{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:15:24Z","timestamp":1793042124067,"version":"4.5.0"},"reference-count":156,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DFG)","doi-asserted-by":"publisher","award":["SL 37\/12-1"],"award-info":[{"award-number":["SL 37\/12-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Originally discovered as a hypothetical protein with unknown function, CEMIP (cell migration-inducing and hyaluronan-binding protein) has been implicated in the pathogenesis of numerous diseases, including deafness, arthritis, atherosclerosis, idiopathic pulmonary fibrosis, and cancer. Although a comprehensive definition of its molecular functions is still in progress, major functions ascribed to CEMIP include the depolymerization of the extracellular matrix component hyaluronic acid (HA) and the regulation of a number of signaling pathways. CEMIP is a promising biomarker for colorectal cancer. Its expression is associated with poor prognosis for patients suffering from colorectal and other types of cancer and functionally contributes to tumor progression and metastasis. Here, we review our current understanding of how CEMIP is able to foster the process of tumor growth and metastasis, focusing particularly on colorectal cancer. Studies in cancer cells suggest that CEMIP exerts its pro-tumorigenic and pro-metastatic activities through stimulating migration and invasion, suppressing cell death and promoting survival, degrading HA, regulating pro-metastatic signaling pathways, inducing the epithelial\u2013mesenchymal transition (EMT) program, and contributing to the metabolic reprogramming and pre-metastatic conditioning of future metastatic microenvironments. There is also increasing evidence indicating that CEMIP may be expressed in cells within the tumor microenvironment that promote tumorigenesis and metastasis formation, although this remains in an early stage of investigation. CEMIP expression and activity can be therapeutically targeted at a number of levels, and preliminary findings in animal models show encouraging results in terms of reduced tumor growth and metastasis, as well as combating therapy resistance. Taken together, CEMIP represents an exciting new player in the progression of colorectal and other types of cancer that holds promise as a therapeutic target and biomarker.<\/jats:p>","DOI":"10.3390\/cancers14205093","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T21:18:02Z","timestamp":1666127882000},"page":"5093","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["CEMIP, a Promising Biomarker That Promotes the Progression and Metastasis of Colorectal and Other Types of Cancer"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1215-4264","authenticated-orcid":false,"given":"Kevin","family":"Domanegg","sequence":"first","affiliation":[{"name":"European Center for Angioscience (ECAS), Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P.","family":"Sleeman","sequence":"additional","affiliation":[{"name":"European Center for Angioscience (ECAS), Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany"},{"name":"Institute of Biological and Chemical Systems-Biological Information Processing, Karlsruhe Institute of Technology (KIT) Campus Nord, 76344 Eggenstein-Leopoldshafen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Schmaus","sequence":"additional","affiliation":[{"name":"European Center for Angioscience (ECAS), Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany"},{"name":"Institute of Biological and Chemical Systems-Biological Information Processing, Karlsruhe Institute of Technology (KIT) Campus Nord, 76344 Eggenstein-Leopoldshafen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/nar\/27.1.338","article-title":"HUGE: A Database for Human Large Proteins Identified by Kazusa CDNA Sequencing Project","volume":"27","author":"Suyama","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/s10038-003-0079-2","article-title":"Mutations in the Gene Encoding KIAA1199 Protein, an Inner-Ear Protein Expressed in Deiters\u2019 Cells and the Fibrocytes, as the Cause of Nonsyndromic Hearing Loss","volume":"48","author":"Abe","year":"2003","journal-title":"J. Hum. Genet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.1073\/pnas.1215432110","article-title":"KIAA1199, a Deafness Gene of Unknown Function, Is a New Hyaluronan Binding Protein Involved in Hyaluronan Depolymerization","volume":"110","author":"Yoshida","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"111507","DOI":"10.1016\/j.biopha.2021.111507","article-title":"The Emerging Role of KIAA1199 in Cancer Development and Therapy","volume":"138","author":"Liu","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"434","DOI":"10.7150\/ijms.58067","article-title":"CEMIP as a Potential Biomarker and Therapeutic Target for Breast Cancer Patients","volume":"19","author":"Xue","year":"2022","journal-title":"Int. J. Med. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1158\/1541-7786.MCR-07-0267","article-title":"Transcriptome Profile of Human Colorectal Adenomas","volume":"5","author":"Cattaneo","year":"2007","journal-title":"Mol. Cancer Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/bjc.2011.268","article-title":"Repression of KIAA1199 Attenuates Wnt-Signalling and Decreases the Proliferation of Colon Cancer Cells","volume":"105","author":"Maghnouj","year":"2011","journal-title":"Br. J. Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1002\/ijc.30656","article-title":"Down-Regulation of KIAA1199\/CEMIP by MiR-216a Suppresses Tumor Invasion and Metastasis in Colorectal Cancer","volume":"140","author":"Zhang","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"LaPointe, L.C., Pedersen, S.K., Dunne, R., Brown, G.S., Pimlott, L., Gaur, S., McEvoy, A., Thomas, M., Wattchow, D., and Molloy, P.L. (2012). Discovery and Validation of Molecular Biomarkers for Colorectal Adenomas and Cancer with Application to Blood Testing. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0029059"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"768140","DOI":"10.3389\/fgene.2021.768140","article-title":"High Expression of CEMIP Correlates Poor Prognosis and the Tumur Microenvironment in Breast Cancer as a Promisingly Prognostic Biomarker","volume":"12","author":"Dong","year":"2021","journal-title":"Front. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Wu, Y.F., Wang, C.Y., Tang, W.C., Lee, Y.C., Ta, H.D.K., Lin, L.C., Pan, S.R., Ni, Y.C., Anuraga, G., and Lee, K.H. (2021). Expression Profile and Prognostic Value of Wnt Signaling Pathway Molecules in Colorectal Cancer. Biomedicines, 9.","DOI":"10.3390\/biomedicines9101331"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"30500","DOI":"10.18632\/oncotarget.5921","article-title":"Induction of KIAA1199\/CEMIP Is Associated with Colon Cancer Phenotype and Poor Patient Survival","volume":"6","author":"Fink","year":"2015","journal-title":"Oncotarget"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"482","DOI":"10.7150\/thno.16816","article-title":"Functional Genomic MRNA Profiling of Colorectal Adenomas: Identification and In Vivo Validation of CD44 and Splice Variant CD44v6 as Molecular Imaging Targets","volume":"7","author":"Hartmans","year":"2017","journal-title":"Theranostics"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"23761","DOI":"10.18632\/aging.103964","article-title":"Serum KIAA1199 Is an Advanced-Stage Prognostic Biomarker and Metastatic Oncogene in Cholangiocarcinoma","volume":"12","author":"Zhai","year":"2020","journal-title":"Aging"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1038\/s41598-018-21823-x","article-title":"Combined Use of CEMIP and CA 19-9 Enhances Diagnostic Accuracy for Pancreatic Cancer","volume":"8","author":"Lee","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_16","first-page":"2909","article-title":"Association between KIAA1199 Overexpression and Tumor Invasion, TNM Stage, and Poor Prognosis in Colorectal Cancer","volume":"8","author":"Xu","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"20723","DOI":"10.18632\/oncotarget.3978","article-title":"Hypoxia Promotes Colon Cancer Dissemination through Up-Regulation of Cell Migration-Inducing Protein (CEMIP)","volume":"6","author":"Evensen","year":"2015","journal-title":"Oncotarget"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1002\/hep.32383","article-title":"KIAA1199 Drives Immune Suppression to Promote Colorectal Cancer Liver Metastasis by Modulating Neutrophil Infiltration","volume":"76","author":"Wang","year":"2022","journal-title":"Hepatology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00109-018-1721-y","article-title":"KIAA1199 Promotes Invasion and Migration in Non-Small-Cell Lung Cancer (NSCLC) via PI3K-Akt Mediated EMT","volume":"97","author":"Tang","year":"2019","journal-title":"J. Mol. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5570","DOI":"10.1002\/cam4.3210","article-title":"Downregulation of KIAA1199 by MiR-486-5p Suppresses Tumorigenesis in Lung Cancer","volume":"9","author":"Wang","year":"2020","journal-title":"Cancer Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"664","DOI":"10.4103\/jcrt.JCRT_61_17","article-title":"Overexpression of KIAA1199: An Independent Prognostic Marker in Nonsmall Cell Lung Cancer","volume":"13","author":"Deng","year":"2017","journal-title":"J. Cancer Res. Ther."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Jia, S., Qu, T., Wang, X., Feng, M., Yang, Y., Feng, X., Ma, R., Li, W., Hu, Y., and Feng, Y. (2017). KIAA1199 Promotes Migration and Invasion by Wnt\/\u03b2-Catenin Pathway and MMPs Mediated EMT Progression and Serves as a Poor Prognosis Marker in Gastric Cancer. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0175058"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3134","DOI":"10.1038\/s41388-018-0642-0","article-title":"The MiR-29c-KIAA1199 Axis Regulates Gastric Cancer Migration by Binding with WBP11 and PTP4A3","volume":"38","author":"Wang","year":"2019","journal-title":"Oncogene"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1245\/s10434-009-0469-6","article-title":"Clinicopathologic Significance of KIAA1199 Overexpression in Human Gastric Cancer","volume":"16","author":"Matsuzaki","year":"2009","journal-title":"Ann. Surg. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.1080\/21655979.2021.1957645","article-title":"Prognostic Marker Identification Based on Weighted Gene Co-Expression Network Analysis and Associated In Vitro Confirmation in Gastric Cancer","volume":"12","author":"Guo","year":"2021","journal-title":"Bioengineered"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.pan.2016.12.007","article-title":"KIAA1199\/CEMIP\/HYBID Overexpression Predicts Poor Prognosis in Pancreatic Ductal Adenocarcinoma","volume":"17","author":"Koga","year":"2017","journal-title":"Pancreatology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/s41556-019-0404-4","article-title":"Tumour Exosomal CEMIP Protein Promotes Cancer Cell Colonization in Brain Metastasis","volume":"21","author":"Rodrigues","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"147490","DOI":"10.1016\/j.brainres.2021.147490","article-title":"HYBID Derived from Tumor Cells and Tumor-Associated Macrophages Contribute to the Glioblastoma Growth","volume":"1764","author":"Tsuji","year":"2021","journal-title":"Brain Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1093\/jnci\/djt224","article-title":"Unraveling the Role of KIAA1199, a Novel Endoplasmic Reticulum Protein, in Cancer Cell Migration","volume":"105","author":"Evensen","year":"2013","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/10799893.2020.1800732","article-title":"Cell Migration Inducing Hyaluronidase 1 (CEMIP) Activates STAT3 Pathway to Facilitate Cell Proliferation and Migration in Breast Cancer","volume":"41","author":"Chen","year":"2020","journal-title":"J. Recept. Signal Transduct."