{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:05:39Z","timestamp":1778864739412,"version":"3.51.4"},"reference-count":127,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil (CAPES)","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Uterine or endometrial cancer (EC) is the sixth most common neoplasia among women worldwide. Cancer can originate from a myriad of causes, and increasing evidence suggests that ion channels (IC) play an important role in the process of carcinogenesis, taking part in many pathways such as self-sufficiency in growth signals, proliferation, evasion of programmed cell death (apoptosis), angiogenesis, cell differentiation, migration, adhesion, and metastasis. Hormones and growth factors are well-known to be involved in the development and\/or progression of many cancers and can also regulate some ion channels and pumps. Since the endometrium is responsive and regulated by these factors, the ICs could make an important contribution to the development and progression of endometrial cancer. In this review, we explore what is beyond (ion) flow regulation by investigating the role of the main families of ICs in EC, including as possible targets for EC treatment.<\/jats:p>","DOI":"10.3390\/cancers14194733","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T20:58:47Z","timestamp":1664398727000},"page":"4733","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ion Channels in Endometrial Cancer"],"prefix":"10.3390","volume":"14","author":[{"given":"Bruna Pasqualotto","family":"Costa","sequence":"first","affiliation":[{"name":"Laboratory fo Cellular, Molecular and Computational Biophysics, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil"},{"name":"Graduate Program in Pathology, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Bordignon","family":"Nunes","sequence":"additional","affiliation":[{"name":"Laboratory fo Cellular, Molecular and Computational Biophysics, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil"},{"name":"Graduate Program in Pathology, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francini Corr\u00eaa","family":"Noal","sequence":"additional","affiliation":[{"name":"Laboratory fo Cellular, Molecular and Computational Biophysics, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil"},{"name":"Graduate Program in Pathology, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2524-8603","authenticated-orcid":false,"given":"Gisele","family":"Branchini","sequence":"additional","affiliation":[{"name":"Laboratory fo Cellular, Molecular and Computational Biophysics, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil"},{"name":"Graduate Program in Pathology, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"ref_1","unstructured":"WHO (2022, July 17). World Health Organization Fact Sheets: Cancer 2018. Available online: https:\/\/www.who.int\/health-topics\/cancer#tab=tab_1."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S0140-6736(15)00130-0","article-title":"Endometrial Cancer","volume":"387","author":"Morice","year":"2016","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijgo.2009.02.012","article-title":"Revised FIGO Staging for Carcinoma of the Vulva, Cervix, and Endometrium","volume":"105","author":"Pecorelli","year":"2009","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1245\/s10434-010-0985-4","article-title":"The American Joint Committee on Cancer: The 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM","volume":"17","author":"Edge","year":"2010","journal-title":"Ann. Surg. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/s41568-019-0177-x","article-title":"Clinical Actionability of Molecular Targets in Endometrial Cancer","volume":"19","author":"Urick","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of Cancer: The Next Generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1006\/gyno.1999.5580","article-title":"Endometrial Intraepithelial Neoplasia (EIN): Will It Bring Order to Chaos?","volume":"76","author":"Mutter","year":"2000","journal-title":"Gynecol. Oncol."},{"key":"ref_9","first-page":"232","article-title":"New Concepts for an Old Problem: The Diagnosis of Endometrial Hyperplasia","volume":"23","author":"Sanderson","year":"2017","journal-title":"Hum. Reprod. Update"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1097\/AOG.0b013e31826bb121","article-title":"Management of Endometrial Precancers","volume":"120","author":"Trimble","year":"2012","journal-title":"Obstet. Gynecol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/his.12053","article-title":"Molecular Pathology of Endometrial Carcinoma","volume":"62","author":"Prat","year":"2013","journal-title":"Histopathology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1158\/1055-9965.EPI-13-0298","article-title":"Oral Contraceptive Use and Risk of Breast, Cervical, Colorectal, and