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They act as multifunctional regulators of intercellular communication by delivering bioactive molecules, including non-coding RNAs (ncRNAs). Metastasis is a major cause of cancer-related death. Most cancer cells disseminate and colonize a specific target organ via EVs, a process known as \u201corgan-specific metastasis\u201d. Mounting evidence has shown that EVs are enriched with ncRNAs, and various EV-ncRNAs derived from tumor cells influence organ-specific metastasis via different mechanisms. Due to the tissue-specific expression of EV-ncRNAs, they could be used as potential biomarkers and therapeutic targets for the treatment of tumor metastasis in various types of cancer. In this review, we have discussed the underlying mechanisms of EV-delivered ncRNAs in the most common organ-specific metastases of liver, bone, lung, brain, and lymph nodes. Moreover, we summarize the potential clinical applications of EV-ncRNAs in organ-specific metastasis to fill the gap between benches and bedsides.<\/jats:p>","DOI":"10.3390\/cancers14225693","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T04:13:36Z","timestamp":1669004016000},"page":"5693","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Non-Coding RNAs of Extracellular Vesicles: Key Players in Organ-Specific Metastasis and Clinical Implications"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6882-1305","authenticated-orcid":false,"given":"Qian","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, First Affiliated Hospital of Yangtze University, Health Science Center, Yangtze University, Jingzhou 434023, China"},{"name":"Digestive Disease Research Institution of Yangtze University, Yangtze University, Jingzhou 434023, China"},{"name":"Department of Cardiovascular Medicine, Honghu Hospital of Traditional Chinese Medicine, Honghu 433200, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ping","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, First Affiliated Hospital of Yangtze University, Health Science Center, Yangtze University, Jingzhou 434023, China"},{"name":"Digestive Disease Research Institution of Yangtze University, Yangtze University, Jingzhou 434023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai-Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou 434023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Honghu Hospital of Traditional Chinese Medicine, Honghu 433200, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Du","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou 434023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou 434023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Xuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingzhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore"},{"name":"Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore"},{"name":"NUS Centre for Cancer Research (N2CR), National University of Singapore, Singapore 117599, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7675-1845","authenticated-orcid":false,"given":"Zhaowu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, First Affiliated Hospital of Yangtze University, Health Science Center, Yangtze University, Jingzhou 434023, China"},{"name":"School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou 434023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.cell.2016.01.043","article-title":"Communication by Extracellular Vesicles: Where We Are and Where We Need to Go","volume":"164","author":"Tkach","year":"2016","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"eaau6977","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"ref_3","unstructured":"Buzas, E. 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