{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:43:31Z","timestamp":1792190611202,"version":"4.4.0"},"reference-count":189,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["RO1 CA194042"],"award-info":[{"award-number":["RO1 CA194042"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Papillary thyroid cancer (PTC) often co-occurs with Hashimoto\u2019s thyroiditis, an association that has long been reported in clinical studies, remaining controversial. Experimental evidence has recently shown that pre-existing thyroiditis has a beneficial effect on PTC growth and progression by a distinctive expansion of effector memory CD8 T cells. Although the link between inflammation and PTC might involve different components of the immune system, a deep characterization of them which includes T cells, B cells and tertiary lymphoid structures, Mye-loid cells, Neutrophils, NK cells and dendritic cells will be desirable. The present review article considers the role of the adaptive and innate immune response surrounding PTC in the context of Hashimoto\u2019s thyroiditis. This review will focus on the current knowledge by in vivo and in vitro studies specifically performed on animals\u2019 models; thyroid cancer cells and human samples including (i) the dual role of tumor-infiltrating lymphocytes; (ii) the emerging role of B cells and tertiary lymphoid structures; (iii) the role of myeloid cells, dendritic cells, and natural killer cells; (iv) the current knowledge of the molecular biomarkers implicated in the complex link between thyroiditis and PTC and the potential implication of cancer immunotherapy in PTC patients in the context of thyroiditis.<\/jats:p>","DOI":"10.3390\/cancers14174287","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T21:27:17Z","timestamp":1662067637000},"page":"4287","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The Immune Landscape of Papillary Thyroid Cancer in the Context of Autoimmune Thyroiditis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2566-7971","authenticated-orcid":false,"given":"Fabiana","family":"Pani","sequence":"first","affiliation":[{"name":"Service des Pathologies Thyro\u00efdiennes et Tumeurs Endocrines, AP-HP, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, GRC n\u00b016, GRC Tumeurs Thyro\u00efdiennes, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Caria","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Biochemistry, Biology and Genetics Unit, University of Cagliari, Cittadella Universitaria di Monserrato, SP 8, Km 0.700, Monserrato, 09042 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0674-2956","authenticated-orcid":false,"given":"Yoshinori","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyara","family":"Makoto","sequence":"additional","affiliation":[{"name":"Inserm, Centre d\u2019Immunologie et des Maladies Infectieuses-Paris (CIMI-PARIS), AP-HP H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1208-7057","authenticated-orcid":false,"given":"Stefano","family":"Mariotti","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Public Health, Endocrinology Unit, University of Cagliari, Monserrato, 09042 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Leenhardt","sequence":"additional","affiliation":[{"name":"Service des Pathologies Thyro\u00efdiennes et Tumeurs Endocrines, AP-HP, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, GRC n\u00b016, GRC Tumeurs Thyro\u00efdiennes, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solmaz","family":"Roshanmehr","sequence":"additional","affiliation":[{"name":"Division of Immunology, Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizio","family":"Caturegli","sequence":"additional","affiliation":[{"name":"Division of Immunology, Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Buffet","sequence":"additional","affiliation":[{"name":"Service des Pathologies Thyro\u00efdiennes et Tumeurs Endocrines, AP-HP, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, GRC n\u00b016, GRC Tumeurs Thyro\u00efdiennes, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1210\/er.2019-00085","article-title":"Contemporary Debates in Adult Papillary Thyroid Cancer Management","volume":"40","author":"McLeod","year":"2019","journal-title":"Endocr. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"686","DOI":"10.4158\/EP14466.DSCR","article-title":"American association of clinical endocrinologists and american college of endocrinology disease state clinical review: The increasing incidence of thyroid cancer","volume":"21","author":"Davies","year":"2015","journal-title":"Endocr. Pract."},{"key":"ref_3","unstructured":"Cancer Genome Atlas Research Network (2014). Integrated genomic characterization of papillary thyroid carcinoma. Cell, 159, 676\u2013690."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1002\/ijc.27497","article-title":"Thyroid cancer in Denmark 1943\u20132008, before and after iodine supplementation","volume":"131","author":"Blomberg","year":"2012","journal-title":"Int. J. Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.14310\/horm.2002.1261","article-title":"Autoimmunity in differentiated thyroid cancer: Significance and related clinical problems","volume":"9","author":"Rasmussen","year":"2010","journal-title":"Hormones"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1056\/NEJMp1604412","article-title":"Worldwide Thyroid-Cancer Epidemic? The Increasing Impact of Overdiagnosis","volume":"375","author":"Vaccarella","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1001\/archsurg.1955.01270080137023","article-title":"Relation of thyroid neoplasms to Hashimoto disease of the thyroid gland","volume":"70","author":"Dailey","year":"1955","journal-title":"AMA Arch. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1002\/cncr.26398","article-title":"Family history of cancer and risk of sporadic differentiated thyroid carcinoma","volume":"118","author":"Xu","year":"2012","journal-title":"Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000371741","article-title":"Iodine, thyroid autoimmunity and cancer","volume":"4","author":"Fiore","year":"2015","journal-title":"Eur. Thyroid J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s40618-017-0757-0","article-title":"High prevalence of papillary thyroid carcinoma in nodular Hashimoto\u2019s thyroiditis at the first diagnosis and during the follow-up","volume":"41","author":"Boi","year":"2018","journal-title":"J. Endocrinol. Investig."