{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:57:51Z","timestamp":1790776671755,"version":"4.1.0"},"reference-count":53,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Lancashire Teaching Hospitals and Lancaster University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Current triage for women with post-menopausal bleeding (PMB) to diagnose endometrial cancer rely on specialist referral for intimate tests to sequentially image, visualise and sample the endometrium. A point-of-care non-invasive triage tool with an instant readout could provide immediate reassurance for low-risk symptomatic women, whilst fast-tracking high-risk women for urgent intrauterine investigations. This study assessed the potential for infrared (IR) spectroscopy and attenuated total reflection (ATR) technology coupled with chemometric analysis of the resulting spectra for endometrial cancer detection in urine samples. Standardised urine collection and processing protocols were developed to ensure spectroscopic differences between cases and controls reflected cancer status. Urine spectroscopy distinguished endometrial cancer (n = 109) from benign gynaecological conditions (n = 110) with a sensitivity of 98% and specificity of 97%. If confirmed in subsequent low prevalence studies embedded in PMB clinics, this novel endometrial cancer detection tool could transform clinical practice by accurately selecting women with malignant pathology for urgent diagnostic work up whilst safely reassuring those without.<\/jats:p>","DOI":"10.3390\/cancers14205015","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T20:55:11Z","timestamp":1665694511000},"page":"5015","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Infrared Spectroscopy of Urine for the Non-Invasive Detection of Endometrial Cancer"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4588-3743","authenticated-orcid":false,"given":"Carlos","family":"Meza Ramirez","sequence":"first","affiliation":[{"name":"Bioengineering, School of Engineering, Faculty of Science and Technology, Lancaster University, Gillow Avenue, Lancaster LA1 4YW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Stringfellow","sequence":"additional","affiliation":[{"name":"Gynaecological Oncology, Clinical Research Facility, Lancashire Teaching Hospitals, Sharoe Green Lane, Preston PR2 9HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Naik","sequence":"additional","affiliation":[{"name":"Gynaecological Oncology, Clinical Research Facility, Lancashire Teaching Hospitals, Sharoe Green Lane, Preston PR2 9HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0284-8630","authenticated-orcid":false,"given":"Emma","family":"Crosbie","sequence":"additional","affiliation":[{"name":"Gynaecological Oncology Research Group, Division of Cancer Sciences, University of Manchester, Oxford Road, Manchester M13 9WL, UK"},{"name":"Department of Obstetrics and Gynaecology, St Mary\u2019s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Oxford Road, Manchester M13 9WL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Paraskevaidi","sequence":"additional","affiliation":[{"name":"Reproductive and Developmental Biology (IRDB), Department of Metabolism, Digestion & Reproduction, Imperial College London, London W12 0HS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2502-7608","authenticated-orcid":false,"given":"Ihtesham","family":"Rehman","sequence":"additional","affiliation":[{"name":"Bioengineering, School of Engineering, Faculty of Science and Technology, Lancaster University, Gillow Avenue, Lancaster LA1 4YW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Martin-Hirsch","sequence":"additional","affiliation":[{"name":"Gynaecological Oncology, Clinical Research Facility, Lancashire Teaching Hospitals, Sharoe Green Lane, Preston PR2 9HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. 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