{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:01:47Z","timestamp":1791475307140,"version":"4.3.4"},"reference-count":176,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010098","name":"Shanghai Association of Science and Technology","doi-asserted-by":"publisher","award":["22WZ2501700"],"award-info":[{"award-number":["22WZ2501700"]}],"id":[{"id":"10.13039\/100010098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010098","name":"Shanghai Association of Science and Technology","doi-asserted-by":"publisher","award":["81771228"],"award-info":[{"award-number":["81771228"]}],"id":[{"id":"10.13039\/100010098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22WZ2501700"],"award-info":[{"award-number":["22WZ2501700"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771228"],"award-info":[{"award-number":["81771228"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The bromodomain and PHD finger\u2013containing protein1 (BRPF1) is a member of family IV of the bromodomain-containing proteins that participate in the post-translational modification of histones. It functions in the form of a tetrameric complex with a monocytic leukemia zinc finger protein (MOZ or KAT6A), MOZ-related factor (MORF or KAT6B) or HAT bound to ORC1 (HBO1 or KAT7) and two small non-catalytic proteins, the inhibitor of growth 5 (ING5) or the paralog ING4 and MYST\/Esa1-associated factor 6 (MEAF6). Mounting studies have demonstrated that all the four core subunits play crucial roles in different biological processes across diverse species, such as embryonic development, forebrain development, skeletal patterning and hematopoiesis. BRPF1, KAT6A and KAT6B mutations were identified as the cause of neurodevelopmental disorders, leukemia, medulloblastoma and other types of cancer, with germline mutations associated with neurodevelopmental disorders displaying intellectual disability, and somatic variants associated with leukemia, medulloblastoma and other cancers. In this paper, we depict the molecular structures and biological functions of the BRPF1-KAT6A\/KAT6B complex, summarize the variants of the complex related to neurodevelopmental disorders and cancers and discuss future research directions and therapeutic potentials.<\/jats:p>","DOI":"10.3390\/cancers14174068","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T21:05:12Z","timestamp":1661288712000},"page":"4068","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["BRPF1-KAT6A\/KAT6B Complex: Molecular Structure, Biological Function and Human Disease"],"prefix":"10.3390","volume":"14","author":[{"given":"Gaoyu","family":"Zu","sequence":"first","affiliation":[{"name":"Department of Human Anatomy & Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy & Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingli","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy & Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baicheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy & Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy & Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2569-0269","authenticated-orcid":false,"given":"Linya","family":"You","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy & Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China"},{"name":"Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention, Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.286.5439.481","article-title":"Epigenetics: Regulation through repression","volume":"286","author":"Wolffe","year":"1999","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF01738673","article-title":"Post-translational modification of proteins catalyzed by aminoacyl-trna-protein transferases","volume":"2","author":"Soffer","year":"1973","journal-title":"Mol. Cell. Biochem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"7342","DOI":"10.1002\/anie.200501023","article-title":"Protein posttranslational modifications: The chemistry of proteome diversifications","volume":"44","author":"Walsh","year":"2005","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/nar\/28.1.231","article-title":"Smart: A web-based tool for the study of genetically mobile domains","volume":"28","author":"Schultz","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/nature09504","article-title":"Selective inhibition of bet bromodomains","volume":"468","author":"Filippakopoulos","year":"2010","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"36944","DOI":"10.1074\/jbc.M111.244400","article-title":"Recognition of unmodified histone h3 by the first phd finger of bromodomain-phd finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (moz) and moz-related factor (morf)","volume":"286","author":"Qin","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/cdd.2009.216","article-title":"Hdac inhibition promotes neuronal outgrowth and counteracts growth cone collapse through cbp\/p300 and p\/caf-dependent p53 acetylation","volume":"17","author":"Gaub","year":"2010","journal-title":"Cell Death Differ."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/sj.onc.1204114","article-title":"The monocytic leukemia zinc finger protein moz is a histone acetyltransferase","volume":"20","author":"Champagne","year":"2001","journal-title":"Oncogene"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"36603","DOI":"10.1074\/jbc.M705812200","article-title":"The human monocytic leukemia zinc finger histone acetyltransferase domain contains dna-binding activity implicated in chromatin targeting","volume":"282","author":"Holbert","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00018-019-03296-x","article-title":"Deciphering structure, function and mechanism of lysine acetyltransferase hbo1 in protein acetylation, transcription regulation, dna replication and its oncogenic properties in cancer","volume":"77","author":"Lan","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.molcel.2005.12.007","article-title":"Ing tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation","volume":"21","author":"Doyon","year":"2006","journal-title":"Mol. Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1101\/gad.223396.113","article-title":"Exchange of associated factors directs a switch in hbo1 acetyltransferase histone tail specificity","volume":"27","author":"Lalonde","year":"2013","journal-title":"Genes Dev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"x21","DOI":"10.1126\/sciadv.aax0021","article-title":"Deficient histone h3 propionylation by brpf1-kat6 complexes in neurodevelopmental disorders and cancer","volume":"6","author":"Yan","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"6828","DOI":"10.1128\/MCB.01297-08","article-title":"Molecular architecture of quartet moz\/morf histone acetyltransferase complexes","volume":"28","author":"Ullah","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/jcp.26010","article-title":"Biological function and histone recognition of family iv bromodomain-containing proteins","volume":"233","author":"Lloyd","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1002\/jcp.24617","article-title":"The moz histone acetyltransferase in epigenetic signaling and disease","volume":"229","author":"Carlson","year":"2014","journal-title":"J. Cell. Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.bbamcr.2015.04.014","article-title":"Moz and morf acetyltransferases: Molecular interaction, animal development and human disease","volume":"1853","author":"Yang","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.str.2019.10.014","article-title":"Molecular basis for the pzp domain of brpf1 association with chromatin","volume":"28","author":"Klein","year":"2020","journal-title":"Structure"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"100479","DOI":"10.1016\/j.xpro.2021.100479","article-title":"Structural and biophysical characterization of the nucleosome-binding pzp domain","volume":"2","author":"Klein","year":"2021","journal-title":"STAR Protoc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/nar\/gkv1321","article-title":"Bivalent interaction of the pzp domain of brpf1 with the nucleosome impacts chromatin dynamics and acetylation","volume":"44","author":"Klein","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/j.jmb.2013.12.007","article-title":"Molecular insights into the recognition of n-terminal histone modifications by the brpf1 bromodomain","volume":"426","author":"Poplawski","year":"2014","journal-title":"J. Mol. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ejmech.2018.05.037","article-title":"Structure-based discovery of selective brpf1 bromodomain inhibitors","volume":"155","author":"Zhu","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.crstbi.2020.05.001","article-title":"The brpf1 bromodomain is a molecular reader of di-acetyllysine","volume":"2","author":"Obi","year":"2020","journal-title":"Curr. Res. Struct. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1016\/j.febslet.2014.09.028","article-title":"Structural insights into recognition of acetylated histone ligands by the brpf1 bromodomain","volume":"588","author":"Lubula","year":"2014","journal-title":"FEBS Lett."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nsmb.1797","article-title":"Molecular basis of histone h3k36me3 recognition by the pwwp domain of brpf1","volume":"17","author":"Vezzoli","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Wu, H., Zeng, H., Lam, R., Tempel, W., Amaya, M.F., Xu, C., Dombrovski, L., Qiu, W., Wang, Y., and Min, J. (2011). Structural and histone binding ability characterizations of human pwwp domains. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0018919"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1038\/s41418-020-0577-1","article-title":"Brpf3-huwe1-mediated regulation of myst2 is required for differentiation and cell-cycle progression in embryonic stem cells","volume":"27","author":"Cho","year":"2020","journal-title":"Cell Death Differ."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1002\/asia.202100793","article-title":"Insights into the molecular mechanisms of histone code recognition by the brpf3 bromodomain","volume":"16","author":"Barman","year":"2021","journal-title":"Chem. Asian J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3724\/SP.J.1005.2013.00079","article-title":"brpf2, a novel transcript of brpf1 and their expression in mice tissues","volume":"35","author":"Guo","year":"2013","journal-title":"Yi Chuan"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Zhang, M., Lei, M., Qin, S., Dong, A., Yang, A., Li, Y., Loppnau, P., Hughes, T.R., Min, J., and Liu, Y. (2021). Crystal structure of the brpf2 pwwp domain in complex with dna reveals a different binding mode than the hdgf family of pwwp domains. Biochim. Biophys. Acta Gene Regul. Mech., 1864.","DOI":"10.2210\/pdb7lh9\/pdb"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/nar\/gkh252","article-title":"The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases","volume":"32","author":"Yang","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1038\/sj.onc.1210609","article-title":"Moz and morf, two large mystic hats in normal and cancer stem cells","volume":"26","author":"Yang","year":"2007","journal-title":"Oncogene"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1093\/nar\/gkt931","article-title":"The double phd finger domain of moz\/myst3 induces alpha-helical structure of the histone h3 tail to facilitate acetylation and methylation sampling and modification","volume":"42","author":"Dreveny","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/s00018-010-0599-9","article-title":"Myst-family histone acetyltransferases: Beyond chromatin","volume":"68","author":"Sapountzi","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1038\/sj.onc.1210608","article-title":"The myst family of histone acetyltransferases and their intimate links to cancer","volume":"26","author":"Avvakumov","year":"2007","journal-title":"Oncogene"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ajhg.2015.01.017","article-title":"De novo nonsense mutations in kat6a, a lysine acetyl-transferase gene, cause a syndrome including microcephaly and global developmental delay","volume":"96","author":"Arboleda","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.ajhg.2015.01.016","article-title":"Dominant mutations in kat6a cause intellectual disability with recognizable syndromic features","volume":"96","author":"Tham","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/ejhg.2014.248","article-title":"Further delineation of the kat6b molecular and phenotypic spectrum","volume":"23","author":"Gannon","year":"2015","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1002\/humu.22141","article-title":"The kat6b-related disorders genitopatellar syndrome and ohdo\/sbbys syndrome have distinct clinical features reflecting distinct molecular mechanisms","volume":"33","author":"Campeau","year":"2012","journal-title":"Hum. Mutat."