{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:22:33Z","timestamp":1777710153146,"version":"3.51.4"},"reference-count":35,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T00:00:00Z","timestamp":1666396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Scientific Foundation of China","award":["81972784"],"award-info":[{"award-number":["81972784"]}]},{"name":"National Natural Scientific Foundation of China","award":["2019-MS-146"],"award-info":[{"award-number":["2019-MS-146"]}]},{"name":"National Natural Scientific Foundation of China","award":["JYTQN2020039"],"award-info":[{"award-number":["JYTQN2020039"]}]},{"name":"Natural Scientific Foundation of Liaoning","award":["81972784"],"award-info":[{"award-number":["81972784"]}]},{"name":"Natural Scientific Foundation of Liaoning","award":["2019-MS-146"],"award-info":[{"award-number":["2019-MS-146"]}]},{"name":"Natural Scientific Foundation of Liaoning","award":["JYTQN2020039"],"award-info":[{"award-number":["JYTQN2020039"]}]},{"name":"Scientific Research Fund of the Liaoning Provincial Department of Education","award":["81972784"],"award-info":[{"award-number":["81972784"]}]},{"name":"Scientific Research Fund of the Liaoning Provincial Department of Education","award":["2019-MS-146"],"award-info":[{"award-number":["2019-MS-146"]}]},{"name":"Scientific Research Fund of the Liaoning Provincial Department of Education","award":["JYTQN2020039"],"award-info":[{"award-number":["JYTQN2020039"]}]},{"name":"\u201cDouble First-Class\u201d Disciplinary Construction Project of Liaoning Medical University","award":["81972784"],"award-info":[{"award-number":["81972784"]}]},{"name":"\u201cDouble First-Class\u201d Disciplinary Construction Project of Liaoning Medical University","award":["2019-MS-146"],"award-info":[{"award-number":["2019-MS-146"]}]},{"name":"\u201cDouble First-Class\u201d Disciplinary Construction Project of Liaoning Medical University","award":["JYTQN2020039"],"award-info":[{"award-number":["JYTQN2020039"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>SLC3A2, the heavy chain of the CD98 protein, is highly expressed in many cancers, including lung cancer. It can regulate the proliferation and the metastasis of cancer cells via the integrin signaling pathway. Liquid biopsy is a novel method for tumor diagnosis. The diagnostic or prognostic roles of serum SLC3A2 in lung cancer are still not clear. In this study, we analyzed SLC3A2 mRNA levels in human lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) using the TCGA database and serum SLC3A2 protein levels using ELISA. We confirmed high SLC3A2 levels in both the serum and tissue of LUAD and LUSC patients. Both serum and tissue SLC3A2 could be used as prognostic markers for overall LUAD and subgroups of LUSC patients. SLC3A2 induced tumorigenesis via the MEK\/ERK signaling pathway in LUAD and LUSC cells.<\/jats:p>","DOI":"10.3390\/cancers14215191","type":"journal-article","created":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T20:43:50Z","timestamp":1666557830000},"page":"5191","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Both In Situ and Circulating SLC3A2 Could Be Used as Prognostic Markers for Human Lung Squamous Cell Carcinoma and Lung Adenocarcinoma"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1231-3616","authenticated-orcid":false,"given":"Dahua","family":"Liu","sequence":"first","affiliation":[{"name":"Biological Anthropology Institute, College of Basic Medical Science, Jinzhou Medical University, Jinzhou 121001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"An","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Jinzhou Central Hospital, Jinzhou 121001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guimin","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Basic Nursing, College of Nursing, Jinzhou Medical University, Jinzhou 121001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9944-7675","authenticated-orcid":false,"given":"Yanan","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5206-0270","authenticated-orcid":false,"given":"Pu","family":"Xia","sequence":"additional","affiliation":[{"name":"Biological Anthropology Institute, College of Basic Medical Science, Jinzhou Medical University, Jinzhou 121001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.21037\/tcr-22-245","article-title":"The identification of hub biomarkers and pathways in lung cancer and prognostic evaluation","volume":"11","author":"Yin","year":"2022","journal-title":"Transl. 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