{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:47:33Z","timestamp":1790639253429,"version":"4.1.0"},"reference-count":172,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82072699"],"award-info":[{"award-number":["82072699"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>As one of the best-studied long noncoding RNAs, nuclear paraspeckle assembly transcript 1 (NEAT1) plays a pivotal role in the progression of cancers. NEAT1, especially its isoform NEAT1-1, facilitates the growth and metastasis of various cancers, excluding acute promyelocytic leukemia. NEAT1 can be elevated via transcriptional activation or stability alteration in cancers changing the aggressive phenotype of cancer cells. NEAT1 can also be secreted from other cells and be delivered to cancer cells through exosomes. Hence, elucidating the molecular interaction of NEAT1 may shed light on the future treatment of cancer. Herein, we review the molecular function of NEAT1 in cancer progression, and explain how NEAT1 interacts with RNAs, proteins, and DNA promoter regions to upregulate tumorigenic factors.<\/jats:p>","DOI":"10.3390\/cancers14164009","type":"journal-article","created":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T21:05:51Z","timestamp":1661115951000},"page":"4009","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Molecular Interactions of the Long Noncoding RNA NEAT1 in Cancer"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7164-8670","authenticated-orcid":false,"given":"Jingtao","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"An","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weikun","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanxing","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature11233","article-title":"Landscape of transcription in human cells","volume":"489","author":"Djebali","year":"2012","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.cell.2018.01.011","article-title":"Functional Classification and Experimental Dissection of Long Noncoding RNAs","volume":"172","author":"Kopp","year":"2018","journal-title":"Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.tig.2017.05.004","article-title":"The Diversity of Long Noncoding RNAs and Their Generation","volume":"33","author":"Wu","year":"2017","journal-title":"Trends Genet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1101\/gad.284661.116","article-title":"Neat1is a p53-inducible lincRNA essential for transformation suppression","volume":"31","author":"Mello","year":"2017","journal-title":"Genes Dev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e12329","DOI":"10.1111\/cpr.12329","article-title":"NEAT1: A novel cancer-related long non-coding RNA","volume":"50","author":"Yu","year":"2017","journal-title":"Cell Prolif."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12967-022-03273-2","article-title":"LncRNA NEAT1 facilitates glioma progression via stabilizing PGK1","volume":"20","author":"Liang","year":"2022","journal-title":"J. Transl. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/1878-0261.12404","article-title":"Involvement of the long noncoding RNA NEAT1 in carcinogenesis","volume":"13","author":"Klec","year":"2019","journal-title":"Mol. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"G150","DOI":"10.1152\/ajpgi.00426.2016","article-title":"Long non-coding RNA NEAT1 promotes hepatocellular carcinoma cell proliferation through the regulation of miR-129-5p-VCP-I\u03baB","volume":"313","author":"Fang","year":"2017","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.biocel.2017.12.005","article-title":"Oncogenic non-coding RNA NEAT1 promotes the prostate cancer cell growth through the SRC3\/IGF1R\/AKT pathway","volume":"94","author":"Xiong","year":"2018","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1111\/cas.13647","article-title":"Long non-coding RNA NEAT1 promoted ovarian cancer cells\u2019 metastasis through regulation of miR-382-3p\/ROCK1 axial","volume":"109","author":"Liu","year":"2018","journal-title":"Cancer Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e23399","DOI":"10.1002\/jcla.23399","article-title":"Long non-coding RNA NEAT1 serves as a novel biomarker for treatment response and survival profiles via microRNA-125a in multiple myeloma","volume":"34","author":"Yu","year":"2020","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1002\/jcp.27039","article-title":"RELA\/NEAT1\/miR-302a-3p\/RELA feedback loop modulates pancreatic ductal adenocarcinoma cell proliferation and migration","volume":"234","author":"Luo","year":"2019","journal-title":"J. Cell Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13045-018-0656-7","article-title":"The lncRNA NEAT1 activates Wnt\/beta-catenin signaling and promotes colorectal cancer progression via interacting with DDX5","volume":"11","author":"Zhang","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"43337","DOI":"10.18632\/oncotarget.9712","article-title":"NEAT1 upregulates EGCG-induced CTR1 to enhance cisplatin sensitivity in lung cancer cells","volume":"7","author":"Jiang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"6373","DOI":"10.2147\/OTT.S239432","article-title":"LncRNA NEAT1 regulates 5-fu sensitivity, apoptosis and invasion in colorectal cancer through the MiR-150-5p\/CPSF4 axis","volume":"13","author":"Wang","year":"2020","journal-title":"OncoTargets Ther."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Zeng, C., Xu, Y., Xu, L., Yu, X., Cheng, J., Yang, L., Chen, S., and Li, Y. (2014). Inhibition of long non-coding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leukemia cells. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-693"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12935-020-01182-2","article-title":"Long non-coding RNA NEAT1\/miR-338-3p axis impedes the progression of acute myeloid leukemia via regulating CREBRF","volume":"20","author":"Feng","year":"2020","journal-title":"Cancer Cell Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3389\/fgene.2018.00471","article-title":"Long Non-coding RNA NEAT1: A Novel Target for Diagnosis and Therapy in Human Tumors","volume":"9","author":"Dong","year":"2018","journal-title":"Front. Genet."