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1038\/sj.onc.1205367","article-title":"Moz and morf histone acetyltransferases interact with the runt-domain transcription factor runx2","volume":"21","author":"Pelletier","year":"2002","journal-title":"Oncogene"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"5707","DOI":"10.1093\/nar\/gkx142","article-title":"Structural and mechanistic insights into regulation of hbo1 histone acetyltransferase activity by brpf2","volume":"45","author":"Tao","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"15956","DOI":"10.1074\/jbc.M710020200","article-title":"Molecular basis of histone h3k4me3 recognition by ing4","volume":"283","author":"Palacios","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1002\/prot.22140","article-title":"The crystal structure of the ing5 phd finger in complex with an h3k4me3 histone peptide","volume":"72","author":"Champagne","year":"2008","journal-title":"Proteins"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1242\/dev.127.4.713","article-title":"The bromodomain protein lin-49 and trithorax-related protein lin-59 affect development and gene expression in caenorhabditis elegans","volume":"127","author":"Chamberlin","year":"2000","journal-title":"Development"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1534\/genetics.110.123661","article-title":"Maintenance of neuronal laterality in caenorhabditis elegans through myst histone acetyltransferase complex components lsy-12, lsy-13 and lin-49","volume":"186","author":"Zhang","year":"2010","journal-title":"Genetics"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/genetics\/153.2.731","article-title":"Characterization of seven genes affecting caenorhabditis elegans hindgut development","volume":"153","author":"Chamberlin","year":"1999","journal-title":"Genetics"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1101\/gad.1117903","article-title":"A transcriptional regulatory cascade that controls left\/right asymmetry in chemosensory neurons of C. elegans","volume":"17","author":"Chang","year":"2003","journal-title":"Genes Dev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1242\/dev.017160","article-title":"The multidomain protein brpf1 binds histones and is required for hox gene expression and segmental identity","volume":"135","author":"Laue","year":"2008","journal-title":"Development"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ydbio.2009.02.021","article-title":"Brpf1, a subunit of the moz histone acetyl transferase complex, maintains expression of anterior and posterior hox genes for proper patterning of craniofacial and caudal skeletons","volume":"329","author":"Hibiya","year":"2009","journal-title":"Dev. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"860","DOI":"10.4161\/epi.28530","article-title":"Expression atlas of the multivalent epigenetic regulator brpf1 and its requirement for survival of mouse embryos","volume":"9","author":"You","year":"2014","journal-title":"Epigenetics-Us"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"11349","DOI":"10.1074\/jbc.M115.643189","article-title":"The chromatin regulator brpf1 regulates embryo development and cell proliferation","volume":"290","author":"You","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"You, L., Yan, K., Zou, J., Zhao, H., Bertos, N.R., Park, M., Wang, E., and Yang, X.J. (2015). The lysine acetyltransferase activator brpf1 governs dentate gyrus development through neural stem cells and progenitors. PLoS Genet., 11.","DOI":"10.1371\/journal.pgen.1005329"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"7114","DOI":"10.1074\/jbc.M114.635250","article-title":"Deficiency of the chromatin regulator brpf1 causes abnormal brain development","volume":"290","author":"You","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1172\/JCI80711","article-title":"Brpf1 is essential for development of fetal hematopoietic stem cells","volume":"126","author":"You","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/jmcb\/mjz092","article-title":"Isoform-specific involvement of brpf1 in expansion of adult hematopoietic stem and progenitor cells","volume":"12","author":"He","year":"2020","journal-title":"J. Mol. Cell Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3389\/fncel.2019.00249","article-title":"Brpf1 haploinsufficiency impairs dendritic arborization and spine formation, leading to cognitive deficits","volume":"13","author":"Su","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"711792","DOI":"10.3389\/fcell.2021.711792","article-title":"Deficiency of intellectual disability-related gene brpf1 attenuated hippocampal excitatory synaptic transmission and impaired spatial learning and memory ability","volume":"9","author":"Xian","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"jkab090","DOI":"10.1093\/g3journal\/jkab090","article-title":"Deficiency of intellectual disability-related gene brpf1 reduced inhibitory neurotransmission in mge-derived gabaergic interneurons","volume":"11","author":"Cao","year":"2021","journal-title":"G3"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1038\/ncomms4630","article-title":"The landscape of somatic mutations in epigenetic regulators across 1000 paediatric cancer genomes","volume":"5","author":"Huether","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/imm.12072","article-title":"The mysterious