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1159\/000468928","article-title":"Thyroid Autoimmunity and Thyroid Cancer: Review Focused on Cytological Studies","volume":"6","author":"Boi","year":"2017","journal-title":"Eur. Thyroid J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1210\/jc.2014-1302","article-title":"Nodules in autoimmune thyroiditis are associated with increased risk of thyroid cancer in surgical series but not in cytological series: Evidence for selection bias","volume":"99","author":"Castagna","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1530\/EJE-20-0350","article-title":"Patients with chronic autoimmune thyroiditis are not at higher risk for developing clinically overt thyroid cancer: A 10-year follow-up study","volume":"183","author":"Rotondi","year":"2020","journal-title":"Eur. J. Endocrinol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e1964189","DOI":"10.1080\/2162402X.2021.1964189","article-title":"Characterization of immune landscape in papillary thyroid cancer reveals distinct tumor immunogenicity and implications for immunotherapy","volume":"10","author":"Sun","year":"2021","journal-title":"Oncoimmunology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"637826","DOI":"10.3389\/fendo.2020.637826","article-title":"Immune Landscape of Thyroid Cancers: New Insights","volume":"11","author":"Menicali","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_16","first-page":"303","article-title":"The association between thyroid malignancy and chronic lymphocytic thyroiditis: Should it alter the surgical approach?","volume":"62","author":"Hasdemir","year":"2011","journal-title":"Endokrynol. Pol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s00405-011-1732-6","article-title":"The clinicopathologic differences in papillary thyroid carcinoma with or without co-existing chronic lymphocytic thyroiditis","volume":"269","author":"Yoon","year":"2012","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1038\/bjc.2013.597","article-title":"Cancer risk in patients with Hashimoto\u2019s thyroiditis: A nationwide cohort study","volume":"109","author":"Chen","year":"2013","journal-title":"Br. J. Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1530\/ERC-14-0258","article-title":"Association of Hashimoto\u2019s thyroiditis with thyroid cancer","volume":"21","author":"Azizi","year":"2014","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_20","first-page":"53","article-title":"Association between Hashimoto\u2019s Thyroiditis and Thyroid Cancer in 64,628 Patients","volume":"7","year":"2017","journal-title":"Front. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.jamcollsurg.2006.12.037","article-title":"Increased incidence of well-differentiated thyroid cancer associated with Hashimoto thyroiditis and the role of the PI3k\/Akt pathway","volume":"204","author":"Larson","year":"2007","journal-title":"J. Am. Coll. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.surg.2009.09.025","article-title":"Incidental papillary carcinoma in patients treated surgically for benign thyroid diseases","volume":"146","author":"Bradly","year":"2009","journal-title":"Surgery"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1210\/jc.2012-2978","article-title":"Clinical Review: Hashimoto\u2019s thyroiditis and papillary thyroid carcinoma: Is there a correlation?","volume":"98","author":"Jankovic","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1530\/EJE-21-0094","article-title":"The diagnostic accuracy of fine-needle aspiration cytology for thyroid nodules is not affected by coexistent chronic autoimmune thyroiditis: Results from a cyto-histological series of patients with indeterminate cytology","volume":"185","author":"Rotondi","year":"2021","journal-title":"Eur. J. Endocrinol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s40618-017-0794-8","article-title":"Chronic lymphocytic thyroiditis (CLT) has a positive prognostic value in papillary thyroid cancer (PTC) patients: The potential key role of Foxp3+ T lymphocytes","volume":"41","author":"Pilli","year":"2018","journal-title":"J. Endocrinol. Investig."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"124264","DOI":"10.4061\/2010\/124264","article-title":"Profile of Hashimoto\u2019s Thyroiditis in Sri Lankans: Is There an Increased Risk of Ancillary Pathologies in Hashimoto\u2019s Thyroiditis?","volume":"2010","author":"Siriweera","year":"2010","journal-title":"J. Thyroid Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1177\/000313480507101018","article-title":"Hashimoto thyroiditis coexistent with papillary thyroid carcinoma","volume":"71","author":"Cipolla","year":"2005","journal-title":"Am. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3803\/EnM.2018.33.4.473","article-title":"Associations between Hashimoto Thyroiditis and Clinical Outcomes of Papillary Thyroid Cancer: A Meta-Analysis of Observational Studies","volume":"33","author":"Moon","year":"2018","journal-title":"Endocrinol. Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1002\/1097-0142(19951201)76:11<2312::AID-CNCR2820761120>3.0.CO;2-H","article-title":"Association of chronic lymphocytic thyroiditis and thyroid papillary carcinoma. A study of surgical cases among Japanese, and white and African Americans","volume":"76","author":"Okayasu","year":"1995","journal-title":"Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF02738789","article-title":"The Relationship of Lymphocytic Thyroiditis to the Development of Thyroid Carcinoma","volume":"8","author":"Okayasu","year":"1997","journal-title":"Endocr. Pathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1210\/js.2018-00287","article-title":"Influence of Hashimoto Thyroiditis on the Development of Thyroid Nodules and Cancer in Children and Adolescents","volume":"3","author":"Radetti","year":"2019","journal-title":"J. Endocr. Soc."