{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:46:28Z","timestamp":1791906388956,"version":"4.3.4"},"reference-count":180,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004097","name":"Fondation ARC, PhD student funding","doi-asserted-by":"publisher","award":["ARCMD-DOC12021030003527"],"award-info":[{"award-number":["ARCMD-DOC12021030003527"]}],"id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004097","name":"Fondation ARC, PhD student funding","doi-asserted-by":"publisher","award":["2021-0132"],"award-info":[{"award-number":["2021-0132"]}],"id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canc\u00e9ropole Est","award":["ARCMD-DOC12021030003527"],"award-info":[{"award-number":["ARCMD-DOC12021030003527"]}]},{"name":"Canc\u00e9ropole Est","award":["2021-0132"],"award-info":[{"award-number":["2021-0132"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Plasmacytoid dendritic cells (pDC) are the main type I interferon producing cells in humans and are able to modulate innate and adaptive immune responses. Tumor infiltration by plasmacytoid dendritic cells is already well described and is associated with poor outcomes in cancers due to the tolerogenic activity of pDC. In hematological diseases, Blastic Plasmacytoid Dendritic Cells Neoplasm (BPDCN), aggressive leukemia derived from pDCs, is well described, but little is known about tumor infiltration by mature pDC described in Myeloid Neoplasms (MN). Recently, mature pDC proliferation (MPDCP) has been described as a differential diagnosis of BPDCN associated with acute myeloid leukemia (pDC-AML), myelodysplastic syndrome (pDC-MDS) and chronic myelomonocytic leukemia (pDC-CMML). Tumor cells are myeloid blasts and\/or mature myeloid cells from related myeloid disorders and pDC derived from a clonal proliferation. The poor prognosis associated with MPDCP requires a better understanding of pDC biology, MN oncogenesis and immune response. This review provides a comprehensive overview about the biological aspects of pDCs, the description of pDC proliferation in MN, and an insight into putative therapies in pDC-AML regarding personalized medicine.<\/jats:p>","DOI":"10.3390\/cancers14143545","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T10:36:56Z","timestamp":1658399816000},"page":"3545","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Plasmacytoid Dendritic Cells, a Novel Target in Myeloid Neoplasms"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5124-8530","authenticated-orcid":false,"given":"Xavier","family":"Roussel","sequence":"first","affiliation":[{"name":"INSERM, EFS BFC, UMR1098 RIGHT, University of Bourgogne Franche-Comt\u00e9, 25000 Besancon, France"},{"name":"Department of Clinical Hematology, University Hospital of Besan\u00e7on, 25000 Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Garnache Ottou","sequence":"additional","affiliation":[{"name":"INSERM, EFS BFC, UMR1098 RIGHT, University of Bourgogne Franche-Comt\u00e9, 25000 Besancon, France"},{"name":"Etablissement Fran\u00e7ais du Sang Bourgogne Franche-Comt\u00e9, Laboratoire d\u2019H\u00e9matologie et d\u2019Immunologie R\u00e9gional, 25020 Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6149-0547","authenticated-orcid":false,"given":"Florian","family":"Renosi","sequence":"additional","affiliation":[{"name":"INSERM, EFS BFC, UMR1098 RIGHT, University of Bourgogne Franche-Comt\u00e9, 25000 Besancon, France"},{"name":"Etablissement Fran\u00e7ais du Sang Bourgogne Franche-Comt\u00e9, Laboratoire d\u2019H\u00e9matologie et d\u2019Immunologie R\u00e9gional, 25020 Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nri3865","article-title":"The Multifaceted Biology of Plasmacytoid Dendritic Cells","volume":"15","author":"Swiecki","year":"2015","journal-title":"Nat. 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