moz, a histone acetyltransferase with a key role in haematopoiesis","volume":"139","author":"Costa","year":"2013","journal-title":"Immunology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1101\/gad.1382606","article-title":"Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells","volume":"20","author":"Thomas","year":"2006","journal-title":"Genes Dev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1101\/gad.1393106","article-title":"Moz is essential for maintenance of hematopoietic stem cells","volume":"20","author":"Katsumoto","year":"2006","journal-title":"Genes Dev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/stem.1606","article-title":"Moz-mediated repression of p16(ink) (4) (a) is critical for the self-renewal of neural and hematopoietic stem cells","volume":"32","author":"Costa","year":"2014","journal-title":"Stem Cells"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.devcel.2009.10.006","article-title":"Moz and retinoic acid coordinately regulate h3k9 acetylation, hox gene expression, and segment identity","volume":"17","author":"Voss","year":"2009","journal-title":"Dev. Cell"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1073\/pnas.1422872112","article-title":"Moz and bmi1 play opposing roles during hox gene activation in es cells and in body segment identity specification in vivo","volume":"112","author":"Sheikh","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.isci.2018.12.016","article-title":"Moz forms an autoregulatory feedback loop with mir-223 in aml and monocyte\/macrophage development","volume":"11","author":"Jiang","year":"2019","journal-title":"iScience"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1182\/blood-2014-08-594655","article-title":"Moz regulates b-cell progenitors and, consequently, moz haploinsufficiency dramatically retards myc-induced lymphoma development","volume":"125","author":"Sheikh","year":"2015","journal-title":"Blood"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"28528","DOI":"10.1074\/jbc.274.40.28528","article-title":"Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein","volume":"274","author":"Champagne","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2741\/1208","article-title":"Querkopf, a histone acetyltransferase, is essential for embryonic neurogenesis","volume":"9","author":"Thomas","year":"2004","journal-title":"Front. Biosci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1242\/jcs.077271","article-title":"Querkopf is a key marker of self-renewal and multipotency of adult neural stem cells","volume":"125","author":"Sheikh","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"11359","DOI":"10.1523\/JNEUROSCI.2247-06.2006","article-title":"The transcriptional coactivator querkopf controls adult neurogenesis","volume":"26","author":"Merson","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"7852742","DOI":"10.1155\/2018\/7852742","article-title":"The kat in the hat: The histone acetyl transferase kat6b (myst4) is downregulated in murine macrophages in response to lps","volume":"2018","author":"Shukla","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"15397","DOI":"10.1074\/jbc.M011556200","article-title":"Replication factors mcm2 and orc1 interact with the histone acetyltransferase hbo1","volume":"276","author":"Burke","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"23027","DOI":"10.1074\/jbc.274.33.23027","article-title":"Histone acetyltransferase hbo1 interacts with the orc1 subunit of the human initiator protein","volume":"274","author":"Iizuka","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1128\/MCB.00662-07","article-title":"Hbo1 links p53-dependent stress signaling to dna replication licensing","volume":"28","author":"Iizuka","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1128\/MCB.26.3.1098-1108.2006","article-title":"Regulation of replication licensing by acetyltransferase hbo1","volume":"26","author":"Iizuka","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1073\/pnas.0712063105","article-title":"Role for plk1 phosphorylation of hbo1 in regulation of replication licensing","volume":"105","author":"Wu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1016\/j.febslet.2005.05.039","article-title":"Cyclin-dependent kinase 11(p58) interacts with hbo1 and enhances its histone acetyltransferase activity","volume":"579","author":"Zong","year":"2005","journal-title":"FEBS Lett."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1074\/jbc.M707880200","article-title":"Fad24 acts in concert with histone acetyltransferase hbo1 to promote adipogenesis by controlling dna replication","volume":"283","author":"Johmura","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1101\/gad.1674108","article-title":"Hbo1 histone acetylase is a coactivator of the replication licensing factor cdt1","volume":"22","author":"Miotto","year":"2008","journal-title":"Genes Dev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1182\/blood-2011-01-331892","article-title":"The hbo1-brd1\/brpf2 complex is responsible for global acetylation of h3k14 and required for fetal liver erythropoiesis","volume":"118","author":"Mishima","year":"2011","journal-title":"Blood"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"176","DOI":"10.15252\/embj.201591293","article-title":"Brpf3-hbo1 regulates replication origin activation and histone h3k14 acetylation","volume":"35","author":"Feng","year":"2016","journal-title":"EMBO J."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1128\/MCB.00159-10","article-title":"Hbo1 is required for h3k14 acetylation and normal transcriptional activity during embryonic development","volume":"31","author":"Kueh","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1182\/blood.2021013954","article-title":"The histone lysine acetyltransferase hbo1 (kat7) regulates hematopoietic stem cell quiescence and self-renewal","volume":"139","author":"Yang","year":"2022","journal-title":"Blood"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"dev199581","DOI":"10.1242\/dev.199581","article-title":"Correction: The histone acetyltransferase hbo1 promotes efficient tip cell sprouting during angiogenesis","volume":"148","author":"Grant","year":"2021","journal-title":"Development"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1189\/jlb.1MA0816-338R","article-title":"Essential role for the histone acetyltransferase kat7 in t cell development, fitness, and survival","volume":"101","author":"Newman","year":"2017","journal-title":"J. Leukoc. Biol."