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"456","DOI":"10.4161\/rna.23547","article-title":"Paraspeckle formation during the biogenesis of long non-coding RNAs","volume":"10","author":"Naganuma","year":"2013","journal-title":"RNA Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1091\/mbc.e13-09-0558","article-title":"NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies","volume":"25","author":"Hirose","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1007\/s00018-020-03503-0","article-title":"Long non-coding RNA NEAT1-centric gene regulation","volume":"77","author":"Wang","year":"2020","journal-title":"Cell Mol. Life Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e00269","DOI":"10.1128\/MCB.00269-19","article-title":"ARS2 Regulates Nuclear Paraspeckle Formation through 3\u2032-End Processing and Stability of NEAT1 Long Noncoding RNA","volume":"40","author":"Machitani","year":"2020","journal-title":"Mol. Cell. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"6399","DOI":"10.1038\/s41388-018-0416-8","article-title":"PTBP3 splicing factor promotes hepatocellular carcinoma by destroying the splicing balance of NEAT1 and pre-miR-612","volume":"37","author":"Yang","year":"2018","journal-title":"Oncogene"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1093\/nar\/gky046","article-title":"Structural analyses of NEAT1 lncRNAs suggest long-range RNA interactions that may contribute to paraspeckle architecture","volume":"46","author":"Lin","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Prinz, F., Kapeller, A., Pichler, M., and Klec, C. (2019). The Implications of the Long Non-Coding RNA NEAT1 in Non-Cancerous Diseases. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20030627"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1756-6606-6-31","article-title":"The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis","volume":"6","author":"Nishimoto","year":"2013","journal-title":"Mol. Brain"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.biopha.2018.12.070","article-title":"Nuclear Enriched Abundant Transcript 1 (NEAT1): A long non-coding RNA with diverse functions in tumorigenesis","volume":"111","author":"Taheri","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cell.2005.08.033","article-title":"Regulating gene expression through RNA nuclear retention","volume":"123","author":"Prasanth","year":"2005","journal-title":"Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0092-8674(01)00466-4","article-title":"The fate of dsRNA in the nucleus: A p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs","volume":"106","author":"Zhang","year":"2001","journal-title":"Cell"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Xu, L.D., and \u00d6hman, M. (2018). ADAR1 Editing and its Role in Cancer. Genes, 10.","DOI":"10.3390\/genes10010012"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/s41586-022-04823-w","article-title":"Synonymous mutations in representative yeast genes are mostly strongly non-neutral","volume":"606","author":"Shen","year":"2022","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2014.01.009","article-title":"Long noncoding RNA NEAT1-dependent SFPQ relocation from promoter region to paraspeckle mediates IL8 expression upon immune stimuli","volume":"53","author":"Imamura","year":"2014","journal-title":"Mol. Cell"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jcmgh.2021.02.010","article-title":"Paraspeckle Promotes Hepatocellular Carcinoma Immune Escape by Sequestering IFNGR1 mRNA","volume":"12","author":"Zan","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature12986","article-title":"The multilayered complexity of ceRNA crosstalk and competition","volume":"505","author":"Tay","year":"2014","journal-title":"Nature"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"610547","DOI":"10.3389\/fonc.2021.610547","article-title":"The NEAT1_2\/miR-491 Axis Modulates Papillary Thyroid Cancer Invasion and Metastasis Through TGM2\/NF\u03bab\/FN1 Signaling","volume":"11","author":"Sun","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1172\/JCI94233","article-title":"The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer","volume":"127","author":"Li","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"8558","DOI":"10.1002\/jcp.26470","article-title":"NEAT1 contributes to breast cancer progression through modulating miR-448 and ZEB1","volume":"233","author":"Jiang","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3233\/CBM-190721","article-title":"LncRNA NEAT1 accelerates breast cancer progression through regulating miR-410-3p\/CCND1 axis","volume":"29","author":"Liu","year":"2020","journal-title":"Cancer Biomark."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ijbiomac.2017.07.053","article-title":"The lncRNA NEAT1 facilitates cell growth and invasion via the miR-211\/HMGA2 axis in breast cancer","volume":"105","author":"Li","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_40","unstructured":"Yao, L., Chen, L., Zhou, H., Duan, F., Wang, L., and Zhang, Y. (2020). Long Noncoding RNA NEAT1 Promotes the Progression of Breast Cancer by Regulating miR-138-5p\/ZFX Axis. Cancer Biother. Radiopharm."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13578-021-00556-x","article-title":"Long non-coding RNA NEAT1 transported by extracellular vesicles contributes to breast cancer development by sponging microRNA-141-3p and regulating KLF12","volume":"11","author":"Zhou","year":"2021","journal-title":"Cell Biosci."},{"key":"ref_42","first-page":"1125","article-title":"Long non-coding RNA nuclear paraspeckle assembly transcript 1 interacts with microRNA-107 to modulate breast cancer growth and metastasis by targeting carnitine palmitoyltransferase-1","volume":"55","author":"Xiong","year":"2019","journal-title":"Int. J. Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1615\/JEnvironPatholToxicolOncol.2020032508","article-title":"Evaluation of Potential of Long Noncoding RNA NEAT1 in Colorectal Cancer","volume":"39","author":"Cheng","year":"2020","journal-title":"J. Environ. Pathol. Toxicol. Oncol. Off. Organ Int. Soc. Environ. Toxicol. Cancer"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1093\/abbs\/gmy130","article-title":"LncRNA NEAT1 promotes colorectal cancer cell proliferation and migration via regulating glial cell-derived neurotrophic factor by sponging miR-196a-5p","volume":"50","author":"Zhong","year":"2018","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"652831","DOI":"10.3389\/fonc.2021.652831","article-title":"A Novel Mechanism of the c-Myc\/NEAT1 Axis Mediating Colorectal Cancer Cell Response to Photodynamic Therapy Treatment","volume":"11","author":"Liu","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e1125","DOI":"10.1002\/mgg3.1125","article-title":"LncRNA NEAT1\/miR-185-5p\/IGF2 axis regulates the invasion and migration of colon cancer","volume":"8","author":"Zhuang","year":"2020","journal-title":"Mol. Genet. Genom. Med."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Gao, Z., Shi, Y., Wang, J., Li, W., Bao, Y., Wu, D., and Gu, Y. (2021). Long non-coding RNA NEAT1 absorbs let-7 g-5p to induce epithelial-mesenchymal transition of colon cancer cells through upregulating BACH1. Dig. Liver Dis.","DOI":"10.1016\/j.dld.2021.04.031"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1515\/med-2020-0218","article-title":"LncRNA NEAT1 promotes gastric cancer progression via miR-1294\/AKT1 axis","volume":"15","author":"Wu","year":"2020","journal-title":"Open Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.2147\/OTT.S245557","article-title":"Long non-coding rna neat1 serves as sponge for mir-365a-3p to promote gastric cancer progression via regulating abcc4","volume":"13","author":"Gao","year":"2020","journal-title":"OncoTargets Ther."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1186\/s12935-020-01655-4","article-title":"Long noncoding RNA NEAT1 regulates radio-sensitivity via microRNA-27b-3p in gastric cancer","volume":"20","author":"Jiang","year":"2020","journal-title":"Cancer Cell Int."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3892\/mmr.2021.12142","article-title":"lncRNA NEAT1 regulates gastric carcinoma cell proliferation, invasion and apoptosis via the miR-500a-3p\/XBP-1 axis","volume":"24","author":"Zhou","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1002\/jcb.26691","article-title":"Long noncoding RNA NEAT1-modulated miR-506 regulates gastric cancer development through targeting STAT3","volume":"120","author":"Tan","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"862","DOI":"10.3892\/etm.2021.10294","article-title":"Long non-coding RNA NEAT1 increases the aggressiveness of gastric cancer by regulating the microRNA-142-5p\/JAG1 axis","volume":"22","author":"Zhang","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_54","first-page":"33","article-title":"Lncrna neat1 enhances cell proliferation and invasion by regulating the MIR-221-5p\/ SOX11 axis in gastric cancer","volume":"128","author":"Zhai","year":"2021","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e12847","DOI":"10.1111\/hel.12847","article-title":"Long noncoding RNA NEAT1 promotes tumorigenesis in H. pylori gastric cancer by sponging miR-30a to regulate COX-2\/BCL9 pathway","volume":"26","author":"Rao","year":"2021","journal-title":"Helicobacter"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"135086","DOI":"10.1016\/j.neulet.2020.135086","article-title":"Long non-coding RNA NEAT1 promotes human glioma tumor progression via miR-152-3p\/CCT6A pathway","volume":"732","author":"Li","year":"2020","journal-title":"Neurosci. Lett."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12943-018-0849-2","article-title":"Knockdown of long non-coding RNA NEAT1 inhibits glioma cell migration and invasion via modulation of SOX2 targeted by miR-132","volume":"17","author":"Zhou","year":"2018","journal-title":"Mol. Cancer"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/jcp.29644","article-title":"Long noncoding RNA NEAT1 promotes progression of glioma as a ceRNA by sponging miR-185-5p to stimulate DNMT1\/mTOR signaling","volume":"236","author":"Yu","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s13277-015-3843-y","article-title":"Long noncoding RNA NEAT1 promotes glioma pathogenesis by regulating miR-449b-5p\/c-Met axis","volume":"37","author":"Li","year":"2016","journal-title":"Tumor Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"5972","DOI":"10.1002\/jcp.27093","article-title":"Long noncoding RNA nuclear enriched abundant transcript 1 impacts cell proliferation, invasion, and migration of glioma through regulating miR-139-5p\/ CDK6","volume":"234","author":"Wu","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.1002\/jcp.26371","article-title":"The long noncoding RNA NEAT1 contributes to hepatocellular carcinoma development by sponging miR-485 and enhancing the expression of the STAT3","volume":"233","author":"Zhang","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"790916","DOI":"10.3389\/fonc.2022.790916","article-title":"The Potential Roles of Exosomal Non-Coding RNAs in Hepatocellular Carcinoma","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3892\/mmr.2020.11807","article-title":"Silencing of long non-coding RNA NEAT1 inhibits hepatocellular carcinoma progression by downregulating SMO by sponging microRNA-503","volume":"23","author":"Sun","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"8991","DOI":"10.2147\/OTT.S224521","article-title":"Long noncoding rna neat1 promotes cell proliferation and invasion and suppresses apoptosis in hepatocellular carcinoma by regulating mirna-22-3p\/akt2 in vitro and in vivo","volume":"12","author":"Zhou","year":"2019","journal-title":"OncoTargets Ther."