{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:44:57Z","timestamp":1789472697601,"version":"build-2803163510"},"reference-count":46,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cancer Institute New South Wales","award":["2020\/TPG1081"],"award-info":[{"award-number":["2020\/TPG1081"]}]},{"name":"Sydney Local Health District","award":["2020\/TPG1081"],"award-info":[{"award-number":["2020\/TPG1081"]}]},{"name":"Royal Australasian College of Surgeons","award":["2020\/TPG1081"],"award-info":[{"award-number":["2020\/TPG1081"]}]},{"name":"Lang Walker Family Foundation","award":["2020\/TPG1081"],"award-info":[{"award-number":["2020\/TPG1081"]}]},{"name":"Chris O\u2019Brien Lifehouse","award":["2020\/TPG1081"],"award-info":[{"award-number":["2020\/TPG1081"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Long-term health-related quality of life (HRQOL) and functional outcomes following mandibular and maxillary reconstruction are lacking. To determine these outcomes, a cross-sectional study of patients with a history of cancer who underwent jaw reconstruction was undertaken. Participants were identified from a database of jaw reconstruction procedures at the Chris O\u2019Brien Lifehouse (Sydney, Australia). Eligible patients had at least one month follow-up, were aged \u226518 years at surgery, and had history of malignancy. HRQOL was measured using the FACE-Q Head and Neck Cancer Module (FACE-Q H&amp;N). Functional outcomes were measured using the FACE-Q H&amp;N, MD Anderson Dysphagia Inventory (MDADI) and Speech Handicap Index (SHI). Ninety-seven questionnaires were completed (62% response rate). Mean age of respondents was 63.7 years, 61% were male, and 64% underwent radiotherapy. Treatment with radiotherapy was associated with worse outcomes across 10\/14 FACE-Q H&amp;N scales, three MDADI subscales and one composite score, and the SHI. Mean differences in scores between irradiated and non-irradiated patients exceeded clinically meaningful differences for the MDADI and SHI. Issues with oral competence, saliva, speaking, and swallowing worsened with increasing time since surgery. Younger patients reported greater concerns with appearance, smiling, speaking, and cancer worry. Women reported greater concerns regarding appearance and associated distress. History of radiotherapy substantially impacts HRQOL and function after jaw reconstruction. Age at surgery and gender were also predictors of outcomes and associated distress. Pre-treatment counselling of patients requiring jaw reconstruction may lead to improved survivorship for patients with head and neck cancer.<\/jats:p>","DOI":"10.3390\/cancers14194557","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T21:12:53Z","timestamp":1663708373000},"page":"4557","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effect of Radiotherapy on Functional and Health-Related Quality of Life Outcomes after Jaw Reconstruction"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6493-7933","authenticated-orcid":false,"given":"Rebecca L.","family":"Venchiarutti","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery, Chris O\u2019Brien Lifehouse, 119-143 Missenden Road, Camperdown, NSW 2050, Australia"},{"name":"Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Dunn","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Chris O\u2019Brien Lifehouse, 119-143 Missenden Road, Camperdown, NSW 2050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Charters","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Chris O\u2019Brien Lifehouse, 119-143 Missenden Road, Camperdown, NSW 2050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Chris O\u2019Brien Lifehouse, 119-143 Missenden Road, Camperdown, NSW 2050, Australia"},{"name":"Royal Prince Alfred Institute of Academic Surgery, Sydney Local Health District, 145 Missenden Road, Camperdown, NSW 2050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6393-9531","authenticated-orcid":false,"given":"Catriona","family":"Froggatt","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Chris O\u2019Brien Lifehouse, 119-143 Missenden Road, Camperdown, NSW 2050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payal","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Chris O\u2019Brien Lifehouse, 119-143 Missenden Road, Camperdown, NSW 2050, Australia"},{"name":"Royal Prince Alfred Institute of Academic Surgery, Sydney Local Health District, 145 Missenden Road, Camperdown, NSW 2050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Chris O\u2019Brien Lifehouse, 119-143 Missenden Road, 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of Medicine and Health, The University of Sydney, Camperdown, NSW 2006, Australia"},{"name":"Department of Otolaryngology\u2014Head & Neck Surgery, Faculty of Medicine and Health Sciences, Macquarie University, Macquarie Park, NSW 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4011-1253","authenticated-orcid":false,"given":"Sydney","family":"Ch\u2019ng","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Chris O\u2019Brien Lifehouse, 119-143 Missenden Road, Camperdown, NSW 2050, Australia"},{"name":"Royal Prince Alfred Institute of Academic Surgery, Sydney Local Health District, 145 Missenden Road, Camperdown, NSW 2050, Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2006, Australia"},{"name":"Department of Plastic Surgery, Royal Prince Alfred Hospital, 50 Missenden Road, Camperdown, NSW 2050, 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