},{"key":"ref_87","first-page":"b6032","article-title":"The acetyltransferase kat7 is required for thymic epithelial cell expansion, expression of aire target genes, and thymic tolerance","volume":"7","author":"Heinlein","year":"2022","journal-title":"Sci. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.febslet.2015.02.029","article-title":"The histone acetyltransferase myst2 regulates nanog expression, and is involved in maintaining pluripotency and self-renewal of embryonic stem cells","volume":"589","author":"Kim","year":"2015","journal-title":"FEBS Lett."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/34675","article-title":"The candidate tumour suppressor p33ing1 cooperates with p53 in cell growth control","volume":"391","author":"Garkavtsev","year":"1998","journal-title":"Nature"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Thalappilly, S., Feng, X., Pastyryeva, S., Suzuki, K., Muruve, D., Larocque, D., Richard, S., Truss, M., von Deimling, A., and Riabowol, K. (2011). The p53 tumor suppressor is stabilized by inhibitor of growth 1 (ing1) by blocking polyubiquitination. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0021065"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature04835","article-title":"Ing2 phd domain links histone h3 lysine 4 methylation to active gene repression","volume":"442","author":"Shi","year":"2006","journal-title":"Nature"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.molcel.2008.12.016","article-title":"Ing4 mediates crosstalk between histone h3 k4 trimethylation and h3 acetylation to attenuate cellular transformation","volume":"33","author":"Hung","year":"2009","journal-title":"Mol. Cell"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Melekhova, A., and Baniahmad, A. (2021). Ing tumour suppressors and ing splice variants as coregulators of the androgen receptor signalling in prostate cancer. Cells, 10.","DOI":"10.3390\/cells10102599"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1158\/0008-5472.CAN-12-3684","article-title":"Ing5 is a tip60 cofactor that acetylates p53 in response to dna damage","volume":"73","author":"Liu","year":"2013","journal-title":"Cancer Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1038\/onc.2013.145","article-title":"Ing4 regulates a secretory phenotype in primary fibroblasts with dual effects on cell proliferation and tumor growth","volume":"33","author":"Moreno","year":"2014","journal-title":"Oncogene"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/cas.13184","article-title":"Impact of senescence-associated secretory phenotype and its potential as a therapeutic target for senescence-associated diseases","volume":"108","author":"Watanabe","year":"2017","journal-title":"Cancer Sci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nature02329","article-title":"The candidate tumour suppressor protein ing4 regulates brain tumour growth and angiogenesis","volume":"428","author":"Garkavtsev","year":"2004","journal-title":"Nature"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"79017","DOI":"10.18632\/oncotarget.12984","article-title":"Ing4 suppresses tumor angiogenesis and functions as a prognostic marker in human colorectal cancer","volume":"7","author":"Chen","year":"2016","journal-title":"Oncotarget"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1101\/gad.254292.114","article-title":"Scf(jfk) is a bona fide e3 ligase for ing4 and a potent promoter of the angiogenesis and metastasis of breast cancer","volume":"29","author":"Yan","year":"2015","journal-title":"Genes Dev."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"6632","DOI":"10.1128\/MCB.00697-08","article-title":"The ing4 tumor suppressor attenuates nf-kappab activity at the promoters of target genes","volume":"28","author":"Nozell","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1089\/scd.2011.0695","article-title":"Microrna-193 pro-proliferation effects for bone mesenchymal stem cells after low-level laser irradiation treatment through inhibitor of growth family, member 5","volume":"21","author":"Wang","year":"2012","journal-title":"Stem Cells Dev."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/ncb2520","article-title":"Diverse epigenetic strategies interact to control epidermal differentiation","volume":"14","author":"Mulder","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.celrep.2018.10.017","article-title":"Splicing and chromatin factors jointly regulate epidermal differentiation","volume":"25","author":"Tanis","year":"2018","journal-title":"Cell Rep."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/1759-7714.13013","article-title":"Ing5 inhibits lung cancer invasion and epithelial-mesenchymal transition by inhibiting the wnt\/beta-catenin pathway","volume":"10","author":"Liu","year":"2019","journal-title":"Thorac. Cancer"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/onc.2017.324","article-title":"Ing5 activity in self-renewal of glioblastoma stem cells via calcium and follicle stimulating hormone pathways","volume":"37","author":"Wang","year":"2018","journal-title":"Oncogene"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ajhg.2016.11.011","article-title":"Mutations in the chromatin regulator gene brpf1 cause syndromic intellectual disability and deficient histone acetylation","volume":"100","author":"Yan","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ajhg.2016.11.010","article-title":"Mutations in histone acetylase modifier brpf1 cause an autosomal-dominant form of intellectual disability with associated ptosis","volume":"100","author":"Mattioli","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1002\/ajmg.a.62706","article-title":"Brpf1-associated syndrome: A patient with congenital ptosis, neurological findings, and normal intellectual development","volume":"188","author":"Souza","year":"2022","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jad.2018.10.363","article-title":"Increased expression of a novel mirna in peripheral blood is negatively correlated with hippocampal volume in patients with major depressive disorder","volume":"245","author":"Zhao","year":"2019","journal-title":"J. Affect. Disord."