{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:14:53Z","timestamp":1789636493801,"version":"4.0.0"},"reference-count":30,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Upper urinary tract urothelial carcinoma (UTUC) is an uncommon disease and its gold-standard treatment is radical nephroureterectomy (RNU). Distal ureterectomy (DU) might be an alternative for tumors of the distal ureter but its indications remain unclear. Here, we aimed to evaluate the oncological outcomes of DU for UTUC of the pelvic ureter. We performed a multicenter retrospective analysis of patients with UTUC who underwent DU. The primary endpoint was 5-year cancer-specific survival (CSS), followed by overall survival (OS), intravesical recurrence-free (IVR) and homolateral urinary tract recurrence-free (HUR) survivals as secondary endpoints. Univariate and multivariate Cox regressions were performed to assess factors associated with outcomes. 155 patients were included, 91% of which were high-risk. 5-year CSS was 84.4%, OS was 71.9%, IVR-free survival was 43.6% and HUR-free survival was 74.4%. Multifocality, high grade and tumor size were the most significant predictors of survival endpoints. Of note, neither hydronephrosis nor pre-operative diagnostic ureteroscopy\/JJ stent were associated with any of the endpoints. Perioperative morbidity was minimal. In conclusion, DU stands as a possible alternative to RNU for UTUC of the pelvic ureter. Close monitoring is mandatory due to the high risk of recurrence in the remaining urinary tract.<\/jats:p>","DOI":"10.3390\/cancers14215452","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T02:43:51Z","timestamp":1667789031000},"page":"5452","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Oncological Outcomes of Distal Ureterectomy for High-Risk Urothelial Carcinoma: A Multicenter Study by The French Bladder Cancer Committee"],"prefix":"10.3390","volume":"14","author":[{"given":"Alexandra","family":"Masson-Lecomte","sequence":"first","affiliation":[{"name":"Department of Urology, APHP, H\u00f4pital Saint Louis, 75010 Paris, France"},{"name":"Inserm, CEA, HIPI, Universit\u00e9 Paris Cit\u00e9, 75475 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoire","family":"Vaillant","sequence":"additional","affiliation":[{"name":"Department of Urology, APHP, H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est Cr\u00e9teil, 94000 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Roumigui\u00e9","sequence":"additional","affiliation":[{"name":"Department of Urology, CHU de Toulouse, UPS, Universit\u00e9 de Toulouse, 31000 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phan","family":"L\u00e9vy","sequence":"additional","affiliation":[{"name":"Department of Urology, CHU de Toulouse, UPS, Universit\u00e9 de Toulouse, 31000 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7768-8558","authenticated-orcid":false,"given":"Benjamin","family":"Prad\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Urology-UROSUD, La Croix du Sud Hospital, 31130 Quint-Fonsegrives, France"},{"name":"Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u00ebl","family":"Peyromaure","sequence":"additional","affiliation":[{"name":"Department of Urology, APHP, H\u00f4pital Cochin, Universit\u00e9 Paris Cit\u00e9, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Duquesne","sequence":"additional","affiliation":[{"name":"Department of Urology, APHP, H\u00f4pital Cochin, Universit\u00e9 Paris Cit\u00e9, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"De La Taille","sequence":"additional","affiliation":[{"name":"Department of Urology, APHP, H\u00f4pital Henri Mondor, Universit\u00e9 Paris-Est Cr\u00e9teil, 94000 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Leb\u00e2cle","sequence":"additional","affiliation":[{"name":"Department of Urology, APHP, H\u00f4pital Bic\u00eatre, Universit\u00e9 Paris Sud-Saclay, 94270 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Panis","sequence":"additional","affiliation":[{"name":"Department of Urology, APHP, H\u00f4pital Bic\u00eatre, Universit\u00e9 Paris Sud-Saclay, 94270 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Traxer","sequence":"additional","affiliation":[{"name":"GRC 10 Lithiase Urinaire, Department of Urology, APHP, Tenon Hospital, Sorbonne University, 75020 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Leon","sequence":"additional","affiliation":[{"name":"Department of Urology, clinique Pasteur, 17200 Royan, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Hulin","sequence":"additional","affiliation":[{"name":"Department of Urology, clinique Pasteur, 17200 Royan, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evanguelos","family":"Xylinas","sequence":"additional","affiliation":[{"name":"Department of Urology, APHP, H\u00f4pital Bichat Claude-Bernard, Universit\u00e9 Paris Cit\u00e9, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5722-2075","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Audenet","sequence":"additional","affiliation":[{"name":"Department of Urology, APHP, H\u00f4pital Europ\u00e9en Georges Pompidou, Universit\u00e9 Paris Cit\u00e9, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Seisen","sequence":"additional","affiliation":[{"name":"GRC 5 Predictive Onco-Urology, Department of Urology, APHP, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Sorbonne University, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohann","family":"Loriot","sequence":"additional","affiliation":[{"name":"Department of Cancer Medicine, INSERM U981, Gustave Roussy, Universit\u00e9 Paris-Saclay, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5526-077X","authenticated-orcid":false,"given":"Yves","family":"Allory","sequence":"additional","affiliation":[{"name":"Department of Pathology, Curie Institute, University of Paris-Saclay\u2013UVSQ, 92210 Saint-Cloud, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Roupr\u00eat","sequence":"additional","affiliation":[{"name":"GRC 5 Predictive Onco-Urology, Department of Urology, APHP, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Sorbonne University, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Neuzillet","sequence":"additional","affiliation":[{"name":"Department of Urology, H\u00f4pital Foch, University of Paris-Saclay\u2013UVSQ, 92150 Suresnes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer Statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA A Cancer J. 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Urol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.eururo.2012.04.052","article-title":"Impact of Distal Ureter Management on Oncologic Outcomes Following Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma","volume":"65","author":"Xylinas","year":"2014","journal-title":"Eur. Urol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1111\/iju.12554","article-title":"Equivalent Survival and Improved Preservation of Renal Function after Distal Ureterectomy Compared with Nephroureterectomy in Patients with Urothelial Carcinoma of the Distal Ureter: A Propensity Score-Matched Multicenter Study: Clinical Outcomes of Distal Ureterectomy","volume":"21","author":"Fukushima","year":"2014","journal-title":"Int. J. 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Focus"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.euf.2021.03.018","article-title":"Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-Stratify Patients Eligible for Kidney-Sparing Strategies: An International Collaborative Study","volume":"8","author":"Marcq","year":"2022","journal-title":"Eur. Urol. Focus"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.eururo.2021.05.004","article-title":"Pretreatment Risk Stratification for Endoscopic Kidney-Sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study","volume":"80","author":"Foerster","year":"2021","journal-title":"Eur. 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A Systematic Review and Meta-Analysis","volume":"205","author":"Sountoulides","year":"2021","journal-title":"J. Urol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/21\/5452\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:11:26Z","timestamp":1760145086000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/21\/5452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,6]]},"references-count":30,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["cancers14215452"],"URL":"https:\/\/doi.org\/10.3390\/cancers14215452","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,6]]}}}