{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:42:03Z","timestamp":1787625723833,"version":"build-2736575974"},"reference-count":212,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Associazione Italiana per la Ricerca sul Cancro","award":["ID-065"],"award-info":[{"award-number":["ID-065"]}]},{"name":"Associazione Italiana per la Ricerca sul Cancro","award":["IG-22082"],"award-info":[{"award-number":["IG-22082"]}]},{"name":"European Hematology Association","award":["ID-065"],"award-info":[{"award-number":["ID-065"]}]},{"name":"European Hematology Association","award":["IG-22082"],"award-info":[{"award-number":["IG-22082"]}]},{"name":"Fondazione Regionale per la Ricerca Biomedica\/ERA-NET TRANSCAN-2","award":["ID-065"],"award-info":[{"award-number":["ID-065"]}]},{"name":"Fondazione Regionale per la Ricerca Biomedica\/ERA-NET TRANSCAN-2","award":["IG-22082"],"award-info":[{"award-number":["IG-22082"]}]},{"DOI":"10.13039\/501100007076","name":"Associazione Italiana Ricerca sul Cancro","doi-asserted-by":"publisher","award":["ID-065"],"award-info":[{"award-number":["ID-065"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007076","name":"Associazione Italiana Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG-22082"],"award-info":[{"award-number":["IG-22082"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Within the context of precision medicine, the scientific community is giving particular attention to early diagnosis and intervention, guided by non-invasive methodologies. Liquid biopsy (LBx) is a recent laboratory approach consisting of a non-invasive blood draw, which allows the detection of information about potential prognostic factors, or markers to be used for diagnostic purposes; it might also allow the clinician to establish a treatment regimen and predict a patient\u2019s response. Since the discovery of circulating tumor cells (CTCs) in the nineteenth century, the possibility of integrating LBx into clinical practice has been explored, primarily because of its safeness and easy execution: indeed, compared to solid biopsy, sampling-related risks are less of a concern, and the quickness and repeatability of the process could help confirm a prompt diagnosis or to further corroborate the existence of a metastatic spreading of the disease. LBx\u2019s usefulness has been consolidated in a narrow range of oncological settings, first of all, non-small cell lung carcinoma (NSCLC), and it is now gradually being assessed also in lymphoproliferative diseases, such as acute lymphocytic leukemia (ALL), B-cell lymphomas, and multiple myeloma. The present review aims to summarize LBx\u2019s overall characteristics (such as its advantages and flaws, collection and analysis methodologies, indications, and targets of the test), and to highlight the applications of this technique within the specific field of B-cell malignancies. The perspectives on how such a simple and convenient technique could improve hemato-oncological clinical practice are broadly encouraging, yet far from a complete integration in routine clinical settings.<\/jats:p>","DOI":"10.3390\/cancers14215378","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T23:26:32Z","timestamp":1667258792000},"page":"5378","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Liquid Biopsy in Cancer: Focus on Lymphoproliferative Disorders"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0385-0935","authenticated-orcid":false,"given":"Francesco D.","family":"Savino","sequence":"first","affiliation":[{"name":"Clinical Research Development and Phase I Unit, ASST Spedali Civili di Brescia, 25121 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6029-0930","authenticated-orcid":false,"given":"Fabio","family":"Rigali","sequence":"additional","affiliation":[{"name":"Clinical Research Development and Phase I Unit, ASST Spedali Civili di Brescia, 25121 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Giustini","sequence":"additional","affiliation":[{"name":"Clinical Research Development and Phase I Unit, ASST Spedali Civili di Brescia, 25121 Brescia, Italy"},{"name":"Clinical Chemistry Laboratory, Flow Cytometry Unit, ASST Spedali Civili di Brescia, 25121 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"D\u2019Aliberti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy"},{"name":"Hematology and Clinical Research Unit, San Gerardo Hospital, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy"},{"name":"Hematology and Clinical Research Unit, San Gerardo Hospital, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4198-9620","authenticated-orcid":false,"given":"Rocco","family":"Piazza","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy"},{"name":"Hematology and Clinical Research Unit, San Gerardo Hospital, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Sacco","sequence":"additional","affiliation":[{"name":"Clinical Research Development and Phase I Unit, ASST Spedali Civili di Brescia, 25121 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1872-5128","authenticated-orcid":false,"given":"Aldo M.","family":"Roccaro","sequence":"additional","affiliation":[{"name":"Clinical Research Development and Phase I Unit, ASST Spedali Civili di Brescia, 25121 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nrclinonc.2017.14","article-title":"Integrating liquid biopsies into the management of cancer","volume":"14","author":"Siravegna","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1056\/NEJMra1706174","article-title":"Application of Cell-free DNA Analysis to Cancer Treatment","volume":"379","author":"Corcoran","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/ejhg.2015.281","article-title":"Genomic complexity of urothelial bladder cancer revealed in urinary cfDNA","volume":"24","author":"Togneri","year":"2016","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bbcan.2019.05.007","article-title":"Clinical validity of saliva and novel technology for cancer detection","volume":"1872","author":"Wei","year":"2019","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"ref_5","first-page":"187","article-title":"Multitarget stool DNA testing for colorectal-cancer screening","volume":"371","author":"Imperiale","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"8839","DOI":"10.1038\/ncomms9839","article-title":"Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma","volume":"6","author":"Mayor","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/14737159.2017.1288568","article-title":"Profile of the Roche cobas(R) EGFR mutation test v2 for non-small cell lung cancer","volume":"17","author":"Malapelle","year":"2017","journal-title":"Expert. Rev. Mol. Diagn."},{"key":"ref_8","unstructured":"FDA (2020). FDA Approves First Liquid Biopsy Next-Generation Sequencing Companion Diagnostic Test."},{"key":"ref_9","unstructured":"FDA (2020). FDA Approves Liquid Biopsy NGS Companion Diagnostic Test for Multiple Cancers and Biomarkers."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.jtho.2018.05.030","article-title":"Liquid Biopsy for Advanced Non-Small Cell Lung Cancer (NSCLC): A Statement Paper from the IASLC","volume":"13","author":"Rolfo","year":"2018","journal-title":"J. Thorac. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1158\/1078-0432.CCR-19-0624","article-title":"Clinical Utility of Comprehensive Cell-free DNA Analysis to Identify Genomic Biomarkers in Patients with Newly Diagnosed Metastatic Non-small Cell Lung Cancer","volume":"25","author":"Leighl","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1001\/jamaoncol.2018.4305","article-title":"Clinical Implications of Plasma-Based Genotyping With the Delivery of Personalized Therapy in Metastatic Non-Small Cell Lung Cancer","volume":"5","author":"Aggarwal","year":"2019","journal-title":"JAMA Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s43018-020-0043-5","article-title":"Circulating tumor DNA and liquid biopsy in oncology","volume":"1","author":"Cescon","year":"2020","journal-title":"Nat. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.annonc.2020.07.014","article-title":"Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: A report from the ESMO Precision Medicine Working Group","volume":"31","author":"Mosele","year":"2020","journal-title":"Ann. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.semcancer.2022.03.013","article-title":"The potential of liquid biopsy in the management of cancer patients","volume":"84","author":"Markou","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.eururo.2016.08.004","article-title":"Complications After Systematic, Random, and Image-guided Prostate Biopsy","volume":"71","author":"Borghesi","year":"2017","journal-title":"Eur. Urol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Lu, M., Shi, B., Wang, J., Cao, Q., and Cui, Q. (2010). TAM: A method for enrichment and depletion analysis of a microRNA category in a list of microRNAs. BMC Bioinform., 11.","DOI":"10.1186\/1471-2105-11-419"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.molmed.2021.07.001","article-title":"Cell-free circulating tumor DNA profiling in cancer management","volume":"27","author":"Roy","year":"2021","journal-title":"Trends Mol. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Roy, D., Pascher, A., Juratli, M.A., and Sporn, J.C. (2021). The Potential of Aptamer-Mediated Liquid Biopsy for Early Detection of Cancer. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115601"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1001\/jamaoncol.2016.0173","article-title":"Prospective Validation of Rapid Plasma Genotyping for the Detection of EGFR and KRAS Mutations in Advanced Lung Cancer","volume":"2","author":"Sacher","year":"2016","journal-title":"JAMA Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"100825","DOI":"10.1016\/j.mam.2019.10.002","article-title":"Circulating miRNA analysis for cancer diagnostics and therapy","volume":"72","author":"Valihrach","year":"2020","journal-title":"Mol. Aspects Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"562","DOI":"10.24953\/turkjped.2016.05.019","article-title":"Bone marrow aspiration complications: Iliopsoas abscess and sacroiliac osteomyelitis","volume":"58","author":"Ozdemir","year":"2016","journal-title":"Turk J. Pediatr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4103\/0974-2077.172206","article-title":"Complications of skin biopsy","volume":"8","author":"Abhishek","year":"2015","journal-title":"J. Cutan. Aesthet. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJMoa1113205","article-title":"Intratumor heterogeneity and branched evolution revealed by multiregion sequencing","volume":"366","author":"Gerlinger","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1111\/cas.13972","article-title":"Clinical utility of circulating tumor DNA for colorectal cancer","volume":"110","author":"Osumi","year":"2019","journal-title":"Cancer Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1039\/D1NR06804K","article-title":"A novel phage display based platform for exosome diversity characterization","volume":"14","author":"Maisano","year":"2022","journal-title":"Nanoscale"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1177\/1129729817747543","article-title":"Complications and adequacy of transplant kidney biopsies: A comparison of techniques","volume":"19","author":"Plattner","year":"2018","journal-title":"J. Vasc. Access"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jvir.2019.07.016","article-title":"Percutaneous Lung Biopsy in Immunocompromised Pediatric Patients","volume":"31","author":"Cleveland","year":"2020","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1093\/annonc\/mdz227","article-title":"How liquid biopsies can change clinical practice in oncology","volume":"30","author":"Siravegna","year":"2019","journal-title":"Ann. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"102978","DOI":"10.1016\/j.critrevonc.2020.102978","article-title":"Challenges and opportunities of cfDNA analysis implementation in clinical practice: Perspective of the International Society of Liquid Biopsy (ISLB)","volume":"151","author":"Rolfo","year":"2020","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.jtho.2016.05.035","article-title":"A Highly Sensitive and Quantitative Test Platform for Detection of NSCLC EGFR Mutations in Urine and Plasma","volume":"11","author":"Reckamp","year":"2016","journal-title":"J. Thorac. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1002\/1878-0261.12574","article-title":"Prospective detection of mutations in cerebrospinal fluid, pleural effusion, and ascites of advanced cancer patients to guide treatment decisions","volume":"13","author":"Villatoro","year":"2019","journal-title":"Mol. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jtho.2020.10.008","article-title":"Genotyping of Cerebrospinal Fluid Associated With Osimertinib Response and Resistance for Leptomeningeal Metastases in EGFR-Mutated NSCLC","volume":"16","author":"Zheng","year":"2021","journal-title":"J. Thorac. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1200\/JCO.2012.45.2011","article-title":"Liquid biopsies: Genotyping circulating tumor DNA","volume":"32","author":"Diaz","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1373\/clinchem.2014.222679","article-title":"Circulating tumor DNA as a liquid biopsy for cancer","volume":"61","author":"Heitzer","year":"2015","journal-title":"Clin. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jhep.2019.04.003","article-title":"Liver-derived cell-free nucleic acids in plasma: Biology and applications in liquid biopsies","volume":"71","author":"Jiang","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.1158\/1078-0432.CCR-18-0969","article-title":"Clonal Hematopoiesis: A New Layer in the Liquid Biopsy Story in Lung Cancer","volume":"24","author":"Bauml","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41392-020-00261-0","article-title":"Exosomes: Key players in cancer and potential therapeutic strategy","volume":"5","author":"Dai","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5068","DOI":"10.1038\/s41467-018-07466-6","article-title":"Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease","volume":"9","author":"Moss","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13148-019-0689-y","article-title":"Comprehensive DNA methylation analysis of tissue of origin of plasma cell-free DNA by methylated CpG tandem amplification and sequencing (MCTA-Seq)","volume":"11","author":"Liu","year":"2019","journal-title":"Clin. Epigenetics"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1089\/neu.2013.3178","article-title":"Elevated cell-free plasma DNA level as an independent predictor of mortality in patients with severe traumatic brain injury","volume":"31","author":"Simon","year":"2014","journal-title":"J. Neurotrauma"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1080\/02699052.2017.1312018","article-title":"Circulating extracellular DNA levels are acutely elevated in ischaemic stroke and associated with innate immune system activation","volume":"31","author":"Petrone","year":"2017","journal-title":"Brain Inj."