{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:16:04Z","timestamp":1790972164755,"version":"4.1.0"},"reference-count":90,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T00:00:00Z","timestamp":1661126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background and Objectives: Cannabinoids are currently used in cancer patients primarily for their pain-relieving and antiemetic properties. The aim of our review was to synthesize all available data of studies evaluating the therapeutic efficacy of cannabis in combination with oncological treatments in cancer patients and to explore ongoing studies with different goals and medical areas registered in the field of oncology worldwide. Materials and Methods: This study was performed in accordance with the PRISMA guidelines. A search using MEDLINE\/PubMed database was performed between 1 January 2006 and 1 March 2022. Search terms included the following: cannabidiol, cannabis, CBD, dronabinol, endocannabinoids, medical marijuana, nabiximols, nabilone, THC, and cancer. All studies that examined the efficacy of cannabis administered during oncological treatments, regardless of cancer localization, subtype, and sample size, were considered eligible. Results: In three studies, cannabis was administered to patients with glioblastoma, and in two other studies, cannabis was used in combination with immunotherapy in various cancer subgroups. The results of the clinical trials in cancer patients are not sufficient to draw conclusions at this time. Interestingly, several other studies addressing the systemic effects of cannabinoids in cancer patients are currently listed in the U.S. National Library of Medicine\u2019s registry on the ClinicalTrials.gov website. However, only one of the registered studies examined the efficacy of cannabinoids as a potential option for systemic cancer treatment. Conclusions: Although cannabis is touted to the public as a cancer cure, clinical trials need to clarify which combinations of chemotherapeutic agents with cannabinoids are useful for cancer patients.<\/jats:p>","DOI":"10.3390\/cancers14164057","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T21:30:34Z","timestamp":1661203834000},"page":"4057","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Controversial Link between Cannabis and Anticancer Treatments\u2014Where Are We and Where Are We Going? A Systematic Review of the Literature"],"prefix":"10.3390","volume":"14","author":[{"given":"Bianca","family":"Hanganu","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3635-6466","authenticated-orcid":false,"given":"Diana Elena","family":"Lazar","sequence":"additional","affiliation":[{"name":"Department of Oncology, Municipal Hospital \u201cSt. Hierarch Dr. Luca\u201d, 601048 Onesti, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina Smaranda","family":"Manoilescu","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9330-1691","authenticated-orcid":false,"given":"Veronica","family":"Mocanu","sequence":"additional","affiliation":[{"name":"Department of Morpho-Functional Sciences (Pathophysiology), \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 16, Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doina","family":"Butcovan","sequence":"additional","affiliation":[{"name":"Department of Morpho-Functional Sciences (Morphopathology), \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 16, Universitatii Street, 700115 Iasi, Romania"},{"name":"Department of Pathology, \u201cProf. George Georgescu\u201d Institute of Cardiovascular Diseases, 50, Carol I Avenue, 700503 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camelia Liana","family":"Buhas","sequence":"additional","affiliation":[{"name":"Department of Morphological Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea Silvana","family":"Szalontay","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice Gabriela","family":"Ioan","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.4103\/0970-2113.142109","article-title":"Bhang\u2014Beyond the purview of the narcotic drugs and psychotropic substances act","volume":"31","author":"Balhara","year":"2014","journal-title":"Lung India"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/S0140-6736(98)05021-1","article-title":"Adverse effects of cannabis","volume":"352","author":"Hall","year":"1998","journal-title":"Lancet"},{"key":"ref_3","unstructured":"EMCDDA (2012). European Monitoring Centre for Drugs and Drug Addiction\u2014Annual Report 2012: The State of the Drugs Problem in Europe, Publications Office of the European Union."},{"key":"ref_4","unstructured":"(2022, March 05). World Drug Report. United Nations Publication, Sales No. E.19.XI.8. Available online: https:\/\/wdr.unodc.org\/wdr2019\/prelaunch\/WDR19_Booklet_5_CANNABIS_HALLUCINOGENS.pdf."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nrn2253","article-title":"Cannabis, the mind and society: The hash realities","volume":"8","author":"Murray","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_6","first-page":"495","article-title":"The therapeutic potential of cannabis and cannabinoids","volume":"109","author":"Grotenhermen","year":"2012","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_7","unstructured":"UNODC (2021). World Drug Report 2021, United Nations Office on Drugs and Crime."