Endometrial Cancers: A Systematic Review","volume":"22","author":"Gierisch","year":"2013","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_13","first-page":"1531","article-title":"Obesity, Endogenous Hormones, and Endometrial Cancer Risk: A Synthetic Review","volume":"11","author":"Kaaks","year":"2002","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"14243","DOI":"10.1038\/srep14243","article-title":"Parity and Endometrial Cancer Risk: A Meta-Analysis of Epidemiological Studies","volume":"5","author":"Wu","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1002\/ijc.27457","article-title":"Incidence Rates of Endometrial Hyperplasia, Endometrial Cancer and Hysterectomy from 1980 to 2003 within a Large Prepaid Health Plan","volume":"131","author":"Lacey","year":"2012","journal-title":"Int. J. Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1517\/14656566.2016.1127351","article-title":"An Update on the Current Pharmacotherapy for Endometrial Cancer","volume":"17","author":"Black","year":"2016","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_17","unstructured":"Howlader, N., Noone, A., Krapcho, M., Miller, D., Brest, A., Yu, M., Ruhl, J., Tatalovich, Z., Mariotto, A., and Lewis, D. (2019). SEER Cancer Statistics Review, 1975\u20132016, National Cancer Institute."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.ygyno.2006.02.011","article-title":"Follow-up after Primary Therapy for Endometrial Cancer: A Systematic Review","volume":"101","author":"Dodge","year":"2006","journal-title":"Gynecol. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1097\/IGC.0b013e3182169239","article-title":"Adjuvant Chemotherapy for Endometrial Cancer","volume":"21","author":"Tangjitgamol","year":"2011","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1200\/JCO.2007.10.8431","article-title":"Systemic Chemotherapy for Uterine Carcinoma: Metastatic and Adjuvant","volume":"25","author":"Fleming","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3389\/fonc.2019.00359","article-title":"Anti-Estrogen Treatment in Endometrial Cancer: A Systematic Review","volume":"9","author":"Massuger","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Eritja, N., Yeramian, A., Chen, B.-J., Llobet-Navas, D., Ortega, E., Colas, E., Abal, M., Dolcet, X., Reventos, J., and Matias-Guiu, X. (2017). Endometrial Carcinoma: Specific Targeted Pathways. Advances in Experimental Medicine and Biology, Springer.","DOI":"10.1007\/978-3-319-43139-0_6"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"20130092","DOI":"10.1098\/rstb.2013.0092","article-title":"Ion Transport and Cancer: From Initiation to Metastasis","volume":"369","author":"Djamgoz","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nrm2668","article-title":"Ion Channels versus Ion Pumps: The Principal Difference, in Principle","volume":"10","author":"Gadsby","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_25","unstructured":"Purves, D., Augustine, G.J., Fitzpatrick, D., Katz, L.C., LaMantia, A.-S., McNamara, J.O., and Williams, S.M. (2001). Neuroscience, Sinauer Associates Inc.. [2nd ed.]. Chapter 4\u2014Channels and Transporters."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fncel.2015.00086","article-title":"Cancer as a Channelopathy: Ion Channels and Pumps in Tumor Development and Progression","volume":"9","author":"Litan","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.3390\/ph3041202","article-title":"New Trends in Cancer Therapy: Targeting Ion Channels and Transporters","volume":"3","author":"Arcangeli","year":"2010","journal-title":"Pharmaceuticals"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.molmed.2010.01.005","article-title":"Ion Channels and the Hallmarks of Cancer","volume":"16","author":"Prevarskaya","year":"2010","journal-title":"Trends Mol. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"20130105","DOI":"10.1098\/rstb.2013.0105","article-title":"Regulation of Voltage-Gated Sodium Channel Expression in Cancer: Hormones, Growth Factors and Auto-Regulation","volume":"369","author":"Fraser","year":"2014","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/112_2020_28","article-title":"Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer","volume":"Volume 183","author":"Camacho","year":"2020","journal-title":"Targets of Cancer Diagnosis and Treatment. Reviews of Physiology, Biochemistry and Pharmacology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1743-8454-4-8","article-title":"Ion Channel Diversity, Channel Expression and Function in the Choroid Plexuses","volume":"4","author":"Millar","year":"2007","journal-title":"Cerebrospinal Fluid Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez, C., Baez-Nieto, D., Valencia, I., Oyarz\u00fan, I., Rojas, P., Naranjo, D., and Latorre, R. (2012). K+ Channels: Function-Structural Overview. Comprehensive Physiology, John Wiley & Sons, Inc.","DOI":"10.1002\/cphy.c110047"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3389\/fphys.2013.00185","article-title":"Membrane Potential and Cancer Progression","volume":"4","author":"Yang","year":"2013","journal-title":"Front. Physiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1152\/physrev.00007.2002","article-title":"Epithelial Sodium Channel\/Degenerin Family of Ion Channels: A Variety of Functions for a Shared Structure","volume":"82","author":"Kellenberger","year":"2002","journal-title":"Physiol. Rev."