{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:09:12Z","timestamp":1790813352032,"version":"4.1.0"},"reference-count":53,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Finnish Cancer Research Foundation, Jane and Aatos Erkko Foundation, Sigrid Jus\u00e9lius Foundation, the State Research Funding of the Turku University Hospital","award":["13336"],"award-info":[{"award-number":["13336"]}]},{"name":"Kymenlaakso Regional Fund of the Finnish Cultural Foundation","award":["13336"],"award-info":[{"award-number":["13336"]}]},{"name":"Ida Montin Foundation","award":["13336"],"award-info":[{"award-number":["13336"]}]},{"name":"Instrumentarium Science Foundation","award":["13336"],"award-info":[{"award-number":["13336"]}]},{"name":"Paulo Foundation","award":["13336"],"award-info":[{"award-number":["13336"]}]},{"name":"Maud Kuistila Memorial Foundation","award":["13336"],"award-info":[{"award-number":["13336"]}]},{"name":"University of Turku Graduate School Funding, Finnish Medical Foundation","award":["13336"],"award-info":[{"award-number":["13336"]}]},{"name":"Cancer Foundation of Southwest Finland","award":["13336"],"award-info":[{"award-number":["13336"]}]},{"name":"Finnish Dermatological Society","award":["13336"],"award-info":[{"award-number":["13336"]}]},{"name":"Turku University Foundation","award":["13336"],"award-info":[{"award-number":["13336"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Long non-coding RNAs (lncRNAs) have emerged as important regulators of cancer progression. Super enhancers (SE) play a role in tumorigenesis and regulate the expression of specific lncRNAs. We examined the role of BRD3OS, also named LINC00094, in cutaneous squamous cell carcinoma (cSCC). Elevated BRD3OS (LINC00094) expression was detected in cSCC cells, and expression was downregulated by SE inhibitors THZ1 and JQ1 and via the MEK1\/ERK1\/2 pathway. Increased expression of BRD3OS (LINC00094) was noted in tumor cells in cSCCs and their metastases compared to normal skin, actinic keratoses, and cSCCs in situ. Higher BRD3OS (LINC00094) expression was noted in metastatic cSCCs than in non-metastatic cSCCs. RNA-seq analysis after BRD3OS (LINC00094) knockdown revealed significantly regulated GO terms Cell-matrix adhesion, Basement membrane, Metalloendopeptidase activity, and KEGG pathway Extracellular matrix\u2013receptor interaction. Among the top-regulated genes were MMP1, MMP10, and MMP13. Knockdown of BRD3OS (LINC00094) resulted in decreased production of MMP-1 and MMP-13 by cSCC cells, suppressed invasion of cSCC cells through collagen I, and growth of human cSCC xenografts in vivo. Based on these observations, BRD3OS (LINC00094) was named SERLOC (super enhancer and ERK1\/2-Regulated Long Intergenic non-protein coding transcript Overexpressed in Carcinomas). These results reveal the role of SERLOC in cSCC invasion and identify it as a potential therapeutic target in advanced cSCC.<\/jats:p>","DOI":"10.3390\/cancers14163980","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T21:23:56Z","timestamp":1660771436000},"page":"3980","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Super Enhancer-Regulated LINC00094 (SERLOC) Upregulates the Expression of MMP-1 and MMP-13 and Promotes Invasion of Cutaneous Squamous Cell Carcinoma"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5078-3029","authenticated-orcid":false,"given":"Minna","family":"Piipponen","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Turku and Turku University Hospital, H\u00e4meentie 11 TE6, FI-20520 Turku, Finland"},{"name":"FICAN West Cancer Centre Research Laboratory, University of Turku and Turku University Hospital, Kiinamyllynkatu 10, FI-20520 Turku, Finland"},{"name":"Center for Molecular Medicine, Department of Medicine Solna, Dermatology and Venereology Division, Karolinska Institute, 17176 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilvi","family":"Riihil\u00e4","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Turku and Turku University Hospital, H\u00e4meentie 11 TE6, FI-20520 Turku, Finland"},{"name":"FICAN West Cancer Centre Research Laboratory, University of Turku and Turku University Hospital, Kiinamyllynkatu 10, FI-20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko S.","family":"Knuutila","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Turku and Turku University Hospital, H\u00e4meentie 11 TE6, FI-20520 Turku, Finland"},{"name":"FICAN West Cancer Centre Research Laboratory, University of Turku and Turku University Hospital, Kiinamyllynkatu 10, FI-20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"Kallajoki","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Turku and Turku University Hospital, Kiinamyllynkatu 10, FI-20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2421-9368","authenticated-orcid":false,"given":"Veli-Matti","family":"K\u00e4h\u00e4ri","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Turku and Turku University Hospital, H\u00e4meentie 11 TE6, FI-20520 Turku, Finland"},{"name":"FICAN West Cancer Centre Research Laboratory, University of Turku and Turku University Hospital, Kiinamyllynkatu 10, FI-20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6743-6736","authenticated-orcid":false,"given":"Liisa","family":"Nissinen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Turku and Turku University Hospital, H\u00e4meentie 11 TE6, FI-20520 Turku, Finland"},{"name":"FICAN West Cancer Centre Research Laboratory, University of Turku and Turku University Hospital, Kiinamyllynkatu 10, FI-20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ccell.2016.03.010","article-title":"Long noncoding RNAs in cancer pathways","volume":"29","author":"Schmitt","year":"2016","journal-title":"Cancer Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrg.2015.10","article-title":"Unique features of long non-coding RNA biogenesis and function","volume":"17","author":"Quinn","year":"2016","journal-title":"Nat. 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