{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:32:56Z","timestamp":1770989576968,"version":"3.50.1"},"reference-count":37,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA267893"],"award-info":[{"award-number":["R01CA267893"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["170711-44096"],"award-info":[{"award-number":["170711-44096"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["170722-44096"],"award-info":[{"award-number":["170722-44096"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["132931-RSG-18-187-01-TBG"],"award-info":[{"award-number":["132931-RSG-18-187-01-TBG"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["IRG-21-147-01-IRG"],"award-info":[{"award-number":["IRG-21-147-01-IRG"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RP170345"],"award-info":[{"award-number":["RP170345"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH-NCI P30 CA054174"],"award-info":[{"award-number":["NIH-NCI P30 CA054174"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1S10OD021805-01"],"award-info":[{"award-number":["1S10OD021805-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RP160732"],"award-info":[{"award-number":["RP160732"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"T.E.A.L.\u00ae\u2019s 2021 Medical Research Program","award":["R01CA267893"],"award-info":[{"award-number":["R01CA267893"]}]},{"name":"T.E.A.L.\u00ae\u2019s 2021 Medical Research Program","award":["170711-44096"],"award-info":[{"award-number":["170711-44096"]}]},{"name":"T.E.A.L.\u00ae\u2019s 2021 Medical Research Program","award":["170722-44096"],"award-info":[{"award-number":["170722-44096"]}]},{"name":"T.E.A.L.\u00ae\u2019s 2021 Medical Research Program","award":["132931-RSG-18-187-01-TBG"],"award-info":[{"award-number":["132931-RSG-18-187-01-TBG"]}]},{"name":"T.E.A.L.\u00ae\u2019s 2021 Medical Research Program","award":["IRG-21-147-01-IRG"],"award-info":[{"award-number":["IRG-21-147-01-IRG"]}]},{"name":"T.E.A.L.\u00ae\u2019s 2021 Medical Research Program","award":["RP170345"],"award-info":[{"award-number":["RP170345"]}]},{"name":"T.E.A.L.\u00ae\u2019s 2021 Medical Research Program","award":["NIH-NCI P30 CA054174"],"award-info":[{"award-number":["NIH-NCI P30 CA054174"]}]},{"name":"T.E.A.L.\u00ae\u2019s 2021 Medical Research Program","award":["1S10OD021805-01"],"award-info":[{"award-number":["1S10OD021805-01"]}]},{"name":"T.E.A.L.\u00ae\u2019s 2021 Medical Research Program","award":["RP160732"],"award-info":[{"award-number":["RP160732"]}]},{"name":"ThriveWell Cancer Foundation","award":["R01CA267893"],"award-info":[{"award-number":["R01CA267893"]}]},{"name":"ThriveWell Cancer Foundation","award":["170711-44096"],"award-info":[{"award-number":["170711-44096"]}]},{"name":"ThriveWell Cancer Foundation","award":["170722-44096"],"award-info":[{"award-number":["170722-44096"]}]},{"name":"ThriveWell Cancer Foundation","award":["132931-RSG-18-187-01-TBG"],"award-info":[{"award-number":["132931-RSG-18-187-01-TBG"]}]},{"name":"ThriveWell Cancer Foundation","award":["IRG-21-147-01-IRG"],"award-info":[{"award-number":["IRG-21-147-01-IRG"]}]},{"name":"ThriveWell Cancer Foundation","award":["RP170345"],"award-info":[{"award-number":["RP170345"]}]},{"name":"ThriveWell Cancer Foundation","award":["NIH-NCI P30 CA054174"],"award-info":[{"award-number":["NIH-NCI P30 CA054174"]}]},{"name":"ThriveWell Cancer Foundation","award":["1S10OD021805-01"],"award-info":[{"award-number":["1S10OD021805-01"]}]},{"name":"ThriveWell Cancer Foundation","award":["RP160732"],"award-info":[{"award-number":["RP160732"]}]},{"name":"American Cancer Society Research Scholar Grants","award":["R01CA267893"],"award-info":[{"award-number":["R01CA267893"]}]},{"name":"American Cancer Society Research Scholar Grants","award":["170711-44096"],"award-info":[{"award-number":["170711-44096"]}]},{"name":"American Cancer Society Research Scholar Grants","award":["170722-44096"],"award-info":[{"award-number":["170722-44096"]}]},{"name":"American Cancer Society Research Scholar