},{"key":"ref_35","first-page":"124","article-title":"Voltage-Gated Sodium Channels: Biophysics, Pharmacology, and Related Channelopathies","volume":"3","author":"Gollob","year":"2012","journal-title":"Front. Pharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev-physiol-030212-183702","article-title":"Chloride in Vesicular Trafficking and Function","volume":"75","author":"Stauber","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fphar.2017.00151","article-title":"ClC Channels and Transporters: Structure, Physiological Functions, and Implications in Human Chloride Channelopathies","volume":"8","author":"Poroca","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1016\/j.bbamem.2014.12.012","article-title":"Chloride Channels in Cancer: Focus on Chloride Intracellular Channel 1 and 4 (CLIC1 AND CLIC4) Proteins in Tumor Development and as Novel Therapeutic Targets","volume":"1848","author":"Peretti","year":"2015","journal-title":"Biochim. Biophys. Acta-Biomembr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"282","DOI":"10.4251\/wjgo.v8.i3.282","article-title":"Emerging Role of Cystic Fibrosis Transmembrane Conductance Regulator\u2014An Epithelial Chloride Channel in Gastrointestinal Cancers","volume":"8","author":"Hou","year":"2016","journal-title":"World J. Gastrointest. Oncol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35036035","article-title":"The Versatility and Universality of Calcium Signalling","volume":"1","author":"Berridge","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"a003947","DOI":"10.1101\/cshperspect.a003947","article-title":"Voltage-Gated Calcium Channels","volume":"3","author":"Catterall","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"968","DOI":"10.3389\/fphar.2020.00968","article-title":"Calcium Permeable Channels in Cancer Hallmarks","volume":"11","author":"Tajada","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2174\/157489206775246502","article-title":"Intracellular Calcium, Endothelial Cells and Angiogenesis","volume":"1","author":"Munaron","year":"2006","journal-title":"Recent Pat. Anticancer. Drug Discov."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.mam.2010.03.002","article-title":"VDAC, a Multi-Functional Mitochondrial Protein Regulating Cell Life and Death","volume":"31","author":"Zweckstetter","year":"2010","journal-title":"Mol. Asp. Med."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Chow, P.H., Bowen, J., and Yool, A.J. (2020). Combined Systematic Review and Transcriptomic Analyses of Mammalian Aquaporin Classes 1 to 10 as Biomarkers and Prognostic Indicators in Diverse Cancers. Cancers, 12.","DOI":"10.3390\/cancers12071911"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Khan, S., Ricciardelli, C., and Yool, A.J. (2021). Targeting Aquaporins in Novel Therapies for Male and Female Breast and Reproductive Cancers. Cells, 10.","DOI":"10.3390\/cells10020215"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/humupd\/dmu006","article-title":"Ion Channels in the Endometrium: Regulation of Endometrial Receptivity and Embryo Implantation","volume":"20","author":"Ruan","year":"2014","journal-title":"Hum. Reprod. Update"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1152\/physrev.00036.2011","article-title":"HERG K+ Channels: Structure, Function, and Clinical Significance","volume":"92","author":"Vandenberg","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"188355","DOI":"10.1016\/j.bbcan.2020.188355","article-title":"HERG Channel and Cancer: A Mechanistic Review of Carcinogenic Processes and Therapeutic Potential","volume":"1873","author":"He","year":"2020","journal-title":"Biochim. Biophys. Acta-Rev. Cancer"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1054\/bjoc.2000.1497","article-title":"HERG Potassium Channels Are More Frequently Expressed in Human Endometrial Cancer as Compared to Non-Cancerous Endometrium","volume":"83","author":"Cherubini","year":"2000","journal-title":"Br. J. Cancer"},{"key":"ref_51","first-page":"153","article-title":"Selective Expression of HERG and Kv2 Channels Influences Proliferation of Uterine Cancer Cells","volume":"25","author":"Suzuki","year":"2004","journal-title":"Int. J. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s002329900135","article-title":"Potassium Channels, Proliferation and G1 Progression","volume":"154","author":"Wonderlin","year":"1996","journal-title":"J. Membr. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1016\/j.bbamcr.2014.02.019","article-title":"KCa and Ca2+ Channels: The Complex Thought","volume":"1843","author":"Fromont","year":"2014","journal-title":"Biochim. Biophys. Acta-Mol. Cell Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1038\/sj.onc.1210308","article-title":"Blockage of Intermediate-Conductance-Ca2+-Activated K+ Channels Inhibits Progression of Human Endometrial Cancer","volume":"26","author":"Wang","year":"2007","journal-title":"Oncogene"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s12013-014-0497-0","article-title":"Effects of Intermediate-Conductance Ca2+-Activated K+ Channels on Human Endometrial Carcinoma Cells","volume":"72","author":"Zhang","year":"2015","journal-title":"Cell Biochem. Biophys."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Wang, F., Chen, Q., Huang, G., Guo, X., Li, N., Li, Y., and Li, B. (2018). BKCa Participates in E2 Inducing Endometrial Adenocarcinoma by Activating MEK\/ERK Pathway. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-5027-9"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.gene.2018.02.055","article-title":"The Role of BKCa in Endometrial Cancer HEC-1-B Cell Proliferation and Migration","volume":"655","author":"Li","year":"2018","journal-title":"Gene"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1582-4934.2012.01656.x","article-title":"A Role for Two-Pore Potassium (K2P) Channels in Endometrial Epithelial Function","volume":"17","author":"Patel","year":"2013","journal-title":"J. Cell. Mol. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1096\/fj.14-265603","article-title":"Ca2+ Channel Subunit a 1D Promotes Proliferation and Migration of Endometrial Cancer Cells Mediated by 17\u03b2-Estradiol via the G Protein-Coupled Estrogen Receptor","volume":"29","author":"Hao","year":"2015","journal-title":"FASEB J."},{"key":"ref_60","first-page":"3120","article-title":"Nifedipine Induced Autophagy through Beclin1 and MTOR Pathway in Endometrial Carcinoma Cells","volume":"125","author":"Bao","year":"2012","journal-title":"Chin. Med. J. (Engl.)"},{"key":"ref_61","first-page":"121","article-title":"Progesterone Induces Cell Apoptosis via the CACNA2D3\/Ca2+\/P38 MAPK Pathway in Endometrial Cancer","volume":"43","author":"Kong","year":"2020","journal-title":"Oncol. Rep."},{"key":"ref_62","first-page":"3926","article-title":"Decreased Expression of TRPM4 Is Associated with Unfavorable Prognosis and Aggressive Progression of Endometrial Carcinoma","volume":"12","author":"Li","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s00018-021-04023-1","article-title":"TRP Channel Expression Correlates with the Epithelial\u2013Mesenchymal Transition and High-Risk Endometrial Carcinoma","volume":"79","author":"Luyten","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/s41419-020-03181-7","article-title":"Calcium and TRPV4 Promote Metastasis by Regulating Cytoskeleton through the RhoA\/ROCK1 Pathway in Endometrial Cancer","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"966","DOI":"10.12659\/MSM.899341","article-title":"Lower Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Promotes the Proliferation and Migration of Endometrial Carcinoma","volume":"23","author":"Xia","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4954","DOI":"10.7150\/jca.31544","article-title":"The Voltage-Gated Sodium Channel Na v 1.7 Associated with Endometrial Cancer","volume":"10","author":"Liu","year":"2019","journal-title":"J. Cancer"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijgo.2007.12.006","article-title":"Expression of Aquaporin-1 in Normal, Hyperplasic, and Carcinomatous Endometria","volume":"101","author":"Pan","year":"2008","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1210\/jc.2011-0426","article-title":"Identification of Estrogen Response Element in the Aquaporin-2 Gene That Mediates Estrogen-Induced Cell Migration and Invasion in Human Endometrial Carcinoma","volume":"96","author":"Zou","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3892\/ol.2012.738","article-title":"Reduced Migration of Ishikawa Cells Associated with Downregulation of Aquaporin-5","volume":"4","author":"Jiang","year":"2012","journal-title":"Oncol. Lett."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1007\/s12253-020-00813-3","article-title":"Aquaporin 3 Expression in Endometrioid Carcinoma of the Uterine Body Correlated With Early Stage and Lower Grade","volume":"26","author":"Watanabe","year":"2020","journal-title":"Pathol. Oncol. Res."