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1200\/JCO.21.02618","article-title":"Pre-existing Thyroid Autoimmunity and Risk of Papillary Thyroid Cancer: A Nested Case-Control Study of US Active-Duty Personnel","volume":"40","author":"McLeod","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1089\/thy.2009.1609","article-title":"Lessons from mouse models of thyroid cancer","volume":"19","author":"Kim","year":"2009","journal-title":"Thyroid"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev.pathol.3.121806.154244","article-title":"Mouse models of cancer","volume":"6","author":"Cheon","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1210\/endo.137.1.8536638","article-title":"Targeted expression of the ret\/PTC1 oncogene induces papillary thyroid carcinomas","volume":"137","author":"Jhiang","year":"1996","journal-title":"Endocrinology"},{"key":"ref_36","first-page":"5523","article-title":"The RET\/PTC3 oncogene: Metastatic solid-type papillary carcinomas in murine thyroids","volume":"58","author":"Powell","year":"1998","journal-title":"Cancer Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/019262339702500109","article-title":"Mechanistic data and risk assessment of selected toxic end points of the thyroid gland","volume":"25","author":"Capen","year":"1997","journal-title":"Toxicol. Pathol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mce.2017.06.023","article-title":"Oncogene-induced senescence and its evasion in a mouse model of thyroid neoplasia","volume":"460","author":"Bellelli","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/s41416-018-0296-2","article-title":"Combinations of BRAF inhibitor and anti-PD-1\/PD-L1 antibody improve survival and tumour immunity in an immunocompetent model of orthotopic murine anaplastic thyroid cancer","volume":"119","author":"Gunda","year":"2018","journal-title":"Br. J. Cancer"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1002\/ijc.32041","article-title":"Anti-PD-1\/PD-L1 therapy augments lenvatinib\u2019s efficacy by favorably altering the immune microenvironment of murine anaplastic thyroid cancer","volume":"144","author":"Gunda","year":"2019","journal-title":"Int. J. Cancer"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1101\/gad.1516407","article-title":"A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors","volume":"21","author":"Dankort","year":"2007","journal-title":"Genes Dev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"E1600","DOI":"10.1073\/pnas.1404357111","article-title":"p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer","volume":"111","author":"McFadden","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/gene.20043","article-title":"Thyrocyte-specific expression of Cre recombinase in transgenic mice","volume":"39","author":"Kusakabe","year":"2004","journal-title":"Genesis"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1158\/0008-5472.CAN-05-0047","article-title":"Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation","volume":"65","author":"Knauf","year":"2005","journal-title":"Cancer Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1158\/0008-5472.CAN-09-0024","article-title":"Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo","volume":"69","author":"Miller","year":"2009","journal-title":"Cancer Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"417","DOI":"10.4049\/jimmunol.76.6.417","article-title":"Studies on organ specificity. V. Changes in the thyroid glands of rabbits following active immunization with rabbit thyroid extracts","volume":"76","author":"Rose","year":"1956","journal-title":"J. Immunol."},{"key":"ref_47","first-page":"546","article-title":"Experimental auto-immune thyroiditis in the rat","volume":"42","author":"Jones","year":"1961","journal-title":"Br. J. Exp. Pathol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1210\/en.2005-1130","article-title":"Induction of autoimmune thyroiditis and hypothyroidism by immunization of immunoactive T cell epitope of thyroid peroxidase","volume":"147","author":"Ng","year":"2006","journal-title":"Endocrinology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1084\/jem.178.3.793","article-title":"I-E+ nonobese diabetic mice develop insulitis and diabetes","volume":"178","author":"Podolin","year":"1993","journal-title":"J. Exp. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.ai.2014.11.001","article-title":"NOD.H-2h4 mice: An important and underutilized animal model of autoimmune thyroiditis and Sjogren\u2019s syndrome","volume":"126","author":"Yu","year":"2015","journal-title":"Adv. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3109\/08830185.2015.1065828","article-title":"Genes and environment as predisposing factors in autoimmunity: Acceleration of spontaneous thyroiditis by dietary iodide in NOD.H2(h4) mice","volume":"34","author":"Kolypetri","year":"2015","journal-title":"Int. Rev. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-4800(03)80002-3","article-title":"Kinetics of mononuclear cell infiltration and cytokine expression in iodine-induced thyroiditis in the NOD-H2h4 mouse","volume":"74","author":"Bonita","year":"2003","journal-title":"Exp. Mol. Pathol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"874769","DOI":"10.3389\/fimmu.2022.874769","article-title":"The NOD Mouse Beyond Autoimmune Diabetes","volume":"13","author":"Aubin","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"bqab144","DOI":"10.1210\/endocr\/bqab144","article-title":"Pre-existing Thyroiditis Ameliorates Papillary Thyroid Cancer: Insights From a New Mouse Model","volume":"162","author":"Pani","year":"2021","journal-title":"Endocrinology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1161\/ATVBAHA.118.309669","article-title":"Endothelial-Specific Cre Mouse Models","volume":"38","author":"Payne","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev-immunol-032712-095954","article-title":"Memory T cell subsets, migration patterns, and tissue residence","volume":"31","author":"Mueller","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41586-020-2931-3","article-title":"Defining HPV-specific B cell responses in patients with head and neck cancer","volume":"597","author":"Wieland","year":"2021","journal-title":"Nature"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Martinez-Pacheco, S., and O\u2019Driscoll, L. (2021). Pre-Clinical In Vitro Models Used in Cancer Research: Results of a Worldwide Survey. Cancers, 13.","DOI":"10.3390\/cancers13236033"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.biotechadv.2016.11.002","article-title":"3D tumor spheroids: An overview on the tools and techniques used for their analysis","volume":"34","author":"Costa","year":"2016","journal-title":"Biotechnol. Adv."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/jcp.24683","article-title":"3D cell culture systems: Advantages and applications","volume":"230","author":"Ravi","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fsurg.2020.00043","article-title":"The Changing Face of in vitro Culture Models for Thyroid Cancer Research: A Systematic Literature Review","volume":"7","author":"Chew","year":"2020","journal-title":"Front. Surg."