Grants","award":["132931-RSG-18-187-01-TBG"],"award-info":[{"award-number":["132931-RSG-18-187-01-TBG"]}]},{"name":"American Cancer Society Research Scholar Grants","award":["IRG-21-147-01-IRG"],"award-info":[{"award-number":["IRG-21-147-01-IRG"]}]},{"name":"American Cancer Society Research Scholar Grants","award":["RP170345"],"award-info":[{"award-number":["RP170345"]}]},{"name":"American Cancer Society Research Scholar Grants","award":["NIH-NCI P30 CA054174"],"award-info":[{"award-number":["NIH-NCI P30 CA054174"]}]},{"name":"American Cancer Society Research Scholar Grants","award":["1S10OD021805-01"],"award-info":[{"award-number":["1S10OD021805-01"]}]},{"name":"American Cancer Society Research Scholar Grants","award":["RP160732"],"award-info":[{"award-number":["RP160732"]}]},{"name":"Institutional Research Grants","award":["R01CA267893"],"award-info":[{"award-number":["R01CA267893"]}]},{"name":"Institutional Research Grants","award":["170711-44096"],"award-info":[{"award-number":["170711-44096"]}]},{"name":"Institutional Research Grants","award":["170722-44096"],"award-info":[{"award-number":["170722-44096"]}]},{"name":"Institutional Research Grants","award":["132931-RSG-18-187-01-TBG"],"award-info":[{"award-number":["132931-RSG-18-187-01-TBG"]}]},{"name":"Institutional Research Grants","award":["IRG-21-147-01-IRG"],"award-info":[{"award-number":["IRG-21-147-01-IRG"]}]},{"name":"Institutional Research Grants","award":["RP170345"],"award-info":[{"award-number":["RP170345"]}]},{"name":"Institutional Research Grants","award":["NIH-NCI P30 CA054174"],"award-info":[{"award-number":["NIH-NCI P30 CA054174"]}]},{"name":"Institutional Research Grants","award":["1S10OD021805-01"],"award-info":[{"award-number":["1S10OD021805-01"]}]},{"name":"Institutional Research Grants","award":["RP160732"],"award-info":[{"award-number":["RP160732"]}]},{"name":"Institutional CPRIT Research Training Award","award":["R01CA267893"],"award-info":[{"award-number":["R01CA267893"]}]},{"name":"Institutional CPRIT Research Training Award","award":["170711-44096"],"award-info":[{"award-number":["170711-44096"]}]},{"name":"Institutional CPRIT Research Training Award","award":["170722-44096"],"award-info":[{"award-number":["170722-44096"]}]},{"name":"Institutional CPRIT Research Training Award","award":["132931-RSG-18-187-01-TBG"],"award-info":[{"award-number":["132931-RSG-18-187-01-TBG"]}]},{"name":"Institutional CPRIT Research Training Award","award":["IRG-21-147-01-IRG"],"award-info":[{"award-number":["IRG-21-147-01-IRG"]}]},{"name":"Institutional CPRIT Research Training Award","award":["RP170345"],"award-info":[{"award-number":["RP170345"]}]},{"name":"Institutional CPRIT Research Training Award","award":["NIH-NCI P30 CA054174"],"award-info":[{"award-number":["NIH-NCI P30 CA054174"]}]},{"name":"Institutional CPRIT Research Training Award","award":["1S10OD021805-01"],"award-info":[{"award-number":["1S10OD021805-01"]}]},{"name":"Institutional CPRIT Research Training Award","award":["RP160732"],"award-info":[{"award-number":["RP160732"]}]},{"name":"Cancer Center at UT Health San Antonio","award":["R01CA267893"],"award-info":[{"award-number":["R01CA267893"]}]},{"name":"Cancer Center at UT Health San Antonio","award":["170711-44096"],"award-info":[{"award-number":["170711-44096"]}]},{"name":"Cancer Center at UT Health San Antonio","award":["170722-44096"],"award-info":[{"award-number":["170722-44096"]}]},{"name":"Cancer Center at UT Health San Antonio","award":["132931-RSG-18-187-01-TBG"],"award-info":[{"award-number":["132931-RSG-18-187-01-TBG"]}]},{"name":"Cancer Center at UT Health San Antonio","award":["IRG-21-147-01-IRG"],"award-info":[{"award-number":["IRG-21-147-01-IRG"]}]},{"name":"Cancer Center at UT Health San Antonio","award":["RP170345"],"award-info":[{"award-number":["RP170345"]}]},{"name":"Cancer Center at UT Health San Antonio","award":["NIH-NCI P30 CA054174"],"award-info":[{"award-number":["NIH-NCI P30 CA054174"]}]},{"name":"Cancer Center at UT Health San Antonio","award":["1S10OD021805-01"],"award-info":[{"award-number":["1S10OD021805-01"]}]},{"name":"Cancer