{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T11:41:17Z","timestamp":1777290077256,"version":"3.51.4"},"reference-count":43,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T00:00:00Z","timestamp":1666396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III","award":["PI19-00584"],"award-info":[{"award-number":["PI19-00584"]}]},{"name":"Instituto de Salud Carlos III","award":["PI22\/01404"],"award-info":[{"award-number":["PI22\/01404"]}]},{"name":"Instituto de Salud Carlos III","award":["TIRONET2-CM"],"award-info":[{"award-number":["TIRONET2-CM"]}]},{"name":"Instituto de Salud Carlos III","award":["B2017\/BMD-3724"],"award-info":[{"award-number":["B2017\/BMD-3724"]}]},{"name":"Instituto de Salud Carlos III","award":["PEJ-2020-AI_BMD-18292"],"award-info":[{"award-number":["PEJ-2020-AI_BMD-18292"]}]},{"name":"Comunidad de Madrid","award":["PI19-00584"],"award-info":[{"award-number":["PI19-00584"]}]},{"name":"Comunidad de Madrid","award":["PI22\/01404"],"award-info":[{"award-number":["PI22\/01404"]}]},{"name":"Comunidad de Madrid","award":["TIRONET2-CM"],"award-info":[{"award-number":["TIRONET2-CM"]}]},{"name":"Comunidad de Madrid","award":["B2017\/BMD-3724"],"award-info":[{"award-number":["B2017\/BMD-3724"]}]},{"name":"Comunidad de Madrid","award":["PEJ-2020-AI_BMD-18292"],"award-info":[{"award-number":["PEJ-2020-AI_BMD-18292"]}]},{"name":"FEDER funds","award":["PI19-00584"],"award-info":[{"award-number":["PI19-00584"]}]},{"name":"FEDER funds","award":["PI22\/01404"],"award-info":[{"award-number":["PI22\/01404"]}]},{"name":"FEDER funds","award":["TIRONET2-CM"],"award-info":[{"award-number":["TIRONET2-CM"]}]},{"name":"FEDER funds","award":["B2017\/BMD-3724"],"award-info":[{"award-number":["B2017\/BMD-3724"]}]},{"name":"FEDER funds","award":["PEJ-2020-AI_BMD-18292"],"award-info":[{"award-number":["PEJ-2020-AI_BMD-18292"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are heterogeneous rare diseases causing malnutrition and cachexia in which the study of body composition may have an impact in prognosis. Aim: Evaluation of muscle and fat tissues by computed tomography (CT) at the level of the third lumbar (L3 level) at diagnosis and at the end of follow-up in GET-NET patients and their relationships with clinical and biochemical variables as predictors of survival. Methodology: Ninety-eight GEP-NET patients were included. Clinical and biochemical parameters were evaluated. Total body, subcutaneous, visceral and total fat areas and very low-density, low-density, normal density, high-density, very high-density and total muscle areas were obtained from CT images. Results: Body composition measures and overall mortality correlated with age, ECOG (Eastern Cooperative Oncology Group performance status) metastases, lactate dehydrogenase (LDH), albumin and urea levels. Although there was no relationship between body composition variables at diagnosis and overall and specific mortality, an increase in low-density muscle and a decrease in normal-density muscle during follow-up were independently correlated to overall (p &lt;0.05) and tumor-cause mortality (p &lt; 0.05). Conclusion: Although body composition measures obtained by CT at diagnosis did not impact survival of GEP-NET patients, a loss of good quality muscle during follow-up was associated with an increased overall and tumor-related mortality. Nutritional status should therefore be supervised by nutrition specialists and an increase in good quality muscle could improve prognosis.<\/jats:p>","DOI":"10.3390\/cancers14215189","type":"journal-article","created":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T20:43:50Z","timestamp":1666557830000},"page":"5189","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of Change in Body Composition during Follow-Up on the Survival of GEP-NET"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4127-0483","authenticated-orcid":false,"given":"Fernando","family":"Sebastian-Valles","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria de La Princesa, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"S\u00e1nchez de la Blanca Carrero","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4581-0993","authenticated-orcid":false,"given":"V\u00edctor","family":"Rodr\u00edguez-Laval","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital Universitario de La Princesa, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeca","family":"Martinez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Serrano-Somavilla","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Knott-Torcal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria de La Princesa, 28006 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1439-5632","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Mu\u00f1oz de Nova","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery, Hospital Universitario de La Princesa, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Mart\u00edn-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery, Hospital Universitario de La Princesa, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1158-9618","authenticated-orcid":false,"given":"M\u00f3nica","family":"Marazuela","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria de La Princesa, 28006 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Antonio","family":"Sampedro-Nu\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigaci\u00f3n Sanitaria de La Princesa, 28006 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa, 28006 Madrid, 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