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"8578","DOI":"10.1002\/jcp.26524","article-title":"NEAT1 upregulates TGF-\u03b21 to induce hepatocellular carcinoma progression by sponging hsa-mir-139-5p","volume":"233","author":"Tu","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_66","first-page":"1001","article-title":"LncRNA NEAT1 regulates the proliferation and migration of hepatocellular carcinoma cells by acting as a miR-320a molecular sponge and targeting L antigen family member 3","volume":"57","author":"Zhang","year":"2020","journal-title":"Int. J. Oncol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12943-018-0838-5","article-title":"Long non-coding RNA NEAT1-modulated abnormal lipolysis via ATGL drives hepatocellular carcinoma proliferation","volume":"17","author":"Liu","year":"2018","journal-title":"Mol. Cancer"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"51784","DOI":"10.18632\/oncotarget.10108","article-title":"Long non-coding RNA NEAT1 promotes non-small cell lung cancer progression through regulation of miR-377-3p-E2F3 pathway","volume":"7","author":"Sun","year":"2016","journal-title":"Oncotarget"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"368","DOI":"10.33594\/000000026","article-title":"Overexpression of HIF-2\u03b1-dependent NEAT1 promotes the progression of non-small cell lung cancer through miR-101-3p\/SOX9\/Wnt\/\u03b2-catenin signal pathway","volume":"52","author":"Kong","year":"2019","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"13357","DOI":"10.2147\/CMAR.S277524","article-title":"Lncrna neat1\/mir-204\/nuak1 axis is a potential therapeutic target for non-small cell lung cancer","volume":"12","author":"Zhao","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_71","first-page":"4810","article-title":"LncRNA NEAT1 regulated cell proliferation, invasion, migration and apoptosis by targeting has-miR-376b-3p\/SULF1 axis in non-small cell lung cancer","volume":"24","author":"Chen","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_72","first-page":"3429","article-title":"Long non-coding RNA NEAT1 promotes ovarian cancer cell invasion and migration by interacting with miR-1321 and regulating tight junction protein 3 expression","volume":"22","author":"Luo","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1186\/s12935-021-02018-3","article-title":"Long non-coding RNA NEAT1 facilitates the growth, migration, and invasion of ovarian cancer cells via the let-7 g\/MEST\/ATGL axis","volume":"21","author":"Yin","year":"2021","journal-title":"Cancer Cell Int."},{"key":"ref_74","first-page":"3347","article-title":"Long non-coding RNA NEAT1 modifies cell proliferation, colony formation, apoptosis, migration and invasion via the miR-4500\/BZW1 axis in ovarian cancer","volume":"22","author":"Xu","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"BSR20190635","DOI":"10.1042\/BSR20190635","article-title":"Long non-coding RNA-NEAT1, a sponge for MIR-98-5p, promotes expression of oncogene HMGA2 in prostate cancer","volume":"39","author":"Guo","year":"2019","journal-title":"Biosci. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"109422","DOI":"10.1016\/j.cellsig.2019.109422","article-title":"LncRNA NEAT1 promotes docetaxel resistance in prostate cancer by regulating ACSL4 via sponging miR-34a-5p and miR-204-5p","volume":"65","author":"Jiang","year":"2020","journal-title":"Cell. Signal."},{"key":"ref_77","first-page":"A128","article-title":"Lncrna neat1-mediated mir-361 downregulation contributes to EMT and sphere formation of cervical cancer cells via increasing hsp90 expression","volume":"30","author":"Dong","year":"2020","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/kjm2.12354","article-title":"LncRNA NEAT1 promotes cell proliferation, migration, and invasion via the miR-186-5p\/PTP4A1 axis in cholangiocarcinoma","volume":"37","author":"Li","year":"2021","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.neo.2021.05.004","article-title":"Exosomal lncRNA NEAT1 from cancer-associated fibroblasts facilitates endometrial cancer progression via miR-26a\/b-5p-mediated STAT3\/YKL-40 signaling pathway","volume":"23","author":"Fan","year":"2021","journal-title":"Neoplasia"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"5314649","DOI":"10.1155\/2017\/5314649","article-title":"LncRNA NEAT1 Regulates Cell Viability and Invasion in Esophageal Squamous Cell Carcinoma through the miR-129\/CTBP2 Axis","volume":"2017","author":"Li","year":"2017","journal-title":"Dis. Markers"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.2147\/OTT.S236350","article-title":"Long noncoding RNA NEAT1 upregulates survivin and facilitates gallbladder cancer progression by sponging microRNA-335","volume":"13","author":"Yang","year":"2020","journal-title":"OncoTargets Ther."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Lulli, V., Buccarelli, M., Ilari, R., Castellani, G., De Dominicis, C., Di Giamberardino, A., D\u2032Alessandris, Q.G., Giannetti, S., Martini, M., and Stumpo, V. (2020). Mir-370-3p impairs glioblastoma stem-like cell malignancy regulating a complex interplay between HMGA2\/HIF1A and the oncogenic long non-coding RNA (LncRNA) neat1. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103610"},{"key":"ref_83","first-page":"6219","article-title":"Long non-coding RNA NEAT1 regulates Hodgkin\u2019s lymphoma cell proliferation and invasion via miR-448 mediated regulation of DCLK1","volume":"24","author":"Fan","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"802","DOI":"10.3892\/ol.2021.13063","article-title":"Long non-coding RNA NEAT1 promotes the malignancy of laryngeal squamous cell carcinoma by regulating the microRNA-204-5p\/SEMA4B axis","volume":"22","author":"Han","year":"2021","journal-title":"Oncol. Lett."