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3389\/fgene.2020.00368","article-title":"Novel missense variant in heterozygous state in the brpf1 gene leading to intellectual developmental disorder with dysmorphic facies and ptosis","volume":"11","author":"Naseer","year":"2020","journal-title":"Front. Genet."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e665","DOI":"10.1002\/mgg3.665","article-title":"Brpf1-associated intellectual disability, ptosis, and facial dysmorphism in a multiplex family","volume":"7","author":"Barel","year":"2019","journal-title":"Mol. Genet. Genom. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"104002","DOI":"10.1016\/j.ejmg.2020.104002","article-title":"A de novo brpf1 variant in a case of sudden unexplained death in childhood","volume":"63","author":"Keywan","year":"2020","journal-title":"Eur. J. Med. Genet."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/ng.902","article-title":"Exome sequencing supports a de novo mutational paradigm for schizophrenia","volume":"43","author":"Xu","year":"2011","journal-title":"Nat. Genet."},{"key":"ref_114","unstructured":"McRae, J.R., Clayton, S., Fitzgerald, T.W., Kaplanis, J., Prigmore, E., Rajan, D., Sifrim, A.W., Aitken, S., Akawi, M., and Alvi, M. (2016). Prevalence, phenotype and architecture of developmental disorders caused by de novo mutation. bioRxiv, 049056."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature13908","article-title":"The contribution of de novo coding mutations to autism spectrum disorder","volume":"515","author":"Iossifov","year":"2014","journal-title":"Nature"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.parkreldis.2021.02.013","article-title":"Clinically relevant copy-number variants in exome sequencing data of patients with dystonia","volume":"84","author":"Zech","year":"2021","journal-title":"Park. Relat. Disord."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Haug, P., Koller, S., Maggi, J., Lang, E., Feil, S., Wlodarczyk, A., Bahr, L., Steindl, K., Rohrbach, M., and Gerth-Kahlert, C. (2021). Whole exome sequencing in coloboma\/microphthalmia: Identification of novel and recurrent variants in seven genes. Genes, 12.","DOI":"10.3390\/genes12010065"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1172\/JCI43428","article-title":"Disruption of the histone acetyltransferase myst4 leads to a noonan syndrome-like phenotype and hyperactivated mapk signaling in humans and mice","volume":"121","author":"Kraft","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.ajhg.2011.10.008","article-title":"Whole-exome-sequencing identifies mutations in histone acetyltransferase gene kat6b in individuals with the say-barber-biesecker variant of ohdo syndrome","volume":"89","author":"Daly","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.ajhg.2011.11.024","article-title":"De novo mutations of the gene encoding the histone acetyltransferase kat6b cause genitopatellar syndrome","volume":"90","author":"Simpson","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ajhg.2011.11.023","article-title":"Mutations in kat6b, encoding a histone acetyltransferase, cause genitopatellar syndrome","volume":"90","author":"Campeau","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1002\/ajmg.a.36379","article-title":"An individual with blepharophimosis-ptosis-epicanthus inversus syndrome (bpes) and additional features expands the phenotype associated with mutations in kat6b","volume":"164A","author":"Yu","year":"2014","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/s41436-018-0259-2","article-title":"Kat6a syndrome: Genotype-phenotype correlation in 76 patients with pathogenic kat6a variants","volume":"21","author":"Kennedy","year":"2019","journal-title":"Genet. Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/ajmg.a.60689","article-title":"Novel truncating variants expand the phenotypic spectrum of kat6b-related disorders","volume":"179","author":"Dacruz","year":"2019","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1055\/s-0038-1676649","article-title":"A novel de novo frameshift mutation in kat6a identified by whole exome sequencing","volume":"8","author":"Alkhateeb","year":"2019","journal-title":"J. Pediatr. Genet."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1055\/s-0040-1710330","article-title":"A novel frameshift mutation in kat6a is associated with pancraniosynostosis","volume":"10","author":"Marji","year":"2021","journal-title":"J. Pediatr. Genet."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13023-020-1317-9","article-title":"Five new cases of syndromic intellectual disability due to kat6a mutations: Widening the molecular and clinical spectrum","volume":"15","author":"Urreizti","year":"2020","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"100686","DOI":"10.1016\/j.ymgmr.2020.100686","article-title":"Diagnosis of arboleda-tham syndrome by whole genome sequencing in an asian boy with severe developmental delay","volume":"25","author":"Lin","year":"2020","journal-title":"Mol. Genet. Metab. Rep."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Bae, S., Yang, A., Kim, J., Lee, H.J., and Park, H.K. (2021). Identification of a novel kat6a variant in an infant presenting with facial dysmorphism and developmental delay: A case report and literature review. BMC Med. Genom., 14.","DOI":"10.1186\/s12920-021-01148-x"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00381-021-05111-0","article-title":"First case of pan-suture craniosynostosis due to de novo mosaic kat6a mutation","volume":"38","author":"Korakavi","year":"2022","journal-title":"Childs Nerv. Syst."