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1755-8166-4-26","article-title":"Centrosomal and mitotic abnormalities in cell lines derived from papillary thyroid cancer harboring specific gene alterations","volume":"4","author":"Maric","year":"2011","journal-title":"Mol. Cytogenet."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fendo.2012.00081","article-title":"Thyroid cancer cell lines: Critical models to study thyroid cancer biology and new therapeutic targets","volume":"3","author":"Schweppe","year":"2012","journal-title":"Front. Endocrinol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3389\/fendo.2012.00133","article-title":"Thyroid cancer cell lines: An overview","volume":"3","author":"Saiselet","year":"2012","journal-title":"Front. Endocrinol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.7150\/jca.18855","article-title":"Thyrospheres from B-CPAP Cell Line with BRAF and TERT Promoter Mutations have Different Functional and Molecular Features than Parental Cells","volume":"8","author":"Caria","year":"2017","journal-title":"J. Cancer"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Caria, P., Tronci, L., Dettori, T., Murgia, F., Santoru, M.L., Griffin, J.L., Vanni, R., and Atzori, L. (2018). Metabolomic Alterations in Thyrospheres and Adherent Parental Cells in Papillary Thyroid Carcinoma Cell Lines: A Pilot Study. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19102948"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"5175","DOI":"10.1002\/jcp.27321","article-title":"Characterizing the three-dimensional organization of telomeres in papillary thyroid carcinoma cells","volume":"234","author":"Caria","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Tronci, L., Caria, P., Frau, D.V., Liggi, S., Piras, C., Murgia, F., Santoru, M.L., Pibiri, M., Deiana, M., and Griffin, J.L. (2019). Crosstalk between Metabolic Alterations and Altered Redox Balance in PTC-Derived Cell Lines. Metabolites, 9.","DOI":"10.3390\/metabo9020023"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Tronci, L., Serreli, G., Piras, C., Frau, D.V., Dettori, T., Deiana, M., Murgia, F., Santoru, M.L., Spada, M., and Leoni, V.P. (2021). Vitamin C Cytotoxicity and Its Effects in Redox Homeostasis and Energetic Metabolism in Papillary Thyroid Carcinoma Cell Lines. Antioxidants, 10.","DOI":"10.3390\/antiox10050809"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1476-4598-7-44","article-title":"ret\/PTC-1 expression alters the immunoprofile of thyroid follicular cells","volume":"7","author":"Denning","year":"2008","journal-title":"Mol. Cancer"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1038\/sj.onc.1206759","article-title":"Tyrosine kinase oncoprotein, RET\/PTC3, induces the secretion of myeloid growth and chemotactic factors","volume":"22","author":"Russell","year":"2003","journal-title":"Oncogene"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"52131","DOI":"10.1074\/jbc.M306003200","article-title":"Microsomal prostaglandin E2 synthase-1 is induced by conditional expression of RET\/PTC in thyroid PCCL3 cells through the activation of the MEK-ERK pathway","volume":"278","author":"Puxeddu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1210\/jc.2003-031425","article-title":"BRAF(V599E) mutation is the leading genetic event in adult sporadic papillary thyroid carcinomas","volume":"89","author":"Puxeddu","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13000-019-0832-2","article-title":"IL-17A increases MHC class I expression and promotes T cell activation in papillary thyroid cancer patients with coexistent Hashimoto\u2019s thyroiditis","volume":"14","author":"Han","year":"2019","journal-title":"Diagn. Pathol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"bqaa062","DOI":"10.1210\/endocr\/bqaa062","article-title":"IL-10 Restores MHC Class I Expression and Interferes With Immunity in Papillary Thyroid Cancer With Hashimoto Thyroiditis","volume":"161","author":"Lu","year":"2020","journal-title":"Endocrinology"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"784975","DOI":"10.3389\/fimmu.2021.784975","article-title":"Proteomics and Organoid Culture Reveal the Underlying Pathogenesis of Hashimoto\u2019s Thyroiditis","volume":"12","author":"Xiao","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"101367","DOI":"10.1016\/j.beem.2019.101367","article-title":"Hashimotos\u2019 thyroiditis: Epidemiology, pathogenesis, clinic and therapy","volume":"33","author":"Ragusa","year":"2019","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3389\/fimmu.2019.00856","article-title":"The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review","volume":"10","author":"Deng","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1016\/j.jaci.2009.09.017","article-title":"Adaptive immunity","volume":"125","author":"Bonilla","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.coi.2005.09.014","article-title":"CD8+ T cells in autoimmunity","volume":"17","author":"Walter","year":"2005","journal-title":"Curr. Opin. Immunol."},{"key":"ref_81","first-page":"10","article-title":"T cells and thyroid autoimmunity","volume":"28","author":"Tandon","year":"1994","journal-title":"J. R. Coll. Physicians Lond."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1365-2249.1994.tb05515.x","article-title":"Perforin expression by thyroid-infiltrating T cells in autoimmune thyroid disease","volume":"98","author":"Wu","year":"1994","journal-title":"Clin. Exp. Immunol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nri3158","article-title":"Standardizing immunophenotyping for the Human Immunology Project","volume":"12","author":"Maecker","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.immuni.2018.02.010","article-title":"Understanding Subset Diversity in T Cell Memory","volume":"48","author":"Jameson","year":"2018","journal-title":"Immunity"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3109\/08916939209014632","article-title":"Cytokines and immune regulation in thyroid autoimmunity","volume":"13","author":"Nagataki","year":"1992","journal-title":"Autoimmunity"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.3389\/fimmu.2018.02692","article-title":"Defining Memory CD8 T Cell","volume":"9","author":"Martin","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41577-019-0223-7","article-title":"Precursor exhausted T cells: Key to successful immunotherapy?","volume":"20","author":"Kallies","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ni.2035","article-title":"T cell exhaustion","volume":"12","author":"Wherry","year":"2011","journal-title":"Nat. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.3389\/fimmu.2019.01018","article-title":"Editorial: Tissue Resident Memory T Cells","volume":"10","author":"Tartour","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"16073","DOI":"10.1038\/ncomms16073","article-title":"Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8(+) T cells","volume":"8","author":"Enamorado","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1089\/thy.2012.0514","article-title":"Impairment of regulatory T-cell function in autoimmune thyroid disease","volume":"23","author":"Glick","year":"2013","journal-title":"Thyroid"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3389\/fimmu.2020.00601","article-title":"Tissue Infiltrating LTi-Like Group 3 Innate Lymphoid Cells and T Follicular Helper Cells in Graves\u2019 and Hashimoto\u2019s Thyroiditis","volume":"11","author":"Mohr","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.mce.2009.10.003","article-title":"Thyroid cancer and inflammation","volume":"321","author":"Guarino","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1530\/ERC-19-0074","article-title":"Papillary thyroid carcinoma behavior: Clues in the tumor microenvironment","volume":"26","author":"Bergdorf","year":"2019","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/nm.3909","article-title":"The prognostic landscape of genes and infiltrating immune cells across human cancers","volume":"21","author":"Gentles","year":"2015","journal-title":"Nat. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/bjc.2011.189","article-title":"The prognostic influence of tumour-infiltrating lymphocytes in cancer: A systematic review with meta-analysis","volume":"105","author":"Gooden","year":"2011","journal-title":"Br. J. Cancer"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/(SICI)1097-0142(19960401)77:7<1303::AID-CNCR12>3.0.CO;2-5","article-title":"Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma","volume":"77","author":"Clemente","year":"1996","journal-title":"Cancer"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1056\/NEJMoa020177","article-title":"Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer","volume":"348","author":"Zhang","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1126\/science.1129139","article-title":"Type, density, and location of immune cells within human colorectal tumors predict clinical outcome","volume":"313","author":"Galon","year":"2006","journal-title":"Science"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41523-021-00346-1","article-title":"The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group","volume":"7","author":"Haynes","year":"2021","journal-title":"NPJ Breast Cancer"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e1168556","DOI":"10.1080\/2162402X.2016.1168556","article-title":"The immune network in thyroid cancer","volume":"5","author":"Galdiero","year":"2016","journal-title":"Oncoimmunology"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1111\/j.1365-2265.2012.04482.x","article-title":"Infiltration of a mixture of immune cells may be related to good prognosis in patients with differentiated thyroid carcinoma","volume":"77","author":"Cunha","year":"2012","journal-title":"Clin. Endocrinol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"R85","DOI":"10.1530\/ERC-13-0431","article-title":"The role of the inflammatory microenvironment in thyroid carcinogenesis","volume":"21","author":"Cunha","year":"2014","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_105","first-page":"e403","article-title":"Is diffuse and peritumoral lymphocyte infiltration in papillary thyroid cancer a marker of good prognosis?","volume":"34","author":"Villagelin","year":"2011","journal-title":"J. Endocrinol. Investig."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1210\/jc.2015-4227","article-title":"Tumor-Infiltrating T Cells and the PD-1 Checkpoint Pathway in Advanced Differentiated and Anaplastic Thyroid Cancer","volume":"101","author":"Bastman","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.1210\/jc.2003-030342","article-title":"Papillary thyroid carcinomas from young adults and children contain a mixture of lymphocytes","volume":"88","author":"Modi","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1210\/jc.2009-2564","article-title":"Tumor-associated lymphocytes and increased FoxP3+ regulatory T cell frequency correlate with more aggressive papillary thyroid cancer","volume":"95","author":"French","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1210\/jcem-69-4-832","article-title":"Phenotypic and functional analysis at the clonal level of infiltrating T lymphocytes in papillary carcinoma of the thyroid: Prevalence of cytolytic T cells with natural killer-like or lymphokine-activated killer activity","volume":"69","author":"Bagnasco","year":"1989","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/0959-8049(96)00017-2","article-title":"Phenotypic and functional characterisation of tumour-infiltrating lymphocytes derived from thyroid tumours","volume":"32a","author":"Lee","year":"1996","journal-title":"Eur. J. Cancer"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/00000478-199606000-00006","article-title":"Papillary carcinoma of the thyroid. Tall-cell variant with extensive lymphocyte infiltration","volume":"20","author":"Ozaki","year":"1996","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"840811","DOI":"10.3389\/fimmu.2022.840811","article-title":"Single-Cell Transcriptome Analysis Reveals Inter-Tumor Heterogeneity in Bilateral Papillary Thyroid Carcinoma","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"570604","DOI":"10.3389\/fendo.2020.570604","article-title":"Immune Cell Confrontation in the Papillary Thyroid Carcinoma Microenvironment","volume":"11","author":"Xie","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1089\/thy.2011.0059","article-title":"Higher intratumoral expression of CD1a, tryptase, and CD68 in a follicular variant of papillary thyroid carcinoma compared to adenomas: Correlation with clinical and pathological parameters","volume":"21","author":"Proietti","year":"2011","journal-title":"Thyroid"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1210\/jc.2011-1838","article-title":"Phenotypical analysis of lymphocytes with suppressive and