},{"key":"ref_71","first-page":"1010428320951057","article-title":"Expression of Voltage-Dependent Anion Channels in Endometrial Cancer and Its Potential Prognostic Significance","volume":"42","author":"Ciesielski","year":"2020","journal-title":"Tumor Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1083\/jcb.201404136","article-title":"Targeting Potassium Channels in Cancer","volume":"206","author":"Huang","year":"2014","journal-title":"J. Cell Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-030920-111536","article-title":"Two-Pore Domain Potassium Channels as Drug Targets: Anesthesia and Beyond","volume":"61","author":"Mathie","year":"2021","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Wang, C.-Y., Lai, M.-D., Phan, N.N., Sun, Z., and Lin, Y.-C. (2015). Meta-Analysis of Public Microarray Datasets Reveals Voltage-Gated Calcium Gene Signatures in Clinical Cancer Patients. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0125766"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3389\/fphar.2020.00152","article-title":"Ion Channel Regulation by Sex Steroid Hormones and Vitamin D in Cancer: A Potential Opportunity for Cancer Diagnosis and Therapy","volume":"11","author":"Camacho","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1093\/humrep\/dew034","article-title":"Overexpression of Chloride Channel-3 Is Associated with the Increased Migration and Invasion Ability of Ectopic Endometrial Cells from Patients with Endometriosis","volume":"31","author":"Guan","year":"2016","journal-title":"Hum. Reprod."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12935-018-0721-x","article-title":"Overexpression of Chloride Channel-3 (ClC-3) Is Associated with Human Cervical Carcinoma Development and Prognosis","volume":"19","author":"Guan","year":"2019","journal-title":"Cancer Cell Int."},{"key":"ref_78","first-page":"1149","article-title":"Heterogeneous Expression of the Aquaporin 1 (AQP1) Water Channel in Tumors of the Prostate, Breast, Ovary, Colon and Lung: A Study Using High Density Multiple Human Tumor Tissue Microarrays","volume":"26","author":"Mobasheri","year":"2005","journal-title":"Int. J. Oncol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.lfs.2006.01.020","article-title":"Aquaporin-2 Expression in Human Endometrium Correlates with Serum Ovarian Steroid Hormones","volume":"79","author":"He","year":"2006","journal-title":"Life Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3389\/fphys.2013.00233","article-title":"Cell Volume Regulation in Epithelial Physiology and Cancer","volume":"4","author":"Pedersen","year":"2013","journal-title":"Front. Physiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3389\/fphys.2013.00227","article-title":"Intracellular Ion Channels and Cancer","volume":"4","author":"Leanza","year":"2013","journal-title":"Front. Physiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer Statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1095\/biolreprod65.5.1311","article-title":"Developmental Biology of Uterine Glands","volume":"65","author":"Gray","year":"2001","journal-title":"Biol. Reprod."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/humupd\/dmy035","article-title":"The Role of Mesenchymal\u2013Epithelial Transition in Endometrial Function","volume":"25","author":"Krishnamoorthy","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11154-012-9221-9","article-title":"Endometrial Regeneration and Endometrial Stem\/Progenitor Cells","volume":"13","author":"Gargett","year":"2012","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_86","first-page":"1","article-title":"Age at Menopause and Risk of Developing Endometrial Cancer: A Meta-Analysis","volume":"2019","author":"Wu","year":"2019","journal-title":"Biomed Res. Int."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"14051","DOI":"10.1038\/srep14051","article-title":"Age at Menarche and Endometrial Cancer Risk: A Dose-Response Meta-Analysis of Prospective Studies","volume":"5","author":"Gong","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.bpobgyn.2011.12.009","article-title":"Gynaecological Cancer in Pregnancy","volume":"26","author":"Ilancheran","year":"2012","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-3-319-56895-9_6","article-title":"Estrogen Receptors in Cell Membranes: Regulation and Signaling","volume":"227","author":"Saczko","year":"2017","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0039-128X(00)00187-2","article-title":"Neuroendocrine Effects of Progesterone","volume":"65","author":"Skinner","year":"2000","journal-title":"Steroids"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"C162","DOI":"10.1152\/ajpcell.00014.2017","article-title":"Estradiol Activates Chloride Channels via Estrogen Receptor-\u03b1 in the Cell Membranes of Osteoblasts","volume":"313","author":"Deng","year":"2017","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1136\/ijgc-00009577-200601000-00019","article-title":"Growth Regulation and Transcriptional Activities of Estrogen and Progesterone in Human Endometrial Cancer Cells","volume":"16","author":"Gielen","year":"2006","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1002\/j.1460-2075.1990.tb08280.x","article-title":"Two Distinct Estrogen-Regulated Promoters Generate Transcripts Encoding the Two Functionally Different Human Progesterone Receptor Forms A and B","volume":"9","author":"Kastner","year":"1990","journal-title":"EMBO J."