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"6788","DOI":"10.12659\/MSM.918682","article-title":"KIAA1199, a Target of MicoRNA-486-5p, Promotes Papillary Thyroid Cancer Invasion by Influencing Epithelial-Mesenchymal Transition (EMT)","volume":"25","author":"Jiao","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e23369","DOI":"10.1097\/MD.0000000000023369","article-title":"Co-Expression of KIAA1199 and Hypoxia-Inducible Factor 1\u03b1 Is a Biomarker for an Unfavorable Prognosis in Hepatocellular Carcinoma","volume":"99","author":"Wang","year":"2020","journal-title":"Medicine"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"8341","DOI":"10.2147\/OTT.S187389","article-title":"KIAA1199 Overexpression Is Associated with Abnormal Expression of EMT Markers and Is a Novel Independent Prognostic Biomarker for Hepatocellular Carcinoma","volume":"11","author":"Jiang","year":"2018","journal-title":"Onco. Targets. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e9637","DOI":"10.7717\/peerj.9637","article-title":"Overexpression of KIAA1199 Is an Independent Prognostic Marker in Laryngeal Squamous Cell Carcinoma","volume":"8","author":"Huang","year":"2020","journal-title":"PeerJ"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/j.archoralbio.2013.08.002","article-title":"Comparative Proteomic Analysis of Oral Squamous Cell Carcinoma and Adjacent Non-Tumour Tissue from Thailand","volume":"58","author":"Chanthammachat","year":"2013","journal-title":"Arch. Oral Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1186\/s13018-021-02590-4","article-title":"Overexpression of KIAA1199, a Novel Strong Hyaluronidase, Is a Poor Prognostic Factor in Patients with Osteosarcoma","volume":"16","author":"Ito","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/s41388-018-0493-8","article-title":"KIAA1199 Promotes Metastasis of Colorectal Cancer Cells via Microtubule Destabilization Regulated by a PP2A\/Stathmin Pathway","volume":"38","author":"Zhao","year":"2019","journal-title":"Oncogene"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"6443","DOI":"10.1038\/s41388-021-02023-w","article-title":"CEMIP, a Novel Adaptor Protein of OGT, Promotes Colorectal Cancer Metastasis through Glutamine Metabolic Reprogramming via Reciprocal Regulation of \u03b2-Catenin","volume":"40","author":"Hua","year":"2021","journal-title":"Oncogene"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Jami, M.S., Hou, J., Liu, M., Varney, M.L., Hassan, H., Dong, J., Geng, L., Wang, J., Yu, F., and Huang, X. (2014). Functional Proteomic Analysis Reveals the Involvement of KIAA1199 in Breast Cancer Growth, Motility and Invasiveness. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-194"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41420-018-0099-5","article-title":"Knockdown of KIAA1199 Attenuates Growth and Metastasis of Hepatocellular Carcinoma","volume":"4","author":"Liu","year":"2018","journal-title":"Cell Death Discov."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.canlet.2019.03.049","article-title":"KIAA1199 Promotes Sorafenib Tolerance and the Metastasis of Hepatocellular Carcinoma by Activating the EGF\/EGFR-Dependent Epithelial-Mesenchymal Transition Program","volume":"454","author":"Xu","year":"2019","journal-title":"Cancer Lett."},{"key":"ref_42","unstructured":"CEMIP (2021, January 10). Cell Migration Inducing Hyaluronidase 1 [Homo Sapiens (Human)]\u2014Gene\u2014NCBI, Available online: https:\/\/www.ncbi.nlm.nih.gov\/gene\/57214."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.canlet.2005.07.028","article-title":"Upregulation of the KIAA1199 Gene Is Associated with Cellular Mortality","volume":"239","author":"Michishita","year":"2006","journal-title":"Cancer Lett."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Kuscu, C., Evensen, N., Kim, D., Hu, Y.J., Zucker, S., and Cao, J. (2012). Transcriptional and Epigenetic Regulation of KIAA1199 Gene Expression in Human Breast Cancer. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0044661"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1038\/s12276-021-00694-9","article-title":"Decreased Expression of ATF3, Orchestrated by \u03b2-Catenin\/TCF3, MiR-17-5p and HOXA11-AS, Promoted Gastric Cancer Progression via Increased \u03b2-Catenin and CEMIP","volume":"53","author":"Xie","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1800564","DOI":"10.1183\/13993003.00564-2018","article-title":"Transcriptome Profiling Reveals the Complexity of Pirfenidone Effects in Idiopathic Pulmonary Fibrosis","volume":"52","author":"Kwapiszewska","year":"2018","journal-title":"Eur. Respir. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1158\/0008-5472.CAN-17-3149","article-title":"The Endosomal Protein CEMIP Links WNT Signaling to MEK1\u2013ERK1\/2 Activation in Selumetinib-Resistant Intestinal Organoids","volume":"78","author":"Duong","year":"2018","journal-title":"Cancer Res."