{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:46:52Z","timestamp":1792118812330,"version":"4.4.0"},"reference-count":49,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Radical prostatectomy is considered the gold-standard treatment for patients with localized prostate cancer. The literature suggests there is no difference in oncological and functional outcomes between robotic-assisted radical prostatectomy (RARP) and open (RRP). (2) Methods: The aim of this study was to compare continence recovery rates after RARP and RRP measured with 24 h pad weights and the International Consultation on Incontinence Questionnaire\u2014Short Form (ICIQ-SF). After matching the population (1:1), 482 met the inclusion criteria, 241 patients per group. Continent patients with a 24 h pad test showing &lt;20 g of urinary leakage were considered, despite severe incontinence, and categorized as having &gt;200 g of urinary leakage. (3) Results: There was no difference between preoperative data. As for urinary continence (UC) and incontinence (UI) rates, RARP performed significantly better than RRP based on objective and subjective results at all evaluations. Univariable and multivariable Cox Regression Analysis pointed out that the only significant predictors of continence rates were the bilateral nerve sparing technique (1.25 (CI 1.02,1.54), p = 0.03) and the robotic surgical approach (1.42 (CI 1.18,1.69) p \u2264 0.001). (4) Conclusions: The literature reports different incidences of UC depending on assessment and definition of continence \u201cwithout pads\u201d or \u201csocial continence\u201d based on number of used pads per day. In this, our first evaluation, the advantage of objective measurement through the weight of the 24 h and subjective measurement with the ICIQ-SF questionnaire best demonstrates the difference between the two surgical techniques by enhancing the use of robotic surgery over traditional surgery.<\/jats:p>","DOI":"10.3390\/cancers14184350","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T01:51:57Z","timestamp":1662515517000},"page":"4350","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A Matched-Pair Analysis after Robotic and Retropubic Radical Prostatectomy: A New Definition of Continence and the Impact of Different Surgical Techniques"],"prefix":"10.3390","volume":"14","author":[{"given":"Nicola","family":"d\u2019Altilia","sequence":"first","affiliation":[{"name":"Department of Urology and Renal Transplantation, Policlinico Riuniti di Foggia, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Mancini","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation, Policlinico Riuniti di Foggia, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugo Giovanni","family":"Falagario","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation, Policlinico Riuniti di Foggia, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Martino","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation, Policlinico Riuniti di Foggia, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Di Nauta","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation, Policlinico Riuniti di Foggia, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beppe","family":"Cal\u00f2","sequence":"additional","affiliation":[{"name":"Department of Urology, Bonomo Teaching Hospital, 76123 Andria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3865-5988","authenticated-orcid":false,"given":"Francesco","family":"Del Giudice","sequence":"additional","affiliation":[{"name":"Department of Urology, Sapienza Rome University, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satvir","family":"Basran","sequence":"additional","affiliation":[{"name":"Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin I.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Porreca","sequence":"additional","affiliation":[{"name":"Oncological Urology, Veneto Institute of Oncology (IOV), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 37138 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7321-1536","authenticated-orcid":false,"given":"Lorenzo","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Schiavina","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Brunocilla","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7291-0316","authenticated-orcid":false,"given":"Gian Maria","family":"Busetto","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation, Policlinico Riuniti di Foggia, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Bettocchi","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation, Policlinico Riuniti di Foggia, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Annese","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation, Policlinico Riuniti di Foggia, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Cormio","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation, Policlinico Riuniti di Foggia, University of Foggia, 71122 Foggia, Italy"},{"name":"Department