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/s10038-018-0469-0","article-title":"A kat6a variant in a family with autosomal dominantly inherited microcephaly and developmental delay","volume":"63","author":"Trinh","year":"2018","journal-title":"J. Hum. Genet."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1055\/s-0038-1651526","article-title":"Paroxysmal movement disorder and epilepsy caused by a de novo truncating mutation in kat6a","volume":"7","author":"Efthymiou","year":"2018","journal-title":"J. Pediatr. Genet."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.21037\/tp-21-206","article-title":"A de novo heterozygous variant in kat6a is associated with a newly named neurodevelopmental disorder arboleda-tham syndrome-a case report","volume":"10","author":"Jiang","year":"2021","journal-title":"Transl. Pediatr."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ccr.2014.02.004","article-title":"Genome sequencing of shh medulloblastoma predicts genotype-related response to smoothened inhibition","volume":"25","author":"Kool","year":"2014","journal-title":"Cancer Cell"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1016\/j.celrep.2019.11.046","article-title":"Truncated brpf1 cooperates with smoothened to promote adult shh medulloblastoma","volume":"29","author":"Aiello","year":"2019","journal-title":"Cell Rep."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"766656","DOI":"10.3389\/fonc.2021.766656","article-title":"Transcriptional networks identify brpf1 as a potential drug target based on inflammatory signature in primary lower-grade gliomas","volume":"11","author":"Xia","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/s42003-021-02405-6","article-title":"Bromodomain-containing protein brpf1 is a therapeutic target for liver cancer","volume":"4","author":"Cheng","year":"2021","journal-title":"Commun. Biol."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Sole, C., Goicoechea, I., Goni, A., Schramm, M., Armesto, M., Arestin, M., Manterola, L., Tellaetxe, M., Alberdi, A., and Nogueira, L. (2020). The urinary transcriptome as a source of biomarkers for prostate cancer. Cancers, 12.","DOI":"10.3390\/cancers12020513"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"178","DOI":"10.2174\/1386207323666200219122057","article-title":"Exploring the role of asp1116 in selective drug targeting of crebcamp- responsive element-binding protein implicated in prostate cancer","volume":"23","author":"Akinsiku","year":"2020","journal-title":"Comb. Chem. High Throughput Screen"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/ng.2760","article-title":"Pan-cancer patterns of somatic copy number alteration","volume":"45","author":"Zack","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nature15251","article-title":"Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth","volume":"525","author":"Zhu","year":"2015","journal-title":"Nature"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/s41586-018-0387-5","article-title":"Inhibitors of histone acetyltransferases kat6a\/b induce senescence and arrest tumour growth","volume":"560","author":"Baell","year":"2018","journal-title":"Nature"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"40594","DOI":"10.18632\/oncotarget.9745","article-title":"Interaction of dna demethylase and histone methyltransferase upregulates nrf2 in 5-fluorouracil-resistant colon cancer cells","volume":"7","author":"Kang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/gcc.10172","article-title":"Rearrangement of the moz gene in pediatric therapy-related myelodysplastic syndrome with a novel chromosomal translocation t(2;8)(p23;p11)","volume":"36","author":"Imamura","year":"2003","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.gene.2009.01.020","article-title":"Histone acetyltransferase hbo1: Catalytic activity, cellular abundance, and links to primary cancers","volume":"436","author":"Iizuka","year":"2009","journal-title":"Gene"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/gcc.10039","article-title":"Identification of amplified and expressed genes in breast cancer by comparative hybridization onto microarrays of randomly selected cdna clones","volume":"34","author":"Clark","year":"2002","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_147","first-page":"6240","article-title":"Impact of dna amplification on gene expression patterns in breast cancer","volume":"62","author":"Hyman","year":"2002","journal-title":"Cancer Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41586-019-1835-6","article-title":"Hbo1 is required for the maintenance of leukaemia stem cells","volume":"577","author":"Macpherson","year":"2020","journal-title":"Nature"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.7150\/thno.55655","article-title":"The histone acetyltransferase hbo1 functions as a novel oncogenic gene in osteosarcoma","volume":"11","author":"Gao","year":"2021","journal-title":"Theranostics"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/s41419-021-03818-1","article-title":"Hbo1 overexpression is important for hepatocellular carcinoma cell growth","volume":"12","author":"Zhong","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/bs.acr.2021.05.004","article-title":"Roles of the tumor suppressor inhibitor of growth family member 4 (ing4) in cancer","volume":"152","author":"Shatnawi","year":"2021","journal-title":"Adv. Cancer Res."