},{"key":"ref_48","first-page":"4253","article-title":"Genome-Wide ChIP-Seq Analysis of TCF4 Binding Regions in Colorectal Cancer Cells","volume":"7","author":"Chen","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"18193","DOI":"10.1038\/s41598-021-97752-z","article-title":"Hypoxia Increases KIAA1199\/CEMIP Expression and Enhances Cell Migration in Pancreatic Cancer","volume":"11","author":"Oba","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.omtn.2020.01.026","article-title":"Circ_001653 Silencing Promotes the Proliferation and ECM Synthesis of NPCs in IDD by Downregulating MiR-486-3p-Mediated CEMIP","volume":"20","author":"Cui","year":"2020","journal-title":"Mol. Ther.-Nucleic Acids"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.3748\/wjg.v25.i14.1697","article-title":"Functional Role of Long Non-Coding RNA CASC19\/MiR-140-5p\/CEMIP Axis in Colorectal Cancer Progression In Vitro","volume":"25","author":"Wang","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_52","first-page":"328","article-title":"Long Non-Coding RNA HCP5 Promotes Prostate Cancer Cell Proliferation by Acting as the Sponge of MiR-4656 to Modulate CEMIP Expression","volume":"43","author":"Hu","year":"2020","journal-title":"Oncol. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bbrc.2021.08.039","article-title":"MiR-148a-3p Targets CEMIP to Suppress the Genesis of Gastric Cancer Cells","volume":"575","author":"Song","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1080\/15384101.2021.1971375","article-title":"MiR-4677-3p Participates Proliferation and Metastases of Gastric Cancer Cell via CEMIP-PI3K\/AKT Signaling Pathway","volume":"20","author":"Mi","year":"2021","journal-title":"Cell Cycle"},{"key":"ref_55","first-page":"3182","article-title":"LncRNA LINC00958 Promotes Tumor Progression through MiR-4306\/CEMIP Axis in Osteosarcoma","volume":"25","author":"Zhou","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.febslet.2013.11.017","article-title":"N-Terminal Signal Sequence Is Required for Cellular Trafficking and Hyaluronan-Depolymerization of KIAA1199","volume":"588","author":"Yoshida","year":"2014","journal-title":"FEBS Lett."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.febslet.2005.12.076","article-title":"GG: A Domain Involved in Phage LTF Apparatus and Implicated in Human MEB and Non-Syndromic Hearing Loss Diseases","volume":"580","author":"Guo","year":"2006","journal-title":"FEBS Lett."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1093\/bioinformatics\/btl123","article-title":"G8: A Novel Domain Associated with Polycystic Kidney Disease and Non-Syndromic Hearing Loss","volume":"22","author":"He","year":"2006","journal-title":"Bioinformatics"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Tiwari, A., Schneider, M., Fiorino, A., Haider, R., Okoniewski, M.J., Roschitzki, B., Uzozie, A., Menigatti, M., Jiricny, J., and Marra, G. (2013). Early Insights into the Function of KIAA1199, a Markedly Overexpressed Protein in Human Colorectal Tumors. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0069473"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41419-021-03393-5","article-title":"Secreted KIAA1199 Promotes the Progression of Rheumatoid Arthritis by Mediating Hyaluronic Acid Degradation in an ANXA1-Dependent Manner","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/0959-440X(94)90259-3","article-title":"Parallel \u03b2-Domains: A New Fold in Protein Structures","volume":"4","author":"Jurnak","year":"1994","journal-title":"Curr. Opin. Struct. Biol."},{"key":"ref_62","unstructured":"(2021, March 31). CEMIP\u2014Cell Migration-Inducing and Hyaluronan-Binding Protein Precursor\u2014Homo Sapiens (Human)\u2014CEMIP Gene & Protein. Available online: https:\/\/www.uniprot.org\/uniprot\/Q8WUJ3."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neuroscience.2008.03.018","article-title":"The Localization of Proteins Encoded by CRYM, KIAA1199, UBA52, COL9A3, and COL9A1, Genes Highly Expressed in the Cochlea","volume":"154","author":"Usami","year":"2008","journal-title":"Neuroscience"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"5232","DOI":"10.1038\/ncomms6232","article-title":"NF-\u039aB-Induced KIAA1199 Promotes Survival through EGFR Signalling","volume":"5","author":"Shostak","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"7040","DOI":"10.18632\/oncotarget.2220","article-title":"KIAA1199 Interacts with Glycogen Phosphorylase Kinase SS-Subunit (PHKB) to Promote Glycogen Breakdown and Cancer Cell Survival","volume":"5","author":"Terashima","year":"2014","journal-title":"Oncotarget"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1111\/cas.15356","article-title":"CEMIP Promotes Extracellular Matrix-Detached Prostate Cancer Cell Survival by Inhibiting Ferroptosis","volume":"113","author":"Liu","year":"2022","journal-title":"Cancer Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2017.01.049","article-title":"Distribution and Function of Hyaluronan Binding Protein Involved in Hyaluronan Depolymerization (HYBID, KIAA1199) in the Mouse Central Nervous System","volume":"347","author":"Yoshino","year":"2017","journal-title":"Neuroscience"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.ajpath.2017.01.005","article-title":"Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization Controls Endochondral Ossification through Hyaluronan Metabolism","volume":"187","author":"Shimoda","year":"2017","journal-title":"Am. J. Pathol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1093\/glycob\/cwy064","article-title":"KIAA1199 Expression and Hyaluronan Degradation Colocalize in Multiple Sclerosis Lesions","volume":"28","author":"Marella","year":"2018","journal-title":"Glycobiology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1139\/bcb-2017-0151","article-title":"Knockdown of CEMIP Suppresses Proliferation