regulatory properties (Tregs) and NK cells in the papillary carcinoma of thyroid","volume":"97","author":"Gogali","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.autrev.2014.01.007","article-title":"Hashimoto thyroiditis: Clinical and diagnostic criteria","volume":"13","author":"Caturegli","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"107770","DOI":"10.1016\/j.intimp.2021.107770","article-title":"Advances in regulatory B cells in autoimmune thyroid diseases","volume":"96","author":"Kang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1089\/thy.2021.0694","article-title":"Lymphocytic Thyroiditis Transcriptomic Profiles Support the Role of Checkpoint Pathways and B Cells in Pathogenesis","volume":"32","author":"Bello","year":"2022","journal-title":"Thyroid"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jaci.2013.01.046","article-title":"B-cell biology and development","volume":"131","author":"Pieper","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S2213-8587(16)30277-7","article-title":"Leveraging the immune system to treat advanced thyroid cancers","volume":"5","author":"French","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.3389\/fonc.2019.01285","article-title":"Patterns of Immune Infiltration in HNC and Their Clinical Implications: A Gene Expression-Based Study","volume":"9","author":"Song","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1158\/2326-6066.CIR-19-0240","article-title":"Myeloid-Derived Suppressive Cells Promote B cell-Mediated Immunosuppression via Transfer of PD-L1 in Glioblastoma","volume":"7","author":"Rashidi","year":"2019","journal-title":"Cancer Immunol. Res."},{"key":"ref_123","unstructured":"Pinto, R., Petriella, D., Lacalamita, R., Montrone, M., Catino, A., Pizzutilo, P., Botticella, M.A., Zito, F.A., Del Bene, G., and Zonno, A. (2019). KRAS-Driven Lung Adenocarcinoma and B Cell Infiltration: Novel Insights for Immunotherapy. Cancers, 11."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s00428-021-03137-y","article-title":"Diagnostic and prognostic value of tumor-infiltrating B cells in lymph node metastases of papillary thyroid carcinoma","volume":"479","author":"Yang","year":"2021","journal-title":"Virchows Arch."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"758339","DOI":"10.3389\/fcell.2021.758339","article-title":"Papillary Thyroid Carcinoma Landscape and Its Immunological Link With Hashimoto Thyroiditis at Single-Cell Resolution","volume":"9","author":"Pan","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"865596","DOI":"10.3389\/fimmu.2022.865596","article-title":"CD20(+)CD22(+)ADAM28(+) B Cells in Tertiary Lymphoid Structures Promote Immunotherapy Response","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"6203","DOI":"10.1038\/onc.2010.348","article-title":"Mast cells have a protumorigenic role in human thyroid cancer","volume":"29","author":"Melillo","year":"2010","journal-title":"Oncogene"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"5175","DOI":"10.1038\/onc.2014.441","article-title":"Mast cells induce epithelial-to-mesenchymal transition and stem cell features in human thyroid cancer cells through an IL-8-Akt-Slug pathway","volume":"34","author":"Visciano","year":"2015","journal-title":"Oncogene"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1210\/jc.2006-0492","article-title":"Clinicopathological significance of major histocompatibility complex class I-related chain a and B expression in thyroid cancer","volume":"91","author":"Xu","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.1158\/1078-0432.CCR-14-0879","article-title":"MHC class I loss is a frequent mechanism of immune escape in papillary thyroid cancer that is reversed by interferon and selumetinib treatment in vitro","volume":"20","author":"Angell","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1089\/thy.2011.0452","article-title":"Density of tumor-associated macrophages correlates with lymph node metastasis in papillary thyroid carcinoma","volume":"22","author":"Qing","year":"2012","journal-title":"Thyroid"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1677\/ERC-08-0036","article-title":"Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer","volume":"15","author":"Ryder","year":"2008","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0002-9440(10)64951-6","article-title":"Papillary carcinoma of the thyroid: Hepatocyte growth factor (HGF) stimulates tumor cells to release chemokines active in recruiting dendritic cells","volume":"156","author":"Scarpino","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/JLB.3MR0717-292R","article-title":"Roles of neutrophils in cancer growth and progression","volume":"103","author":"Galdiero","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00281-013-0374-8","article-title":"Neutrophils in innate and adaptive immunity","volume":"35","author":"Jaillon","year":"2013","journal-title":"Semin. Immunopathol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/ijc.30076","article-title":"Occurrence and significance of tumor-associated neutrophils in patients with colorectal cancer","volume":"139","author":"Galdiero","year":"2016","journal-title":"Int. J. Cancer"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.semcancer.2013.02.001","article-title":"Immunomonitoring and prognostic relevance of neutrophils in clinical trials","volume":"23","author":"Donskov","year":"2013","journal-title":"Semin. Cancer Biol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jaci.2012.07.025","article-title":"Human versus mouse eosinophils: \u201cthat which we call an eosinophil, by any other name would stain as red\u201d","volume":"130","author":"Lee","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1089\/thy.2020.0779","article-title":"Correlation of Performance Status and Neutrophil-Lymphocyte Ratio with Efficacy in Radioiodine-Refractory Differentiated Thyroid Cancer Treated with Lenvatinib","volume":"31","author":"Taylor","year":"2021","journal-title":"Thyroid"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.critrevonc.2013.03.010","article-title":"The systemic inflammation-based neutrophil-lymphocyte ratio: Experience in patients with cancer","volume":"88","author":"Guthrie","year":"2013","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.7150\/ijms.28498","article-title":"An Increased Neutrophil-to-Lymphocyte Ratio Predicts Incomplete Response to Therapy in Differentiated Thyroid Cancer","volume":"15","author":"Lee","year":"2018","journal-title":"Int. J. Med. Sci."