{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T10:42:16Z","timestamp":1781260936904,"version":"3.54.1"},"reference-count":137,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>When presenting with major pathological risk factors, adjuvant radio-chemotherapy for oral cavity cancers (OCC) is recommended, but the addition of chemotherapy to radiotherapy (POCRT) when only minor pathological risk factors are present is controversial. A systematic review following the PICO-PRISMA methodology (PROSPERO registration ID: CRD42021267498) was conducted using the PubMed, Embase, and Cochrane libraries. Studies assessing outcomes of POCRT in patients with solely minor risk factors (perineural invasion or lymph vascular invasion; pN1 single; DOI \u2265 5 mm; close margin &lt; 2\u20135 mm; node-positive level IV or V; pT3 or pT4; multiple lymph nodes without ENE) were evaluated. A meta-analysis technique with a single-arm study was performed. Radiotherapy was combined with chemotherapy in all studies. One study only included patients treated with POCRT. In the other 12 studies, patients were treated with only PORT (12,883 patients) and with POCRT (10,663 patients). Among the patients treated with POCRT, the pooled 3 year OS rate was 72.9% (95%CI: 65.5\u201379.2%); the pooled 3 year DFS was 70.9% (95%CI: 48.8\u201386.2%); and the pooled LRFS was 69.8% (95%CI: 46.1\u201386.1%). Results are in favor of POCRT in terms of OS but not significant for DFS and LRFS, probably due to the heterogeneity of the included studies and a combination of different prognostic factors.<\/jats:p>","DOI":"10.3390\/cancers14153704","type":"journal-article","created":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T21:49:02Z","timestamp":1659304142000},"page":"3704","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Adding Concomitant Chemotherapy to Postoperative Radiotherapy in Oral Cavity Carcinoma with Minor Risk Factors: Systematic Review of the Literature and Meta-Analysis"],"prefix":"10.3390","volume":"14","author":[{"given":"Alessia","family":"Di Rito","sequence":"first","affiliation":[{"name":"Radiotherapy Unit, P.O. \u201cMons. A.R. Dimiccoli\u201d, Viale Ippocrate 15, 76121 Barletta, BT, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9404-3655","authenticated-orcid":false,"given":"Francesco","family":"Fiorica","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Nuclear Medicine, State Hospital Mater Salutis AULSS 9, Via Carlo Gianella, 1, 37045 Legnago, VR, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Carbonara","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, General Regional Hospital \u201cF. Miulli\u201d, 70021 Acquaviva delle Fonti, BA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Di Pressa","sequence":"additional","affiliation":[{"name":"Radiotherapy Unit, Azienda Ospedaliero Universitaria di Modena, Via del Pozzo 71, 41121 Modena, MO, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Bertolini","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Azienda Ospedaliero Universitaria di Modena, Via del Pozzo 71, 41121 Modena, MO, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Mannavola","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, AOU Consorziale Policlinico di Bari, 70124 Bari, BA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Lohr","sequence":"additional","affiliation":[{"name":"Radiotherapy Unit, Azienda Ospedaliero Universitaria di Modena, Via del Pozzo 71, 41121 Modena, MO, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Sardaro","sequence":"additional","affiliation":[{"name":"Interdisciplinary Department of Medicine, Section of Radiology and Radiation Oncology, University of Bari \u201cAldo Moro\u201d, 70124 Bari, BA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5954-0939","authenticated-orcid":false,"given":"Elisa","family":"D\u2019Angelo","sequence":"additional","affiliation":[{"name":"Radiotherapy Unit, Azienda Ospedaliero Universitaria di Modena, Via del Pozzo 71, 41121 Modena, MO, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"key":"ref_1","unstructured":"(2021, November 01). 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