and Induces Apoptosis in Colorectal Cancer Cells: Downregulation of GRP78 and Attenuation of Unfolded Protein Response","volume":"96","author":"Liang","year":"2018","journal-title":"Biochem. Cell Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrm3270","article-title":"The Unfolded Protein Response: Controlling Cell Fate Decisions under ER Stress and Beyond","volume":"13","author":"Hetz","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"6557","DOI":"10.21873\/anticanres.13872","article-title":"Clinical Significance of KIAA1199 as a Novel Target for Gastric Cancer Drug Therapy","volume":"39","author":"Oneyama","year":"2019","journal-title":"Anticancer Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.acthis.2017.11.002","article-title":"Silencing of CEMIP Suppresses Wnt\/\u03b2-Catenin\/Snail Signaling Transduction and Inhibits EMT Program of Colorectal Cancer Cells","volume":"120","author":"Liang","year":"2018","journal-title":"Acta Histochem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"108787","DOI":"10.1016\/j.biopha.2019.108787","article-title":"CEMIP Promotes Ovarian Cancer Development and Progression via the PI3K\/AKT Signaling Pathway","volume":"114","author":"Shen","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"893947","DOI":"10.1155\/2012\/893947","article-title":"Chain Gangs: New Aspects of Hyaluronan Metabolism","volume":"2012","author":"Erickson","year":"2012","journal-title":"Biochem. Res. Int."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nrc1391","article-title":"Hyaluronan: From Extracellular Glue to Pericellular Cue","volume":"4","author":"Toole","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Kobayashi, T., Chanmee, T., and Itano, N. (2020). Hyaluronan: Metabolism and Function. Biomolecules, 10.","DOI":"10.3390\/biom10111525"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"H203","DOI":"10.1152\/ajpheart.01237.2003","article-title":"Glycosaminoglycan Polymerization May Enable Osmotically Inactive Na+ Storage in the Skin","volume":"287","author":"Titze","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_79","first-page":"777","article-title":"The Contribution of Skin Glycosaminoglycans to the Regulation of Sodium Homeostasis in Rats","volume":"67","author":"Sulyok","year":"2018","journal-title":"Physiol. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1042\/BST0350672","article-title":"The Molecular Basis of Inter-Alpha-Inhibitor Heavy Chain Transfer on to Hyaluronan","volume":"35","author":"Milner","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s10555-014-9532-2","article-title":"Sugars in the Microenvironment: The Sticky Problem of HA Turnover in Tumors","volume":"33","author":"Schmaus","year":"2014","journal-title":"Cancer Metastasis Rev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.canlet.2016.02.031","article-title":"Hyaluronan: A Modulator of the Tumor Microenvironment","volume":"375","author":"Chanmee","year":"2016","journal-title":"Cancer Lett."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1084\/jem.20001858","article-title":"Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4","volume":"195","author":"Termeer","year":"2002","journal-title":"J. Exp. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1600-0625.2007.00638.x","article-title":"Hyaluronan Fragments Induce Cytokine and Metalloprotease Upregulation in Human Melanoma Cells in Part by Signalling via TLR4","volume":"17","author":"Voelcker","year":"2008","journal-title":"Exp. Dermatol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.7150\/thno.31073","article-title":"Hyaluronic Acid Oligosaccharides Improve Myocardial Function Reconstruction and Angiogenesis against Myocardial Infarction by Regulation of Macrophages","volume":"9","author":"Wang","year":"2019","journal-title":"Theranostics"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/cm.20544","article-title":"Interaction of Low Molecular Weight Hyaluronan with CD44 and Toll-like Receptors Promotes the Actin Filament-Associated Protein 110-Actin Binding and MyD88-NF\u03baB Signaling Leading to Proinflammatory Cytokine\/Chemokine Production and Breast Tumor Invasion","volume":"68","author":"Bourguignon","year":"2011","journal-title":"Cytoskeleton"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.matbio.2009.11.002","article-title":"Hyaluronan Oligosaccharides Promote Excisional Wound Healing through Enhanced Angiogenesis","volume":"29","author":"Gao","year":"2010","journal-title":"Matrix Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00109-017-1615-4","article-title":"TGF\u03b2 Counteracts LYVE-1-Mediated Induction of Lymphangiogenesis by Small Hyaluronan Oligosaccharides","volume":"96","author":"Bauer","year":"2018","journal-title":"J. Mol. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.fob.2013.08.003","article-title":"Murine Homologue of the Human KIAA1199 Is Implicated in Hyaluronan Binding and Depolymerization","volume":"3","author":"Yoshida","year":"2013","journal-title":"FEBS Open Bio"},{"key":"ref_90","first-page":"358","article-title":"Crohn\u2019s Disease Fibroblasts Overproduce the Novel Protein KIAA1199 to Create Proinflammatory Hyaluronan Fragments","volume":"2","author":"Soroosh","year":"2016","journal-title":"CMGH"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"17156","DOI":"10.18632\/oncotarget.15052","article-title":"KIAA1199 Is Induced by Inflammation and Enhances Malignant Phenotype in Pancreatic Cancer","volume":"8","author":"Kohi","year":"2017","journal-title":"Oncotarget"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0945-053X(01)00172-X","article-title":"The Six Hyaluronidase-like Genes in the Human and Mouse Genomes","volume":"20","author":"Csoka","year":"2001","journal-title":"Matrix Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0092-8674(00)80151-8","article-title":"Solution Structure of the Link Module: A Hyaluronan-Binding Domain Involved in Extracellular Matrix Stability and Cell Migration","volume":"86","author":"Kohda","year":"1996","journal-title":"Cell"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/j.1460-2075.1994.tb06261.x","article-title":"Identification of a Common Hyaluronan Binding Motif in the Hyaluronan Binding Proteins RHAMM, CD44 and Link Protein","volume":"13","author":"Yang","year":"1994","journal-title":"EMBO J."