{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:02:24Z","timestamp":1768521744998,"version":"3.49.0"},"reference-count":46,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Simple and accessible prognostic factors are paramount for solid cancer patients experiencing life-threatening complications. The aim of this study is to appraise the impact of functional and nutritional status and skeletal muscle mass in this population. We conducted a retrospective (2007\u20132020) single-center study by enrolling adult patients with solid cancers requiring unplanned ICU admission. Performance status, body weight, and albumin level were collected at ICU admission and over six months. Skeletal muscle mass was assessed at ICU admission by measuring muscle areas normalized by height (SMI). Four-hundred and sixty-two patients were analyzed, mainly with gastro-intestinal (34.8%) and lung (29.9%) neoplasms. Moreover, 92.8% of men and 67.3% of women were deemed cachectic. In the multivariate analysis, performance status at ICU admission (CSH 1.74 [1.27\u20132.39], p &lt; 0.001) and the six month increase in albumin level (CSH 0.38 [0.16\u20130.87], p = 0.02) were independent predictors of ICU mortality. In the subgroup of mechanically ventilated patients, the psoas SMI was independently associated with ICU mortality (CSH 0.82 [0.67\u20130.98], p = 0.04). Among the 368 ICU-survivors, the performance status at ICU admission (CSH 1.34 [1.14\u20131.59], p &lt; 0.001) and the six-month weight loss (CSH 1.33 [1.17\u20132.99], p = 0.01) were associated with a one-year mortality rate. Most cancer patients displayed cachexia at ICU admission. Time courses of nutritional parameters may aid the prediction of short- and long-term outcomes.<\/jats:p>","DOI":"10.3390\/cancers14235870","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T02:09:58Z","timestamp":1669687798000},"page":"5870","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Assessment of Functional and Nutritional Status and Skeletal Muscle Mass for the Prognosis of Critically Ill Solid Cancer Patients"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6966-5268","authenticated-orcid":false,"given":"Clara","family":"Vigneron","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, H\u00f4pital Cochin, Assistance Publique-H\u00f4pitaux de Paris, Centre-Universit\u00e9 Paris Cit\u00e9, 75014 Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, 75014 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Othmane","family":"Laousy","sequence":"additional","affiliation":[{"name":"Service de Radiologie, H\u00f4pital Cochin, Assistance Publique-H\u00f4pitaux de Paris, Centre-Universit\u00e9 Paris Cit\u00e9, 75014 Paris, France"},{"name":"Ecole CentraleSupelec, Math\u00e9matiques et Informatique pour la Complexit\u00e9 et les Syst\u00e8mes, Universit\u00e9 Paris-Saclay, 91190 Gif-sur-Yvette, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Chassagnon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, 75014 Paris, France"},{"name":"Service de Radiologie, H\u00f4pital Cochin, Assistance Publique-H\u00f4pitaux de Paris, Centre-Universit\u00e9 Paris Cit\u00e9, 75014 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Vakalopoulou","sequence":"additional","affiliation":[{"name":"Ecole CentraleSupelec, Math\u00e9matiques et Informatique pour la Complexit\u00e9 et les Syst\u00e8mes, Universit\u00e9 Paris-Saclay, 91190 Gif-sur-Yvette, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Charpentier","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, H\u00f4pital Cochin, Assistance Publique-H\u00f4pitaux de Paris, Centre-Universit\u00e9 Paris Cit\u00e9, 75014 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Alexandre","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, 75014 Paris, France"},{"name":"Service D\u2019oncologie M\u00e9dicale, H\u00f4pital Cochin, Assistance Publique-H\u00f4pitaux de Paris, Centre-Universit\u00e9 Paris Cit\u00e9, 75014 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthieu","family":"Jamme","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, H\u00f4pital Priv\u00e9 de l\u2019Ouest Parisien, Ramsay G\u00e9n\u00e9rale de Sant\u00e9, 78190 Trappes, France"},{"name":"Team 5 (EpReC, Renal and Cardiovascular Epidemiology), Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations, Universit\u00e9 de Versailles Saint-Quentin, 78000 Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"P\u00e8ne","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Intensive-R\u00e9animation, H\u00f4pital Cochin, Assistance Publique-H\u00f4pitaux de Paris, Centre-Universit\u00e9 Paris Cit\u00e9, 75014 Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, 75014 Paris, France"},{"name":"INSERM U1016, CNRS UMR8104, Institut Cochin, 75014 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S2213-2600(14)70061-X","article-title":"Assessment of the Worldwide Burden of Critical Illness: The Intensive Care Over Nations (ICON) Audit","volume":"2","author":"Vincent","year":"2014","journal-title":"Lancet Respir. 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