{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:25:06Z","timestamp":1783488306846,"version":"3.55.0"},"reference-count":177,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"OP Integrated Infrastructure","award":["313011V578"],"award-info":[{"award-number":["313011V578"]}]},{"name":"OP Integrated Infrastructure","award":["313011V446"],"award-info":[{"award-number":["313011V446"]}]},{"name":"European Regional Development Fund","award":["313011V578"],"award-info":[{"award-number":["313011V578"]}]},{"name":"European Regional Development Fund","award":["313011V446"],"award-info":[{"award-number":["313011V446"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Colorectal cancer (CRC) is the 3rd most common malignant neoplasm worldwide, with more than two million new cases diagnosed yearly. Despite increasing efforts in screening, many cases are still diagnosed at a late stage, when mortality is high. This paper briefly reviews known genetic causes of CRC (distinguishing between sporadic and familial forms) and discusses potential and confirmed nucleic acid biomarkers obtainable from liquid biopsies, classified by their molecular features, focusing on clinical relevance. We comment on advantageous aspects such as better patient compliance due to blood sampling being minimally invasive, the possibility to monitor mutation characteristics of sporadic and hereditary CRC in a disease showing genetic heterogeneity, and using up- or down-regulated circulating RNA markers to reveal metastasis or disease recurrence. Current difficulties and thoughts on some possible future directions are also discussed. We explore current evidence in the field pointing towards the introduction of personalized CRC management.<\/jats:p>","DOI":"10.3390\/cancers14153712","type":"journal-article","created":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T21:49:02Z","timestamp":1659304142000},"page":"3712","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Extracellular Nucleic Acids in the Diagnosis and Progression of Colorectal Cancer"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5717-3522","authenticated-orcid":false,"given":"Jakub","family":"Styk","sequence":"first","affiliation":[{"name":"Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia"},{"name":"Comenius University Science Park, Comenius University, 841 04 Bratislava, Slovakia"},{"name":"Geneton Ltd., 841 04 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5994-2658","authenticated-orcid":false,"given":"Gergely","family":"Bugly\u00f3","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2491-2285","authenticated-orcid":false,"given":"Ondrej","family":"P\u00f6s","sequence":"additional","affiliation":[{"name":"Comenius University Science Park, Comenius University, 841 04 Bratislava, Slovakia"},{"name":"Geneton Ltd., 841 04 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1d\u00e1m","family":"Cs\u00f3k","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0037-2774","authenticated-orcid":false,"given":"Be\u00e1ta","family":"Solt\u00e9sz","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Lukasz","sequence":"additional","affiliation":[{"name":"Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, 1082 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanda","family":"Repisk\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia"},{"name":"Medirex Group Academy, n.p.o., 949 05 Nitra, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0295-185X","authenticated-orcid":false,"given":"B\u00e1lint","family":"Nagy","sequence":"additional","affiliation":[{"name":"Comenius University Science Park, Comenius University, 841 04 Bratislava, Slovakia"},{"name":"Department of Human Genetics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Szemes","sequence":"additional","affiliation":[{"name":"Comenius University Science Park, Comenius University, 841 04 Bratislava, Slovakia"},{"name":"Geneton Ltd., 841 04 Bratislava, Slovakia"},{"name":"Department of Molecular Biology, Faculty of Natural Sciences, Comenius University, 842 05 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"654","DOI":"10.4251\/wjgo.v14.i3.654","article-title":"Colorectal Cancer Carcinogenesis: From Bench to Bedside","volume":"14","author":"Currais","year":"2022","journal-title":"World J. 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