{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:15:23Z","timestamp":1792624523333,"version":"4.5.0"},"reference-count":42,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Ameloblastoma is a rare, benign, odontogenic tumor of epithelial origin, characterized by locally aggressive, expansive growth. Treatment is controversial due to the risk of relapse. The aim of this multicenter retrospective study was to evaluate the effectiveness of complete resection in cases of complex ameloblastoma, which is considered at a higher risk of recurrence. Patients who met at least one of these criteria were included: recurrence, soft-tissue involvement, complete erosion of internal\/external cortical walls with involvement of the inferior margin of the mandible, and invasion of the maxillary sinus or nasal cavity. Demographic data, tumor site, type of surgery, histological features, and follow-up information were collected for each patient. The cohort included 55 patients with a mean follow-up of 108 \u00b1 66 months. A multivariate logistic model was used to evaluate variables independently associated with relapse. There were six soft-tissue or maxillary sinus relapses, with a recurrence rate of 10.9%. Most of them arose in patients previously treated. The statistical analysis identified the maxillary location as a fundamental relapse risk factor. En bloc resection with large surgical safety margins seemed to be effective in preventing the relapses. However, complete resection was less effective in preventing recurrences in the soft tissues or maxillary sinus.<\/jats:p>","DOI":"10.3390\/cancers14194608","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T21:10:05Z","timestamp":1663881005000},"page":"4608","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness of Resective Surgery in Complex Ameloblastoma of the Jaws: A Retrospective Multicenter Observational Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6281-5307","authenticated-orcid":false,"given":"Davide","family":"Sozzi","sequence":"first","affiliation":[{"name":"Maxillofacial Surgery Unit, ASST Monza\u2014San Gerardo Hospital, 20900 Monza, Italy"},{"name":"Department of Medicine and Surgery, School of Medicine and Surgery, University of Milano Bicocca, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6647-504X","authenticated-orcid":false,"given":"Andrea","family":"Cassoni","sequence":"additional","affiliation":[{"name":"Oncological and Reconstructive Maxillofacial Surgery Unit, Policlinico Umberto I of Rome, 00161 Rome, Italy"},{"name":"Department of Oral Maxillofacial Sciences, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"De Ponti","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, ASST Monza\u2014San Gerardo Hospital, University of Milano Bicocca, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Moretti","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgery Unit, ASST Monza\u2014San Gerardo Hospital, 20900 Monza, Italy"},{"name":"Postgraduate School of Maxillofacial Surgery, University of Milan, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6237-2334","authenticated-orcid":false,"given":"Resi","family":"Pucci","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillofacial Sciences, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Spadoni","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgery Unit, ASST Santi Paolo e Carlo\u2014Ospedale San Paolo, 20142 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2513-369X","authenticated-orcid":false,"given":"Gabriele","family":"Canzi","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgery Unit, Emergency Department, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2357-6726","authenticated-orcid":false,"given":"Giorgio","family":"Novelli","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgery Unit, ASST Monza\u2014San Gerardo Hospital, 20900 Monza, Italy"},{"name":"Department of Medicine and Surgery, School of Medicine and Surgery, University of Milano Bicocca, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentino","family":"Valentini","sequence":"additional","affiliation":[{"name":"Oncological and Reconstructive Maxillofacial Surgery Unit, Policlinico Umberto I of Rome, 00161 Rome, Italy"},{"name":"Department of Oral Maxillofacial Sciences, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/odi.13031","article-title":"Global incidence and profile of ameloblastoma: A systematic review and meta-analysis","volume":"26","author":"Hendra","year":"2020","journal-title":"Oral Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/1117-1936.180909","article-title":"Clinicopathological study of 100 Nigerian cases of ameloblastoma","volume":"15","author":"Odukoya","year":"2008","journal-title":"Niger. 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