},{"key":"ref_8","first-page":"149","article-title":"Chemistry, metabolism, and toxicology of cannabis: Clinical implications","volume":"7","author":"Sharma","year":"2012","journal-title":"Iran. J. Psychiatry"},{"key":"ref_9","unstructured":"National Cancer Institute (2022, May 12). Cannabis and Cannabinoids (PDQ\u00ae)\u2013Health Professional Version, Available online: https:\/\/www.cancer.gov\/about-cancer\/treatment\/cam\/hp\/cannabis-pdq."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0091-3057(91)90384-E","article-title":"The pharmacologic effects of daily marijuana smoking in humans","volume":"40","author":"White","year":"1991","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1002\/cbdv.200790146","article-title":"On the pharmacological properties of \u03949-tetrahydrocannabinol (THC)","volume":"4","author":"Costa","year":"2007","journal-title":"Chem. Biodivers."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.2174\/138161212802884681","article-title":"A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation","volume":"18","author":"Zuardi","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.2174\/138161212802884780","article-title":"Acute effects of a single, oral dose of d9-tetrahydrocannabinol (THC) and cannabidiol (CBD) administration in healthy volunteers","volume":"18","author":"Crippa","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2174\/187152709789824660","article-title":"The endocannabinoid system and pain","volume":"8","author":"Guindon","year":"2009","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/sj.bjp.0707442","article-title":"The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: \u03949-tetrahydrocannabinol, cannabidiol and \u03949-tetrahydrocannabivarin","volume":"153","author":"Pertwee","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.biopsych.2015.07.028","article-title":"An Introduction to the Endogenous Cannabinoid System","volume":"79","author":"Lu","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"ref_17","first-page":"217","article-title":"Neurobiology of cannabis addiction","volume":"52","author":"Jain","year":"2008","journal-title":"Indian J. Physiol. Pharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.pharma.2008.07.003","article-title":"Neuropsychopharmacology of \u03949-tetrahydrocannabinol","volume":"66","author":"Costentin","year":"2008","journal-title":"Ann. Pharm. Fr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/sj.bjp.0707531","article-title":"Cannabinoid CB2 receptors: A therapeutic target for the treatment of inflammatory and neuropathic pain","volume":"153","author":"Guindon","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/sj.bjp.0705464","article-title":"Tetrahydrocannabinol-induced neurotoxicity depends on CB1 receptor-mediated c-Jun N-terminal kinase activation in cultured cortical neurons","volume":"140","author":"Downer","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.imbio.2009.04.001","article-title":"Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression","volume":"215","author":"Rieder","year":"2010","journal-title":"Immunobiology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1158\/0008-5472.CAN-07-5176","article-title":"Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression","volume":"68","author":"Salazar","year":"2008","journal-title":"Cancer Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Bahji, A., and Stephenson, C. (2019). International Perspectives on the Implications of Cannabis Legalization: A Systematic Review & Thematic Analysis. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16173095"},{"key":"ref_24","unstructured":"European Monitoring Centre for Drugs and Drug Addiction (2022, April 15). Medical Use of Cannabis and Cannabinoids: Questions and Answers for Policymaking, Available online: https:\/\/www.emcdda.europa.eu\/system\/files\/publications\/10171\/20185584_TD0618186ENN_PDF.pdf."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/jnci\/55.3.597","article-title":"Antineoplastic activity of cannabinoids","volume":"55","author":"Munson","year":"1975","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_26","first-page":"1071","article-title":"Marijuana use and increased risk of squamous cell carcinoma of the head and neck","volume":"8","author":"Zhang","year":"1999","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"103S","DOI":"10.1002\/j.1552-4604.2002.tb06010.x","article-title":"Marijuana smoking and head and neck cancer","volume":"42","author":"Hashibe","year":"2002","journal-title":"J. Clin. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1183\/09031936.00065707","article-title":"Cannabis use and risk of lung cancer: A case-control study","volume":"31","author":"Aldington","year":"2008","journal-title":"Eur. Respir. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/01243894-200607000-00013","article-title":"Risk of lung cancer and past use of cannabis in Tunisia","volume":"1","author":"Voirin","year":"2006","journal-title":"J. Thorac. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1097\/JTO.0b013e31818ddcde","article-title":"Cannabis smoking and risk of lung cancer in men: A pooled analysis of three studies in Maghreb","volume":"3","author":"Berthiller","year":"2008","journal-title":"J. Thorac. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1023\/A:1018427320658","article-title":"Marijuana use and cancer incidence (California, United States)","volume":"8","author":"Sidney","year":"1997","journal-title":"Cancer Causes Control"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4103\/0970-1591.94942","article-title":"The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications","volume":"28","author":"Ramos","year":"2012","journal-title":"Indian J. Urol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1158\/1055-9965.EPI-17-0428","article-title":"Cannabis use and incidence of testicular cancer: A 42-year follow-up of Swedish men between 1970 and 2011","volume":"26","author":"Callaghan","year":"2017","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/cncr.24159","article-title":"Association of marijuana use and the incidence of testicular germ cell tumors","volume":"115","author":"Daling","year":"2009","journal-title":"Cancer"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5374","DOI":"10.1002\/cncr.27554","article-title":"Population-based case-control study of recreational drug use and testis cancer risk confirms an association between marijuana use and nonseminoma risk","volume":"118","author":"Lacson","year":"2012","journal-title":"Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/cncr.25499","article-title":"Marijuana use and testicular germ cell tumors","volume":"117","author":"Trabert","year":"2011","journal-title":"Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000499164","article-title":"Cannabinoids in Gynecological Diseases","volume":"2","author":"Luschnig","year":"2019","journal-title":"Med. Cannabis Cannabinoids"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1023\/B:NEON.0000024746.87666.ed","article-title":"The risk for malignant primary adult-onset glioma in a large, multiethnic, managed-care cohort: Cigarette smoking and other lifestyle behaviors","volume":"68","author":"Efird","year":"2004","journal-title":"J. Neurooncol."},{"key":"ref_39","first-page":"165","article-title":"Transitional cell carcinoma in a young heavy marihuana smoker","volume":"54","author":"Moiche","year":"2001","journal-title":"Arch. Esp. Urol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.urology.2005.07.005","article-title":"Association between marijuana use and transitional cell carcinoma","volume":"67","author":"Chacko","year":"2006","journal-title":"Urology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.urology.2005.08.006","article-title":"Transitional cell carcinoma associated with marijuana: Case report and review of the literature","volume":"67","author":"Nieder","year":"2006","journal-title":"Urology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s10552-005-0580-3","article-title":"Maternal use of recreational drugs and neuroblastoma in offspring: A report from the Children\u2019s Oncology Group (United States)","volume":"17","author":"Bluhm","year":"2006","journal-title":"Cancer Causes Control"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.alcohol.2005.04.008","article-title":"Epidemiologic review of marijuana use and cancer risk","volume":"35","author":"Hashibe","year":"2005","journal-title":"Alcohol"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1002\/1097-0142(19890515)63:10<1904::AID-CNCR2820631006>3.0.CO;2-W","article-title":"Maternal drug use and risk of childhood nonlymphoblastic leukemia among offspring. An epidemiologic investigation implicating marijuana (a report from the Childrens Cancer Study Group)","volume":"63","author":"Robison","year":"1989","journal-title":"Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nature25480","article-title":"The landscape of genomic alterations across childhood cancers","volume":"555","author":"Grobner","year":"2018","journal-title":"Nature"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nature25795","article-title":"Pan-cancer genome and transcriptome analyses of 1699 paediatric leukaemias and solid tumours","volume":"555","author":"Ma","year":"2018","journal-title":"Nature"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3389\/fphar.2017.00144","article-title":"Cannabidiol Reduces Leukemic Cell Size\u2014But Is It Important?","volume":"8","author":"Kalenderoglou","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e664","DOI":"10.1038\/cddis.2013.151","article-title":"Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells","volume":"4","author":"Dando","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/cdd.2011.32","article-title":"Anti-tumoral action of cannabinoids on hepatocellular carcinoma: Role of AMPK-dependent activation of autophagy","volume":"18","author":"Vara","year":"2011","journal-title":"Cell Death Differ."