},{"key":"ref_85","first-page":"22759","article-title":"NEAT1\/miR-200b-3p\/SMAD2 axis promotes progression of melanoma","volume":"12","author":"Zhou","year":"2020","journal-title":"Aging"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"70156","DOI":"10.18632\/oncotarget.19596","article-title":"Long non-coding RNA NEAT1 regulates epithelial membrane protein 2 expression to repress nasopharyngeal carcinoma migration and irradiation-resistance through miR-101-3p as a competing endogenous RNA mechanism","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12935-021-01780-8","article-title":"The lncRNA NEAT1 promotes the epithelial-mesenchymal transition and metastasis of osteosarcoma cells by sponging miR-483 to upregulate STAT3 expression","volume":"21","author":"Chen","year":"2021","journal-title":"Cancer Cell Int."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"5622","DOI":"10.7150\/jca.58824","article-title":"NEAT1\/miR-101-dependent up-regulation of DNA-PKcs enhances malignant behaviors of pancreatic ductal adenocarcinoma cells","volume":"12","author":"Hu","year":"2021","journal-title":"J. Cancer"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"574145","DOI":"10.3389\/fgene.2020.574145","article-title":"LncRNA NEAT1 Knockdown Inhibits Retinoblastoma Progression by miR-3619-5p\/LASP1 Axis","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Genet."},{"key":"ref_90","first-page":"1172","article-title":"MicroRNA-592 suppresses the malignant phenotypes of thyroid cancer by regulating lncRNA NEAT1 and downregulating NOVA1","volume":"44","author":"Luo","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_91","first-page":"267","article-title":"LncRNA NEAT1 regulates proliferation, migration and invasion of tongue squamous cell carcinoma cells by regulating miR-339-5p\/ITGA3 axis","volume":"29","author":"Li","year":"2020","journal-title":"Shanghai J. Stomatol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"BSR20200533","DOI":"10.1042\/BSR20200533","article-title":"Inhibition of lncRNA-NEAT1 sensitizes 5-Fu resistant cervical cancer cells through de-repressing the microRNA-34a\/LDHA axis","volume":"41","author":"Shao","year":"2021","journal-title":"Biosci. Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"106807","DOI":"10.1016\/j.leukres.2022.106807","article-title":"Altered expression of NEAT1 variants and P53, PTEN, and BCL-2 genes in patients with acute myeloid leukemia","volume":"115","author":"Rostami","year":"2022","journal-title":"Leuk. Res."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Li, X., Deng, S., Pang, X., Song, Y., Luo, S., Jin, L., and Pan, Y. (2019). LncRNA NEAT1 silenced miR-133b promotes migration and invasion of breast cancer cells. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20153616"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.21037\/atm-21-2668","article-title":"Tumor protein D52 promotes breast cancer proliferation and migration via the long non-coding RNA NEAT1\/microRNA-218-5p axis","volume":"9","author":"Ren","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"65067","DOI":"10.18632\/oncotarget.11364","article-title":"Dysregulation of the BRCA1\/long non-coding RNA NEAT1 signaling axis contributes to breast tumorigenesis","volume":"7","author":"Lo","year":"2016","journal-title":"Oncotarget"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.2147\/OTT.S220306","article-title":"Long non-coding RNA-neat1 promotes cell migration and invasion via regulating MiR-124\/NF-\u03baB pathway in cervical cancer","volume":"13","author":"Shen","year":"2020","journal-title":"OncoTargets Ther."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"18985","DOI":"10.1002\/jcp.28538","article-title":"Involvement of NEAT1\/miR-133a axis in promoting cervical cancer progression via targeting SOX4","volume":"234","author":"Yuan","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/cam4.1798","article-title":"Knockdown long noncoding RNA nuclear paraspeckle assembly transcript 1 suppresses colorectal cancer through modulating miR-193a-3p\/KRAS","volume":"8","author":"Zhu","year":"2019","journal-title":"Cancer Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3233\/CBM-201733","article-title":"Upregulation lnc-NEAT1 contributes to colorectal cancer progression through sponging miR-486-5p and activating NR4A1\u03b2-catenin pathway","volume":"30","author":"Liu","year":"2021","journal-title":"Cancer Biomark."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s13577-019-00301-0","article-title":"Long non-coding RNA NEAT1 promotes colorectal cancer progression by regulating miR-205-5p\/VEGFA axis","volume":"33","author":"Liu","year":"2020","journal-title":"Hum. Cell"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.canlet.2018.10.002","article-title":"Long non-coding RNA NEAT1 promotes colorectal cancer progression by competitively binding miR-34a with SIRT1 and enhancing the Wnt\/\u03b2-catenin signaling pathway","volume":"440\u2013441","author":"Luo","year":"2019","journal-title":"Cancer Lett."},{"key":"ref_103","unstructured":"Xu, C., Zhai, J., and Fu, Y. (2020). Overexpression of Nuclear Enriched Autosomal Transcript 1 Facilitates Cell Proliferation, Migration Invasion, and Suppresses Apoptosis in Endometrial Cancer by Targeting MicroRNA-202-3p\/T Cell Immunoglobulin and Mucin Domain 4 Axis. Cancer Biother. Radiopharm."