Center at UT Health San Antonio","award":["RP160732"],"award-info":[{"award-number":["RP160732"]}]},{"name":"NIH Shared Instrument","award":["R01CA267893"],"award-info":[{"award-number":["R01CA267893"]}]},{"name":"NIH Shared Instrument","award":["170711-44096"],"award-info":[{"award-number":["170711-44096"]}]},{"name":"NIH Shared Instrument","award":["170722-44096"],"award-info":[{"award-number":["170722-44096"]}]},{"name":"NIH Shared Instrument","award":["132931-RSG-18-187-01-TBG"],"award-info":[{"award-number":["132931-RSG-18-187-01-TBG"]}]},{"name":"NIH Shared Instrument","award":["IRG-21-147-01-IRG"],"award-info":[{"award-number":["IRG-21-147-01-IRG"]}]},{"name":"NIH Shared Instrument","award":["RP170345"],"award-info":[{"award-number":["RP170345"]}]},{"name":"NIH Shared Instrument","award":["NIH-NCI P30 CA054174"],"award-info":[{"award-number":["NIH-NCI P30 CA054174"]}]},{"name":"NIH Shared Instrument","award":["1S10OD021805-01"],"award-info":[{"award-number":["1S10OD021805-01"]}]},{"name":"NIH Shared Instrument","award":["RP160732"],"award-info":[{"award-number":["RP160732"]}]},{"name":"CPRIT Core Facility Award","award":["R01CA267893"],"award-info":[{"award-number":["R01CA267893"]}]},{"name":"CPRIT Core Facility Award","award":["170711-44096"],"award-info":[{"award-number":["170711-44096"]}]},{"name":"CPRIT Core Facility Award","award":["170722-44096"],"award-info":[{"award-number":["170722-44096"]}]},{"name":"CPRIT Core Facility Award","award":["132931-RSG-18-187-01-TBG"],"award-info":[{"award-number":["132931-RSG-18-187-01-TBG"]}]},{"name":"CPRIT Core Facility Award","award":["IRG-21-147-01-IRG"],"award-info":[{"award-number":["IRG-21-147-01-IRG"]}]},{"name":"CPRIT Core Facility Award","award":["RP170345"],"award-info":[{"award-number":["RP170345"]}]},{"name":"CPRIT Core Facility Award","award":["NIH-NCI P30 CA054174"],"award-info":[{"award-number":["NIH-NCI P30 CA054174"]}]},{"name":"CPRIT Core Facility Award","award":["1S10OD021805-01"],"award-info":[{"award-number":["1S10OD021805-01"]}]},{"name":"CPRIT Core Facility Award","award":["RP160732"],"award-info":[{"award-number":["RP160732"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Endometrial cancer (EC) is the fourth most common cancer in women, and half of the endometrioid EC (EEC) cases are attributable to obesity. However, the underlying mechanism(s) of obesity-driven EEC remain(s) unclear. In this study, we examined whether LIF signaling plays a role in the obesity-driven progression of EEC. RNA-seq analysis of EEC cells stimulated by adipose conditioned medium (ADP-CM) showed upregulation of LIF\/LIFR-mediated signaling pathways including JAK\/STAT and interleukin pathways. Immunohistochemistry analysis of normal and EEC tissues collected from obese patients revealed that LIF expression is upregulated in EEC tissues compared to the normal endometrium. Treatment of both primary and established EEC cells with ADP-CM increased the expression of LIF and its receptor LIFR and enhanced proliferation of EEC cells. Treatment of EEC cells with the LIFR inhibitor EC359 abolished ADP-CM induced colony formation andcell viability and decreased growth of EEC organoids. Mechanistic studies using Western blotting, RT-qPCR and reporter assays confirmed that ADP-CM activated LIF\/LIFR downstream signaling, which can be effectively attenuated by the addition of EC359. In xenograft assays, co-implantation of adipocytes significantly enhanced EEC xenograft tumor growth. Further, treatment with EC359 significantly attenuated adipocyte-induced EEC progression in vivo. Collectively, our data support the premise that LIF\/LIFR signaling plays an important role in obesity-driven EEC progression and the LIFR inhibitor EC359 has the potential to suppress adipocyte-driven tumor progression.