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0144797"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1038\/s41598-017-04796-1","article-title":"Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells","volume":"7","author":"Metts","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.tiv.2006.10.011","article-title":"Desipramine-induced Ca2+ movement and cytotoxicity in PC3 human prostate cancer cells","volume":"21","author":"Huang","year":"2007","journal-title":"Toxicol. Vitr."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ctarc.2017.01.001","article-title":"Relationship between anti-depressant use and lung cancer survival","volume":"10","author":"Zingone","year":"2017","journal-title":"Cancer Treat. Res. Commun."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"6016","DOI":"10.1177\/0300060519862469","article-title":"Impact of tricyclic antidepressants, selective serotonin reuptake inhibitors, and other antidepressants on overall survival of patients with advanced lung cancer from 2004 to 2014: University of Cincinnati experience","volume":"47","author":"Hassan","year":"2019","journal-title":"J. Int. Med. Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1007\/s10552-012-0073-0","article-title":"Survival of glioma and colorectal cancer patients using tricyclic antidepressants post-diagnosis","volume":"23","author":"Walker","year":"2012","journal-title":"Cancer Causes Control"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e20185","DOI":"10.1097\/MD.0000000000020185","article-title":"Antidepressant use and colorectal cancer morbidity and mortality: A dose-response meta analysis","volume":"99","author":"Chen","year":"2020","journal-title":"Medicine"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/pon.5015","article-title":"Use of antidepressants after colon cancer diagnosis and risk of recurrence","volume":"28","author":"Pocobelli","year":"2019","journal-title":"Psychooncology"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10552-015-0689-y","article-title":"Breast cancer recurrence in relation to antidepressant use","volume":"27","author":"Chubak","year":"2016","journal-title":"Cancer Causes Control"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"100174","DOI":"10.1016\/j.ctarc.2020.100174","article-title":"A Phase Iia Study Repositioning Desipramine in Small Cell Lung Cancer and Other High-Grade Neuroendocrine Tumors","volume":"23","author":"Riess","year":"2020","journal-title":"Cancer Treat. Res. Commun."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/13\/3248\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:41:54Z","timestamp":1760139714000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/13\/3248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,1]]},"references-count":134,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["cancers14133248"],"URL":"https:\/\/doi.org\/10.3390\/cancers14133248","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,1]]}}}