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00262-021-03020-4","article-title":"An immune-related prognostic signature for thyroid carcinoma to predict survival and response to immune checkpoint inhibitors","volume":"71","author":"Wu","year":"2022","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.ccell.2021.04.004","article-title":"Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer","volume":"39","author":"Hornburg","year":"2021","journal-title":"Cancer Cell"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nrc.2017.58","article-title":"Unravelling biology and shifting paradigms in cancer with single-cell sequencing","volume":"17","author":"Baslan","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13578-021-00549-w","article-title":"Single-cell transcriptomic landscape reveals the differences in cell differentiation and immune microenvironment of papillary thyroid carcinoma between genders","volume":"11","author":"Peng","year":"2021","journal-title":"Cell Biosci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"eabf3657","DOI":"10.1126\/sciadv.abf3657","article-title":"Characterizing dedifferentiation of thyroid cancer by integrated analysis","volume":"7","author":"Luo","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1210\/jc.2012-2926","article-title":"Tumor suppressor role of the CL2\/DRO1\/CCDC80 gene in thyroid carcinogenesis","volume":"98","author":"Ferraro","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1210\/jc.2011-2178","article-title":"Evidence of a combined cytotoxic thyroglobulin and thyroperoxidase epitope-specific cellular immunity in Hashimoto\u2019s thyroiditis","volume":"97","author":"Ehlers","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_149","first-page":"1121","article-title":"Serum thyroglobulin autoantibodies: Prevalence, influence on serum thyroglobulin measurement, and prognostic significance in patients with differentiated thyroid carcinoma","volume":"83","author":"Spencer","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1210\/jc.2012-2406","article-title":"Thyroglobulin autoantibodies in patients with papillary thyroid carcinoma: Comparison of different assays and evaluation of causes of discrepancies","volume":"97","author":"Latrofa","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1365-2265.2009.03748.x","article-title":"Characterization of thyroglobulin epitopes in Sardinian adults and juveniles with Hashimoto\u2019s thyroiditis: Evidence against a major effect of age and genetic background on B-cell epitopes","volume":"73","author":"Latrofa","year":"2010","journal-title":"Clin. Endocrinol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1089\/thy.2013.0130","article-title":"Association of HLA-B*51:01 with papillary thyroid carcinoma in the Chinese Han population of the Shandong coastal areas","volume":"24","author":"Shuxian","year":"2014","journal-title":"Thyroid"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1210\/jc.2014-2725","article-title":"Prognostic significance of thyroglobulin antibody epitopes in differentiated thyroid cancer","volume":"100","author":"Lupoli","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1210\/jc.2016-2469","article-title":"Epitope-Specific Antitumor Immunity Suppresses Tumor Spread in Papillary Thyroid Cancer","volume":"102","author":"Ehlers","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1056\/NEJMra1501993","article-title":"Biologic and Clinical Perspectives on Thyroid Cancer","volume":"375","author":"Fagin","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00005537-199701000-00019","article-title":"Expression of the RET\/PTC fusion gene as a marker for papillary carcinoma in Hashimoto\u2019s thyroiditis","volume":"107","author":"Wirtschafter","year":"1997","journal-title":"Laryngoscope"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1158\/1078-0432.CCR-18-2953","article-title":"Comprehensive Genetic Characterization of Human Thyroid Cancer Cell Lines: A Validated Panel for Preclinical Studies","volume":"25","author":"Landa","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/j.1365-2265.2009.03699.x","article-title":"The tight relationship between papillary thyroid cancer, autoimmunity and inflammation: Clinical and molecular studies","volume":"72","author":"Muzza","year":"2010","journal-title":"Clin. Endocrinol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1054\/bjoc.2001.2187","article-title":"Papillary thyroid carcinoma: 6 cases from 2 families with associated lymphocytic thyroiditis harbouring RET\/PTC rearrangements","volume":"85","author":"Mechler","year":"2001","journal-title":"Br. J. Cancer"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1089\/thy.2007.0035","article-title":"High prevalence of RET, RAS, and ERK expression in Hashimoto\u2019s thyroiditis and in papillary thyroid carcinoma in the Korean population","volume":"17","author":"Kang","year":"2007","journal-title":"Thyroid"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/106689690201000104","article-title":"Prevalence of RET\/PTC rearrangements in Hashimoto\u2019s thyroiditis and papillary thyroid carcinomas","volume":"10","author":"Nikiforova","year":"2002","journal-title":"Int. J. Surg. Pathol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s12022-009-9101-3","article-title":"Absence of BRAF, NRAS, KRAS, HRAS mutations, and RET\/PTC gene rearrangements distinguishes dominant nodules in Hashimoto thyroiditis from papillary thyroid carcinomas","volume":"21","author":"Sadow","year":"2010","journal-title":"Endocr. Pathol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"801925","DOI":"10.3389\/fendo.2022.801925","article-title":"Hashimoto\u2019s Thyroiditis: A \u201cDouble-Edged Sword\u201d in Thyroid Carcinoma","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Endocrinol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1089\/thy.2013.0036","article-title":"Clinicopathologic implications of the BRAF(V600E) mutation in papillary thyroid cancer: A subgroup analysis of 3130 cases in a single center","volume":"23","author":"Lim","year":"2013","journal-title":"Thyroid"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1530\/ERC-13-0291","article-title":"Is BRAFV600E mutation a marker for central nodal metastasis in small papillary thyroid carcinoma?","volume":"21","author":"Lang","year":"2014","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s10147-014-0754-7","article-title":"Does papillary thyroid carcinoma have a better prognosis with or without Hashimoto thyroiditis?","volume":"20","author":"Kwak","year":"2015","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/hed.23854","article-title":"Combined effect of Hashimoto\u2019s thyroiditis and BRAF(V600E) mutation status on aggressiveness in papillary thyroid cancer","volume":"38","author":"Kim","year":"2016","journal-title":"Head Neck"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s12253-019-00580-w","article-title":"Thyroid Carcinoma Coexisting with Hashimoto\u2019s Thyreoiditis: Clinicopathological and Molecular Characteristics Clue up Pathogenesis","volume":"25","author":"Bedekovics","year":"2019","journal-title":"Pathol. Oncol. Res."