{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:12:20Z","timestamp":1791472340580,"version":"4.3.4"},"reference-count":44,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007076","name":"Associazione Italiana per la Ricerca sul Cancro (AIRC)","doi-asserted-by":"publisher","award":["21378"],"award-info":[{"award-number":["21378"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007076","name":"Associazione Italiana per la Ricerca sul Cancro (AIRC)","doi-asserted-by":"publisher","award":["T32CA186873"],"award-info":[{"award-number":["T32CA186873"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondazione Italiana per la Ricerca sul Cancro (FIRC)","award":["21378"],"award-info":[{"award-number":["21378"]}]},{"name":"Fondazione Italiana per la Ricerca sul Cancro (FIRC)","award":["T32CA186873"],"award-info":[{"award-number":["T32CA186873"]}]},{"name":"Italian League for the Fight Against Cancer (LILT)","award":["21378"],"award-info":[{"award-number":["21378"]}]},{"name":"Italian League for the Fight Against Cancer (LILT)","award":["T32CA186873"],"award-info":[{"award-number":["T32CA186873"]}]},{"name":"European Cancer Prevention (ECP) Organization","award":["21378"],"award-info":[{"award-number":["21378"]}]},{"name":"European Cancer Prevention (ECP) Organization","award":["T32CA186873"],"award-info":[{"award-number":["T32CA186873"]}]},{"DOI":"10.13039\/100000002","name":"cancer research training grant from NIH","doi-asserted-by":"publisher","award":["21378"],"award-info":[{"award-number":["21378"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"cancer research training grant from NIH","doi-asserted-by":"publisher","award":["T32CA186873"],"award-info":[{"award-number":["T32CA186873"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background. Gastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by H. pylori infection, evidence regarding the direct relationship between PUD and GC across ethnicities is inconclusive. Therefore, we investigated the association between PUD and GC in the Stomach cancer Pooling (StoP) consortium. Methods. History of peptic ulcer disease was collected using a structured questionnaire in 11 studies in the StoP consortium, including 4106 GC cases and 6922 controls. The two-stage individual-participant data meta-analysis approach was adopted to generate a priori. Unconditional logistic regression and Firth\u2019s penalized maximum likelihood estimator were used to calculate study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between gastric ulcer (GU)\/duodenal ulcer (DU) and risk of GC. Results. History of GU and DU was thoroughly reported and used in association analysis, respectively, by 487 cases (12.5%) and 276 controls (4.1%), and 253 cases (7.8%) and 318 controls (6.0%). We found that GU was associated with an increased risk of GC (OR = 3.04, 95% CI: 2.07\u20134.49). No association between DU and GC risk was observed (OR = 1.03, 95% CI: 0.77\u20131.39). Conclusions. In the pooled analysis of 11 case\u2013control studies in a large consortium (i.e., the Stomach cancer Pooling (StoP) consortium), we found a positive association between GU and risk of GC and no association between DU and GC risk.<\/jats:p>","DOI":"10.3390\/cancers14194905","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T01:52:21Z","timestamp":1665193941000},"page":"4905","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5471-4979","authenticated-orcid":false,"given":"Pedram","family":"Paragomi","sequence":"first","affiliation":[{"name":"Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashir","family":"Dabo","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics Concentration, College of Public Health, University of South Florida, Tampa, FL 33620, USA"},{"name":"Department of Medical Microbiology and Parasitology, College of Health Sciences, Bayero University, Kano 700006, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1425-8945","authenticated-orcid":false,"given":"Claudio","family":"Pelucchi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, University of Milan, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2155-6126","authenticated-orcid":false,"given":"Rossella","family":"Bonzi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, University of Milan, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1584-8114","authenticated-orcid":false,"given":"Abdulaziz T.","family":"Bako","sequence":"additional","affiliation":[{"name":"Center for Health Data Science and Analytics, Houston Methodist Research Institute, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabila Muhammad","family":"Sanusi","sequence":"additional","affiliation":[{"name":"Faculty of Clinical Sciences, College of Health Sciences, Bayero University, Kano 700006, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan H.