{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:37:29Z","timestamp":1787027849963,"version":"build-2736575974"},"reference-count":55,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Thyroid cancer is the most common endocrine malignancy with an increasing incidence over the past few years. Surgery is considered the primary therapeutic option, which often involves lymph node dissection. The aim of this study was to assess the role of carbon nanoparticles, a novel agent, in thyroid cancer surgery. For that purpose, we conducted a systematic review of the literature on MEDLINE, EMBASE, Scopus, Cochrane and Google Scholar databases from 1 January 2002 to 31 January 2022. Ultimately, 20 articles with a total number of 2920 patients were included in the analysis. The outcome of the analysis showed that the use of carbon nanoparticles is associated with a higher number of harvested lymph nodes (WMD, 1.47, 95% CI, 1.13 to 1.82, p &lt; 0.001) and a lower rate of accidental parathyroid gland removal (OR 0.34, CI 95% 0.24 to 0.50, p &lt; 0.001). Based on these results, we suggest that carbon nanoparticles are applied in thyroid cancer surgery on a wider scale, so that these findings can be confirmed by future research on the subject.<\/jats:p>","DOI":"10.3390\/cancers14164016","type":"journal-article","created":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T21:05:51Z","timestamp":1661115951000},"page":"4016","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The Role of Carbon Nanoparticles in Lymph Node Dissection and Parathyroid Gland Preservation during Surgery for Thyroid Cancer: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0669-6980","authenticated-orcid":false,"given":"Georgios","family":"Koimtzis","sequence":"first","affiliation":[{"name":"Cardiff Transplant Unit, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff CF14 4XW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2682-5639","authenticated-orcid":false,"given":"Leandros","family":"Stefanopoulos","sequence":"additional","affiliation":[{"name":"Lab of Computing, Medical Informatics and Biomedical Imaging Technologies, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"},{"name":"Department of Electrical and Computer Engineering, Technological Institute, Robert R. McCormick School of Engineering and Applied Science, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vyron","family":"Alexandrou","sequence":"additional","affiliation":[{"name":"Urology Department, General Hospital of Thessaloniki \u201cG. Gennimata-Agios Dimitrios\u201d, Elenis Zografou 2, 54634 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Tteralli","sequence":"additional","affiliation":[{"name":"Department of General Surgery, North Hampshire NHS Foundation Trust, Basingstoke RG24 9NA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verity","family":"Brooker","sequence":"additional","affiliation":[{"name":"Cardiff Transplant Unit, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff CF14 4XW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6761-9738","authenticated-orcid":false,"given":"Awad Ali","family":"Alawad","sequence":"additional","affiliation":[{"name":"Cardiff Transplant Unit, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff CF14 4XW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliot","family":"Carrington-Windo","sequence":"additional","affiliation":[{"name":"Emergency Department, Grafton Base Hospital, Northern NSW Local Health District, Grafton, NSW 2460, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Karakasis","sequence":"additional","affiliation":[{"name":"Urology Department, General Hospital of Thessaloniki \u201cG. Gennimata-Agios Dimitrios\u201d, Elenis Zografou 2, 54634 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Geropoulos","sequence":"additional","affiliation":[{"name":"Department of Academic Surgery, The Royal Marsden Hospital Foundation Trust, 203 Fulham Rd., London SW3 6JJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7097-9889","authenticated-orcid":false,"given":"Theodosios","family":"Papavramidis","sequence":"additional","affiliation":[{"name":"1st Propedeutic Surgical Department, University Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki (AUTH), 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fendo.2020.00082","article-title":"New Therapies for Advanced Thyroid Cancer","volume":"11","author":"Laha","year":"2020","journal-title":"Front. 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