{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:46:40Z","timestamp":1788281200592,"version":"build-2803163510"},"reference-count":22,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T00:00:00Z","timestamp":1669420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Advances in imaging technologies have increased the opportunities for treating small-diameter renal cell carcinomas (RCCs) in the elderly. This retrospective study based on real-world clinical practice compared perioperative complications, preoperative and postoperative renal function, recurrence-free survival, and overall survival in elderly patients with RCC who had undergone robot-assisted partial nephrectomy (RAPN) or percutaneous cryoablation (PCA). A total of 99 patients (aged \u226570 years), including 50 and 49 patients in the RAPN and PCA groups, respectively, were analyzed. In the entire cohort, Clavien\u2013Dindo grade \u22653 complications occurred in only one patient who had undergone RAPN. Renal function was significantly lower in the postoperative period than in the preoperative period in both the RAPN and PCA groups. The recurrence-free survival and overall survival rates were worse in the PCA group than in the RAPN group, albeit not significantly. RAPN was considered a safe and effective method for treating RCCs in elderly patients. Moreover, although the recurrence rate was slightly higher in the PCA group than in the RAPN group, PCA was deemed to be a safe alternative, especially for treating patients in whom general anesthesia poses a high risk.<\/jats:p>","DOI":"10.3390\/cancers14235843","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T07:01:30Z","timestamp":1669618890000},"page":"5843","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of Clinical Outcomes between Robot-Assisted Partial Nephrectomy and Cryoablation in Elderly Patients with Renal Cancer"],"prefix":"10.3390","volume":"14","author":[{"given":"Shohei","family":"Kawaguchi","sequence":"first","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8480-9100","authenticated-orcid":false,"given":"Kouji","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suguru","family":"Kadomoto","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3599-2217","authenticated-orcid":false,"given":"Hiroaki","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3188-8834","authenticated-orcid":false,"given":"Hiroshi","family":"Yaegashi","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Nohara","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2118-9135","authenticated-orcid":false,"given":"Kazuyoshi","family":"Shigehara","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8398-0969","authenticated-orcid":false,"given":"Kotaro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5780-4032","authenticated-orcid":false,"given":"Yoshifumi","family":"Kadono","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Mizokami","sequence":"additional","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.eururo.2022.03.006","article-title":"European association of urology guidelines on renal cell carcinoma: The 2022 update","volume":"82","author":"Ljungberg","year":"2022","journal-title":"Eur. Urol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/bju.14530","article-title":"Peri-operative and local control outcomes of robot-assisted partial nephrectomy vs percutaneous cryoablation for renal masses: Comparison after matching on radiological stage and renal score","volume":"123","author":"Fraisse","year":"2019","journal-title":"BJU Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.21873\/anticanres.14407","article-title":"The impact of hypertension on the clinicopathological outcome and progression of renal cell carcinoma","volume":"40","author":"Makino","year":"2020","journal-title":"Anticancer Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1159\/000521881","article-title":"A systematic review and meta-analysis of comparison of outcomes of robot-assisted versus open partial nephrectomy in clinical t1 renal cell carcinoma patients","volume":"106","author":"Ni","year":"2022","journal-title":"Urol. Int."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.euo.2018.08.029","article-title":"The role of ablation and minimally invasive techniques in the management of small renal masses","volume":"1","author":"Salagierski","year":"2018","journal-title":"Eur. Urol. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.21873\/invivo.12413","article-title":"Therapeutic and clinical outcomes of robot-assisted partial nephrectomy versus cryoablation for t1 renal cell carcinoma","volume":"35","author":"Uemura","year":"2021","journal-title":"In Vivo"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/iju.14758","article-title":"Percutaneous ablation or minimally invasive partial nephrectomy for ct1a renal masses? A propensity score-matched analysis","volume":"29","author":"Bianchi","year":"2022","journal-title":"Int. J. Urol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.juro.2009.05.035","article-title":"The R.E.N.A.L. Nephrometry score: A comprehensive standardized system for quantitating renal tumor size, location and depth","volume":"182","author":"Kutikov","year":"2009","journal-title":"J. Urol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s00270-016-1414-2","article-title":"Transcatheter arterial embolization with a mixture of absolute ethanol and iodized oil for poorly visualized endophytic renal masses prior to ct-guided percutaneous cryoablation","volume":"39","author":"Michimoto","year":"2016","journal-title":"Cardiovasc. Interv. Radiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"938.e1","DOI":"10.1016\/j.urolonc.2020.09.024","article-title":"Functional and oncological outcome of percutaneous cryoablation versus laparoscopic partial nephrectomy for clinical t1 renal tumors: A propensity score-matched analysis","volume":"38","author":"Yanagisawa","year":"2020","journal-title":"Urol. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.juro.2012.09.042","article-title":"\u201cTrifecta\u201d in partial nephrectomy","volume":"189","author":"Hung","year":"2013","journal-title":"J. Urol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e1963","DOI":"10.1002\/rcs.1963","article-title":"Open versus robotic partial nephrectomy: Systematic review and meta-analysis of contemporary studies","volume":"15","author":"Tsai","year":"2019","journal-title":"Int. J. Med. Robot."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Kawase, K., Enomoto, T., Kawase, M., Takai, M., Kato, D., Fujimoto, S., Iinuma, K., Nakane, K., Kato, S., and Hagiwara, N. (2022). The impact of postoperative renal function recovery after laparoscopic and robot-assisted partial nephrectomy in patients with renal cell carcinoma. Medicina, 58.","DOI":"10.3390\/medicina58040485"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.21873\/anticanres.15792","article-title":"Preservation of split renal function after laparoscopic and robot-assisted partial nephrectomy","volume":"42","author":"Ohba","year":"2022","journal-title":"Anticancer Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"101588","DOI":"10.1016\/j.suronc.2021.101588","article-title":"Partial nephrectomy in frail patients: Benefits of robot-assisted surgery","volume":"38","author":"Rosiello","year":"2021","journal-title":"Surg. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"106194","DOI":"10.1016\/j.ijsu.2021.106194","article-title":"Ablative therapies versus partial nephrectomy for small renal masses\u2014A systematic review and meta-analysis","volume":"97","author":"Chan","year":"2022","journal-title":"Int. J. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.jvir.2018.12.013","article-title":"Radiofrequency ablation, cryoablation, and microwave ablation for t1a renal cell carcinoma: A comparative evaluation of therapeutic and renal function outcomes","volume":"30","author":"Zhou","year":"2019","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1681\/ASN.2020020151","article-title":"Gfr in healthy aging: An individual participant data meta-analysis of iohexol clearance in european population-based cohorts","volume":"31","author":"Eriksen","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Abdulkader, R., Burdmann, E.A., Lebr\u00e3o, M.L., Duarte, Y.A.O., and Zanetta, D.M.T. (2017). Aging and decreased glomerular filtration rate: An elderly population-based study. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0189935"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00345-010-0549-z","article-title":"The role of radiologic imaging and biopsy in renal tumor ablation","volume":"28","author":"Anderson","year":"2010","journal-title":"World J. Urol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s11604-019-00821-7","article-title":"Cryoablation of renal cell carcinoma for patients with stage 4 or 5 non-dialysis chronic kidney disease","volume":"37","author":"Gobara","year":"2019","journal-title":"Jpn. J. Radiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1007\/s00259-019-04613-z","article-title":"Follow-up imaging after cryoablation of clear cell renal cell carcinoma is feasible using single photon emission computed tomography with (111)in-girentuximab","volume":"47","author":"Langenhuijsen","year":"2020","journal-title":"Eur. J. Nucl. Med. Mol. 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