of Urology, Bonomo Teaching Hospital, 76123 Andria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Carrieri","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation, Policlinico Riuniti di Foggia, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.eururo.2020.09.042","article-title":"EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent","volume":"79","author":"Mottet","year":"2021","journal-title":"Eur. Urol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.euf.2018.10.002","article-title":"The Past, the Present, and the Future of Robotic Urology: Robot-assisted Surgery and Human-assisted Robots","volume":"4","author":"Mottrie","year":"2018","journal-title":"Eur. Urol. Focus"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1007\/s00268-016-3543-9","article-title":"30 Years of Robotic Surgery","volume":"40","year":"2016","journal-title":"World J. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0140-6736(16)30592-X","article-title":"Robot-assisted laparoscopic prostatectomy versus open radical retropubic prostatectomy: Early outcomes from a randomised controlled phase 3 study","volume":"388","author":"Yaxley","year":"2016","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S1470-2045(18)30357-7","article-title":"Robot-assisted laparoscopic prostatectomy versus open radical retropubic prostatectomy: 24-month outcomes from a randomised controlled study","volume":"19","author":"Coughlin","year":"2018","journal-title":"Lancet Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.eururo.2012.05.046","article-title":"Systematic review and meta-analysis of studies reporting potency rates after robot-assisted radical prostatectomy","volume":"62","author":"Ficarra","year":"2012","journal-title":"Eur. Urol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.eururo.2012.05.045","article-title":"Systematic review and meta-analysis of studies reporting urinary continence recovery after robot-assisted radical prostatectomy","volume":"62","author":"Ficarra","year":"2012","journal-title":"Eur. Urol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"728","DOI":"10.4103\/1008-682X.128515","article-title":"The surgical learning curve for robotic-assisted laparoscopic radical prostatectomy: Experience of a single surgeon with 500 cases in Taiwan, China","volume":"16","author":"Ou","year":"2014","journal-title":"Asian J. Androl."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e2551","DOI":"10.1097\/MD.0000000000002551","article-title":"Absence of Bladder Outlet Obstruction Is an Independent Risk Factor for Prostate Cancer in Men Undergoing Prostate Biopsy","volume":"95","author":"Cormio","year":"2016","journal-title":"Medicine"},{"key":"ref_10","first-page":"2175","article-title":"Post-void residual urinary volume is an independent predictor of biopsy results in men at risk for prostate cancer","volume":"35","author":"Cormio","year":"2015","journal-title":"Anticancer Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3389\/fonc.2018.00438","article-title":"Development and Internal Validation of Novel Nomograms Based on Benign Prostatic Obstruction-Related Parameters to Predict the Risk of Prostate Cancer at First Prostate Biopsy","volume":"16","author":"Cormio","year":"2018","journal-title":"Front. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1016\/S0022-5347(01)62202-X","article-title":"Anatomic radical prostatectomy: Evolution of the surgical technique","volume":"160","author":"Walsh","year":"1998","journal-title":"J. Urol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1097\/01.ju.0000067464.53313.dd","article-title":"Vattikuti Institute prostatectomy: Technique","volume":"169","author":"Menon","year":"2003","journal-title":"J. Urol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.eururo.2020.07.017","article-title":"Contemporary Techniques of Prostate Dissection for Robot-assisted Prostatectomy","volume":"78","author":"Martini","year":"2020","journal-title":"Eur. Urol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"746","DOI":"10.23736\/S0393-2249.20.03688-7","article-title":"Performance of prostate multiparametric MRI for prediction of prostate cancer extra-prostatic extension according to NCCN risk categories: Implication for surgical planning","volume":"72","author":"Falagario","year":"2020","journal-title":"Minerva Urol. Nefrol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"502","DOI":"10.23736\/S0393-2249.19.03370-8","article-title":"Clinical implications of prostatic capsular abutment or bulging on multiparametric magnetic resonance imaging","volume":"71","author":"Martini","year":"2019","journal-title":"Minerva Urol. Nefrol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e201913","DOI":"10.1001\/jamanetworkopen.2020.1913","article-title":"Estimated Costs Associated with Radiation Therapy for Positive Surgical Margins During Radical Prostatectomy","volume":"3","author":"Martini","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.eururo.2006.10.014","article-title":"Posterior