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4669-3995","authenticated-orcid":false,"given":"Zuo-Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5558-2437","authenticated-orcid":false,"given":"Domenico","family":"Palli","sequence":"additional","affiliation":[{"name":"Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4542-4996","authenticated-orcid":false,"given":"Monica","family":"Ferraroni","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, University of Milan, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khanh Truong","family":"Vu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Pancreato-Hepatobiliary, Tam Anh General Hospital, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Pei","family":"Yu","sequence":"additional","affiliation":[{"name":"Medical Informatics Center, Peking University, Beijing 100871, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5841-5773","authenticated-orcid":false,"given":"Federica","family":"Turati","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, University of Milan, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zaridze","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, N.N. Blokhin National Medical Research Center for Oncology, 115478 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Maximovitch","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, N.N. Blokhin National Medical Research Center for Oncology, 115478 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harbin Medical University, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY 14214, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1864-749X","authenticated-orcid":false,"given":"Stefania","family":"Boccia","sequence":"additional","affiliation":[{"name":"Section of Hygiene, University Department of Life Sciences and Public Health, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Roma, Italy"},{"name":"Department of Woman and Child Health and Public Health - Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Pastorino","sequence":"additional","affiliation":[{"name":"Section of Hygiene, University Department of Life Sciences and Public Health, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Roma, Italy"},{"name":"Department of Woman and Child Health and Public Health - Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4105-2774","authenticated-orcid":false,"given":"Shoichiro","family":"Tsugane","sequence":"additional","affiliation":[{"name":"Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo 104-0045, Japan"},{"name":"National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo 162-8636, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihisa","family":"Hidaka","sequence":"additional","affiliation":[{"name":"Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo 104-0045, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Kurtz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Centre, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6687-358X","authenticated-orcid":false,"given":"Areti","family":"Lagiou","sequence":"additional","affiliation":[{"name":"Department of Public and Community Health, School of Public Health, University of West Attica, 115 21 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pagona","family":"Lagiou","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece"},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115-5810, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Constanza","family":"Camargo","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paula","family":"Curado","sequence":"additional","affiliation":[{"name":"Centro Internacional de Pesquisa, A. C. Camargo Cancer Center, 01509-010 S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1870-1430","authenticated-orcid":false,"given":"Nuno","family":"Lunet","sequence":"additional","affiliation":[{"name":"EPIUnit, Instituto de Sa\u00fade P\u00fablica da Universidade do Porto, 4050-600 Porto, Portugal"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR), 4050-600 Porto, Portugal"},{"name":"Departamento de Ci\u00eancias da Sa\u00fade P\u00fablica e Forenses e Educa\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina, Universidade do Porto, 4200-319 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2284-148X","authenticated-orcid":false,"given":"Jesus","family":"Vioque","sequence":"additional","affiliation":[{"name":"Department, Instituto de Investigaci\u00f3n Sanitaria y Biom\u00e9dica de Alicante, Universidad Miguel Hernandez (ISABIAL-UMH), 46020 Alicante, Spain"},{"name":"Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3811-2791","authenticated-orcid":false,"given":"Paolo","family":"Boffetta","sequence":"additional","affiliation":[{"name":"Stony Brook Cancer Center, Stony Brooke University, Stony Brook, NY 11794, USA"},{"name":"Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9712-8526","authenticated-orcid":false,"given":"Eva","family":"Negri","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1441-897X","authenticated-orcid":false,"given":"Carlo","family":"La Vecchia","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, University of Milan, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung N.","family":"Luu","sequence":"additional","affiliation":[{"name":"Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA"},{"name":"Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4143\/crt.2011.43.1.1","article-title":"Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2008","volume":"43","author":"Jung","year":"2011","journal-title":"Cancer Res. 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