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"105302","DOI":"10.1016\/j.phrs.2020.105302","article-title":"Cannabis and its constituents for cancer: History, biogenesis, chemistry and pharmacological activities","volume":"163","author":"Lal","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1111\/bph.13497","article-title":"An update on PPAR activation by cannabinoids","volume":"173","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Solinas, M., Massi, P., Cinquina, V., Valenti, M., Bolognini, D., Gariboldi, M., Monti, E., Rubino, T., and Parolaro, D. (2013). Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076918"},{"key":"ref_53","first-page":"3799","article-title":"Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent","volume":"31","author":"Sreevalsan","year":"2011","journal-title":"Anticancer Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1158\/1078-0432.CCR-08-0149","article-title":"Targeting inflammatory pathways for prevention and therapy of cancer: Short-term friend, long-term foe","volume":"15","author":"Aggarwal","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Lukhele, S.T., and Motadi, L.R. (2016). Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells. BMC Complement. Altern. Med., 16.","DOI":"10.1186\/s12906-016-1280-0"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3892\/ijo.2012.1476","article-title":"Cannabinoid-associated cell death mechanisms in tumor models (Review)","volume":"41","author":"Calvaruso","year":"2012","journal-title":"Int. J. Oncol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1080\/02841860701678787","article-title":"\u03949-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells","volume":"47","author":"Galanti","year":"2008","journal-title":"Acta Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.1158\/0008-5472.CAN-05-4566","article-title":"\u03949-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation","volume":"66","author":"Caffarel","year":"2006","journal-title":"Cancer Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1007\/s00432-021-03710-7","article-title":"Cannabinoids in the landscape of cancer","volume":"147","author":"Mangal","year":"2021","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.4155\/fmc.09.93","article-title":"Cannabinoids as novel anti-inflammatory drugs","volume":"1","author":"Nagarkatti","year":"2009","journal-title":"Future Med. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/sj.bjp.0706632","article-title":"Cannabinoids and cancer: Pros and cons of an antitumour strategy","volume":"148","author":"Bifulco","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neuropharm.2018.03.001","article-title":"The anxiolytic effects of cannabidiol in chronically stressed mice are mediated by the endocannabinoid system: Role of neurogenesis and dendritic remodeling","volume":"135","author":"Fogaca","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jpainsymman.2012.07.014","article-title":"An open-label extension study to investigate the long-term safety and tolerability of THC\/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics","volume":"46","author":"Johnson","year":"2013","journal-title":"J. Pain Symptom Manag."},{"key":"ref_64","first-page":"1","article-title":"The cannabinoid system and cytokine network","volume":"225","author":"Klein","year":"2000","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/s41419-019-2001-7","article-title":"Cannabidiol promotes apoptosis via regulation of XIAP\/Smac in gastric cancer","volume":"10","author":"Jeong","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1177\/1060028020965224","article-title":"Use of Cannabis and Cannabinoids in Patients with Cancer","volume":"55","author":"Sawtelle","year":"2021","journal-title":"Ann. Pharmacother."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"713153","DOI":"10.3389\/fmed.2021.713153","article-title":"Cannabinoids, Medical Cannabis, and Colorectal Cancer Immunotherapy","volume":"8","author":"Zaiachuk","year":"2021","journal-title":"Front. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.18632\/oncotarget.27528","article-title":"Synergistic cytotoxic activity of cannabinoids from Cannabis sativa against cutaneous T-cell lymphoma (CTCL) in-vitro and ex-vivo","volume":"11","author":"Mazuz","year":"2020","journal-title":"Oncotarget"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/SPC.0000000000000493","article-title":"Cannabis and cannabinoids in cancer pain management","volume":"14","author":"Meng","year":"2020","journal-title":"Curr. Opin. Support. Palliat. Care."