{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:42:21Z","timestamp":1788406941852,"version":"build-2803163510"},"reference-count":68,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Lambert Initiative for Cannabinoid Therapeutics"},{"name":"Proud Family Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Mesothelioma is an aggressive cancer with limited treatment options and a poor prognosis. Phytocannabinoids possess anti-tumour and palliative properties in multiple cancers, however their effects in mesothelioma are unknown. We investigated the anti-cancer effects and potential mechanisms of action for several phytocannabinoids in mesothelioma cell lines. A panel of 13 phytocannabinoids inhibited growth of human (MSTO and H2452) and rat (II-45) mesothelioma cells in vitro, and cannabidiol (CBD) and cannabigerol (CBG) were the most potent compounds. Treatment with CBD or CBG resulted in G0\/G1 arrest, delayed entry into S phase and induced apoptosis. CBD and CBG also significantly reduced mesothelioma cell migration and invasion. These effects were supported by changes in the expression of genes associated with the cell cycle, proliferation, and cell movement following CBD or CBG treatment. Gene expression levels of CNR1, GPR55, and 5HT1A also increased with CBD or CBG treatment. However, treatment with CBD or CBG in a syngeneic orthotopic rat mesothelioma model was unable to increase survival. Our data show that cannabinoids have anti-cancer effects on mesothelioma cells in vitro and alternatives of drug delivery may be needed to enhance their effects in vivo.<\/jats:p>","DOI":"10.3390\/cancers14153813","type":"journal-article","created":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T21:03:50Z","timestamp":1659906230000},"page":"3813","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["An Examination of the Anti-Cancer Properties of Plant Cannabinoids in Preclinical Models of Mesothelioma"],"prefix":"10.3390","volume":"14","author":[{"given":"Emily K.","family":"Colvin","sequence":"first","affiliation":[{"name":"Bill Walsh Translational Cancer Research Laboratory, Kolling Institute, St Leonards 2065, Australia"},{"name":"School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L.","family":"Hudson","sequence":"additional","affiliation":[{"name":"Bill Walsh Translational Cancer Research Laboratory, Kolling Institute, St Leonards 2065, Australia"},{"name":"School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyndsey L.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Lambert Initiative for Cannabinoid Therapeutics, University of Sydney, Sydney 2050, Australia"},{"name":"Department of Pharmacology, Sydney Pharmacy School, University of Sydney, Sydney 2006, Australia"},{"name":"Brain and Mind Centre, University of Sydney, Sydney 2050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramyashree Prasanna","family":"Kumar","sequence":"additional","affiliation":[{"name":"School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney 2052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain S.","family":"McGregor","sequence":"additional","affiliation":[{"name":"Lambert Initiative for Cannabinoid Therapeutics, University of Sydney, Sydney 2050, Australia"},{"name":"Brain and Mind Centre, University of Sydney, Sydney 2050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2356-3231","authenticated-orcid":false,"given":"Viive M.","family":"Howell","sequence":"additional","affiliation":[{"name":"Bill Walsh Translational Cancer Research Laboratory, Kolling Institute, St Leonards 2065, Australia"},{"name":"School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0159-9997","authenticated-orcid":false,"given":"Jonathon C.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Lambert Initiative for Cannabinoid Therapeutics, University of Sydney, Sydney 2050, Australia"},{"name":"Department of Pharmacology, Sydney Pharmacy School, University of Sydney, Sydney 2006, Australia"},{"name":"Brain and Mind Centre, University of Sydney, Sydney 2050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Brims, F. 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