<\/jats:p>","DOI":"10.3390\/cancers14215400","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T03:11:21Z","timestamp":1667445081000},"page":"5400","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Inhibition of LIFR Blocks Adiposity-Driven Endometrioid Endometrial Cancer Growth"],"prefix":"10.3390","volume":"14","author":[{"given":"Logan","family":"Blankenship","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uday P.","family":"Pratap","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA"},{"name":"Department of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zexuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3439-0655","authenticated-orcid":false,"given":"Kristin A.","family":"Altwegg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA"},{"name":"Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bindu","family":"Santhamma","sequence":"additional","affiliation":[{"name":"Evestra, Inc., San Antonio, TX 78245, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumaraguruparan","family":"Ramasamy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swapna","family":"Konda","sequence":"additional","affiliation":[{"name":"Evestra, Inc., San Antonio, TX 78245, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yidong","family":"Chen","sequence":"additional","affiliation":[{"name":"Greehey Children\u2019s Cancer Research Institute, University of Texas Health San Antonio, San Antonio, TX 78229, USA"},{"name":"Department of Population Health Sciences, University of Texas Health San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Lai","sequence":"additional","affiliation":[{"name":"Greehey Children\u2019s Cancer Research Institute, University of Texas Health San Antonio, San Antonio, TX 78229, USA"},{"name":"Department of Molecular Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1031-9424","authenticated-orcid":false,"given":"Siyuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Greehey Children\u2019s Cancer Research Institute, University of Texas Health San Antonio, San Antonio, TX 78229, USA"},{"name":"Department of Population Health Sciences, University of Texas Health San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9977-3932","authenticated-orcid":false,"given":"Gangadhara R.","family":"Sareddy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA"},{"name":"Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip T.","family":"Valente","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward R.","family":"Kost","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4309-9560","authenticated-orcid":false,"given":"Hareesh B.","family":"Nair","sequence":"additional","affiliation":[{"name":"Evestra, Inc., San Antonio, TX 78245, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeshwar R.","family":"Tekmal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2849-4076","authenticated-orcid":false,"given":"Ratna K.","family":"Vadlamudi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA"},{"name":"Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX 78229, USA"},{"name":"Audie L. Murphy Division, South Texas Veterans Health Care System, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7381-6962","authenticated-orcid":false,"given":"Suryavathi","family":"Viswanadhapalli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA"},{"name":"Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1200\/EDBK_175666","article-title":"Endometrial Cancer: Is This a New Disease?","volume":"37","author":"Moore","year":"2017","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10552-019-1129-1","article-title":"Rapid increase in endometrial cancer incidence and ethnic differences in New Zealand","volume":"30","author":"Scott","year":"2019","journal-title":"Cancer Causes Control"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12672-019-0358-9","article-title":"Estrogen Signaling in Endometrial Cancer: A Key Oncogenic Pathway with Several Open Questions","volume":"10","author":"Rodriguez","year":"2019","journal-title":"Horm. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1200\/JCO.2012.48.2596","article-title":"Type I and II endometrial cancers: Have they different risk factors?","volume":"31","author":"Setiawan","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3747\/co.v15i3.204","article-title":"Adjuvant hormonal therapy for stage I endometrial cancer","volume":"15","author":"Gien","year":"2008","journal-title":"Curr. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1200\/JCO.2016.69.4638","article-title":"Addressing the Role of Obesity in Endometrial Cancer Risk, Prevention, and Treatment","volume":"34","author":"Onstad","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_7","first-page":"2170","article-title":"Reversal of obesity-driven aggressiveness of endometrial cancer by metformin","volume":"9","author":"Guo","year":"2019","journal-title":"Am. J. Cancer Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1136\/bmj.39367.495995.AE","article-title":"Cancer incidence and mortality in relation to body mass index in the Million Women Study: Cohort study","volume":"335","author":"Reeves","year":"2007","journal-title":"BMJ"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/jog.14560","article-title":"Does visceral adiposity have an effect on the survival outcomes of the patients with endometrial cancer?","volume":"47","author":"Celik","year":"2021","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1515\/hmbci-2014-0049","article-title":"Molecular cues on obesity signals, tumor markers and endometrial cancer","volume":"21","author":"Lee","year":"2015","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1242\/bio.011890","article-title":"Dysregulated LIF-STAT3 pathway is responsible for impaired embryo implantation in a Streptozotocin-induced diabetic mouse model","volume":"4","author":"Wang","year":"2015","journal-title":"Biol. Open"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1210\/en.2004-0383","article-title":"Leptin-induced increase in leukemia inhibitory factor and its receptor by human endometrium is partially mediated by interleukin 1 receptor signaling","volume":"145","author":"Gonzalez","year":"2004","journal-title":"Endocrinology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.cytogfr.2015.07.001","article-title":"Leukemia inhibitory factor (LIF)","volume":"26","author":"Nicola","year":"2015","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1126\/science.8272873","article-title":"Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components","volume":"263","author":"Stahl","year":"1994","journal-title":"Science"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/sj.bjc.6603597","article-title":"Stat3 activation in human endometrial and cervical cancers","volume":"96","author":"Chen","year":"2007","journal-title":"Br. J. Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41420-021-00603-z","article-title":"LIF\/LIFR oncogenic signaling is a novel therapeutic target in endometrial cancer","volume":"7","author":"Tang","year":"2021","journal-title":"Cell Death Discov."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1158\/1535-7163.MCT-18-1258","article-title":"EC359-A first-in-class small molecule inhibitor for targeting oncogenic LIFR signaling in triple negative breast cancer","volume":"18","author":"Viswanadhapalli","year":"2019","journal-title":"Mol. Cancer Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/978-1-61779-367-7_14","article-title":"Culture of isolated human adipocytes and isolated adipose tissue","volume":"806","author":"Carswell","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","article-title":"TopHat: Discovering splice junctions with RNA-Seq","volume":"25","author":"Trapnell","year":"2009","journal-title":"Bioinformatics"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"9482","DOI":"10.1038\/s41598-018-27210-w","article-title":"Adipocytes induce distinct gene expression profiles in mammary tumor cells and enhance inflammatory signaling in invasive breast cancer cells","volume":"8","author":"Nickel","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1158\/0008-5472.CAN-18-1615","article-title":"Adipokines Deregulate Cellular Communication via Epigenetic Repression of Gap Junction Loci in Obese Endometrial