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"E1019","DOI":"10.1002\/hed.24149","article-title":"Potential relationship between Hashimoto\u2019s thyroiditis and BRAF(V600E) mutation status in papillary thyroid cancer","volume":"38","author":"Zeng","year":"2016","journal-title":"Head Neck"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1016\/j.ijsu.2015.12.059","article-title":"Coexistence of chronic lymphocytic thyroiditis and papillary thyroid carcinoma. Impact on presentation, management, and outcome","volume":"28","author":"Dobrinja","year":"2016","journal-title":"Int. J. Surg."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S0046-8177(03)00239-9","article-title":"Expression of p63 in papillary thyroid carcinoma and in Hashimoto\u2019s thyroiditis: A pathobiologic link?","volume":"34","author":"Unger","year":"2003","journal-title":"Hum. Pathol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1210\/en.2006-0921","article-title":"RET\/PTC rearrangements and BRAF mutations in thyroid tumorigenesis","volume":"148","author":"Ciampi","year":"2007","journal-title":"Endocrinology"},{"key":"ref_173","first-page":"1044","article-title":"Molecular genotyping in refractory thyroid cancers in 2021: When, how and why? A review from the TUTHYREF network","volume":"108","author":"Wassermann","year":"2021","journal-title":"Bull. Cancer"},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Busaidy, N., Konda, B., Wei, L., Wirth, L.J., Devine, C., Daniels, G.A., DeSouza, J.A., Poi, M., Seligson, N.D., and Cabanillas, M. (2022). Dabrafenib vs dabrafenib + trametinib in BRAF-mutated radioactive iodine refractory differentiated thyroid cancer\u2014Results of a randomized, phase 2, open-label, multicenter trial. Thyroid.","DOI":"10.1089\/thy.2022.0115"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.3892\/ol.2017.6395","article-title":"Aggressive differentiated thyroid cancer with multiple metastases and NRAS and TERT promoter mutations: A case report","volume":"14","author":"Pani","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/nyas.14526","article-title":"Frontiers in cancer immunotherapy-a symposium report","volume":"1489","author":"Cable","year":"2021","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"eaax0182","DOI":"10.1126\/science.aax0182","article-title":"Neoadjuvant checkpoint blockade for cancer immunotherapy","volume":"367","author":"Topalian","year":"2020","journal-title":"Science"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1056\/NEJMoa1200690","article-title":"Safety, activity, and immune correlates of anti-PD-1 antibody in cancer","volume":"366","author":"Topalian","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1073\/pnas.1016791108","article-title":"Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance","volume":"108","author":"Pedicord","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1126\/science.271.5256.1734","article-title":"Enhancement of antitumor immunity by CTLA-4 blockade","volume":"271","author":"Leach","year":"1996","journal-title":"Science"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.3390\/curroncol29050247","article-title":"Immune Checkpoint Inhibitors in Cancer Therapy","volume":"29","author":"Shiravand","year":"2022","journal-title":"Curr. Oncol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"E934","DOI":"10.1210\/jc.2011-3428","article-title":"Programmed death-1+ T cells and regulatory T cells are enriched in tumor-involved lymph nodes and associated with aggressive features in papillary thyroid cancer","volume":"97","author":"French","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1158\/2326-6066.CIR-14-0201","article-title":"PD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid Cancer","volume":"3","author":"Severson","year":"2015","journal-title":"Cancer Immunol. Res."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41574-020-0398-9","article-title":"Immunotherapy for advanced thyroid cancers\u2014Rationale, current advances and future strategies","volume":"16","author":"French","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"R41","DOI":"10.1530\/EJE-20-0283","article-title":"THERAPY OF ENDOCRINE DISEASE Immunotherapy of advanced thyroid cancer: From bench to bedside","volume":"183","author":"Moretti","year":"2020","journal-title":"Eur. J. Endocrinol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s40425-019-0698-6","article-title":"Immune microenvironment modulation unmasks therapeutic benefit of radiotherapy and checkpoint inhibition","volume":"7","author":"Newton","year":"2019","journal-title":"J. Immunother. Cancer"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.aan3706","article-title":"Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors","volume":"359","author":"Routy","year":"2018","journal-title":"Science"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00262-019-02318-8","article-title":"Autoimmune genetic risk variants as germline biomarkers of response to melanoma immune-checkpoint inhibition","volume":"68","author":"Chat","year":"2019","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"19075","DOI":"10.1073\/pnas.0509603102","article-title":"The role of microRNA genes in papillary thyroid carcinoma","volume":"102","author":"He","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/17\/4287\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:22:04Z","timestamp":1760142124000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/17\/4287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":189,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["cancers14174287"],"URL":"https:\/\/doi.org\/10.3390\/cancers14174287","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,1]]}}}