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"434","DOI":"10.2478\/raon-2019-0051","article-title":"LncRNA NEAT1 promotes endometrial cancer cell proliferation, migration and invasion by regulating the MIR-144-3p\/EZH2 axis","volume":"53","author":"Wang","year":"2019","journal-title":"Radiol. Oncol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s13046-019-1306-9","article-title":"Long noncoding RNA NEAT1 drives aggressive endometrial cancer progression via miR-361-regulated networks involving STAT3 and tumor microenvironment-related genes","volume":"38","author":"Dong","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1007\/s00404-017-4365-1","article-title":"Regulation of NEAT1\/miR-214-3p on the growth, migration and invasion of endometrial carcinoma cells","volume":"295","author":"Wang","year":"2017","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"618930","DOI":"10.3389\/fonc.2020.618930","article-title":"Long Noncoding RNA Nuclear Paraspeckle Assembly Transcript 1 Promotes Progression and Angiogenesis of Esophageal Squamous Cell Carcinoma Through miR-590-3p\/MDM2 Axis","volume":"10","author":"Luo","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"11845","DOI":"10.2147\/CMAR.S267666","article-title":"Lncrna neat1 promotes the progression of gastric cancer through modifying the mir-1224-5p\/rsf1 signaling axis","volume":"12","author":"Yang","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_109","first-page":"150","article-title":"Long non-coding RNA NEAT1 regulates the proliferation, migration and invasion of gastric cancer cells via targeting miR-335-5p\/ROCK1 axis","volume":"73","author":"Wang","year":"2018","journal-title":"Pharmazie"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"9887","DOI":"10.2147\/OTT.S228917","article-title":"LncRNA neat1 promotes proliferation, migration and invasion via regulating miR-296-5p\/CNN2 axis in hepatocellular carcinoma cells","volume":"12","author":"Li","year":"2019","journal-title":"OncoTargets Ther."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"19592","DOI":"10.1002\/jcp.28559","article-title":"lncRNA NEAT1 facilitates melanoma cell proliferation, migration, and invasion via regulating miR-495-3p and E2F3","volume":"234","author":"Xia","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s12935-019-0927-6","article-title":"NEAT1\/miR-23a-3p\/KLF3: A novel regulatory axis in melanoma cancer progression","volume":"19","author":"Ding","year":"2019","journal-title":"Cancer Cell Int."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.molimm.2019.10.026","article-title":"LncRNA NEAT1 sponges miR-214 to regulate M2 macrophage polarization by regulation of B7-H3 in multiple myeloma","volume":"117","author":"Gao","year":"2020","journal-title":"Mol. Immunol."},{"key":"ref_114","first-page":"94","article-title":"Mir-222 emerges as a cerna of lncrna neat1, and inhibits cell viability and migration of nasopharyngeal carcinoma cells via aldh1","volume":"128","author":"Wang","year":"2021","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.biopha.2018.04.053","article-title":"lncRNA NEAT1 competes against let-7a to contribute to non-small cell lung cancer proliferation and metastasis","volume":"103","author":"Qi","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1002\/jcb.26442","article-title":"NEAT1\/hsa-mir-98-5p\/MAPK6 axis is involved in non\u2013small-cell lung cancer development","volume":"120","author":"Wu","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1186\/s12935-020-01697-8","article-title":"The interplay between ATF2 and NEAT1 contributes to lung adenocarcinoma progression","volume":"20","author":"Liu","year":"2020","journal-title":"Cancer Cell Int."},{"key":"ref_118","first-page":"8403","article-title":"LncRNA NEAT1\/MIR-1224\/KLF3 contributes to cell proliferation, apoptosis and invasion in lung cancer","volume":"23","author":"Yu","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"5097","DOI":"10.1002\/jcp.27313","article-title":"NEAT1 induces osteosarcoma development by modulating the miR-339-5p\/TGF-\u03b21 pathway","volume":"234","author":"Zhang","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"6502","DOI":"10.1002\/jcb.27941","article-title":"lncRNA nuclear-enriched abundant transcript 1 promotes cell proliferation and invasion by targeting miR-186-5p\/HIF-1\u03b1 in osteosarcoma","volume":"120","author":"Tan","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_121","first-page":"2361","article-title":"NEAT1 regulates pancreatic cancer cell growth, invasion and migration though mircroRNA-335-5p\/c-met axis","volume":"6","author":"Cao","year":"2016","journal-title":"Am. J. Cancer Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3892\/etm.2021.9798","article-title":"Knockdown of lncRNA NEAT1 expression inhibits cell migration, invasion and EMT by regulating the miR-24-3p\/LRG1 axis in retinoblastoma cells","volume":"21","author":"Luan","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"5587","DOI":"10.2147\/CMAR.S271326","article-title":"Lncrna neat1 acts as an mir-148b-3p sponge to regulate rock1 inhibition of retinoblastoma growth","volume":"13","author":"Lu","year":"2021","journal-title":"Cancer Manag. Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"11567","DOI":"10.1002\/jcp.27812","article-title":"Long noncoding RNA NEAT1 promotes the growth of human retinoblastoma cells via regulation of miR-204\/CXCR4 axis","volume":"234","author":"Zhong","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"6638","DOI":"10.1002\/jcp.26425","article-title":"Long noncoding RNA NEAT1 regulate papillary thyroid cancer progression by modulating miR-129-5p\/KLK7 expression","volume":"233","author":"Zhang","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41419-018-0418-z","article-title":"NEAT1-2 functions as a competing endogenous RNA to regulate ATAD2 expression by sponging microRNA-106b-5p in papillary thyroid cancer","volume":"9","author":"Sun","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"773","DOI":"10.21037\/atm-21-34","article-title":"LncRNA NEAT1 mediates intestinal inflammation by regulating TNFRSF1B","volume":"9","author":"Pan","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_128","first-page":"237","article-title":"LncRNA NEAT1 facilitates pancreatic cancer growth and metastasis through stabilizing ELF3 mRNA","volume":"10","author":"Feng","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3389\/fgene.2020.00250","article-title":"LncRNA NEAT1 Interacted With DNMT1 to Regulate Malignant Phenotype of Cancer Cell and Cytotoxic T Cell Infiltration via Epigenetic Inhibition of p53, cGAS, and STING in Lung Cancer","volume":"11","author":"Ma","year":"2020","journal-title":"Front. Genet."