Cancer","volume":"79","author":"Polusani","year":"2019","journal-title":"Cancer Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1158\/1541-7786.MCR-17-0466","article-title":"Adipose-Derived VEGF-mTOR Signaling Promotes Endometrial Hyperplasia and Cancer: Implications for Obese Women","volume":"16","author":"Sahoo","year":"2018","journal-title":"Mol. Cancer Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.ygyno.2019.10.013","article-title":"Carboplatin-paclitaxel compared to Carboplatin-Paclitaxel-Bevacizumab in advanced or recurrent endometrial cancer: MITO END-2\u2014A randomized phase II trial","volume":"155","author":"Lorusso","year":"2019","journal-title":"Gynecol. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ogc.2018.09.006","article-title":"Endometrial Cancer: Obesity, Genetics, and Targeted Agents","volume":"46","author":"McDonald","year":"2019","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1158\/1078-0432.CCR-19-0471","article-title":"Everolimus, Letrozole, and Metformin in Women with Advanced or Recurrent Endometrioid Endometrial Cancer: A Multi-Center, Single Arm, Phase II Study","volume":"26","author":"Soliman","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrc1408","article-title":"Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms","volume":"4","author":"Calle","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1152\/physiol.00054.2015","article-title":"Aromatase: Contributions to Physiology and Disease in Women and Men","volume":"31","author":"Blakemore","year":"2016","journal-title":"Physiology"},{"key":"ref_31","first-page":"977","article-title":"Leukemia inhibitory factor functions as a growth factor in pancreas carcinoma cells: Involvement of regulation of LIF and its receptor expression","volume":"30","author":"Kamohara","year":"2007","journal-title":"Int. J. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10059-011-0020-z","article-title":"Epigenetic up-regulation of leukemia inhibitory factor (LIF) gene during the progression to breast cancer","volume":"31","author":"Shin","year":"2011","journal-title":"Mol. Cells"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"26052","DOI":"10.18632\/oncotarget.4482","article-title":"Leukemia inhibitory factor protects cholangiocarcinoma cells from drug-induced apoptosis via a PI3K\/AKT-dependent Mcl-1 activation","volume":"6","author":"Morton","year":"2015","journal-title":"Oncotarget"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/j.celrep.2014.04.036","article-title":"LIF mediates proinvasive activation of stromal fibroblasts in cancer","volume":"7","author":"Albrengues","year":"2014","journal-title":"Cell Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s12672-018-0337-6","article-title":"RNA Sequencing of Carboplatin- and Paclitaxel-Resistant Endometrial Cancer Cells Reveals New Stratification Markers and Molecular Targets for Cancer Treatment","volume":"9","author":"Hellweg","year":"2018","journal-title":"Horm. Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/(SICI)1097-0215(19960516)66:4<515::AID-IJC15>3.0.CO;2-6","article-title":"Leukemia-inhibitory factor stimulates breast, kidney and prostate cancer cell proliferation by paracrine and autocrine pathways","volume":"66","author":"Talpaz","year":"1996","journal-title":"Int. J. Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1210\/endo.141.12.7855","article-title":"Leukemia inhibitory factor can substitute for nidatory estrogen and is essential to inducing a receptive uterus for implantation but is not essential for subsequent embryogenesis","volume":"141","author":"Chen","year":"2000","journal-title":"Endocrinology"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/21\/5400\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:09:16Z","timestamp":1760144956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/21\/5400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,2]]},"references-count":37,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["cancers14215400"],"URL":"https:\/\/doi.org\/10.3390\/cancers14215400","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,2]]}}}