{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:56:37Z","timestamp":1790776597285,"version":"4.1.0"},"reference-count":353,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Multidisciplinary supportive care, integrating the dimensions of exercise alongside oncological treatments, is now regarded as a new paradigm to improve patient survival and quality of life. Its impact is important on the factors that control tumor development, such as the immune system, inflammation, tissue perfusion, hypoxia, insulin resistance, metabolism, glucocorticoid levels, and cachexia. An increasing amount of research has been published in the last years on the effects of physical activity within the framework of oncology, marking the appearance of a new medical field, commonly known as \u201cexercise oncology\u201d. This emerging research field is trying to determine the biological mechanisms by which, aerobic exercise affects the incidence of cancer, the progression and\/or the appearance of metastases. We propose an overview of the current state of the art physical exercise interventions in the management of cancer patients, including a pragmatic perspective with tips for routine practice. We then develop the emerging mechanistic views about physical exercise and their potential clinical applications. Moving toward a more personalized, integrated, patient-centered, and multidisciplinary management, by trying to understand the different interactions between the cancer and the host, as well as the impact of the disease and the treatments on the different organs, this seems to be the most promising method to improve the care of cancer patients.<\/jats:p>","DOI":"10.3390\/cancers14215402","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T03:11:21Z","timestamp":1667445081000},"page":"5402","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Physical Activity as the Best Supportive Care in Cancer: The Clinician\u2019s and the Researcher\u2019s Perspectives"],"prefix":"10.3390","volume":"14","author":[{"given":"C\u00e9cile","family":"Torregrosa","sequence":"first","affiliation":[{"name":"Oncologie Digestive, D\u00e9partement d\u2019Oncologie M\u00e9dicale Institut Curie, Universit\u00e9 Versailles Saint-Quentin\u2014Universit\u00e9 Paris Saclay, 35, rue Dailly, 92210 Saint-Cloud, France"},{"name":"D\u00e9partement de Chirurgie Digestive et Oncologique, H\u00f4pital Universitaire Ambroise Par\u00e9, Assistance Publique-H\u00f4pitaux de Paris, 9 avenue Charles de Gaulle, 92100 Boulogne Billancourt, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Chorin","sequence":"additional","affiliation":[{"name":"Laboratoire Motricit\u00e9 Humaine, Expertise, Sport, Sant\u00e9 (LAMHESS), HEALTHY Graduate School, Universit\u00e9 C\u00f4te d\u2019Azur, 06205 Nice, France"},{"name":"Clinique G\u00e9riatrique du Cerveau et du Mouvement, Centre Hospitalier Universitaire de Nice, Universit\u00e9 C\u00f4te d\u2019Azur, 06205 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Ester Molina","family":"Beltran","sequence":"additional","affiliation":[{"name":"Oncologie Digestive, D\u00e9partement d\u2019Oncologie M\u00e9dicale Institut Curie, Universit\u00e9 Versailles Saint-Quentin\u2014Universit\u00e9 Paris Saclay, 35, rue Dailly, 92210 Saint-Cloud, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7037-7477","authenticated-orcid":false,"given":"Cindy","family":"Neuzillet","sequence":"additional","affiliation":[{"name":"Oncologie Digestive, D\u00e9partement d\u2019Oncologie M\u00e9dicale Institut Curie, Universit\u00e9 Versailles Saint-Quentin\u2014Universit\u00e9 Paris Saclay, 35, rue Dailly, 92210 Saint-Cloud, France"},{"name":"GERCOR, 151 rue du Faubourg Saint-Antoine, 75011 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5595-187X","authenticated-orcid":false,"given":"Victoire","family":"Cardot-Ruffino","sequence":"additional","affiliation":[{"name":"Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA"},{"name":"Department of Immunology, Harvard Medical School, Boston, MA 02215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0140-6736(10)62231-3","article-title":"Cancer Survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995\u20132007 (the International Cancer Benchmarking Partnership): An Analysis of Population-Based Cancer Registry Data","volume":"377","author":"Coleman","year":"2011","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1200\/JCO.20.00611","article-title":"Management of Cancer Cachexia: ASCO Guideline","volume":"38","author":"Roeland","year":"2020","journal-title":"J. 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