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1136\/bmj.298.6667.147","article-title":"Risk of Endometrial Cancer after Treatment with Oestrogens Alone or in Conjunction with Progestogens: Results of a Prospective Study","volume":"298","author":"Persson","year":"1989","journal-title":"BMJ"},{"key":"ref_95","first-page":"4576","article-title":"Relative Expression of Progesterone Receptors A and B in Endometrioid Cancers of the Endometrium","volume":"61","author":"DeFazio","year":"2001","journal-title":"Cancer Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1158\/1535-7163.MCT-07-0478","article-title":"The Role of TRPV6 in Breast Carcinogenesis","volume":"7","author":"Bolanz","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/jcp.25963","article-title":"Activation of ClC-3 Chloride Channel by 17\u03b2-estradiol Relies on the Estrogen Receptor \u03b1 Expression in Breast Cancer","volume":"233","author":"Yang","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cyto.2014.04.005","article-title":"Expression Profiling and Significance of VEGF-A, VEGFR2, VEGFR3 and Related Proteins in Endometrial Carcinoma","volume":"68","author":"Wang","year":"2014","journal-title":"Cytokine"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3892\/ol.2010.206","article-title":"Ductal Adenocarcinoma of the Pancreas: Expression of Growth Factor Receptors, Oncogenes and Suppressor Genes, and Their Relationship to Pathological Features, Staging and Survival","volume":"2","author":"Varo","year":"2011","journal-title":"Oncol. Lett."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s10549-010-0758-6","article-title":"Epidermal Growth Factor Receptor and Vascular Endothelial Growth Factor Receptor 2 Are Specific Biomarkers in Triple-Negative Breast Cancer. Results from a Controlled Randomized Trial with Long-Term Follow-Up","volume":"120","author":"Jirstrom","year":"2010","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1600-0463.2011.02752.x","article-title":"Prognostic Significance of Epidermal Growth Factor Receptor and Vascular Endothelial Growth Factor Receptor in Colorectal Adenocarcinoma","volume":"119","author":"Kim","year":"2011","journal-title":"Apmis"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Ioannidou, E., Moschetta, M., Shah, S., Parker, J.S., Ozturk, M.A., Pappas-Gogos, G., Sheriff, M., Rassy, E., and Boussios, S. (2021). Angiogenesis and Anti-Angiogenic Treatment in Prostate Cancer: Mechanisms of Action and Molecular Targets. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22189926"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3389\/fonc.2017.00182","article-title":"Vascular Endothelial Growth Factor, Irradiation, and Axitinib Have Diverse Effects on Motility and Proliferation of Glioblastoma Multiforme Cells","volume":"7","author":"Krcek","year":"2017","journal-title":"Front. Oncol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s10555-011-9337-5","article-title":"Significance of Vascular Endothelial Growth Factor in Growth and Peritoneal Dissemination of Ovarian Cancer","volume":"31","author":"Amini","year":"2012","journal-title":"Cancer Metastasis Rev."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1080\/14728222.2017.1371137","article-title":"VEGF as a Potential Target in Lung Cancer","volume":"21","author":"Frezzetti","year":"2017","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3389\/fendo.2014.00076","article-title":"The IGF Hormonal Network in Endometrial Cancer: Functions, Regulation, and Targeting Approaches","volume":"5","author":"Bruchim","year":"2014","journal-title":"Front. Endocrinol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"6373","DOI":"10.1158\/1078-0432.CCR-06-0912","article-title":"Overexpression of the Insulin-like Growth Factor I Receptor and Activation of the AKT Pathway in Hyperplastic Endometrium","volume":"12","author":"McCampbell","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s11010-011-0790-9","article-title":"Down-Regulation of IGF-1R Expression Inhibits Growth and Enhances Chemosensitivity of Endometrial Carcinoma in Vitro","volume":"353","author":"Shu","year":"2011","journal-title":"Mol. Cell. Biochem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/jcp.21065","article-title":"IGF-1 Activates HEAG K+ Channels through an Akt-Dependent Signaling Pathway in Breast Cancer Cells: Role in Cell Proliferation","volume":"212","author":"Borowiec","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2174\/157488407780598153","article-title":"Targeting