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41419-019-1742-7","article-title":"Long noncoding RNA Neat1 modulates myogenesis by recruiting Ezh2","volume":"10","author":"Wang","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1158\/1078-0432.CCR-17-0605","article-title":"Long Noncoding RNA NEAT1, Regulated by the EGFR Pathway, Contributes to Glioblastoma Progression Through the WNT\/beta-Catenin Pathway by Scaffolding EZH2","volume":"24","author":"Chen","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s12276-020-0387-z","article-title":"Long noncoding RNA NEAT1 suppresses hepatocyte proliferation in fulminant hepatic failure through increased recruitment of EZH2 to the LATS2 promoter region and promotion of H3K27me3 methylation","volume":"52","author":"Wang","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"E8660","DOI":"10.1073\/pnas.1803725115","article-title":"Long noncoding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) is critical for phenotypic switching of vascular smooth muscle cells","volume":"115","author":"Ahmed","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1007\/s00018-019-03074-9","article-title":"NEAT1 regulates neuroglial cell mediating Abeta clearance via the epigenetic regulation of endocytosis-related genes expression","volume":"76","author":"Wang","year":"2019","journal-title":"Cell Mol. Life Sci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.omtn.2020.09.003","article-title":"KLF5-Modulated lncRNA NEAT1 Contributes to Tumorigenesis by Acting as a Scaffold for BRG1 to Silence GADD45A in Gastric Cancer","volume":"22","author":"Ma","year":"2020","journal-title":"Mol. Nucleic Acids"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1016\/j.cmet.2021.11.011","article-title":"NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis","volume":"33","author":"Park","year":"2021","journal-title":"Cell Metab."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s12943-020-01293-4","article-title":"Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine","volume":"19","author":"Wen","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fncel.2020.00028","article-title":"Depletion of LncRNA NEAT1 Rescues Mitochondrial Dysfunction Through NEDD4L-Dependent PINK1 Degradation in Animal Models of Alzheimer\u2019s Disease","volume":"14","author":"Huang","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.3389\/fphys.2019.01503","article-title":"Long Non-coding RNA NEAT1 Alleviates Acute-on-Chronic Liver Failure Through Blocking TRAF6 Mediated Inflammatory Response","volume":"10","author":"Xu","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"22477","DOI":"10.1002\/jcp.28811","article-title":"Knockdown of lncRNA NEAT1 inhibits Th17\/CD4(+) T cell differentiation through reducing the STAT3 protein level","volume":"234","author":"Shui","year":"2019","journal-title":"J. Cell Physiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1158\/0008-5472.CAN-18-0688","article-title":"Oncogenic Properties of NEAT1 in Prostate Cancer Cells Depend on the CDC5L-AGRN Transcriptional Regulation Circuit","volume":"78","author":"Li","year":"2018","journal-title":"Cancer Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s00018-016-2398-4","article-title":"NEAT1 modulates herpes simplex virus-1 replication by regulating viral gene transcription","volume":"74","author":"Wang","year":"2017","journal-title":"Cell Mol. Life Sci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1080\/21691401.2019.1604536","article-title":"Long non-coding RNA NEAT1 promotes steatosis via enhancement of estrogen receptor alpha-mediated AQP7 expression in HepG2 cells","volume":"47","author":"Fu","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/nsmb.3455","article-title":"NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing","volume":"24","author":"Jiang","year":"2017","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Shen, W., Liang, X.H., Sun, H., De Hoyos, C.L., and Crooke, S.T. (2017). Depletion of NEAT1 lncRNA attenuates nucleolar stress by releasing sequestered P54nrb and PSF to facilitate c-Myc translation. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0173494"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Jen, H.W., Gu, D.L., Lang, Y.D., and Jou, Y.S. (2020). PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility. Cells, 9.","DOI":"10.3390\/cells9061490"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.3390\/genes5041050","article-title":"Long Non-Coding RNA NEAT1 Associates with SRp40 to Temporally Regulate PPAR\u03b32 Splicing during Adipogenesis in 3T3-L1 Cells","volume":"5","author":"Cooper","year":"2014","journal-title":"Genes"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.2147\/OTT.S116319","article-title":"Long noncoding RNA NEAT1 promotes cell proliferation and invasion by regulating hnRNP A2 expression in hepatocellular carcinoma cells","volume":"10","author":"Mang","year":"2017","journal-title":"Oncol. Targets"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1093\/nar\/gkv156","article-title":"The structure of human SFPQ reveals a coiled-coil mediated polymer essential for functional aggregation in gene regulation","volume":"43","author":"Lee","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1038\/emboj.2012.251","article-title":"Alternative 3\u2019-end processing of long noncoding RNA initiates construction of nuclear paraspeckles","volume":"31","author":"Naganuma","year":"2012","journal-title":"EMBO J."