{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:30:05Z","timestamp":1793089805574,"version":"4.5.0"},"reference-count":314,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003323","name":"Agence Nationale de la Recherche sur le Sida et les Hepatites Virales","doi-asserted-by":"publisher","award":["D22157"],"award-info":[{"award-number":["D22157"]}],"id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Viruses play an important role in cancer development as about 12% of cancer types are linked to viral infections. Viruses that induce cellular transformation are known as oncoviruses. Although the mechanisms of viral oncogenesis differ between viruses, all oncogenic viruses share the ability to establish persistent chronic infections with no obvious symptoms for years. During these prolonged infections, oncogenic viruses manipulate cell signaling pathways that control cell cycle progression, apoptosis, inflammation, and metabolism. Importantly, it seems that most oncoviruses depend on these changes for their persistence and amplification. Metabolic changes induced by oncoviruses share many common features with cancer metabolism. Indeed, viruses, like proliferating cancer cells, require increased biosynthetic precursors for virion production, need to balance cellular redox homeostasis, and need to ensure host cell survival in a given tissue microenvironment. Thus, like for cancer cells, viral replication and persistence of infected cells frequently depend on metabolic changes. Here, we draw parallels between metabolic changes observed in cancers or induced by oncoviruses, with a focus on pathways involved in the regulation of glucose, lipid, and amino acids. We describe whether and how oncoviruses depend on metabolic changes, with the perspective of targeting them for antiviral and onco-therapeutic approaches in the context of viral infections.<\/jats:p>","DOI":"10.3390\/cancers14235742","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T03:15:24Z","timestamp":1669173324000},"page":"5742","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["An Update on the Metabolic Landscape of Oncogenic Viruses"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9038-6597","authenticated-orcid":false,"given":"Ahmed","family":"Gaballah","sequence":"first","affiliation":[{"name":"Pathogenesis of Chronic Hepatitis B and C Laboratory\u2014LabEx DEVweCAN, Inserm U1052, Cancer Research Centre of Lyon, 69424 Lyon, France"},{"name":"University of Lyon, 69424 Lyon, France"},{"name":"Institut des Sciences Pharmaceutiques et Biologiques, University Lyon 1, 69424 Lyon, France"},{"name":"CNRS UMR5286, 69424 Lyon, France"},{"name":"Centre L\u00e9on B\u00e9rard, 69424 Lyon, France"},{"name":"Microbiology Department, Medical Research Institute, Alexandria University, Alexandria 5424041, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6354-4660","authenticated-orcid":false,"given":"Birke","family":"Bartosch","sequence":"additional","affiliation":[{"name":"Pathogenesis of Chronic Hepatitis B and C Laboratory\u2014LabEx DEVweCAN, Inserm U1052, Cancer Research Centre of Lyon, 69424 Lyon, France"},{"name":"University of Lyon, 69424 Lyon, France"},{"name":"Institut des Sciences Pharmaceutiques et Biologiques, University Lyon 1, 69424 Lyon, France"},{"name":"CNRS UMR5286, 69424 Lyon, France"},{"name":"Centre L\u00e9on B\u00e9rard, 69424 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref_2","first-page":"3","article-title":"About the formation of cancer cells","volume":"34","author":"Warburg","year":"1956","journal-title":"Strahlentherapie"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000223920","article-title":"Origin of cancer cells","volume":"9","author":"Warburg","year":"1956","journal-title":"Oncologia"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-cellbio-092910-154237","article-title":"Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation","volume":"27","author":"Lunt","year":"2011","journal-title":"Annu. 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