{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:38:56Z","timestamp":1789774736680,"version":"4.0.1"},"reference-count":68,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Surgery is the key treatment in retroperitoneal sarcoma (RPS), as completeness of resection is the most important prognostic factor related to treatment. Compartmental surgery\/frontline extended approach is based on soft-tissue sarcoma surgical principles, and involves resecting adjacent viscera to achieve a wide negative margin. This extended approach is associated with improved local control and survival. This surgery must be tailored to tumor histology, tumor localization, and patient performance status. We herein present a review of compartmental surgery principles, covering the oncological and technical basis, and describing the tailored approach to each tumor subtype and localization in the retroperitoneum.<\/jats:p>","DOI":"10.3390\/cancers14174091","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T21:03:51Z","timestamp":1661375031000},"page":"4091","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Surgical Principles of Primary Retroperitoneal Sarcoma in the Era of Personalized Treatment: A Review of the Frontline Extended Surgery"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6334-3014","authenticated-orcid":false,"given":"Paula","family":"Munoz","sequence":"first","affiliation":[{"name":"Department of General Surgery, Hospital Quironsalud Torrevieja, 03184 Torrevieja, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0530-2142","authenticated-orcid":false,"given":"Pedro","family":"Bretcha-Boix","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical Oncology, Hospital Quironsalud Torrevieja, 03184 Torrevieja, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Artigas","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, Universidad Aut\u00f3noma de Barcelona, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7533-5513","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Asencio","sequence":"additional","affiliation":[{"name":"Department of General Surgery, CSUR Sarcoma and Mesenchymal Tumors, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1002\/cncr.21761","article-title":"Retroperitoneal sarcoma: A population-based analysis of epidemiology, surgery, and radiotherapy","volume":"106","author":"Porter","year":"2006","journal-title":"Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/00000658-199107000-00002","article-title":"Diagnosis and Management of Retroperitoneal Soft-tissue Sarcoma","volume":"214","author":"Storm","year":"1991","journal-title":"Ann. 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