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Belvedere, R., Bizzarro, V., Popolo, A., Dal Piaz, F., Vasaturo, M., Picardi, P., Parente, L., and Petrella, A. (2014). Role of Intracellular and Extracellular Annexin A1 in Migration and Invasion of Human Pancreatic Carcinoma Cells. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-961"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"712561","DOI":"10.1155\/2013\/712561","article-title":"Stimulation of TLR4 by LMW-HA Induces Metastasis in Human Papillary Thyroid Carcinoma through CXCR7","volume":"2013","author":"Dang","year":"2013","journal-title":"Clin. Dev. Immunol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"32259","DOI":"10.1074\/jbc.M300347200","article-title":"Hyaluronan Oligosaccharides Induce CD44 Cleavage and Promote Cell Migration in CD44-Expressing Tumor Cells","volume":"278","author":"Sugahara","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Hanabayashi, M., Takahashi, N., Sobue, Y., Hirabara, S., Ishiguro, N., and Kojima, T. (2016). Hyaluronan Oligosaccharides Induce MMP-1 and -3 via Transcriptional Activation of NF-\u039aB and P38 MAPK in Rheumatoid Synovial Fibroblasts. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0161875"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.4049\/jimmunol.162.7.4171","article-title":"Induction and Regulation of Macrophage Metalloelastase by Hyaluronan Fragments in Mouse Macrophages","volume":"162","author":"Horton","year":"1999","journal-title":"J. Immunol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/PPO.0000000000000138","article-title":"The Contribution of Angiogenesis to the Process of Metastasis","volume":"21","author":"Bielenberg","year":"2015","journal-title":"Cancer J."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1742-4658.2010.07919.x","article-title":"Roles of Matrix Metalloproteinases in Cancer Progression and Their Pharmacological Targeting","volume":"278","author":"Gialeli","year":"2011","journal-title":"FEBS J."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1152\/physrev.00052.2009","article-title":"Hyaluronan as an Immune Regulator in Human Diseases","volume":"91","author":"Jiang","year":"2011","journal-title":"Physiol. Rev."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/bjc.2014.332","article-title":"Accumulation of Small Hyaluronan Oligosaccharides in Tumour Interstitial Fluid Correlates with Lymphatic Invasion and Lymph Node Metastasis","volume":"111","author":"Schmaus","year":"2014","journal-title":"Br. J. Cancer"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.intimp.2019.05.018","article-title":"Knockdown of KIAA1199 Suppresses IL-1\u03b2-Induced Cartilage Degradation and Inflammatory Responses in Human Chondrocytes through the Wnt\/\u03b2-Catenin Signalling Pathway","volume":"73","author":"Ding","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41419-018-1202-9","article-title":"KIAA1199 Is a Secreted Molecule That Enhances Osteoblastic Stem Cell Migration and Recruitment","volume":"10","author":"Chen","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"130019","DOI":"10.1016\/j.bbagen.2021.130019","article-title":"Der Therapeutic DNA Vaccine Encoding CEMIP (KIAA1199) Ameliorates Kidney Fibrosis in Obesity through Inhibiting the Wnt\/\u03b2-Catenin Pathway","volume":"1865","author":"Chen","year":"2021","journal-title":"Biochim. Biophys. Acta-Gen. Subj."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1139\/bcb-2019-0249","article-title":"CEMIP Regulates the Proliferation and Migration of Vascular Smooth Muscle Cells in Atherosclerosis through the WNT-Beta-Catenin Signaling Pathway","volume":"98","author":"Xue","year":"2020","journal-title":"Biochem. Cell Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"30910","DOI":"10.1074\/jbc.M115.673566","article-title":"Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-Binding Protein Involved in HA Depolymerization, KIAA1199) and HA Synthases in Growth Factor-Stimulated Fibroblasts","volume":"290","author":"Nagaoka","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1002\/glia.23188","article-title":"KIAA1199: A Novel Regulator of MEK\/ERK-Induced Schwann Cell Dedifferentiation","volume":"65","author":"Boerboom","year":"2017","journal-title":"Glia"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Ohtsuki, T., Hatipoglu, O.F., Asano, K., Inagaki, J., Nishida, K., and Hirohata, S. (2020). Induction of Cemip in Chondrocytes by Inflammatory Cytokines: Underlying Mechanisms and Potential Involvement in Osteoarthritis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21093140"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/onc.2016.304","article-title":"Wnt Signaling in Cancer","volume":"36","author":"Zhan","year":"2017","journal-title":"Oncogene"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0092-8674(00)00122-7","article-title":"Linking Colorectal Cancer to Wnt Signaling","volume":"103","author":"Bienz","year":"2000","journal-title":"Cell"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1096\/fj.13-243535","article-title":"O-GlcNAcylation Stabilizes \u03b2-Catenin through Direct Competition with Phosphorylation at Threonine 41","volume":"28","author":"Dehennaut","year":"2014","journal-title":"FASEB J."