Ion Channels for New Strategies in Cancer Diagnosis and Therapy","volume":"2","author":"Conti","year":"2008","journal-title":"Curr. Clin. Pharmacol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Njoku, K., Chiasserini, D., Whetton, A.D., and Crosbie, E.J. (2019). Proteomic Biomarkers for the Detection of Endometrial Cancer. Cancers, 11.","DOI":"10.3390\/cancers11101572"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Ghose, A., Gullapalli, S.V.N., Chohan, N., Bolina, A., Moschetta, M., Rassy, E., and Boussios, S. (2022). Applications of Proteomics in Ovarian Cancer: Dawn of a New Era. Proteomes, 10.","DOI":"10.3390\/proteomes10020016"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1373\/clinchem.2012.184614","article-title":"The Long Journey of Cancer Biomarkers from the Bench to the Clinic","volume":"59","author":"Pavlou","year":"2013","journal-title":"Clin. Chem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/annonc\/mdv484","article-title":"ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: Diagnosis, Treatment and Follow-Up","volume":"27","author":"Colombo","year":"2016","journal-title":"Ann. Oncol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/112_2020_46","article-title":"Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges","volume":"Volume 183","author":"Capatina","year":"2020","journal-title":"Targets of Cancer Diagnosis and Treatment. Reviews of Physiology, Biochemistry and Pharmacology"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"20130102","DOI":"10.1098\/rstb.2013.0102","article-title":"Ion Channels and Transporters in Tumour Cell Migration and Invasion","volume":"369","author":"Schwab","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.vascn.2017.02.020","article-title":"Potential Functional and Pathological Side Effects Related to Off-Target Pharmacological Activity","volume":"87","author":"Lynch","year":"2017","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e193","DOI":"10.1038\/cddis.2011.77","article-title":"Novel Roles for HERG K+ Channels in Cell Proliferation and Apoptosis","volume":"2","author":"Jehle","year":"2011","journal-title":"Cell Death Dis."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1200\/JCO.2005.05.4569","article-title":"Phase I Single-Dose Study of Intracavitary-Administered Iodine-131-TM-601 in Adults With Recurrent High-Grade Glioma","volume":"24","author":"Mamelak","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3389\/fphar.2019.00606","article-title":"Monoclonal Antibodies Targeting Ion Channels and Their Therapeutic Potential","volume":"10","author":"Haustrate","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"793","DOI":"10.3389\/fphar.2020.00793","article-title":"P2X7 in Cancer: From Molecular Mechanisms to Therapeutics","volume":"11","author":"Lara","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41388-018-0426-6","article-title":"ATP in the Tumour Microenvironment Drives Expression of NfP2X7, a Key Mediator of Cancer Cell Survival","volume":"38","author":"Gilbert","year":"2019","journal-title":"Oncogene"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/bjd.15364","article-title":"A Phase I Clinical Trial Demonstrates That NfP2X 7 -Targeted Antibodies Provide a Novel, Safe and Tolerable Topical Therapy for Basal Cell Carcinoma","volume":"177","author":"Gilbert","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s10637-017-0438-z","article-title":"First-in-Human Phase I Study of SOR-C13, a TRPV6 Calcium Channel Inhibitor, in Patients with Advanced Solid Tumors","volume":"35","author":"Fu","year":"2017","journal-title":"Investig. New Drugs"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1016\/j.bbamem.2015.03.034","article-title":"Targeting Ion Channels for Cancer Therapy by Repurposing the Approved Drugs","volume":"1848","author":"Kale","year":"2015","journal-title":"Biochim. Biophys. Acta-Biomembr."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.7150\/ijbs.68591","article-title":"Calcium and Calcium-Related Proteins in Endometrial Cancer: Opportunities for Pharmacological Intervention","volume":"18","author":"Huang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"ref_127","first-page":"113","article-title":"Grand Challenge for Ion Channels: An Underexploited Resource for Therapeutics","volume":"1","author":"Camerino","year":"2010","journal-title":"Front. Pharmacol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/19\/4733\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:41:17Z","timestamp":1760143277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/19\/4733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,28]]},"references-count":127,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["cancers14194733"],"URL":"https:\/\/doi.org\/10.3390\/cancers14194733","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,28]]}}}