{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:02:13Z","timestamp":1791223333595,"version":"4.1.0"},"reference-count":32,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University Cancer Research Fund of North Carolina, the Susan G Komen Foundation","award":["OGUNC1202"],"award-info":[{"award-number":["OGUNC1202"]}]},{"name":"University Cancer Research Fund of North Carolina, the Susan G Komen Foundation","award":["P01CA151135"],"award-info":[{"award-number":["P01CA151135"]}]},{"name":"University Cancer Research Fund of North Carolina, the Susan G Komen Foundation","award":["NIH\/NCI P50-CA058223"],"award-info":[{"award-number":["NIH\/NCI P50-CA058223"]}]},{"name":"National Cancer Institute of the National Institutes of Health","award":["OGUNC1202"],"award-info":[{"award-number":["OGUNC1202"]}]},{"name":"National Cancer Institute of the National Institutes of Health","award":["P01CA151135"],"award-info":[{"award-number":["P01CA151135"]}]},{"name":"National Cancer Institute of the National Institutes of Health","award":["NIH\/NCI P50-CA058223"],"award-info":[{"award-number":["NIH\/NCI P50-CA058223"]}]},{"name":"National Cancer Institute Specialised Program of Research Excellence (SPORE) in Breast Cancer","award":["OGUNC1202"],"award-info":[{"award-number":["OGUNC1202"]}]},{"name":"National Cancer Institute Specialised Program of Research Excellence (SPORE) in Breast Cancer","award":["P01CA151135"],"award-info":[{"award-number":["P01CA151135"]}]},{"name":"National Cancer Institute Specialised Program of Research Excellence (SPORE) in Breast Cancer","award":["NIH\/NCI P50-CA058223"],"award-info":[{"award-number":["NIH\/NCI P50-CA058223"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The objectives of this work were to (i) describe upper-body symptoms post-breast cancer; (ii) explore the relationship between symptoms and upper-body function, breast cancer-related lymphoedema (BCRL), physical activity levels, and quality of life; and (iii) determine whether the presence of upper-body symptoms predicts BCRL. Nine symptoms, upper-body function, lymphoedema, physical activity, and quality of life were assessed in women with invasive breast cancer at baseline (2- to 9-months post-diagnosis; n = 2442), and at 2- and 7-years post-diagnosis. Mann\u2013Whitney tests, unpaired t-tests, and chi-squared analyses were used to assess cross-sectional relationships, while regression analyses were used to assess the predictive relationships between symptoms at baseline, and BCRL at 2- and 7-years post-diagnosis. Symptoms are common post-breast cancer and persist at 2- and 7-years post-diagnosis. Approximately two in three women, and one in three women, reported &gt;2 symptoms of at least mild severity, and of at least moderate severity, respectively. The presence of symptoms is associated with poorer upper-body function, and lower physical activity levels and quality of life. One or more symptoms of at least moderate severity increases the odds of developing BCRL by 2- and 7-years post-diagnosis (p &lt; 0.05). Consequently, improved monitoring and management of symptoms following breast cancer have the potential to improve health outcomes.<\/jats:p>","DOI":"10.3390\/cancers14235998","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T09:46:45Z","timestamp":1670233605000},"page":"5998","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Do Patient-Reported Upper-Body Symptoms Predict Breast Cancer-Related Lymphoedema: Results from a Population-Based, Longitudinal Breast Cancer Cohort Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Sandra C.","family":"Hayes","sequence":"first","affiliation":[{"name":"Menzies Health Institute Queensland, Griffith University, Brisbane 4111, Australia"},{"name":"School of Health Sciences and Social Work, Griffith University, Brisbane 4111, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Dunn","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie L.","family":"Plinsinga","sequence":"additional","affiliation":[{"name":"Menzies Health Institute Queensland, Griffith University, Brisbane 4111, Australia"},{"name":"School of Health Sciences and Social Work, Griffith University, Brisbane 4111, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hildegard","family":"Reul-Hirche","sequence":"additional","affiliation":[{"name":"Menzies Health Institute Queensland, Griffith University, Brisbane 4111, Australia"},{"name":"School of Health Sciences and Social Work, Griffith University, Brisbane 4111, Australia"},{"name":"Royal Brisbane and Women\u2019s Hospital, Physiotherapy Department, Brisbane 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4820-1090","authenticated-orcid":false,"given":"E-Liisa","family":"Laakso","sequence":"additional","affiliation":[{"name":"Menzies Health Institute Queensland, Griffith University, Brisbane 4111, Australia"},{"name":"Mater Research, South Brisbane 4101, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A.","family":"Troester","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.breast.2022.08.010","article-title":"Current and future burden of breast cancer: Global statistics for 2020 and 2040","volume":"66","author":"Arnold","year":"2022","journal-title":"Breast"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0140-6736(17)33326-3","article-title":"Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): Analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries","volume":"391","author":"Allemani","year":"2018","journal-title":"Lancet"},{"key":"ref_3","unstructured":"(2022, March 07). 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