reconstruction of the rhabdosphincter allows a rapid recovery of continence after transperitoneal videolaparoscopic radical prostatectomy","volume":"51","author":"Rocco","year":"2007","journal-title":"Eur. Urol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e1918911","DOI":"10.1001\/jamanetworkopen.2019.18911","article-title":"Trends in the Adoption of Robotic Surgery for Common Surgical Procedures","volume":"3","author":"Sheetz","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.eururo.2015.02.029","article-title":"Urinary Incontinence and Erectile Dysfunction after Robotic Versus Open Radical Prostatectomy: A Prospective, Controlled, Nonrandomised Trial","volume":"68","author":"Haglind","year":"2015","journal-title":"Eur. Urol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.eururo.2011.05.011","article-title":"Factors determining functional outcomes after radical prostatectomy: Robot-assisted versus retropubic","volume":"60","author":"Kim","year":"2011","journal-title":"Eur. Urol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/ans.16491","article-title":"Surgeon case volume and continence recovery following radical prostatectomy: A systematic review","volume":"91","author":"Trieu","year":"2021","journal-title":"ANZ J. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1586\/era.10.35","article-title":"Robotic-assisted radical prostatectomy in 2010","volume":"10","author":"Singh","year":"2010","journal-title":"Expert Rev. Anticancer Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.eururo.2011.01.032","article-title":"Pentafecta: A new concept for reporting outcomes of robot-assisted laparoscopic radical prostatectomy","volume":"59","author":"Patel","year":"2011","journal-title":"Eur. Urol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1464-410X.2009.08419.x","article-title":"A prospective, non-randomized trial comparing robot-assisted laparoscopic and retropubic radical prostatectomy in one European institution","volume":"104","author":"Ficarra","year":"2009","journal-title":"BJU Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eururo.2010.10.026","article-title":"A prospective trial comparing consecutive series of open retropubic and robot-assisted laparoscopic radical prostatectomy in a centre with a limited caseload","volume":"59","author":"Baumeister","year":"2011","journal-title":"Eur. Urol."},{"key":"ref_27","first-page":"1637","article-title":"Comparison of robotic-assisted versus retropubic radical prostatectomy performed by a single surgeon","volume":"29","author":"Ou","year":"2009","journal-title":"Anticancer Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.3349\/ymj.2016.57.5.1165","article-title":"Comparison of Robot-Assisted Radical Prostatectomy and Open Radical Prostatectomy Outcomes: A Systematic Review and Meta-Analysis","volume":"57","author":"Seo","year":"2016","journal-title":"Yonsei Med. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"32237","DOI":"10.18632\/oncotarget.13332","article-title":"Robotic vs. Retropubic radical prostatectomy in prostate cancer: A systematic review and an meta-analysis update","volume":"8","author":"Tang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e15770","DOI":"10.1097\/MD.0000000000015770","article-title":"Robot-assisted and laparoscopic vs open radical prostatectomy in clinically localized prostate cancer: Perioperative, functional, and oncological outcomes: A Systematic review and meta-analysis","volume":"98","author":"Cao","year":"2019","journal-title":"Medicine"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1464-410X.2008.08012.x","article-title":"Radical prostatectomy for prostatic adenocarcinoma: A matched comparison of open retropubic and robot-assisted techniques","volume":"103","author":"Krambeck","year":"2009","journal-title":"BJU Int."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.juro.2014.03.031","article-title":"Correlation of patient perception of pad use with objective degree of incontinence measured by pad test in men with post-prostatectomy incontinence: The SUFU Pad Test Study","volume":"192","author":"Nitti","year":"2014","journal-title":"J. Urol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Holze, S., Mende, M., Healy, K.V., Koehler, N., Gansera, L., Truss, M.C., Rebmann, U., Degener, S., and Stolzenburg, J.U. (2019). Comparison of various continence definitions in a large group of patients undergoing radical prostatectomy: A multicentre, prospective study. BMC Urol., 19.","DOI":"10.1186\/s12894-019-0500-6"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/01.WON.0000270821.91694.56","article-title":"Urinary incontinence after radical prostatectomy: Can men at risk be identified preoperatively?","volume":"34","author":"Moore","year":"2007","journal-title":"J. Wound Ostomy Cont. Nurs."