},{"key":"ref_43","first-page":"164","article-title":"Exercise-induced increases in cell free DNA in human plasma originate predominantly from cells of the haematopoietic lineage","volume":"21","author":"Tug","year":"2015","journal-title":"Exerc. Immunol. Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"13336","DOI":"10.1073\/pnas.1517494112","article-title":"Noninvasive monitoring of infection and rejection after lung transplantation","volume":"112","author":"Martin","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12941-019-0309-x","article-title":"Plasma cell-free DNA: A potential biomarker for early prediction of severe dengue","volume":"18","author":"Phuong","year":"2019","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"eaat4921","DOI":"10.1126\/scitranslmed.aat4921","article-title":"Enhanced detection of circulating tumor DNA by fragment size analysis","volume":"10","author":"Mouliere","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Underhill, H.R., Kitzman, J.O., Hellwig, S., Welker, N.C., Daza, R., Baker, D.N., Gligorich, K.M., Rostomily, R.C., Bronner, M.P., and Shendure, J. (2016). Fragment Length of Circulating Tumor DNA. PLoS Genet., 12.","DOI":"10.1371\/journal.pgen.1006162"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature22364","article-title":"Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution","volume":"545","author":"Abbosh","year":"2017","journal-title":"Nature"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"86253","DOI":"10.18632\/oncotarget.21134","article-title":"Liquid biopsy in colon cancer: Comparison of different circulating DNA extraction systems following absolute quantification of KRAS mutations using Intplex allele-specific PCR","volume":"8","author":"Kloten","year":"2017","journal-title":"Oncotarget"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"665","DOI":"10.21037\/tlcr.2016.12.03","article-title":"Comparison of methods for circulating cell-free DNA isolation using blood from cancer patients: Impact on biomarker testing","volume":"5","author":"Torrente","year":"2016","journal-title":"Transl. Lung Cancer Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jmoldx.2016.09.009","article-title":"A Comparison of Cell-Free DNA Isolation Kits: Isolation and Quantification of Cell-Free DNA in Plasma","volume":"19","author":"Sorber","year":"2017","journal-title":"J. Mol. Diagn."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cancergen.2018.02.004","article-title":"Comparison of 4 commercial kits for the extraction of circulating DNA from plasma","volume":"228\u2013229","author":"Warton","year":"2018","journal-title":"Cancer Genet."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cancergen.2018.08.005","article-title":"Evaluation of commercial kits for purification of circulating free DNA","volume":"228\u2013229","author":"Diefenbach","year":"2018","journal-title":"Cancer Genet."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.jmoldx.2022.02.005","article-title":"Quantitative PCR-Based Method to Assess Cell-Free DNA Quality, Adjust Input Mass, and Improve Next-Generation Sequencing Assay Performance","volume":"24","author":"Saelee","year":"2022","journal-title":"J. Mol. Diagn."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41597-022-01276-8","article-title":"Ultra-deep sequencing data from a liquid biopsy proficiency study demonstrating analytic validity","volume":"9","author":"Gong","year":"2022","journal-title":"Sci. Data"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","article-title":"Initial sequencing and analysis of the human genome","volume":"409","author":"Lander","year":"2001","journal-title":"Nature"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/nm.3519","article-title":"An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage","volume":"20","author":"Newman","year":"2014","journal-title":"Nat. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nbt.3520","article-title":"Integrated digital error suppression for improved detection of circulating tumor DNA","volume":"34","author":"Newman","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1093\/annonc\/mdv177","article-title":"Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer","volume":"26","author":"Tie","year":"2015","journal-title":"Ann. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Mellert, H., Reese, J., Jackson, L., Maxwell, V., Tschida, C., and Pestano, G.A. (2021). Targeted Next-Generation Sequencing of Liquid Biopsy Samples from Patients with NSCLC. Diagnostics, 11.","DOI":"10.3390\/diagnostics11020155"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41416-022-01776-9","article-title":"Integrating circulating-free DNA (cfDNA) analysis into clinical practice: Opportunities and challenges","volume":"127","author":"Makarem","year":"2022","journal-title":"Br. J. Cancer"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13073-020-00735-4","article-title":"Shallow whole-genome sequencing of plasma cell-free DNA accurately differentiates small from non-small cell lung carcinoma","volume":"12","author":"Raman","year":"2020","journal-title":"Genome Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1582-4934.2008.00510.x","article-title":"MicroRNA and cancer--focus on apoptosis","volume":"13","author":"Wang","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"D98","DOI":"10.1093\/nar\/gkn714","article-title":"miR2 Disease: A manually curated database for microRNA deregulation in human disease","volume":"37","author":"Jiang","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1039\/c2mb25180a","article-title":"RWRMDA: Predicting novel human microRNA-disease associations","volume":"8","author":"Chen","year":"2012","journal-title":"Mol. Biosyst."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"D1070","DOI":"10.1093\/nar\/gkt1023","article-title":"HMDD v2.0: A database for experimentally supported human microRNA and disease associations","volume":"42","author":"Li","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.molmed.2012.10.006","article-title":"Could circulating miRNAs contribute to cancer therapy?","volume":"19","author":"Chen","year":"2013","journal-title":"Trends Mol. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nmeth.1682","article-title":"Toward the blood-borne miRNome of human diseases","volume":"8","author":"Keller","year":"2011","journal-title":"Nat. Methods"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"432","DOI":"10.7150\/jca.4919","article-title":"Cell-free Circulating miRNA Biomarkers in Cancer","volume":"3","author":"Mo","year":"2012","journal-title":"J. Cancer"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1126\/science.1203543","article-title":"A perspective on cancer cell metastasis","volume":"331","author":"Chaffer","year":"2011","journal-title":"Science"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1373\/clinchem.2012.194258","article-title":"Circulating tumor cells: Liquid biopsy of cancer","volume":"59","author":"Pantel","year":"2013","journal-title":"Clin. Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S1470-2045(14)70069-5","article-title":"Clinical validity of circulating tumour cells in patients with metastatic breast cancer: A pooled analysis of individual patient data","volume":"15","author":"Bidard","year":"2014","journal-title":"Lancet Oncol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"21083","DOI":"10.1073\/pnas.1320659110","article-title":"Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients","volume":"110","author":"Ni","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nbt.2892","article-title":"Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer","volume":"32","author":"Lohr","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s12094-015-1275-1","article-title":"Correlation of hormone receptor status between circulating tumor cells, primary tumor, and metastasis in breast cancer patients","volume":"17","author":"Kalinsky","year":"2015","journal-title":"Clin. Transl. Oncol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nature11217","article-title":"RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis","volume":"487","author":"Yu","year":"2012","journal-title":"Nature"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Wallwiener, M., Hartkopf, A.D., Riethdorf, S., Nees, J., Sprick, M.R., Schonfisch, B., Taran, F.A., Heil, J., Sohn, C., and Pantel, K. (2015). The impact of HER2 phenotype of circulating tumor cells in metastatic breast cancer: A retrospective study in 107 patients. BMC Cancer, 15.","DOI":"10.1186\/s12885-015-1423-6"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1073\/pnas.1617032114","article-title":"An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma","volume":"114","author":"Kalinich","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41568-019-0180-2","article-title":"Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells","volume":"19","author":"Keller","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ccell.2017.01.002","article-title":"Liquid Biopsies, What We Do Not Know (Yet)","volume":"31","author":"Bardelli","year":"2017","journal-title":"Cancer Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.molonc.2016.01.011","article-title":"Gene expression profiling and DNA methylation analyses of CTCs","volume":"10","author":"Lianidou","year":"2016","journal-title":"Mol. Oncol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41467-017-00196-1","article-title":"Molecular characterization of breast cancer CTCs associated with brain metastasis","volume":"8","author":"Boral","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s10549-017-4452-9","article-title":"Molecular characterization and heterogeneity of circulating tumor cells in breast cancer","volume":"166","author":"Jakabova","year":"2017","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1373\/clinchem.2010.154328","article-title":"Molecular characterization of circulating tumor cells in breast cancer by a liquid bead array hybridization assay","volume":"57","author":"Markou","year":"2011","journal-title":"Clin. Chem."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Strati, A., Markou, A., Parisi, C., Politaki, E., Mavroudis, D., Georgoulias, V., and Lianidou, E. (2011). Gene expression profile of circulating tumor cells in breast cancer by RT-qPCR. BMC Cancer, 11.","DOI":"10.1186\/1471-2407-11-422"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrc3820","article-title":"Challenges in circulating tumour cell research","volume":"14","author":"Pantel","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"ref_87","first-page":"427","article-title":"A new device for rapid isolation by size and characterization of rare circulating tumor cells","volume":"31","author":"Desitter","year":"2011","journal-title":"Anticancer Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"850241","DOI":"10.3389\/fbioe.2022.850241","article-title":"Nanomaterial-Based Immunocapture Platforms for the Recognition, Isolation, and Detection of Circulating Tumor Cells","volume":"10","author":"Liu","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.addr.2018.01.011","article-title":"Clinical applications of the CellSearch platform in cancer patients","volume":"125","author":"Riethdorf","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1056\/NEJMra072067","article-title":"Epigenetics in cancer","volume":"358","author":"Esteller","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.3390\/genes6041053","article-title":"Characterization of DNA Methylation in Circulating Tumor Cells","volume":"6","author":"Pixberg","year":"2015","journal-title":"Genes"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1373\/clinchem.2011.165902","article-title":"DNA methylation of tumor suppressor and metastasis suppressor genes in circulating tumor cells","volume":"57","author":"Chimonidou","year":"2011","journal-title":"Clin. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"9239","DOI":"10.1038\/s41598-020-66197-1","article-title":"DNA methylation markers panel can improve prediction of response to neoadjuvant chemotherapy in luminal B breast cancer","volume":"10","author":"Sigin","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4939-1804-1_1","article-title":"Cancer epigenetics: An introduction","volume":"1238","author":"Kanwal","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1093\/annonc\/mdy119","article-title":"Targeted methylation sequencing of plasma cell-free DNA for cancer detection and classification","volume":"29","author":"Liu","year":"2018","journal-title":"Ann. Oncol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.annonc.2020.02.011","article-title":"Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA","volume":"31","author":"Liu","year":"2020","journal-title":"Ann. Oncol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.annonc.2021.05.806","article-title":"Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set","volume":"32","author":"Klein","year":"2021","journal-title":"Ann. Oncol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.clinbiochem.2012.09.015","article-title":"CST6 promoter methylation in circulating cell-free DNA of breast cancer patients","volume":"46","author":"Chimonidou","year":"2013","journal-title":"Clin. Biochem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1373\/clinchem.2012.191551","article-title":"SOX17 promoter methylation in circulating tumor cells and matched cell-free DNA isolated from plasma of patients with breast cancer","volume":"59","author":"Chimonidou","year":"2013","journal-title":"Clin. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ejca.2008.12.008","article-title":"Methylated genes as new cancer biomarkers","volume":"45","author":"Duffy","year":"2009","journal-title":"Eur. J. Cancer"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tcb.2016.11.003","article-title":"Extracellular Vesicles: Unique Intercellular Delivery Vehicles","volume":"27","author":"Maas","year":"2017","journal-title":"Trends Cell Biol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1242\/jcs.064386","article-title":"Microvesicles: Mediators of extracellular communication during cancer progression","volume":"123","author":"Clancy","year":"2010","journal-title":"J. Cell Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1172\/JCI66517","article-title":"BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression","volume":"123","author":"Roccaro","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"100734","DOI":"10.1016\/j.blre.2020.100734","article-title":"Deciphering the messages carried by extracellular vesicles in hematological malignancies","volume":"46","author":"Longjohn","year":"2021","journal-title":"Blood Rev."