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"11423","DOI":"10.1073\/pnas.0912116107","article-title":"Inhibitor of growth-4 promotes ikappab promoter activation to suppress nf-kappab signaling and innate immunity","volume":"107","author":"Coles","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1750-3639.2009.00325.x","article-title":"Loss of inhibitor of growth (ing-4) is implicated in the pathogenesis and progression of human astrocytomas","volume":"20","author":"Klironomos","year":"2010","journal-title":"Brain Pathol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.3892\/ol.2017.6450","article-title":"Association between the expression of inhibitor of growth family member 4 and the progression of clear cell renal carcinoma","volume":"14","author":"Ren","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.3892\/ol.2017.6618","article-title":"Expression of ing4 is negatively correlated with cellular proliferation and microvessel density in human glioma","volume":"14","author":"Shao","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"369","DOI":"10.7150\/ijbs.28422","article-title":"Ing4 suppresses hepatocellular carcinoma via a nf-kappab\/mir-155\/foxo3a signaling axis","volume":"15","author":"Qian","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00432-016-2219-z","article-title":"Ings are potential drug targets for cancer","volume":"143","author":"Zhang","year":"2017","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.humpath.2009.12.018","article-title":"The nuclear to cytoplasmic shift of ing5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas","volume":"42","author":"Zheng","year":"2011","journal-title":"Hum. Pathol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1007\/s00432-010-0815-x","article-title":"Decreased nuclear expression and increased cytoplasmic expression of ing5 may be linked to tumorigenesis and progression in human head and neck squamous cell carcinoma","volume":"136","author":"Li","year":"2010","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"5872","DOI":"10.1038\/ncomms6872","article-title":"Histone acetylation mediated by brd1 is crucial for cd8 gene activation during early thymocyte development","volume":"5","author":"Mishima","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/leu.2008.306","article-title":"Incidence and diversity of pax5 fusion genes in childhood acute lymphoblastic leukemia","volume":"23","author":"Nebral","year":"2009","journal-title":"Leukemia"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/ajmg.b.31023","article-title":"Support of association between brd1 and both schizophrenia and bipolar affective disorder","volume":"153B","author":"Nyegaard","year":"2010","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1074\/jbc.M115.703041","article-title":"The chromatin regulator brpf3 preferentially activates the hbo1 acetyltransferase but is dispensable for mouse development and survival","volume":"291","author":"Yan","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ccr.2012.06.008","article-title":"Cancer genetics and epigenetics: Two sides of the same coin?","volume":"22","author":"You","year":"2012","journal-title":"Cancer Cell"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cell.2013.03.008","article-title":"Interplay between the cancer genome and epigenome","volume":"153","author":"Shen","year":"2013","journal-title":"Cell"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1101\/gad.188359.112","article-title":"Combinatorial readout of unmodified h3r2 and acetylated h3k14 by the tandem phd finger of moz reveals a regulatory mechanism for hoxa9 transcription","volume":"26","author":"Qiu","year":"2012","journal-title":"Genes Dev."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1021\/acs.jmedchem.5b01514","article-title":"Disrupting acetyl-lysine recognition: Progress in the development of bromodomain inhibitors","volume":"59","author":"Romero","year":"2016","journal-title":"J. Med. Chem."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1021\/acs.jmedchem.5b00405","article-title":"Structure-guided design of iacs-9571, a selective high-affinity dual trim24-brpf1 bromodomain inhibitor","volume":"59","author":"Palmer","year":"2016","journal-title":"J. Med. Chem."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1039\/C6MD00373G","article-title":"Chemical probes and inhibitors of bromodomains outside the bet family","volume":"7","author":"Moustakim","year":"2016","journal-title":"Medchemcomm"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/cmdc.201800738","article-title":"Advancements in the development of non-bet bromodomain chemical probes","volume":"14","author":"Clegg","year":"2019","journal-title":"Chemmedchem"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1021\/acsmedchemlett.6b00092","article-title":"Gsk6853, a chemical probe for inhibition of the brpf1 bromodomain","volume":"7","author":"Bamborough","year":"2016","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"6998","DOI":"10.1021\/acs.jmedchem.7b00611","article-title":"Design of a chemical probe for the bromodomain and plant homeodomain finger-containing (brpf) family of proteins","volume":"60","author":"Igoe","year":"2017","journal-title":"J. Med. Chem."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1021\/acs.jmedchem.5b00458","article-title":"Discovery of a chemical tool inhibitor targeting the bromodomains of trim24 and brpf","volume":"59","author":"Bennett","year":"2016","journal-title":"J. Med. Chem."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"112338","DOI":"10.1016\/j.ejmech.2020.112338","article-title":"Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6\/8 and bromodomain brpf1","volume":"200","author":"Ghazy","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"114311","DOI":"10.1016\/j.ejmech.2022.114311","article-title":"Discovery, optimization and evaluation of 1-(indolin-1-yl)ethan-1-ones as novel selective trim24\/brpf1 bromodomain inhibitors","volume":"236","author":"Xiang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"4002","DOI":"10.1021\/acs.jmedchem.7b00306","article-title":"Benzoisoquinolinediones as potent and selective inhibitors of brpf2 and taf1\/taf1l bromodomains","volume":"60","author":"Bouche","year":"2017","journal-title":"J. Med. Chem."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/17\/4068\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:13:53Z","timestamp":1760141633000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/17\/4068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,23]]},"references-count":176,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["cancers14174068"],"URL":"https:\/\/doi.org\/10.3390\/cancers14174068","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,23]]}}}