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.1002\/cncr.30879","article-title":"Cannabis use among patients at a comprehensive cancer center in a state with legalized medicinal and recreational use","volume":"123","author":"Pergam","year":"2017","journal-title":"Cancer"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1200\/JCO.2017.76.1221","article-title":"Medical oncologists\u2019 beliefs, practices, and knowledge regarding marijuana used thera-peutically: A nationally representative survey study","volume":"36","author":"Braun","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1089\/can.2018.0029","article-title":"Oncology clinicians and the Minnesota medical cannabis program: A survey on medical cannabis practice patterns, barriers to enrollment, and educational needs","volume":"3","author":"Zylla","year":"2018","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_73","first-page":"e3918","article-title":"False news of a cannabis cancer cure","volume":"11","author":"Shi","year":"2019","journal-title":"Cureus"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1089\/can.2021.0045","article-title":"Cannabis as an anticancer agent: A review of clinical data and assessment of case reports","volume":"7","author":"Guggisberg","year":"2022","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_75","unstructured":"(2022, June 22). Available online: www.catasurvey.com."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1038\/s41416-021-01259-3","article-title":"A phase 1b randomised, placebo-controlled trial of nabiximols cannabinoid oromucosal spray with temozolomide in patients with recurrent glioblastoma","volume":"124","author":"Twelves","year":"2021","journal-title":"Br. J. Cancer"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Bar-Sela, G., Cohen, I., Campisi-Pinto, S., Lewitus, G.M., Oz-Ari, L., Jehassi, A., Peer, A., Turgeman, I., Vernicova, O., and Berman, P. (2020). Cannabis Consumption Used by Cancer Patients during Immunotherapy Correlates with Poor Clinical Outcome. Cancers, 12.","DOI":"10.3390\/cancers12092447"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1634\/theoncologist.2018-0383","article-title":"Cannabis Impacts Tumor Response Rate to Nivolumab in Patients with Advanced Malignancies","volume":"24","author":"Taha","year":"2019","journal-title":"Oncologist"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/sj.bjc.6603236","article-title":"A pilot clinical study of \u03949-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme","volume":"95","author":"Duarte","year":"2006","journal-title":"Br. J. Cancer"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"649555","DOI":"10.3389\/fonc.2021.649555","article-title":"Phase 2 Randomised Clinical Trial Assessing the Tolerability of Two Different Ratios of Medicinal Cannabis in Patients with High Grade Gliomas","volume":"11","author":"Schloss","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Verkhratsky, A., and Butt, A. (2007). Glial Neurobiology: A Textbook, John Wiley & Sons.","DOI":"10.1002\/9780470517796"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/bmjspcare-2019-002032","article-title":"Cannabinoids for adult cancer related pain: Systematic review and meta-analysis","volume":"10","author":"Boland","year":"2020","journal-title":"BMJ Support. Palliat. Care"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1017\/S1041610210002176","article-title":"Marijuana use among older adults in the U.S.A.: User characteristics, patterns of use, and implications for intervention","volume":"23","author":"Dinitto","year":"2011","journal-title":"Int. Psychogeriatr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.2165\/00003495-200060060-00005","article-title":"Cannabinoids in clinical practice","volume":"60","author":"Williamson","year":"2000","journal-title":"Drugs"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/s11481-018-9782-9","article-title":"Cannabis Addiction and the Brain: A Review","volume":"13","author":"Zehra","year":"2018","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Pearson, N.T., and Berry, J.H. (2019). Cannabis and Psychosis Through the Lens of DSM-5. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16214149"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Batalla, A., Janssen, H., Gangadin, S.S., and Bossong, M.G. (2019). The Potential of Cannabidiol as a Treatment for Psychosis and Addiction: Who Benefits Most? A Systematic Review. J. Clin. Med., 8.","DOI":"10.3390\/jcm8071058"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/jncimonographs\/lgab011","article-title":"The management of cancer symptoms and treatment-induced side effects with cannabis or cannabinoids","volume":"2021","author":"Sexton","year":"2021","journal-title":"JNCI Monogr."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.apsb.2015.07.005","article-title":"Cancer metastases: Challenges and opportunities","volume":"5","author":"Guan","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_90","unstructured":"(2022, June 22). Available online: https:\/\/clinicaltrials.gov\/ct2\/results?term=cannabis&cond=Cancer&Search=Apply&recrs=a&age_v=&gndr=&type=&rslt=."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/16\/4057\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:13:43Z","timestamp":1760141623000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/16\/4057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,22]]},"references-count":90,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["cancers14164057"],"URL":"https:\/\/doi.org\/10.3390\/cancers14164057","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,22]]}}}