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00192-004-1123-2","article-title":"Comparison of the ICIQ-SF and 24-hour pad test with other measures for evaluating the severity of urodynamic stress incontinence","volume":"15","author":"Karantanis","year":"2004","journal-title":"Int. Urogynecol. J. Pelvic Floor Dysfunct."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1464-410X.2010.09159.x","article-title":"The recovery of urinary continence after radical retropubic prostatectomy: A randomized trial comparing the effect of physiotherapist-guided pelvic floor muscle exercises with guidance by an instruction folder only","volume":"106","author":"Dubbelman","year":"2010","journal-title":"BJU Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.21037\/tau.2017.04.11","article-title":"An objective measurement of urinary continence recovery with pelvic floor physiotherapy following robotic assisted radical prostatectomy","volume":"6","author":"Sathianathen","year":"2017","journal-title":"Transl. Androl. Urol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/nau.20840","article-title":"Outcome measure for stress urinary incontinence treatment (OMIT): Results of two society of urodynamics and female urology (SUFU) surveys","volume":"29","author":"Zimmern","year":"2010","journal-title":"Neurourol. Urodyn."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/1520-6777(1994)13:3<261::AID-NAU1930130308>3.0.CO;2-T","article-title":"Twenty-four hour pad weighing test: Reproducibility and dependency of activity level and fluid intake","volume":"13","author":"Rasmussen","year":"1994","journal-title":"Neurourol. Urodyn."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1590\/S1677-5538.IBJU.2014.0506","article-title":"Assessing variability of the 24-hour pad weight test in men with post-prostatectomy incontinence","volume":"42","author":"Malik","year":"2016","journal-title":"Int. Braz. J. Urol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.juro.2010.04.069","article-title":"Evaluating urinary continence and preoperative predictors of urinary continence after robot assisted laparoscopic radical prostatectomy","volume":"184","author":"Novara","year":"2010","journal-title":"J. Urol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.juro.2010.01.016","article-title":"Robotic radical prostatectomy for elderly patients: Probability of achieving continence and potency 1 year after surgery","volume":"183","author":"Shikanov","year":"2010","journal-title":"J. Urol."},{"key":"ref_43","first-page":"168","article-title":"Elderly patients are not at higher risk of urinary incontinence after radical prostatectomy","volume":"66","author":"Falagario","year":"2018","journal-title":"JGG"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00345-013-1127-y","article-title":"Development and validation of nomograms to predict the recovery of urinary continence after radical prostatectomy: Comparisons between immediate, early, and late continence","volume":"32","author":"Jeong","year":"2014","journal-title":"World J. Urol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/bju.12407","article-title":"Functional and oncological outcomes of patients aged <50 years treated with radical prostatectomy for localised prostate cancer in a European population","volume":"114","author":"Becker","year":"2014","journal-title":"BJU Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.eururo.2015.07.037","article-title":"Nerve-sparing Surgery Technique, Not the Preservation of the Neurovascular Bundles, Leads to Improved Long-term Continence Rates After Radical Prostatectomy","volume":"69","author":"Michl","year":"2016","journal-title":"Eur. Urol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.acuro.2019.06.003","article-title":"Early continence after radical prostatectomy: A systematic review","volume":"43","author":"Salazar","year":"2019","journal-title":"Actas Urol. Esp."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.eururo.2014.10.020","article-title":"Preservation of the neurovascular bundles is associated with improved time to continence after radical prostatectomy but not long-term continence rates: Results of a systematic review and meta-analysis","volume":"68","author":"Reeves","year":"2015","journal-title":"Eur. Urol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.eururo.2014.10.011","article-title":"Degree of preservation of the neurovascular bundles during radical prostatectomy and urinary continence 1 year after surgery","volume":"67","author":"Steineck","year":"2015","journal-title":"Eur. Urol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/18\/4350\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:24:37Z","timestamp":1760142277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/18\/4350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,7]]},"references-count":49,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["cancers14184350"],"URL":"https:\/\/doi.org\/10.3390\/cancers14184350","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,7]]}}}