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12943-015-0475-1","article-title":"A Functional Connectome: Regulation of Wnt\/TCF-Dependent Transcription by Pairs of Pathway Activators","volume":"14","author":"Freeman","year":"2015","journal-title":"Mol. Cancer"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1096\/fj.201701078R","article-title":"AMPK\/GSK3b\/b-Catenin Cascade\u2013Triggered Overexpression of CEMIP Promotes Migration and Invasion in Anoikis-Resistant Prostate Cancer Cells by Enhancing Metabolic Reprogramming","volume":"32","author":"Zhang","year":"2018","journal-title":"FASEB J."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s10555-017-9687-8","article-title":"EGFR-Targeted Therapies in the Post-Genomic Era","volume":"36","author":"Xu","year":"2017","journal-title":"Cancer Metastasis Rev."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Uribe, M.L., Marrocco, I., and Yarden, Y. (2021). EGFR in Cancer: Signaling Mechanisms, Drugs, and Acquired Resistance. Cancers, 13.","DOI":"10.3390\/cancers13112748"},{"key":"ref_118","first-page":"9918116","article-title":"Colorectal Cancer: From Genetic Landscape to Targeted Therapy","volume":"2021","author":"Bakkach","year":"2021","journal-title":"J. Oncol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1158\/0008-5472.CAN-17-2020","article-title":"Downregulating Neuropilin-2 Triggers a Novel Mechanism Enabling EGFR-Dependent Resistance to Oncogene-Targeted Therapies","volume":"78","author":"Rizzolio","year":"2018","journal-title":"Cancer Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1172\/JCI66824","article-title":"Metastasis-Associated PRL-3 Induces EGFR Activation and Addiction in Cancer Cells","volume":"123","author":"Yuen","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.18632\/oncotarget.27036","article-title":"CEMIP Upregulates BiP to Promote Breast Cancer Cell Survival in Hypoxia","volume":"10","author":"Banach","year":"2019","journal-title":"Oncotarget"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1126\/science.aaf4405","article-title":"Hypoxic Control of Metastasis","volume":"352","author":"Rankin","year":"2016","journal-title":"Science"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Yao, X., Liu, H., Zhang, X., Zhang, L., Li, X., Wang, C., and Sun, S. (2015). Cell Surface GRP78 Accelerated Breast Cancer Cell Proliferation and Migration by Activating STAT3. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0125634"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1369\/0022155413517701","article-title":"Protein Kinase C, Focal Adhesions and the Regulation of Cell Migration","volume":"62","author":"Fogh","year":"2014","journal-title":"J. Histochem. Cytochem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.3892\/etm.2017.4258","article-title":"Inhibition of PKC\u03b1 Reduces the Ability of Migration of Kidney Cancer Cells but Has No Impact on Cell Apoptosis","volume":"13","author":"Zhan","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2007.11.028","article-title":"Calcium Signaling","volume":"131","author":"Clapham","year":"2007","journal-title":"Cell"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrm1835","article-title":"Complex Networks Orchestrate Epithelial-Mesenchymal Transitions","volume":"7","author":"Thiery","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev-pathol-020117-043854","article-title":"Epithelial Mesenchymal Transition in Tumor Metastasis","volume":"13","author":"Mittal","year":"2018","journal-title":"Annu. Rev. Pathol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"100993","DOI":"10.1016\/j.tranon.2020.100993","article-title":"Analysis of Genomics and Immune Infiltration Patterns of Epithelial-Mesenchymal Transition Related to Metastatic Breast Cancer to Bone","volume":"14","author":"Liu","year":"2021","journal-title":"Transl. Oncol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1242\/jcs.00831","article-title":"Hyaluronan-Oligosaccharide-Induced Transcription of Metalloproteases","volume":"117","author":"Fieber","year":"2004","journal-title":"J. Cell Sci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s10585-008-9143-9","article-title":"Matrix Metalloproteinases Stimulate Epithelial-Mesenchymal Transition during Tumor Development","volume":"25","author":"Orlichenko","year":"2008","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1038\/onc.2013.238","article-title":"EphA2 Promotes Epithelial-Mesenchymal Transition through the Wnt\/\u03b2-Catenin Pathway in Gastric Cancer Cells","volume":"33","author":"Huang","year":"2014","journal-title":"Oncogene"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Nenkov, M., Ma, Y., Ga\u00dfler, N., and Chen, Y. (2021). Metabolic Reprogramming of Colorectal Cancer Cells and the Microenvironment: Implication for Therapy. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126262"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"eaaw5473","DOI":"10.1126\/science.aaw5473","article-title":"Metabolic Reprogramming and Cancer Progression","volume":"368","author":"Faubert","year":"2020","journal-title":"Science"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41568-020-00320-2","article-title":"The Metabolism of Cancer Cells during Metastasis","volume":"21","author":"Bergers","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"618","DOI":"10.2741\/Brushia","article-title":"Phosphorylase Kinase: The Complexity of Its Regulation Is Reflected in the Complexity of Its Structure","volume":"4","author":"Brushia","year":"1999","journal-title":"Front. Biosci."