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.molcel.2014.07.012","article-title":"The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites","volume":"55","author":"West","year":"2014","journal-title":"Mol. Cell"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.molcel.2011.08.027","article-title":"Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions","volume":"44","author":"Chu","year":"2011","journal-title":"Mol. Cell"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12943-017-0674-z","article-title":"Oct4 transcriptionally regulates the expression of long non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression","volume":"16","author":"Jen","year":"2017","journal-title":"Mol. Cancer"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1038\/onc.2014.378","article-title":"Tumor hypoxia induces nuclear paraspeckle formation through HIF-2\u03b1 dependent transcriptional activation of NEAT1 leading to cancer cell survival","volume":"34","author":"Choudhry","year":"2015","journal-title":"Oncogene"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.7150\/thno.33178","article-title":"Knockdown of NEAT1 induces tolerogenic phenotype in dendritic cells by inhibiting activation of NLRP3 inflammasome","volume":"9","author":"Zhang","year":"2019","journal-title":"Theranostics"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.molcel.2019.03.041","article-title":"Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition","volume":"74","author":"Modic","year":"2019","journal-title":"Mol. Cell"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1101\/gr.087775.108","article-title":"MEN epsilon\/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles","volume":"19","author":"Sunwoo","year":"2009","journal-title":"Genome Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00018-022-04402-2","article-title":"ALYREF, a novel factor involved in breast carcinogenesis, acts through transcriptional and post-transcriptional mechanisms selectively regulating the short NEAT1 isoform","volume":"79","author":"Klec","year":"2022","journal-title":"Cell Mol. Life Sci."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s12943-015-0455-5","article-title":"Nuclear-enriched abundant transcript 1 as a diagnostic and prognostic biomarker in colorectal cancer","volume":"14","author":"Wu","year":"2015","journal-title":"Mol. Cancer"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.7150\/thno.72581","article-title":"mTOR regulates aerobic glycolysis through NEAT1 and nuclear paraspeckle-mediated mechanism in hepatocellular carcinoma","volume":"12","author":"Zhang","year":"2022","journal-title":"Theranostics"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1002\/cam4.710","article-title":"HuR-regulated lncRNA NEAT1 stability in tumorigenesis and progression of ovarian cancer","volume":"5","author":"Chai","year":"2016","journal-title":"Cancer Med."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.biocel.2019.06.003","article-title":"The RNA-binding protein SRSF1 is a key cell cycle regulator via stabilizing NEAT1 in glioma","volume":"113","author":"Zhou","year":"2019","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"5876","DOI":"10.1158\/0008-5472.CAN-21-1456","article-title":"ALKBH5 Facilitates Hypoxia-Induced Paraspeckle Assembly and IL8 Secretion to Generate an Immunosuppressive Tumor Microenvironment","volume":"81","author":"Dong","year":"2021","journal-title":"Cancer Res."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/s41419-018-0908-z","article-title":"Long noncoding RNA NEAT1, regulated by LIN28B, promotes cell proliferation and migration through sponging miR-506 in high-grade serous ovarian cancer","volume":"9","author":"Wu","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"802795","DOI":"10.3389\/fimmu.2021.802795","article-title":"PTRF\/Cavin-1 as a Novel RNA-Binding Protein Expedites the NF-\u03baB\/PD-L1 Axis by Stabilizing lncRNA NEAT1, Contributing to Tumorigenesis and Immune Evasion in Glioblastoma","volume":"12","author":"Yi","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"5248","DOI":"10.1038\/ncomms6248","article-title":"PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity","volume":"5","author":"Yoon","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"551681","DOI":"10.3389\/fcell.2020.551681","article-title":"Delivery of Long Non-coding RNA NEAT1 by Peripheral Blood Monouclear Cells-Derived Exosomes Promotes the Occurrence of Rheumatoid Arthritis via the MicroRNA-23a\/MDM2\/SIRT6 Axis","volume":"8","author":"Rao","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201211138","article-title":"Extracellular vesicles: Exosomes, microvesicles, and friends","volume":"200","author":"Raposo","year":"2013","journal-title":"J. Cell Biol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"616220","DOI":"10.3389\/fgene.2021.616220","article-title":"NEAT1 Overexpression Indicates a Poor Prognosis and Induces Chemotherapy Resistance via the miR-491-5p\/SOX3 Signaling Pathway in Ovarian Cancer","volume":"12","author":"Jia","year":"2021","journal-title":"Front. Genet."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"e493","DOI":"10.1002\/ctm2.493","article-title":"LncRNA nuclear-enriched abundant transcript 1 shuttled by prostate cancer cells-secreted exosomes initiates osteoblastic phenotypes in the bone metastatic microenvironment via miR-205-5p\/runt-related transcription factor 2\/splicing factor proline- and glutamine-rich\/polypyrimidine tract-binding protein 2 axis","volume":"11","author":"Mo","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12951-020-00716-0","article-title":"Exosomal LncRNA-NEAT1 derived from MIF-treated mesenchymal stem cells protected against doxorubicin-induced cardiac senescence through sponging miR-221-3p","volume":"18","author":"Zhuang","year":"2020","journal-title":"J. Nanobiotechnol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.molcel.2009.06.027","article-title":"Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: Functional role of a nuclear noncoding RNA","volume":"35","author":"Chen","year":"2009","journal-title":"Mol. 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