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Jurj, A., Zanoaga, O., Braicu, C., Lazar, V., Tomuleasa, C., Irimie, A., and Berindan-Neagoe, I. (2020). A Comprehensive Picture of Extracellular Vesicles and Their Contents. Molecular Transfer to Cancer Cells. Cancers, 12.","DOI":"10.3390\/cancers12020298"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1074\/jbc.C113.532267","article-title":"Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer","volume":"289","author":"Kahlert","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/cr.2014.44","article-title":"Double-stranded DNA in exosomes: A novel biomarker in cancer detection","volume":"24","author":"Thakur","year":"2014","journal-title":"Cell Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13578-022-00771-0","article-title":"DNA in extracellular vesicles: From evolution to its current application in health and disease","volume":"12","author":"Ghanam","year":"2022","journal-title":"Cell Biosci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s10555-013-9441-9","article-title":"Exosomes in cancer development, metastasis, and drug resistance: A comprehensive review","volume":"32","author":"Azmi","year":"2013","journal-title":"Cancer Metastasis. Rev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1182\/blood-2014-12-618470","article-title":"Characterization of CLL exosomes reveals a distinct microRNA signature and enhanced secretion by activation of BCR signaling","volume":"125","author":"Yeh","year":"2015","journal-title":"Blood"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"82920","DOI":"10.18632\/oncotarget.20503","article-title":"RNA-seq reveals distinctive RNA profiles of small extracellular vesicles from different human liver cancer cell lines","volume":"8","author":"Berardocco","year":"2017","journal-title":"Oncotarget"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1080\/15476286.2015.1056975","article-title":"Small RNA deep sequencing discriminates subsets of extracellular vesicles released by melanoma cells--Evidence of unique microRNA cargos","volume":"12","author":"Lunavat","year":"2015","journal-title":"RNA Biol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): A position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Thery","year":"2018","journal-title":"J. Extracell. Vesicles"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Szatanek, R., Baj-Krzyworzeka, M., Zimoch, J., Lekka, M., Siedlar, M., and Baran, J. (2017). The Methods of Choice for Extracellular Vesicles (EVs) Characterization. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18061153"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.cell.2020.07.009","article-title":"Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers","volume":"182","author":"Hoshino","year":"2020","journal-title":"Cell"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Paolino, G., Huber, V., Camerini, S., Casella, M., Macone, A., Bertuccini, L., Iosi, F., Moliterni, E., Cecchetti, S., and Ruspantini, I. (2021). The Fatty Acid and Protein Profiles of Circulating CD81-Positive Small Extracellular Vesicles Are Associated with Disease Stage in Melanoma Patients. Cancers, 13.","DOI":"10.20944\/preprints202105.0577.v1"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ymeth.2015.03.018","article-title":"Proteomics characterization of exosome cargo","volume":"87","author":"Schey","year":"2015","journal-title":"Methods"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5 th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms","volume":"36","author":"Alaggio","year":"2022","journal-title":"Leukemia"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/j.1365-2141.1994.tb04828.x","article-title":"Point mutations of the N-ras gene in the blood plasma DNA of patients with myelodysplastic syndrome or acute myelogenous leukaemia","volume":"86","author":"Vasioukhin","year":"1994","journal-title":"Br. J. Haematol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1182\/blood-2003-06-1840","article-title":"Relative increase in leukemia-specific DNA in peripheral blood plasma from patients with acute myeloid leukemia and myelodysplasia","volume":"103","author":"Rogers","year":"2004","journal-title":"Blood"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/clinchem\/hvz041","article-title":"Mass Spectrometry for Identification, Monitoring, and Minimal Residual Disease Detection of M-Proteins","volume":"66","author":"Zajec","year":"2020","journal-title":"Clin. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/sj.bjc.6606082","article-title":"Assessment of circulating biomarkers for potential pharmacodynamic utility in patients with lymphoma","volume":"104","author":"Greystoke","year":"2011","journal-title":"Br. J. Cancer"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Cheng, S.H., Lau, K.M., Li, C.K., Chan, N.P., Ip, R.K., Cheng, C.K., Lee, V., Shing, M.M., Leung, A.W., and Ha, S.Y. (2013). Minimal residual disease-based risk stratification in Chinese childhood acute lymphoblastic leukemia by flow cytometry and plasma DNA quantitative polymerase chain reaction. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0069467"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1182\/blood-2012-09-454694","article-title":"Plasma Epstein-Barr virus DNA predicts outcome in advanced Hodgkin lymphoma: Correlative analysis from a large North American cooperative group trial","volume":"121","author":"Kanakry","year":"2013","journal-title":"Blood"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1093\/annonc\/mdp006","article-title":"Cell-free circulating DNA in Hodgkin\u2019s and non-Hodgkin\u2019s lymphomas","volume":"20","author":"Hohaus","year":"2009","journal-title":"Ann. Oncol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.cell.2019.06.011","article-title":"Dynamic Risk Profiling Using Serial Tumor Biomarkers for Personalized Outcome Prediction","volume":"178","author":"Kurtz","year":"2019","journal-title":"Cell"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1182\/blood-2015-03-635169","article-title":"Noninvasive monitoring of diffuse large B-cell lymphoma by immunoglobulin high-throughput sequencing","volume":"125","author":"Kurtz","year":"2015","journal-title":"Blood"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S1470-2045(15)70106-3","article-title":"Circulating tumour DNA and CT monitoring in patients with untreated diffuse large B-cell lymphoma: A correlative biomarker study","volume":"16","author":"Roschewski","year":"2015","journal-title":"Lancet Oncol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.jmoldx.2018.07.006","article-title":"Noninvasive Molecular Monitoring in Multiple Myeloma Patients Using Cell-Free Tumor DNA: A Pilot Study","volume":"20","author":"Biancon","year":"2018","journal-title":"J. Mol. Diagn."