},{"key":"ref_137","first-page":"71","article-title":"Cancer-Associated Fibroblasts: How Do They Contribute to Metastasis?","volume":"36","author":"Kwa","year":"2019","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fcell.2018.00048","article-title":"Hyaluronan, Cancer-Associated Fibroblasts and the Tumor Microenvironment in Malignant Progression","volume":"6","author":"McCarthy","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.ajpath.2020.01.003","article-title":"Implication of HYBID (Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization) in Hyaluronan Degradation by Synovial Fibroblasts in Patients with Knee Osteoarthritis","volume":"190","author":"Shiozawa","year":"2020","journal-title":"Am. J. Pathol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1074\/jbc.RA119.010457","article-title":"HYBID (Alias KIAA1199\/CEMIP) and Hyaluronan Synthase Coordinately Regulate Hyaluronan Metabolism in Histamine-Stimulated Skin Fibroblasts","volume":"295","author":"Yoshida","year":"2020","journal-title":"J. Biol. Chem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12307-010-0052-5","article-title":"Tumor-Associated Macrophages (TAM) and Inflammation in Colorectal Cancer","volume":"4","author":"Erreni","year":"2011","journal-title":"Cancer Microenviron."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"dmm036236","DOI":"10.1242\/dmm.036236","article-title":"Immune Regulation of Metastasis: Mechanistic Insights and Therapeutic Opportunities","volume":"11","author":"Blomberg","year":"2018","journal-title":"DMM Dis. Model. Mech."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nri3789","article-title":"Immune Cell Promotion of Metastasis","volume":"15","author":"Kitamura","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1172\/JCI80007","article-title":"Immunity, Inflammation, and Cancer: An Eternal Fight between Good and Evil","volume":"125","author":"Shalapour","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41419-019-1377-8","article-title":"CEMIP (KIAA1199) Induces a Fibrosis-like Process in Osteoarthritic Chondrocytes","volume":"10","author":"Deroyer","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1016\/j.ajpath.2018.05.012","article-title":"Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization Is Up-Regulated and Involved in Hyaluronan Degradation in Human Osteoarthritic Cartilage","volume":"188","author":"Shimizu","year":"2018","journal-title":"Am. J. Pathol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s13075-015-0637-y","article-title":"KIAA1199 as a Potential Diagnostic Biomarker of Rheumatoid Arthritis Related to Angiogenesis","volume":"17","author":"Yang","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1016\/j.ajpath.2021.07.008","article-title":"Deletion of Hybid (Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization) Results in Attenuation of Osteoarthritis in Mice","volume":"191","author":"Momoeda","year":"2021","journal-title":"Am. J. Pathol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/1878-0261.12095","article-title":"EMT and Inflammation: Inseparable Actors of Cancer Progression","volume":"11","author":"Lesage","year":"2017","journal-title":"Mol. Oncol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/emmm.200900043","article-title":"Inflammation and EMT: An Alliance towards Organ Fibrosis and Cancer Progression","volume":"1","author":"Nieto","year":"2009","journal-title":"EMBO Mol. Med."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.matbio.2022.04.001","article-title":"Sulfated Hyaluronic Acid Inhibits the Hyaluronidase CEMIP and Regulates the HA Metabolism, Proliferation and Differentiation of Fibroblasts","volume":"109","author":"Schmaus","year":"2022","journal-title":"Matrix Biol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"109728","DOI":"10.1016\/j.biopha.2019.109728","article-title":"H3K27me3 Loss Plays a Vital Role in CEMIP Mediated Carcinogenesis and Progression of Breast Cancer with Poor Prognosis","volume":"123","author":"Hsieh","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/sj.bjc.6605515","article-title":"Reversal of Gene Expression Changes in the Colorectal Normal-Adenoma Pathway by NS398 Selective COX2 Inhibitor","volume":"102","author":"Galamb","year":"2010","journal-title":"Br. J. Cancer"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.7150\/jca.50292","article-title":"Lenvatinib Induces Anticancer Activity in Gallbladder Cancer by Targeting AKT","volume":"12","author":"Ye","year":"2021","journal-title":"J. Cancer"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.jconrel.2022.03.042","article-title":"Tumor-Oriented Mathematical Models in Hydrogel Regulation for Precise Topical Administration Regimens","volume":"345","author":"Wang","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"10900","DOI":"10.1038\/s41598-020-67904-8","article-title":"Effects of Pirfenidone Targeting the Tumor Microenvironment and Tumor-Stroma Interaction as a Novel Treatment for Non-Small Cell Lung Cancer","volume":"10","author":"Fujiwara","year":"2020","journal-title":"Sci. Rep."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/20\/5093\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:56:15Z","timestamp":1760144175000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/20\/5093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,18]]},"references-count":156,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["cancers14205093"],"URL":"https:\/\/doi.org\/10.3390\/cancers14205093","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,18]]}}}