{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:01:12Z","timestamp":1791475272619,"version":"4.3.4"},"reference-count":132,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/OFIRG\/0073\/2018"],"award-info":[{"award-number":["NMRC\/OFIRG\/0073\/2018"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOE2019-T2-1-024"],"award-info":[{"award-number":["MOE2019-T2-1-024"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NUHSRO\/2020\/149\/T1\/Seed-Sep\/03"],"award-info":[{"award-number":["NUHSRO\/2020\/149\/T1\/Seed-Sep\/03"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Education","award":["NMRC\/OFIRG\/0073\/2018"],"award-info":[{"award-number":["NMRC\/OFIRG\/0073\/2018"]}]},{"name":"Ministry of Education","award":["MOE2019-T2-1-024"],"award-info":[{"award-number":["MOE2019-T2-1-024"]}]},{"name":"Ministry of Education","award":["NUHSRO\/2020\/149\/T1\/Seed-Sep\/03"],"award-info":[{"award-number":["NUHSRO\/2020\/149\/T1\/Seed-Sep\/03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Cancer cachexia (CC) is a multifactorial syndrome characterized by a significant reduction in body weight that is predominantly caused by the loss of skeletal muscle and adipose tissue. Although the ill effects of cachexia are well known, the condition has been largely overlooked, in part due to its complex etiology, heterogeneity in mediators, and the involvement of diverse signaling pathways. For a long time, inflammatory factors have been the focus when developing therapeutics for the treatment of CC. Despite promising pre-clinical results, they have not yet advanced to the clinic. Developing new therapies requires a comprehensive understanding of how deregulated signaling leads to catabolic gene expression that underlies muscle wasting. Here, we review CC-associated signaling pathways and the transcriptional cascade triggered by inflammatory cytokines. Further, we highlight epigenetic factors involved in the transcription of catabolic genes in muscle wasting. We conclude with reflections on the directions that might pave the way for new therapeutic approaches to treat CC.<\/jats:p>","DOI":"10.3390\/cancers14174258","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T23:53:21Z","timestamp":1661990001000},"page":"4258","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cancer Cachexia: Signaling and Transcriptional Regulation of Muscle Catabolic Genes"],"prefix":"10.3390","volume":"14","author":[{"given":"Vinay Kumar","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru 570015, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipanwita","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Physiology, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6214-6177","authenticated-orcid":false,"given":"Reshma","family":"Taneja","sequence":"additional","affiliation":[{"name":"Department of Physiology, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nrc927","article-title":"Cachexia in Cancer Patients","volume":"2","author":"Tisdale","year":"2002","journal-title":"Nat. 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