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/ejh.13358","article-title":"Dynamics of tumor-specific cfDNA in response to therapy in multiple myeloma patients","volume":"104","author":"Vrabel","year":"2020","journal-title":"Eur. J. Haematol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1182\/blood-2013-01-478222","article-title":"Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia","volume":"122","author":"Ferrajoli","year":"2013","journal-title":"Blood"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1182\/blood-2008-09-178228","article-title":"microRNA expression in the biology, prognosis, and therapy of Waldenstrom macroglobulinemia","volume":"113","author":"Roccaro","year":"2009","journal-title":"Blood"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1182\/blood-2014-03-559690","article-title":"MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia","volume":"124","author":"Cui","year":"2014","journal-title":"Blood"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"25355","DOI":"10.3402\/jev.v5.25355","article-title":"Extensive surface protein profiles of extracellular vesicles from cancer cells may provide diagnostic signatures from blood samples","volume":"5","author":"Belov","year":"2016","journal-title":"J. Extracell. Vesicles"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1080\/10428194.2016.1243790","article-title":"Characterization and prognostic relevance of circulating microvesicles in chronic lymphocytic leukemia","volume":"58","author":"Simeon","year":"2017","journal-title":"Leuk. Lymphoma"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.3324\/haematol.2010.039743","article-title":"Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor-beta1","volume":"96","author":"Szczepanski","year":"2011","journal-title":"Haematologica"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"11295","DOI":"10.1038\/srep11295","article-title":"Serum Exosome MicroRNA as a Minimally-Invasive Early Biomarker of AML","volume":"5","author":"Hornick","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1182\/blood-2016-09-742296","article-title":"Prognostic role of circulating exosomal miRNAs in multiple myeloma","volume":"129","author":"Manier","year":"2017","journal-title":"Blood"},{"key":"ref_139","first-page":"e89631","article-title":"Plasma vesicle miRNAs for therapy response monitoring in Hodgkin lymphoma patients","volume":"1","author":"Zijlstra","year":"2016","journal-title":"JCI Insight"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"6669","DOI":"10.1182\/blood-2009-01-198408","article-title":"MicroRNAs 15 a and 16 regulate tumor proliferation in multiple myeloma","volume":"113","author":"Roccaro","year":"2009","journal-title":"Blood"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s41375-020-01104-1","article-title":"Clinical relevance of extracellular vesicles in hematological neoplasms: From liquid biopsy to cell biopsy","volume":"35","author":"Trino","year":"2021","journal-title":"Leukemia"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"9739","DOI":"10.1007\/s13277-015-3741-3","article-title":"High serum levels of extracellular vesicles expressing malignancy-related markers are released in patients with various types of hematological neoplastic disorders","volume":"36","author":"Caivano","year":"2015","journal-title":"Tumour. Biol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.bios.2015.09.061","article-title":"Merging colloidal nanoplasmonics and surface plasmon resonance spectroscopy for enhanced profiling of multiple myeloma-derived exosomes","volume":"77","author":"Bugatti","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neo.2015.11.011","article-title":"Isolation of Human CD138(+) Microparticles from the Plasma of Patients with Multiple Myeloma","volume":"18","author":"Krishnan","year":"2016","journal-title":"Neoplasia"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"e1458809","DOI":"10.1080\/2162402X.2018.1458809","article-title":"Microvesicles released from multiple myeloma cells are equipped with ectoenzymes belonging to canonical and non-canonical adenosinergic pathways and produce adenosine from ATP and NAD","volume":"7","author":"Morandi","year":"2018","journal-title":"Oncoimmunology"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/hon.2648","article-title":"The potential diagnostic power of CD138+ microparticles from the plasma analysis for multiple myeloma clinical monitoring","volume":"37","author":"Liu","year":"2019","journal-title":"Hematol. Oncol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"196","DOI":"10.7150\/thno.27550","article-title":"Tumor-derived extracellular vesicles inhibit osteogenesis and exacerbate myeloma bone disease","volume":"9","author":"Zhang","year":"2019","journal-title":"Theranostics"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41408-020-0304-7","article-title":"A liquid biopsy to detect multidrug resistance and disease burden in multiple myeloma","volume":"10","author":"Suen","year":"2020","journal-title":"Blood Cancer J."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"15336","DOI":"10.1073\/pnas.1102855108","article-title":"Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3","volume":"108","author":"Aung","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1182\/blood.V91.8.3011.3011_3011_3016","article-title":"Serum level of the soluble form of the CD30 molecule identifies patients with Hodgkin\u2019s disease at high risk of unfavorable outcome","volume":"91","author":"Nadali","year":"1998","journal-title":"Blood"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/leu.2016.217","article-title":"Dynamics of microvesicle generation in B-cell chronic lymphocytic leukemia: Implication in disease progression","volume":"31","author":"Boysen","year":"2017","journal-title":"Leukemia"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s13402-016-0300-x","article-title":"MicroRNA-155 in serum-derived extracellular vesicles as a potential biomarker for hematologic malignancies\u2014A short report","volume":"40","author":"Caivano","year":"2017","journal-title":"Cell. Oncol."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Bouyssou, J.M., Liu, C.J., Bustoros, M., Sklavenitis-Pistofidis, R., Aljawai, Y., Manier, S., Yosef, A., Sacco, A., Kokubun, K., and Tsukamoto, S. (2018). Profiling of circulating exosomal miRNAs in patients with Waldenstrom Macroglobulinemia. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0204589"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Raimondo, S., Urzi, O., Conigliaro, A., Bosco, G.L., Parisi, S., Carlisi, M., Siragusa, S., Raimondi, L., Luca, A., and Giavaresi, G. (2020). Extracellular Vesicle microRNAs Contribute to the Osteogenic Inhibition of Mesenchymal Stem Cells in Multiple Myeloma. Cancers, 12.","DOI":"10.3390\/cancers12020449"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/hon.2639","article-title":"Serum exosomal microRNAs as novel biomarkers for multiple myeloma","volume":"37","author":"Zhang","year":"2019","journal-title":"Hematol. Oncol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1200\/JCO.2018.78.5246","article-title":"Circulating Tumor DNA Measurements As Early Outcome Predictors in Diffuse Large B-Cell Lymphoma","volume":"36","author":"Kurtz","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1038\/leu.2014.155","article-title":"Circulating miRNA markers show promise as new prognosticators for multiple myeloma","volume":"28","author":"Rocci","year":"2014","journal-title":"Leukemia"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"50949","DOI":"10.18632\/oncotarget.16435","article-title":"mRNA in exosomas as a liquid biopsy in non-Hodgkin Lymphoma: A multicentric study by the Spanish Lymphoma Oncology Group","volume":"8","author":"Provencio","year":"2017","journal-title":"Oncotarget"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1756-8722-6-52","article-title":"Protein biomarkers distinguish between high- and low-risk pediatric acute lymphoblastic leukemia in a tissue specific manner","volume":"6","author":"Braoudaki","year":"2013","journal-title":"J. Hematol. Oncol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/intimm\/dxr027","article-title":"The B lineage transcription factor E2 A regulates apoptosis in chronic lymphocytic leukemia (CLL) cells","volume":"23","author":"Kardava","year":"2011","journal-title":"Int. Immunol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1182\/blood-2017-03-735639","article-title":"High-throughput sequencing for noninvasive disease detection in hematologic malignancies","volume":"130","author":"Scherer","year":"2017","journal-title":"Blood"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1515\/CCLM.2010.311","article-title":"Increased integrity of circulating cell-free DNA in plasma of patients with acute leukemia","volume":"48","author":"Gao","year":"2010","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s12185-018-2487-2","article-title":"Circulating tumor DNA dynamically predicts response and\/or relapse in patients with hematological malignancies","volume":"108","author":"Nakamura","year":"2018","journal-title":"Int. J. Hematol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1182\/blood-2018-10-880690","article-title":"Prognostic impact of circulating tumor DNA status post-allogeneic hematopoietic stem cell transplantation in AML and MDS","volume":"133","author":"Nakamura","year":"2019","journal-title":"Blood"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.7150\/jca.69639","article-title":"Clinical relevance of serum-derived exosomal messenger RNA sequencing in patients with non-Hodgkin lymphoma","volume":"13","author":"Bang","year":"2022","journal-title":"J. Cancer"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1111\/cas.14176","article-title":"Mutations found in cell-free DNAs of patients with malignant lymphoma at remission can derive from clonal hematopoiesis","volume":"110","author":"Suehara","year":"2019","journal-title":"Cancer Sci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/bjh.14919","article-title":"Detection of clinically relevant early genomic lesions in B-cell malignancies from circulating tumour DNA using a single hybridisation-based next generation sequencing assay","volume":"183","author":"Blombery","year":"2018","journal-title":"Br. J. Haematol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1080\/10428194.2018.1492123","article-title":"Somatic mutations of cell-free circulating DNA detected by targeted next-generation sequencing and digital droplet PCR in classical Hodgkin lymphoma","volume":"60","author":"Bessi","year":"2019","journal-title":"Leuk. Lymphoma"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"102731","DOI":"10.1016\/j.ebiom.2020.102731","article-title":"Circulating tumor DNA predicts response in Chinese patients with relapsed or refractory classical hodgkin lymphoma treated with sintilimab","volume":"54","author":"Shi","year":"2020","journal-title":"EBioMedicine"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1182\/bloodadvances.2020001696","article-title":"Genetic and evolutionary patterns of treatment resistance in relapsed B-cell lymphoma","volume":"4","author":"Rushton","year":"2020","journal-title":"Blood Adv."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"10797","DOI":"10.2147\/OTT.S275334","article-title":"Genotyping on ctDNA Identifies Shifts in Mutation Spectrum Between Newly Diagnosed and Relapse\/Refractory DLBCL","volume":"13","author":"Liu","year":"2020","journal-title":"Onco. Targets Ther."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40364-020-00205-4","article-title":"Plasma circulating tumor DNA assessment reveals KMT2 D as a potential poor prognostic factor in extranodal NK\/T-cell lymphoma","volume":"8","author":"Li","year":"2020","journal-title":"Biomark. Res."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1080\/10428194.2019.1573998","article-title":"Analysis of circulating tumor DNA by targeted ultra-deep sequencing across various non-Hodgkin lymphoma subtypes","volume":"60","author":"Shin","year":"2019","journal-title":"Leuk. Lymphoma"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.2147\/CMAR.S242903","article-title":"Clinicopathological Characteristics and Mutational Profiling of Adult T-Cell Lymphoblastic Lymphoma in a Chinese Population","volume":"12","author":"Chen","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1200\/JCO.19.01231","article-title":"Measurable Residual Disease by Next-Generation Flow Cytometry in Multiple Myeloma","volume":"38","author":"Paiva","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"e1421889","DOI":"10.1080\/2162402X.2017.1421889","article-title":"Specific ADAM10 inhibitors localize in exosome-like vesicles released by Hodgkin lymphoma and stromal cells and prevent sheddase activity carried to bystander cells","volume":"7","author":"Tosetti","year":"2018","journal-title":"Oncoimmunology"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1002\/cncr.24961","article-title":"Circulating endothelial cells in patients with chronic lymphocytic leukemia: Clinical-prognostic and biologic significance","volume":"116","author":"Rigolin","year":"2010","journal-title":"Cancer"},{"key":"ref_178","first-page":"411","article-title":"Introduction to next generation of endothelial progenitor cell therapy: A promise in vascular medicine","volume":"7","author":"Sukmawati","year":"2015","journal-title":"Am. J. Transl. Res."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s11596-013-1112-0","article-title":"Correlation between increased circulating endothelial progenitor cells and stage of non-Hodgkin lymphoma","volume":"33","author":"Yu","year":"2013","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Sci."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3109\/10428194.2011.628880","article-title":"Circulating endothelial progenitor cells as potential prognostic biomarker in multiple myeloma","volume":"53","author":"Bhaskar","year":"2012","journal-title":"Leuk. Lymphoma"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/leu.2016.3","article-title":"Targeting vasculogenesis to prevent progression in multiple myeloma","volume":"30","author":"Moschetta","year":"2016","journal-title":"Leukemia"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1182\/blood.V122.21.680.680","article-title":"Bone Marrow Mobilization Of Endothelial Progenitor Cells Represents An Early Pathogenic Event During Multiple Myeloma Progression","volume":"122","author":"Moschetta","year":"2013","journal-title":"Blood"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1182\/blood-2017-11-812073","article-title":"Circulating tumor DNA reveals genetics, clonal evolution, and residual disease in classical Hodgkin lymphoma","volume":"131","author":"Spina","year":"2018","journal-title":"Blood"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1182\/bloodadvances.2021006397","article-title":"Circulating tumor DNA predicts therapeutic outcome in mantle cell lymphoma","volume":"6","author":"Lakhotia","year":"2022","journal-title":"Blood Adv."