{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:17:04Z","timestamp":1791890224008,"version":"4.3.4"},"reference-count":189,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Far Eastern Memorial Hospital, Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["PI20190001"],"award-info":[{"award-number":["PI20190001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Far Eastern Memorial Hospital, Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["FEMH 110-2314-B-418-006"],"award-info":[{"award-number":["FEMH 110-2314-B-418-006"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Far Eastern Memorial Hospital, Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 110-2314-B-418-006"],"award-info":[{"award-number":["MOST 110-2314-B-418-006"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Image-guided radiotherapy (IGRT) is an advanced auxiliary radiotherapy technique. During cancer treatment, patients with oral cavity cancer (OCC) experience not only disease but also adverse effects due to RT. IGRT provides the relevant advantages of RT by precisely delivering tumoricidal doses via real-time knowledge of the target volume location and achieves maximal tumor control with minimal complications as recommended for cancer treatment. Additionally, studies have shown that IGRT can improve clinical outcomes in terms of not only treatment side effects but also survival benefits for cancer patients. IGRT can be performed alongside various imaging methods, including computed tomography and magnetic resonance imaging, and at different times during the radiotherapy regimen. This article reviews the literature to discuss the effects and importance of IGRT for patients with OCC, examines the rationale underlying the advantages of IGRT, discusses the limitations of IGRT with respect to different techniques, and summarizes the strategies and future prospects of IGRT in the treatment of OCC.<\/jats:p>","DOI":"10.3390\/cancers14194630","type":"journal-article","created":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T21:14:28Z","timestamp":1664140468000},"page":"4630","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Advances in Image-Guided Radiotherapy in the Treatment of Oral Cavity Cancer"],"prefix":"10.3390","volume":"14","author":[{"given":"Hsin-Hua","family":"Nien","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Cathay General Hospital, Taipei 106, Taiwan"},{"name":"School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei 100, Taiwan"},{"name":"Physical Therapy Center, National Taiwan University Hospital, Taipei 100, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-1597","authenticated-orcid":false,"given":"Li-Jen","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Head and Neck Cancer Surveillance and Research Group, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Department of Electrical Engineering, Yuan Ze University, Taoyuan 320, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Head and Neck Cancer Surveillance and Research Group, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yun","family":"Wu","sequence":"additional","affiliation":[{"name":"Head and Neck Cancer Surveillance and Research Group, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Division of Oncology and Hematology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2051-364X","authenticated-orcid":false,"given":"Pei-Wei","family":"Shueng","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9224-4958","authenticated-orcid":false,"given":"Chen-Shuan","family":"Chung","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan"},{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Ultrasonography and Endoscopy Center, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu-Chia","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Head and Neck Cancer Surveillance and Research Group, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Graduate Institute of Medicine, Yuan Ze University, Taoyuan 320, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Chiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Head and Neck Cancer Surveillance and Research Group, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Division of Oncology and Hematology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"General Education Center, Lunghwa University of Science and Technology, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0279-4695","authenticated-orcid":false,"given":"Chen-Hsi","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Head and Neck Cancer Surveillance and Research Group, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan"},{"name":"Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Institute of Traditional Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21654","article-title":"Cancer Statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J. 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