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"364ra155","DOI":"10.1126\/scitranslmed.aai8545","article-title":"Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumor DNA","volume":"8","author":"Scherer","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3324\/haematol.2019.237719","article-title":"Targeted genotyping of circulating tumor DNA for classical Hodgkin lymphoma monitoring: A prospective study","volume":"106","author":"Camus","year":"2021","journal-title":"Haematologica"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1182\/blood.V128.22.3280.3280","article-title":"Mutational Characterisation and Tracking Disease Progression Using Circulating Cell-Free Tumor DNA in Multiple Myeloma Patients","volume":"128","author":"Mithraprabhu","year":"2016","journal-title":"Blood"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1038\/leu.2016.366","article-title":"Circulating tumour DNA analysis demonstrates spatial mutational heterogeneity that coincides with disease relapse in myeloma","volume":"31","author":"Mithraprabhu","year":"2017","journal-title":"Leukemia"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1038\/s41375-019-0469-x","article-title":"Monitoring tumour burden and therapeutic response through analysis of circulating tumour DNA and extracellular RNA in multiple myeloma patients","volume":"33","author":"Mithraprabhu","year":"2019","journal-title":"Leukemia"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.3324\/haematol.2016.161414","article-title":"Monitoring multiple myeloma by next-generation sequencing of V(D)J rearrangements from circulating myeloma cells and cell-free myeloma DNA","volume":"102","author":"Oberle","year":"2017","journal-title":"Haematologica"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1038\/s41375-018-0115-z","article-title":"Genomic discovery and clonal tracking in multiple myeloma by cell-free DNA sequencing","volume":"32","author":"Guo","year":"2018","journal-title":"Leukemia"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/leu.2012.237","article-title":"High levels of peripheral blood circulating plasma cells as a specific risk factor for progression of smoldering multiple myeloma","volume":"27","author":"Bianchi","year":"2013","journal-title":"Leukemia"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1038\/leu.2014.98","article-title":"Quantification of clonal circulating plasma cells in newly diagnosed multiple myeloma: Implications for redefining high-risk myeloma","volume":"28","author":"Gonsalves","year":"2014","journal-title":"Leukemia"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41408-018-0153-9","article-title":"Next generation flow for minimally-invasive blood characterization of MGUS and multiple myeloma at diagnosis based on circulating tumor plasma cells (CTPC)","volume":"8","author":"Garces","year":"2018","journal-title":"Blood Cancer J."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"5668","DOI":"10.1200\/JCO.2005.03.159","article-title":"Prognostic value of circulating plasma cells in monoclonal gammopathy of undetermined significance","volume":"23","author":"Kumar","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1007\/s12032-012-0210-3","article-title":"Circulating microRNA expression is associated with genetic subtype and survival of multiple myeloma","volume":"29","author":"Huang","year":"2012","journal-title":"Med. Oncol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0009-8981(03)00279-1","article-title":"Frequent copresence of methylated DNA and fragmented nucleosomal DNA in plasma of lymphoma patients","volume":"335","author":"Deligezer","year":"2003","journal-title":"Clin. Chim. Acta"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/carcin\/bgl092","article-title":"Discovery of novel epigenetic markers in non-Hodgkin\u2019s lymphoma","volume":"28","author":"Shi","year":"2007","journal-title":"Carcinogenesis"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1007\/s11427-015-4969-2","article-title":"The role of circulating miRNAs in multiple myeloma","volume":"58","author":"Zhang","year":"2015","journal-title":"Sci. China Life Sci."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"30876","DOI":"10.18632\/oncotarget.9021","article-title":"Potential role of exosome-associated microRNA panels and in vivo environment to predict drug resistance for patients with multiple myeloma","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2217\/epi-2018-0123","article-title":"Exosome-derived miRNAs as predictive biomarkers for diffuse large B-cell lymphoma chemotherapy resistance","volume":"11","author":"Feng","year":"2019","journal-title":"Epigenomics"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1182\/blood.V126.23.2759.2759","article-title":"Biomarker Predictive Ibrutinib Response Using Profiled ABC-DLBCL Patient Derived Xenografts","volume":"126","author":"Wu","year":"2015","journal-title":"Blood"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"e90196","DOI":"10.1172\/jci.insight.90196","article-title":"Panobinostat acts synergistically with ibrutinib in diffuse large B cell lymphoma cells with MyD88 L265 P mutations","volume":"2","author":"Mondello","year":"2017","journal-title":"JCI Insight"},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Drandi, D., Decruyenaere, P., Ferrante, M., Offner, F., Vandesompele, J., and Ferrero, S. (2022). Nucleic Acid Biomarkers in Waldenstrom Macroglobulinemia and IgM-MGUS: Current Insights and Clinical Relevance. Diagnostics, 12.","DOI":"10.3390\/diagnostics12040969"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1038\/s41375-018-0197-7","article-title":"Detection of MYD88 and CXCR4 mutations in cell-free DNA of patients with IgM monoclonal gammopathies","volume":"32","author":"Bagratuni","year":"2018","journal-title":"Leukemia"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1182\/blood-2014-01-550905","article-title":"Somatic mutations in MYD88 and CXCR4 are determinants of clinical presentation and overall survival in Waldenstrom macroglobulinemia","volume":"123","author":"Treon","year":"2014","journal-title":"Blood"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1056\/NEJMc1506192","article-title":"MYD88 Mutations and Response to Ibrutinib in Waldenstrom\u2019s Macroglobulinemia","volume":"373","author":"Treon","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1056\/NEJMoa1200710","article-title":"MYD88 L265 P somatic mutation in Waldenstrom\u2019s macroglobulinemia","volume":"367","author":"Treon","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1038\/leu.2014.65","article-title":"Detection of MYD88 L265 P in peripheral blood of patients with Waldenstrom\u2019s Macroglobulinemia and IgM monoclonal gammopathy of undetermined significance","volume":"28","author":"Xu","year":"2014","journal-title":"Leukemia"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1182\/blood-2012-12-475111","article-title":"A mutation in MYD88 (L265 P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenstrom macroglobulinemia","volume":"122","author":"Yang","year":"2013","journal-title":"Blood"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.1182\/blood-2014-03-564583","article-title":"C1013 G\/CXCR4 acts as a driver mutation of tumor progression and modulator of drug resistance in lymphoplasmacytic lymphoma","volume":"123","author":"Roccaro","year":"2014","journal-title":"Blood"},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Luanpitpong, S., Janan, M., Thumanu, K., Poohadsuan, J., Rodboon, N., Klaihmon, P., and Issaragrisil, S. (2019). Deciphering the Elevated Lipid via CD36 in Mantle Cell Lymphoma with Bortezomib Resistance Using Synchrotron-Based Fourier Transform Infrared Spectroscopy of Single Cells. Cancers, 11.","DOI":"10.3390\/cancers11040576"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/21\/5378\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:07:04Z","timestamp":1760144824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/21\/5378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,31]]},"references-count":212,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["cancers14215378"],"URL":"https:\/\/doi.org\/10.3390\/cancers14215378","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,31]]}}}